WO2006083800A3 - Nucleic acid silencing of huntington's disease gene - Google Patents
Nucleic acid silencing of huntington's disease gene Download PDFInfo
- Publication number
- WO2006083800A3 WO2006083800A3 PCT/US2006/003298 US2006003298W WO2006083800A3 WO 2006083800 A3 WO2006083800 A3 WO 2006083800A3 US 2006003298 W US2006003298 W US 2006003298W WO 2006083800 A3 WO2006083800 A3 WO 2006083800A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- huntington
- nucleic acid
- disease gene
- acid silencing
- silencing
- Prior art date
Links
- 208000023105 Huntington disease Diseases 0.000 title abstract 2
- 108090000623 proteins and genes Proteins 0.000 title abstract 2
- 230000030279 gene silencing Effects 0.000 title 1
- 108020004707 nucleic acids Proteins 0.000 title 1
- 150000007523 nucleic acids Chemical class 0.000 title 1
- 102000039446 nucleic acids Human genes 0.000 title 1
- 108020004459 Small interfering RNA Proteins 0.000 abstract 3
- 239000004055 small Interfering RNA Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/11—Antisense
- C12N2310/111—Antisense spanning the whole gene, or a large part of it
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/14—Type of nucleic acid interfering N.A.
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/50—Physical structure
- C12N2310/53—Physical structure partially self-complementary or closed
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Organic Chemistry (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Priority Applications (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU2006210973A AU2006210973A1 (en) | 2005-01-31 | 2006-01-31 | Nucleic acid silencing of Huntington's Disease gene |
CA2596588A CA2596588C (en) | 2005-01-31 | 2006-01-31 | Nucleic acid silencing of huntington's disease gene |
EP06734091A EP1844148A2 (en) | 2005-01-31 | 2006-01-31 | Nucleic acid silencing of huntington's disease gene |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US11/048,627 | 2005-01-31 | ||
US11/048,627 US20050255086A1 (en) | 2002-08-05 | 2005-01-31 | Nucleic acid silencing of Huntington's Disease gene |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2006083800A2 WO2006083800A2 (en) | 2006-08-10 |
WO2006083800A3 true WO2006083800A3 (en) | 2007-03-01 |
Family
ID=36777811
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2006/003298 WO2006083800A2 (en) | 2005-01-31 | 2006-01-31 | Nucleic acid silencing of huntington's disease gene |
Country Status (4)
Country | Link |
---|---|
EP (1) | EP1844148A2 (en) |
AU (1) | AU2006210973A1 (en) |
CA (1) | CA2596588C (en) |
WO (1) | WO2006083800A2 (en) |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9139828B2 (en) | 2008-05-14 | 2015-09-22 | Prosensa Technologies B.V. | Method for efficient exon (44) skipping in duchenne muscular dystrophy and associated means |
US9243245B2 (en) | 2007-10-26 | 2016-01-26 | Academisch Ziekenhuis Leiden | Means and methods for counteracting muscle disorders |
US9260716B2 (en) | 2002-08-05 | 2016-02-16 | University Of Iowa Research Foundation | RNA interference suppression of neurodegenerative diseases and methods of use thereof |
US9487779B2 (en) | 2002-08-05 | 2016-11-08 | University Of Iowa Research Foundation | siRNA-mediated gene silencing |
Families Citing this family (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2002166817A (en) | 1999-10-01 | 2002-06-11 | Daicel Chem Ind Ltd | Hybrid inflator |
US20050042646A1 (en) | 2002-08-05 | 2005-02-24 | Davidson Beverly L. | RNA interference suppresion of neurodegenerative diseases and methods of use thereof |
SI2049664T1 (en) | 2006-08-11 | 2012-04-30 | Prosensa Technologies Bv | Single stranded oligonucleotides complementary to repetitive elements for treating DNA repeat instability associated genetic disorders |
US20080039415A1 (en) * | 2006-08-11 | 2008-02-14 | Gregory Robert Stewart | Retrograde transport of sirna and therapeutic uses to treat neurologic disorders |
CA2688514A1 (en) | 2007-04-26 | 2008-11-06 | University Of Iowa Research Foundation | Rna interference suppression of neurodegenerative diseases and methods of use thereof |
EP2164967B1 (en) | 2007-05-31 | 2015-07-08 | University of Iowa Research Foundation | Reduction of off-target rna interference toxicity |
JP2010533170A (en) | 2007-07-12 | 2010-10-21 | プロセンサ テクノロジーズ ビー.ブイ. | Molecules for targeting compounds to various selected organs, tissues or tumor cells |
JP5706157B2 (en) | 2007-07-12 | 2015-04-22 | プロセンサ テクノロジーズ ビー.ブイ.Prosensa Technologies B.V. | Molecules for targeting compounds to various selected organs or tissues |
USRE48468E1 (en) | 2007-10-26 | 2021-03-16 | Biomarin Technologies B.V. | Means and methods for counteracting muscle disorders |
AU2009210872A1 (en) * | 2008-02-08 | 2009-08-13 | Prosensa Holding Bv | Methods and means for treating DNA repeat instability associated genetic disorders |
CA2759899A1 (en) | 2009-04-24 | 2010-10-28 | Prosensa Technologies B.V. | Oligonucleotide comprising an inosine for treating dmd |
EP2673286B1 (en) | 2011-02-12 | 2019-07-03 | University of Iowa Research Foundation | Therapeutic compounds |
BR112014018427B1 (en) | 2012-01-27 | 2021-11-03 | Biomarin Technologies B.V. | RNA MODULATOR OLIGONUCLEOTIDES WITH IMPROVED FEATURES FOR THE TREATMENT OF DUCHENNE AND BECKER'S MUSCULAR DYSTROPHY |
CN104271741A (en) | 2012-04-23 | 2015-01-07 | 普罗森萨科技有限公司 | RNA modulating oligonucleotides with improved characteristics for the treatment of neuromuscular disorders |
JP6628285B2 (en) | 2013-03-14 | 2020-01-08 | ユニバーシティ オブ フロリダ リサーチ ファンデーション インコーポレーティッド | ALS-related diamino acid repeat-containing protein |
US9523093B2 (en) | 2014-05-20 | 2016-12-20 | University Of Iowa Research Foundation | Huntington's disease therapeutic compounds |
WO2016196324A1 (en) * | 2015-05-29 | 2016-12-08 | University Of Floridia Research Foundation, Inc. | Methods for diagnosing huntington's disease |
EP3440100A4 (en) | 2016-04-04 | 2020-01-22 | University of Florida Research Foundation, Incorporated | Manipulation of eif3 to modulate repeat associated non-atg (ran) translation |
US11951121B2 (en) | 2016-05-18 | 2024-04-09 | Voyager Therapeutics, Inc. | Compositions and methods for treating Huntington's disease |
CA3060250A1 (en) | 2017-04-17 | 2018-10-25 | University Of Florida Research Foundation, Incorporated | Regulation of ran protein translation by pkr and eif2a-p pathways |
AR113134A1 (en) * | 2017-09-22 | 2020-01-29 | Genzyme Corp | ARNI VARIANT |
US11903910B2 (en) | 2017-09-26 | 2024-02-20 | University Of Florida Research Foundation, Incorporated | Use of metformin and analogs thereof to reduce RAN protein levels in the treatment of neurological disorders |
AU2018354195A1 (en) * | 2017-10-23 | 2020-06-04 | Prevail Therapeutics, Inc. | Gene therapies for neurodegenerative disease |
CN112980837B (en) * | 2019-12-13 | 2023-07-04 | 深圳艾码生物科技有限公司 | siRNA for inhibiting HTT gene expression, precursor and application thereof |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2004013280A2 (en) * | 2002-08-05 | 2004-02-12 | University Of Iowa Research Foundation | ALLELE-SPECIFIC siRNA-MEDIATED GENE SILENCING |
WO2004047872A2 (en) * | 2002-11-26 | 2004-06-10 | Medtronic, Inc. | Treatment of neurodegenerative disease through intracranial delivery of short interfering rna (sirna) |
US20050042646A1 (en) * | 2002-08-05 | 2005-02-24 | Davidson Beverly L. | RNA interference suppresion of neurodegenerative diseases and methods of use thereof |
WO2005105995A2 (en) * | 2004-04-14 | 2005-11-10 | Sirna Therapeutics, Inc. | RNA INTERFERENCE MEDIATED TREATMENT OF POLYGLUTAMINE (POLYQ) REPEAT EXPANSION DISEASES USING SHORT INTERFERING NUCLEIC ACID (siNA) |
WO2006031267A2 (en) * | 2004-06-02 | 2006-03-23 | University Of Iowa Research Foundation | Rna interference suppression of neurodegenerative diseases and methods of use thereof |
-
2006
- 2006-01-31 EP EP06734091A patent/EP1844148A2/en not_active Withdrawn
- 2006-01-31 WO PCT/US2006/003298 patent/WO2006083800A2/en active Application Filing
- 2006-01-31 AU AU2006210973A patent/AU2006210973A1/en not_active Abandoned
- 2006-01-31 CA CA2596588A patent/CA2596588C/en active Active
Patent Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2004013280A2 (en) * | 2002-08-05 | 2004-02-12 | University Of Iowa Research Foundation | ALLELE-SPECIFIC siRNA-MEDIATED GENE SILENCING |
WO2004058940A2 (en) * | 2002-08-05 | 2004-07-15 | University Of Iowa Research Foundation | Sirna-mediated gene silencing |
US20050042646A1 (en) * | 2002-08-05 | 2005-02-24 | Davidson Beverly L. | RNA interference suppresion of neurodegenerative diseases and methods of use thereof |
WO2004047872A2 (en) * | 2002-11-26 | 2004-06-10 | Medtronic, Inc. | Treatment of neurodegenerative disease through intracranial delivery of short interfering rna (sirna) |
WO2005105995A2 (en) * | 2004-04-14 | 2005-11-10 | Sirna Therapeutics, Inc. | RNA INTERFERENCE MEDIATED TREATMENT OF POLYGLUTAMINE (POLYQ) REPEAT EXPANSION DISEASES USING SHORT INTERFERING NUCLEIC ACID (siNA) |
WO2006031267A2 (en) * | 2004-06-02 | 2006-03-23 | University Of Iowa Research Foundation | Rna interference suppression of neurodegenerative diseases and methods of use thereof |
Non-Patent Citations (4)
Title |
---|
DAVIDSON B L ET AL: "Molecular medicine for the brain: silencing of disease genes with RNA interference", LANCET NEUROLOGY, vol. 3, no. 3, March 2004 (2004-03-01), pages 145 - 149, XP004808832, ISSN: 1474-4422 * |
DAVIDSON B L ET AL: "VIRAL VECTORS FOR GENE DELIVERY TO THE NERVOUS SYSTEM", NATURE REVIEWS NEUROSCIENCE, vol. 4, no. 5, May 2003 (2003-05-01), pages 353 - 364, XP001180914, ISSN: 1471-0048 * |
LIU W ET AL: "Specific inhibition of Huntington's disease gene expression by siRNAs in cultures cells", PROCEEDINGS OF THE JAPAN ACADEMY. SERIES B, PHYSICAL AND BIOLOGICAL SCIENCES, vol. 79B, no. 10, December 2003 (2003-12-01), pages 293 - 298, XP002983007, ISSN: 0386-2208 * |
XIA H ET AL: "RNAi suppresses polyglutamine-induced neurodegeneration in a model of spinocerebellar ataxia", NATURE MEDICINE, vol. 10, no. 8, August 2004 (2004-08-01), pages 816 - 820, XP002311180, ISSN: 1078-8956 * |
Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9260716B2 (en) | 2002-08-05 | 2016-02-16 | University Of Iowa Research Foundation | RNA interference suppression of neurodegenerative diseases and methods of use thereof |
US9487779B2 (en) | 2002-08-05 | 2016-11-08 | University Of Iowa Research Foundation | siRNA-mediated gene silencing |
US9243245B2 (en) | 2007-10-26 | 2016-01-26 | Academisch Ziekenhuis Leiden | Means and methods for counteracting muscle disorders |
US9499818B2 (en) | 2007-10-26 | 2016-11-22 | BioMarin Technologies, B.V. | Methods and means for efficient skipping of at least one of the exons 51-53, 55, 57 and 59 of the human duchenne muscular dystrophy gene |
US9528109B2 (en) | 2007-10-26 | 2016-12-27 | Biomarin Technologies B.V. | Methods and means for efficient skipping of exon 45 in duchenne muscular dystrophy pre-mRNA |
US9139828B2 (en) | 2008-05-14 | 2015-09-22 | Prosensa Technologies B.V. | Method for efficient exon (44) skipping in duchenne muscular dystrophy and associated means |
Also Published As
Publication number | Publication date |
---|---|
AU2006210973A1 (en) | 2006-08-10 |
CA2596588C (en) | 2017-06-27 |
WO2006083800A2 (en) | 2006-08-10 |
CA2596588A1 (en) | 2006-08-10 |
EP1844148A2 (en) | 2007-10-17 |
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