WO2006104901A3 - Materials and methods for improved tissue engineering - Google Patents

Materials and methods for improved tissue engineering Download PDF

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Publication number
WO2006104901A3
WO2006104901A3 PCT/US2006/010827 US2006010827W WO2006104901A3 WO 2006104901 A3 WO2006104901 A3 WO 2006104901A3 US 2006010827 W US2006010827 W US 2006010827W WO 2006104901 A3 WO2006104901 A3 WO 2006104901A3
Authority
WO
WIPO (PCT)
Prior art keywords
methods
tissue engineering
improved tissue
materials
culturing
Prior art date
Application number
PCT/US2006/010827
Other languages
French (fr)
Other versions
WO2006104901A2 (en
Inventor
Michael H Tollon
Takashi Hamazaki
Bradley Jay Willenberg
Christopher D Batich
Naohiro Terada
Original Assignee
Univ Florida
Michael H Tollon
Takashi Hamazaki
Bradley Jay Willenberg
Christopher D Batich
Naohiro Terada
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Florida, Michael H Tollon, Takashi Hamazaki, Bradley Jay Willenberg, Christopher D Batich, Naohiro Terada filed Critical Univ Florida
Publication of WO2006104901A2 publication Critical patent/WO2006104901A2/en
Publication of WO2006104901A3 publication Critical patent/WO2006104901A3/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/18—Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3604—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel
    • A61L27/3633—Extracellular matrix [ECM]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3804—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by specific cells or progenitors thereof, e.g. fibroblasts, connective tissue cells, kidney cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3804—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by specific cells or progenitors thereof, e.g. fibroblasts, connective tissue cells, kidney cells
    • A61L27/3834—Cells able to produce different cell types, e.g. hematopoietic stem cells, mesenchymal stem cells, marrow stromal cells, embryonic stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3895—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells using specific culture conditions, e.g. stimulating differentiation of stem cells, pulsatile flow conditions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/56—Porous materials, e.g. foams or sponges
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M25/00—Means for supporting, enclosing or fixing the microorganisms, e.g. immunocoatings
    • C12M25/14—Scaffolds; Matrices

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Zoology (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Dermatology (AREA)
  • Medicinal Chemistry (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cell Biology (AREA)
  • Botany (AREA)
  • Urology & Nephrology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Biotechnology (AREA)
  • Immunology (AREA)
  • Dispersion Chemistry (AREA)
  • Hematology (AREA)
  • Microbiology (AREA)
  • Sustainable Development (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)

Abstract

The subject invention provides materials and methods for improved tissue engineering. Specifically, the current invention pertains to the identification of advantageous extracellular matrix material scaffold coatings that can be used as described herein to modulate cell seeding, attachment, culturing, proliferation, and/or differentiation to a target cell. In a further embodiment, the scaffolds of the subject invention are used to modulate stem cells. In specific embodiments, a basement membrane preparation or gelatin can be used to coat polycaprolactone (PCL) scaffolds used for seeding, attaching, culturing, proliferating, and/or differentiating cells.
PCT/US2006/010827 2005-03-28 2006-03-23 Materials and methods for improved tissue engineering WO2006104901A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US66576205P 2005-03-28 2005-03-28
US60/665,762 2005-03-28

Publications (2)

Publication Number Publication Date
WO2006104901A2 WO2006104901A2 (en) 2006-10-05
WO2006104901A3 true WO2006104901A3 (en) 2007-07-05

Family

ID=36940225

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2006/010827 WO2006104901A2 (en) 2005-03-28 2006-03-23 Materials and methods for improved tissue engineering

Country Status (1)

Country Link
WO (1) WO2006104901A2 (en)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102005030614B4 (en) 2005-06-30 2014-05-08 Biotissue Ag Cell-free graft, its use, process for its preparation, matrix thus produced with gel and process for the preparation of this matrix with gel
DE102006047346A1 (en) 2006-10-06 2008-04-10 Transtissue Technologies Gmbh Matrix gel graft without cells
CN101595211B (en) 2006-10-27 2013-04-24 戴念梓 Skin substitutes, preparation methods and uses thereof
EP2229435B1 (en) * 2007-12-06 2016-03-02 Agency for Science, Technology And Research Method for extracellular matrix mediated differentiation and proliferation of stem cells
CN101496913B (en) * 2008-01-31 2012-09-26 中国人民解放军总医院 Cartilage cell epimatrix three-dimensional porous sponge stent for tissue engineering and preparation method thereof
ES2380674B1 (en) * 2010-06-30 2013-05-13 Universidad De Malaga MESENQUIMAL CELLS AND COMPOSITE MEMBRANE FOR THE TREATMENT OF OSTEOCONDRAL INJURIES
CN102242463B (en) * 2011-04-20 2013-06-05 东华大学 Method for preparing gelatin/polycaprolactone composite nanometer fiber membrane through electrostatic spinning
WO2017064667A2 (en) * 2015-10-14 2017-04-20 Universidad De Los Andes Automated fabrication of layer-by-layer tissue engineered complex tubes
WO2022192668A1 (en) * 2021-03-12 2022-09-15 Discoverybiomed, Inc. Human taste bud tissue-derived cells and uses thereof

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5487897A (en) * 1989-07-24 1996-01-30 Atrix Laboratories, Inc. Biodegradable implant precursor
WO2001070293A1 (en) * 2000-03-18 2001-09-27 The University Of Nottingham Polymeric composite materials and their manufacture
US6537567B1 (en) * 1997-07-03 2003-03-25 Massachusetts Institute Of Technology Tissue-engineered tubular construct having circumferentially oriented smooth muscle cells
US20030077311A1 (en) * 1999-06-30 2003-04-24 Vyakarnam Murty N. Foam composite for the repair or regeneration of tissue
WO2003087444A1 (en) * 2002-04-11 2003-10-23 Aston University Polymeric fibre and method for making same
US20040005297A1 (en) * 2002-07-08 2004-01-08 Connelly Patrick R. Biological scaffold
US20050031598A1 (en) * 2002-12-10 2005-02-10 Shulamit Levenberg Engineering three-dimensional tissue structures using differentiating embryonic stem cells

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5487897A (en) * 1989-07-24 1996-01-30 Atrix Laboratories, Inc. Biodegradable implant precursor
US6537567B1 (en) * 1997-07-03 2003-03-25 Massachusetts Institute Of Technology Tissue-engineered tubular construct having circumferentially oriented smooth muscle cells
US20030077311A1 (en) * 1999-06-30 2003-04-24 Vyakarnam Murty N. Foam composite for the repair or regeneration of tissue
WO2001070293A1 (en) * 2000-03-18 2001-09-27 The University Of Nottingham Polymeric composite materials and their manufacture
WO2003087444A1 (en) * 2002-04-11 2003-10-23 Aston University Polymeric fibre and method for making same
US20040005297A1 (en) * 2002-07-08 2004-01-08 Connelly Patrick R. Biological scaffold
US20050031598A1 (en) * 2002-12-10 2005-02-10 Shulamit Levenberg Engineering three-dimensional tissue structures using differentiating embryonic stem cells

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
LEVENBERG S ET AL: "Differentiation of human embryonic stem cells on three-dimensional polymer scaffolds", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, NATIONAL ACADEMY OF SCIENCE, WASHINGTON, DC, US, vol. 100, no. 22, 28 October 2003 (2003-10-28), pages 12741 - 12746, XP002980824, ISSN: 0027-8424 *
TOLLON ET AL: "FABRICATION OF COATED POLYCAPROLACTONE SCAFFOLDS AND THEIR EFFECTS ON MURINE EMBRYONIC CELLS", MATER. RES. SOC. SYMP. PROC., vol. 873E, 2005, pages K9.14.1 - K9.14.5, XP002431014 *
TOLLON MICHEAL: "fabrication of coated biodegradable polymer scaffolds and their effects on murine embryonic stem cells", 2005, UNIVERSITY OF FLORIDA, XP002431323 *
WILLIAMSON M R ET AL: "Gravity spinning of polycaprolactone fibres for applications in tissue engineering", BIOMATERIALS, ELSEVIER SCIENCE PUBLISHERS BV., BARKING, GB, vol. 25, no. 3, February 2004 (2004-02-01), pages 459 - 465, XP004469639, ISSN: 0142-9612 *
YOUNG A T: "MICROCELLULAR FOAMS VIA PHASE SEPARATION", JOURNAL OF VACUUM SCIENCE AND TECHNOLOGY: PART A, AVS /AIP, MELVILLE, NY, US, vol. 4, no. 3, PART II, 1 May 1986 (1986-05-01), pages 1128 - 1133, XP000005423, ISSN: 0734-2101 *

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Publication number Publication date
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