WO2006094800A3 - Cascade reaction process - Google Patents

Cascade reaction process Download PDF

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Publication number
WO2006094800A3
WO2006094800A3 PCT/EP2006/002161 EP2006002161W WO2006094800A3 WO 2006094800 A3 WO2006094800 A3 WO 2006094800A3 EP 2006002161 W EP2006002161 W EP 2006002161W WO 2006094800 A3 WO2006094800 A3 WO 2006094800A3
Authority
WO
WIPO (PCT)
Prior art keywords
reaction process
cascade reaction
chemical
reaction
catalysed
Prior art date
Application number
PCT/EP2006/002161
Other languages
French (fr)
Other versions
WO2006094800A2 (en
Inventor
Paula Leandro L Garcia
Hest Jan C M Van
Alan E Rowan
Joost Nicolaas Hendrik Reek
Aldo Caiazzo
Original Assignee
Synthon Bv
Paula Leandro L Garcia
Hest Jan C M Van
Alan E Rowan
Joost Nicolaas Hendrik Reek
Aldo Caiazzo
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Synthon Bv, Paula Leandro L Garcia, Hest Jan C M Van, Alan E Rowan, Joost Nicolaas Hendrik Reek, Aldo Caiazzo filed Critical Synthon Bv
Publication of WO2006094800A2 publication Critical patent/WO2006094800A2/en
Publication of WO2006094800A3 publication Critical patent/WO2006094800A3/en

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J31/00—Catalysts comprising hydrides, coordination complexes or organic compounds
    • B01J31/003—Catalysts comprising hydrides, coordination complexes or organic compounds containing enzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/02—Amides, e.g. chloramphenicol or polyamides; Imides or polyimides; Urethanes, i.e. compounds comprising N-C=O structural element or polyurethanes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/10—Nitrogen as only ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/10—Nitrogen as only ring hetero atom
    • C12P17/12—Nitrogen as only ring hetero atom containing a six-membered hetero ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Materials Engineering (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Chemically Coating (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

The invention relates to a process, which comprises converting a chemical substrate into a chemical product by a cascade reaction wherein an enzyme-catalysed chemical transformation reaction and a metal-catalysed chemical transformation reaction are carried out essentially simultaneously.
PCT/EP2006/002161 2005-03-04 2006-03-03 Cascade reaction process WO2006094800A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US65836805P 2005-03-04 2005-03-04
US60/658,368 2005-03-04

Publications (2)

Publication Number Publication Date
WO2006094800A2 WO2006094800A2 (en) 2006-09-14
WO2006094800A3 true WO2006094800A3 (en) 2006-11-09

Family

ID=36572959

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2006/002161 WO2006094800A2 (en) 2005-03-04 2006-03-03 Cascade reaction process

Country Status (1)

Country Link
WO (1) WO2006094800A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8835472B2 (en) * 2010-09-02 2014-09-16 Boehringer Ingelheim International Gmbh Compounds, pharmaceutical compositions and uses thereof
CN115151252A (en) * 2020-03-02 2022-10-04 维泰瑞隆有限公司 Iron death inhibitors diarylamine para-acetamides
CN115305244A (en) * 2022-07-26 2022-11-08 南昌大学 Lipase-palladium-copper bimetallic composite catalyst, preparation thereof and application thereof in synthesis of chiral amine compound

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
EL GIHANI MOHAREM T ET AL: "Dynamic kinetic resolution", CURRENT OPINION IN CHEMICAL BIOLOGY, vol. 3, no. 1, February 1999 (1999-02-01), pages 11 - 15, XP002385862, ISSN: 1367-5931 *
GELMAN FAINA ET AL: "One-pot sequences of reactions with sol-gel entrapped opposing reagents: An enzyme and metal-complex catalysts.", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 124, no. 48, 4 December 2002 (2002-12-04), pages 14460 - 14463, XP002385861, ISSN: 0002-7863 *
KIM MAHN-JOO ET AL: "Asymmetric transformations of acyloxyphenyl ketones by enzyme-metal multicatalysis.", JOURNAL OF ORGANIC CHEMISTRY, vol. 67, no. 26, 27 December 2002 (2002-12-27), pages 9481 - 9483, XP002385860, ISSN: 0022-3263 *
PAMIES O ET AL: "Chemoenzymatic dynamic kinetic resolution", TRENDS IN BIOTECHNOLOGY, ELSEVIER PUBLICATIONS, CAMBRIDGE, GB, vol. 22, no. 3, March 2004 (2004-03-01), pages 130 - 135, XP004491828, ISSN: 0167-7799 *
REETZ M T ET AL: "LIPASE-CATALYZED DYNAMIC KINETIC RESOLUTION OF CHIRAL AMINES: USE OF PALLADIUM AS THE RACEMIZATION CATALYST", CHIMIA, AARAU, CH, vol. 50, no. 12, 1 December 1996 (1996-12-01), pages 668 - 669, XP009036319, ISSN: 0009-4293 *

Also Published As

Publication number Publication date
WO2006094800A2 (en) 2006-09-14

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