WO2006084643A3 - Novel gene vcs 07 - Google Patents
Novel gene vcs 07 Download PDFInfo
- Publication number
- WO2006084643A3 WO2006084643A3 PCT/EP2006/001009 EP2006001009W WO2006084643A3 WO 2006084643 A3 WO2006084643 A3 WO 2006084643A3 EP 2006001009 W EP2006001009 W EP 2006001009W WO 2006084643 A3 WO2006084643 A3 WO 2006084643A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- polynucleotides
- production
- vitamin
- relates
- microorganisms
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/02—Oxygen as only ring hetero atoms
- C12P17/04—Oxygen as only ring hetero atoms containing a five-membered hetero ring, e.g. griseofulvin, vitamin C
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Zoology (AREA)
- Biochemistry (AREA)
- Wood Science & Technology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Biotechnology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Microbiology (AREA)
- Biophysics (AREA)
- Gastroenterology & Hepatology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
The present invention relates to newly identified microorganisms capable of direct production of L-ascorbic acid (hereinafter also referred to as Vitamin C). The invention also relates to polynucleotide sequences comprising genes that encode proteins which are involved in the synthesis of Vitamin C. The invention also features polynucleotides comprising the full length polynucleotide sequences of the novel genes and fragments thereof, the novel polypeptides encoded by the polynucleotides and fragments thereof, as well as their functional equivalents. The present invention also relates to the use of said polynucleotides and polypeptides as biotechnological tools in the production of Vitamin C from microorganisms, whereby a modification of said polynucleotides and/or encoded polypeptides has a direct or indirect impact on yield, production, and/or efficiency of production of the fermentation product in said microorganism. Also included are methods/processes of using the polynucleotides and modified polynucleotide sequences to transform host microorganisms. The invention also relates to genetically engineered microorganisms and their use for the direct production of Vitamin C.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP05405098 | 2005-02-11 | ||
EP05405098.4 | 2005-02-11 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2006084643A2 WO2006084643A2 (en) | 2006-08-17 |
WO2006084643A3 true WO2006084643A3 (en) | 2006-11-02 |
Family
ID=36644264
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/EP2006/001009 WO2006084643A2 (en) | 2005-02-11 | 2006-02-06 | Novel gene vcs 07 |
Country Status (1)
Country | Link |
---|---|
WO (1) | WO2006084643A2 (en) |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0832974A2 (en) * | 1996-09-19 | 1998-04-01 | F. Hoffmann-La Roche Ag | Alcohol-aldehyd-dehydrogenases |
WO2004029268A1 (en) * | 2002-09-27 | 2004-04-08 | Dsm Ip Assets B.V. | Microbial production of vitamin c |
WO2005017159A2 (en) * | 2003-08-14 | 2005-02-24 | Dsm Ip Assets B.V. | Microbial production of l-ascorbic acid |
-
2006
- 2006-02-06 WO PCT/EP2006/001009 patent/WO2006084643A2/en not_active Application Discontinuation
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0832974A2 (en) * | 1996-09-19 | 1998-04-01 | F. Hoffmann-La Roche Ag | Alcohol-aldehyd-dehydrogenases |
WO2004029268A1 (en) * | 2002-09-27 | 2004-04-08 | Dsm Ip Assets B.V. | Microbial production of vitamin c |
WO2005017159A2 (en) * | 2003-08-14 | 2005-02-24 | Dsm Ip Assets B.V. | Microbial production of l-ascorbic acid |
Non-Patent Citations (7)
Title |
---|
BREMUS ET AL: "The use of microorganisms in l-ascorbic acid production", JOURNAL OF BIOTECHNOLOGY, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL, vol. 124, no. 1, 25 June 2006 (2006-06-25), pages 196 - 205, XP005480510, ISSN: 0168-1656 * |
DATABASE EMBL EBI; 24 January 2005 (2005-01-24), XP002390336, retrieved from EBI accession no. CP000009 * |
DATABASE UniProt 19 September 2002 (2002-09-19), XP002390337, retrieved from EBI Database accession no. Q8XZJ6 * |
HANCOCK R D ET AL: "Biotechnological approaches for l-ascorbic acid production", TRENDS IN BIOTECHNOLOGY, ELSEVIER PUBLICATIONS, CAMBRIDGE, GB, vol. 20, no. 7, 1 July 2002 (2002-07-01), pages 299 - 305, XP004361398, ISSN: 0167-7799 * |
MACAULEY S ET AL: "THE GENUS GLUCONOBACTER AND ITS APPLICATIONS IN BIOTECHNOLOGY", CRC CRITICAL REVIEWS IN BIOTECHNOLOGY, CRC PRESS, BOCA RATON, FL, US, vol. 21, no. 1, 2001, pages 1 - 25, XP008026977, ISSN: 0738-8551 * |
PRUST C ET AL: "Complete genome sequence of the acetic acid bacterium Gluconobacter oxydans", NATURE BIOTECHNOLOGY, NATURE PUBLISHING GROUP, NEW YORK, NY, US, vol. 23, no. 2, February 2005 (2005-02-01), pages 195 - 200, XP002334906, ISSN: 1087-0156 * |
SUGISAWA T ET AL: "MICROBIAL PRODUCTION OF L-ASCORBIC ACID FROM D-SORBITOL, L-SORBOSE, L-GULOSE, AND L-SORBOSONE BY KETOGULONICIGENIUM VULGARE DSM 4025", BIOSCIENCE BIOTECHNOLOGY BIOCHEMISTRY, JAPAN SOC. FOR BIOSCIENCE, BIOTECHNOLOGY AND AGROCHEM, TOKYO, JP, vol. 69, no. 3, 2005, pages 659 - 662, XP009054184, ISSN: 0916-8451 * |
Also Published As
Publication number | Publication date |
---|---|
WO2006084643A2 (en) | 2006-08-17 |
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