WO2006103452A3 - Improved nitroreductase enzymes - Google Patents
Improved nitroreductase enzymes Download PDFInfo
- Publication number
- WO2006103452A3 WO2006103452A3 PCT/GB2006/001180 GB2006001180W WO2006103452A3 WO 2006103452 A3 WO2006103452 A3 WO 2006103452A3 GB 2006001180 W GB2006001180 W GB 2006001180W WO 2006103452 A3 WO2006103452 A3 WO 2006103452A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- improved
- nitroreductase
- mutants
- prodrug
- nitroreductase enzymes
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0012—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7)
- C12N9/0036—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on NADH or NADPH (1.6)
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB0506642A GB0506642D0 (en) | 2005-04-01 | 2005-04-01 | Improved nitroreductase enzymes |
GB0506642.8 | 2005-04-01 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2006103452A2 WO2006103452A2 (en) | 2006-10-05 |
WO2006103452A3 true WO2006103452A3 (en) | 2006-12-14 |
Family
ID=34586548
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/GB2006/001180 WO2006103452A2 (en) | 2005-04-01 | 2006-03-30 | Improved nitroreductase enzymes |
Country Status (2)
Country | Link |
---|---|
GB (1) | GB0506642D0 (en) |
WO (1) | WO2006103452A2 (en) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2010048976A1 (en) * | 2008-10-31 | 2010-05-06 | Universita' Degli Studi Di Pavia | NITROREDUCTASE NfnB FROM MYCOBACTERIUM SMEGMATIS |
GB0915249D0 (en) | 2009-09-02 | 2009-10-07 | Univ Bangor | Drug carrier |
WO2012008860A2 (en) | 2010-07-16 | 2012-01-19 | Auckland Uniservices Limited | Bacterial nitroreductase enzymes and methods relating thereto |
GB201320679D0 (en) * | 2013-11-22 | 2014-01-08 | Univ Nottingham | Polypeptides,polynucleotides and uses thereof |
LT7046B (en) | 2022-04-15 | 2024-02-12 | Vilniaus Universitetas | Hydrolases and uses thereof |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2003018788A2 (en) * | 2001-08-21 | 2003-03-06 | Ml Laboratories Plc | Improved nitroreductase enzymes |
-
2005
- 2005-04-01 GB GB0506642A patent/GB0506642D0/en not_active Ceased
-
2006
- 2006-03-30 WO PCT/GB2006/001180 patent/WO2006103452A2/en not_active Application Discontinuation
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2003018788A2 (en) * | 2001-08-21 | 2003-03-06 | Ml Laboratories Plc | Improved nitroreductase enzymes |
Non-Patent Citations (3)
Title |
---|
GROVE JANE I ET AL: "Generation of Escherichia coli nitroreductase mutants conferring improved cell sensitization to the prodrug CB1954.", CANCER RESEARCH, vol. 63, no. 17, 1 September 2003 (2003-09-01), pages 5532 - 5537, XP002399200, ISSN: 0008-5472 * |
SEARLE PETER F ET AL: "Nitroreductase: A prodrug-activating enzyme for cancer gene therapy", CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY, vol. 31, no. 11, November 2004 (2004-11-01), pages 811 - 816, XP002399201, ISSN: 0305-1870 * |
ZENNO S ET AL: "Conversion of NfsB, a minor Escherichia coli nitroreductase, to a flavin reductase similar in biochemical properties to FRase I, the major flavin reductase in Vibrio fischeri, by a single amino acid substitution", JOURNAL OF BACTERIOLOGY, WASHINGTON, DC, US, vol. 178, no. 15, August 1996 (1996-08-01), pages 4731 - 4733, XP002227224, ISSN: 0021-9193 * |
Also Published As
Publication number | Publication date |
---|---|
GB0506642D0 (en) | 2005-05-11 |
WO2006103452A2 (en) | 2006-10-05 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
WO2006103452A3 (en) | Improved nitroreductase enzymes | |
WO2008106646A3 (en) | Methods and formulations for topical gene therapy | |
WO2002057664A3 (en) | Bacillus thuringiensis insecticidal proteins | |
MY149422A (en) | 5-(arylsulfonyl)-pyrazolopiperidines | |
WO2002100353A3 (en) | Cd10-activated prodrug compounds | |
WO2008119780A3 (en) | Fungal peroxygenases and methods of application | |
WO2008065372A3 (en) | Modified erythropoietin polypeptides and uses thereof for treatment | |
ATE503009T1 (en) | POLYPEPTIDES WITH LIPASE ACTIVITY AND POLYNUCLEOTIDES ENCODING SAME | |
WO2004055160A3 (en) | Biomolecular coupling methods using 1,3-dipolar cycloaddition chemistry | |
PT1945632E (en) | Heterocyclic modulators of atp-binding cassette transporters | |
WO2004020595A8 (en) | Novel human polypeptides encoded by polynucleotides | |
WO2007067682A3 (en) | In vivo cell surface engineering | |
WO2006047469A8 (en) | Polypeptides having lipase activity and polynucleotides encoding same | |
WO2006026331A3 (en) | Fiber-modified adenoviral vectors for enhanced transduction of tumor cells | |
IL180233A0 (en) | Tumor-homing cells engineered to produce tumor necrosis factor-related apoptosis inducing ligand (trail) | |
ZA200901054B (en) | Skin care compositions and related methods | |
TW200734350A (en) | Polypeptides having antimicrobial activity and polynucleotides encoding same | |
WO2005100587A3 (en) | Methods for obtaining optically active epoxides and vicinal diols from 2,2-disubstituted epoxides | |
WO2010045469A3 (en) | Muc18 targeting peptides | |
WO2006097110A3 (en) | Polypeptides having antimicrobial activity and polynucleotides encoding same | |
WO2009037253A3 (en) | Polypeptides having tyrosinase activity and polynucleotides encoding same | |
WO2002088305A3 (en) | Isolation and identification of mouse and human transcription control elements associated with cytochrome expression | |
WO2005034876A3 (en) | Use of cell lines to produce active therapeutic proteins | |
WO2002012279A3 (en) | Schizophrenia related gene and protein | |
WO2006044045A3 (en) | Cryptosporidium hominis genes and gene products for chemotherapeutic, immunoprophylactic and diagnostic applications |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
NENP | Non-entry into the national phase |
Ref country code: DE |
|
WWW | Wipo information: withdrawn in national office |
Country of ref document: DE |
|
NENP | Non-entry into the national phase |
Ref country code: RU |
|
WWW | Wipo information: withdrawn in national office |
Country of ref document: RU |
|
121 | Ep: the epo has been informed by wipo that ep was designated in this application |
Ref document number: 06726586 Country of ref document: EP Kind code of ref document: A2 |
|
122 | Ep: pct application non-entry in european phase |
Ref document number: 06726586 Country of ref document: EP Kind code of ref document: A2 |
|
WWW | Wipo information: withdrawn in national office |
Ref document number: 6726586 Country of ref document: EP |