WO2006097617A3 - Nouveaux derives dihydropyrimidines et leur utilisation comme agents anti-cancereux - Google Patents

Nouveaux derives dihydropyrimidines et leur utilisation comme agents anti-cancereux Download PDF

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Publication number
WO2006097617A3
WO2006097617A3 PCT/FR2006/000556 FR2006000556W WO2006097617A3 WO 2006097617 A3 WO2006097617 A3 WO 2006097617A3 FR 2006000556 W FR2006000556 W FR 2006000556W WO 2006097617 A3 WO2006097617 A3 WO 2006097617A3
Authority
WO
WIPO (PCT)
Prior art keywords
cancer agents
dihydropyrimidine derivatives
novel dihydropyrimidine
novel
derivatives
Prior art date
Application number
PCT/FR2006/000556
Other languages
English (en)
Other versions
WO2006097617A2 (fr
WO2006097617B1 (fr
Inventor
Roman Lopez
Bernard Rousseau
Frank Kozielsky
Dimitrios Skoufias
Bonis Salvatore De
Original Assignee
Commissariat Energie Atomique
Roman Lopez
Bernard Rousseau
Frank Kozielsky
Dimitrios Skoufias
Bonis Salvatore De
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Commissariat Energie Atomique, Roman Lopez, Bernard Rousseau, Frank Kozielsky, Dimitrios Skoufias, Bonis Salvatore De filed Critical Commissariat Energie Atomique
Priority to US11/908,710 priority Critical patent/US20080145453A1/en
Priority to JP2008501362A priority patent/JP2008534449A/ja
Priority to CA002601425A priority patent/CA2601425A1/fr
Priority to EP06726083A priority patent/EP1885368A2/fr
Publication of WO2006097617A2 publication Critical patent/WO2006097617A2/fr
Publication of WO2006097617A3 publication Critical patent/WO2006097617A3/fr
Publication of WO2006097617B1 publication Critical patent/WO2006097617B1/fr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/20—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D239/22—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Abstract

Molécules répondant à la formule (I) médicaments les comprenant et leur utilisation comme agents anti-cancéreux.
PCT/FR2006/000556 2005-03-15 2006-03-14 Nouveaux derives dihydropyrimidines et leur utilisation comme agents anti-cancereux WO2006097617A2 (fr)

Priority Applications (4)

Application Number Priority Date Filing Date Title
US11/908,710 US20080145453A1 (en) 2005-03-15 2006-03-14 Novel Dihydropyrimidine Derivatives And Their Use As Anti-Cancer Agents
JP2008501362A JP2008534449A (ja) 2005-03-15 2006-03-14 新しいジヒドロピリミジン誘導体およびそれらの抗癌剤としての使用
CA002601425A CA2601425A1 (fr) 2005-03-15 2006-03-14 Nouveaux derives dihydropyrimidines et leur utilisation comme agents anti-cancereux
EP06726083A EP1885368A2 (fr) 2005-03-15 2006-03-14 Nouveaux derives dihydropyrimidines et leur utilisation comme agents anti-cancereux

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0502518A FR2883284A1 (fr) 2005-03-15 2005-03-15 Nouveaux derives dihydropyrimidines et leur utilisation comme agents anti-cancereux
FR0502518 2005-03-25

Publications (3)

Publication Number Publication Date
WO2006097617A2 WO2006097617A2 (fr) 2006-09-21
WO2006097617A3 true WO2006097617A3 (fr) 2006-12-28
WO2006097617B1 WO2006097617B1 (fr) 2007-02-22

Family

ID=35169846

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/FR2006/000556 WO2006097617A2 (fr) 2005-03-15 2006-03-14 Nouveaux derives dihydropyrimidines et leur utilisation comme agents anti-cancereux

Country Status (6)

Country Link
US (1) US20080145453A1 (fr)
EP (1) EP1885368A2 (fr)
JP (1) JP2008534449A (fr)
CA (1) CA2601425A1 (fr)
FR (1) FR2883284A1 (fr)
WO (1) WO2006097617A2 (fr)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010062861A2 (fr) 2008-11-26 2010-06-03 Satiogen Pharmaceuticals, Inc. Inhibiteurs de recyclage de l'acide biliaire pour le traitement de l'obésité et du diabète
CN102316889B (zh) 2008-11-26 2014-11-26 萨蒂奥根制药公司 组合物及使用方法
EP2480086A4 (fr) 2009-09-25 2013-03-20 N30 Pharmaceuticals Inc Nouveaux composés dihydropyrimidine-2(1h)-ones en tant qu'inhibiteurs de la s-nitrosoglutathion réductase
EP2995317A1 (fr) 2010-05-26 2016-03-16 Satiogen Pharmaceuticals, Inc. Inhibiteurs de recyclage d'acide biliaire et satiogènes pour le traitement du diabète, de l'obésité et des conditions gastro-intestinales inflammatoires
WO2012039718A1 (fr) 2010-09-24 2012-03-29 N30 Pharmaceuticals, Llc Composés innovants de dihydropyrimidine-2(1h)-un en tant qu'antagonistes des récepteurs de neurokinine-3
SG10201909122QA (en) 2011-10-28 2019-11-28 Lumena Pharmaceuticals Inc Bile acid recycling inhibitors for treatment of pediatric cholestatic liver diseases
EP2682389A1 (fr) * 2012-07-02 2014-01-08 Commissariat A L'energie Atomique Et Aux Energies Alternatives Dihydropyrimidine-2(1h)-ones et dihydropyrimidin-2(1h)-thiones en tant qu'inhibiteurs de symport d'iodure de sodium
WO2016004028A1 (fr) * 2014-07-01 2016-01-07 Latif Rauf Dérivés 2-oxopyrimidine-5-carboxylate pour le traitement de maladies de la thyroïde
US10052326B1 (en) 2017-10-12 2018-08-21 King Saud University Antihepatotoxic agents
US10047071B1 (en) 2018-01-15 2018-08-14 King Saud University Dihydropyrimidinone derivatives
CN111358792A (zh) * 2020-03-13 2020-07-03 中国人民解放军第四军医大学 Kif11抑制剂monastrol抑制病理性疼痛的应用

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997042956A1 (fr) * 1996-05-16 1997-11-20 Synaptic Pharmaceutical Corporation Dihydropyrimidines et leurs emplois
WO2002066443A2 (fr) * 2001-02-21 2002-08-29 Ono Pharmaceutical Co., Ltd. Derives de 2-thioxo-1,2,3,4-tetrahydropyrimidine
WO2002079169A1 (fr) * 2001-03-29 2002-10-10 Bristol-Myers Squibb Company Composes de dihydropyrimidine cyano-substitues et leur utilisation pour traiter des maladies

Family Cites Families (1)

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Publication number Priority date Publication date Assignee Title
JP2005512542A (ja) * 2001-12-17 2005-05-12 チルドレンズ・メディカル・センター・コーポレイション 化合物をスクリーニングする方法

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997042956A1 (fr) * 1996-05-16 1997-11-20 Synaptic Pharmaceutical Corporation Dihydropyrimidines et leurs emplois
WO2002066443A2 (fr) * 2001-02-21 2002-08-29 Ono Pharmaceutical Co., Ltd. Derives de 2-thioxo-1,2,3,4-tetrahydropyrimidine
WO2002079169A1 (fr) * 2001-03-29 2002-10-10 Bristol-Myers Squibb Company Composes de dihydropyrimidine cyano-substitues et leur utilisation pour traiter des maladies

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"Screening Collection", 11 August 2003, "ZELINSKY INSTITUTE OF ORGANIC CHEMISTRY", 47 LENINSKY PROSPECT, MOSCOW, 117913, RUSSIA *
BRINDABAN C. RANU ET ALL.: "Indium (III) Chloride-Catalysed One-Pot Synthesis of Dihydropyrimidinones by a Three-Component Coupling of 1,3-Dicarbonyl Compounds, Aldehydes, and Urea: An Improved Procedure for the Biginelli Reaction", J.ORG.CHEM., vol. 65, no. 19, 2000, pages 6270 - 6272, XP002403821 *
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KAPPE C O: "Biologically active dihydropyrimidones of the Biginelli-type - a literature survey", EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, EDITIONS SCIENTIFIQUE ELSEVIER, PARIS, FR, vol. 35, no. 12, December 2000 (2000-12-01), pages 1043 - 1052, XP004372823, ISSN: 0223-5234 *
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ZHU, YULIN; PAN, YUANJIANG; HUANG, SHENLIN, SYNTH. COMMUN., vol. 34, no. 17, 2004, pages 3167 - 3174 *

Also Published As

Publication number Publication date
WO2006097617A2 (fr) 2006-09-21
EP1885368A2 (fr) 2008-02-13
CA2601425A1 (fr) 2006-09-21
FR2883284A1 (fr) 2006-09-22
JP2008534449A (ja) 2008-08-28
WO2006097617B1 (fr) 2007-02-22
US20080145453A1 (en) 2008-06-19

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