WO2006079918A1 - Injection device for administering a medication liquid - Google Patents

Injection device for administering a medication liquid Download PDF

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Publication number
WO2006079918A1
WO2006079918A1 PCT/IB2006/000176 IB2006000176W WO2006079918A1 WO 2006079918 A1 WO2006079918 A1 WO 2006079918A1 IB 2006000176 W IB2006000176 W IB 2006000176W WO 2006079918 A1 WO2006079918 A1 WO 2006079918A1
Authority
WO
WIPO (PCT)
Prior art keywords
housing
plunger
injection device
forward movement
preparation
Prior art date
Application number
PCT/IB2006/000176
Other languages
French (fr)
Inventor
Birger Thure Yngvar Hjertman
Original Assignee
Pharmacia Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from EP05100449A external-priority patent/EP1700613A1/en
Application filed by Pharmacia Corporation filed Critical Pharmacia Corporation
Publication of WO2006079918A1 publication Critical patent/WO2006079918A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31565—Administration mechanisms, i.e. constructional features, modes of administering a dose
    • A61M5/31576—Constructional features or modes of drive mechanisms for piston rods
    • A61M5/31578—Constructional features or modes of drive mechanisms for piston rods based on axial translation, i.e. components directly operatively associated and axially moved with plunger rod
    • A61M5/3158—Constructional features or modes of drive mechanisms for piston rods based on axial translation, i.e. components directly operatively associated and axially moved with plunger rod performed by axially moving actuator operated by user, e.g. an injection button
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31533—Dosing mechanisms, i.e. setting a dose
    • A61M5/31535—Means improving security or handling thereof, e.g. blocking means, means preventing insufficient dosing, means allowing correction of overset dose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M2005/3125—Details specific display means, e.g. to indicate dose setting
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M2005/3125—Details specific display means, e.g. to indicate dose setting
    • A61M2005/3126—Specific display means related to dosing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/58—Means for facilitating use, e.g. by people with impaired vision
    • A61M2205/583—Means for facilitating use, e.g. by people with impaired vision by visual feedback
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/24—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31533—Dosing mechanisms, i.e. setting a dose
    • A61M5/31545—Setting modes for dosing
    • A61M5/31548—Mechanically operated dose setting member
    • A61M5/3155—Mechanically operated dose setting member by rotational movement of dose setting member, e.g. during setting or filling of a syringe
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31565—Administration mechanisms, i.e. constructional features, modes of administering a dose
    • A61M5/31566—Means improving security or handling thereof
    • A61M5/31568—Means keeping track of the total dose administered, e.g. since the cartridge was inserted
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31565—Administration mechanisms, i.e. constructional features, modes of administering a dose
    • A61M5/3159—Dose expelling manners
    • A61M5/31593—Multi-dose, i.e. individually set dose repeatedly administered from the same medicament reservoir

Definitions

  • the present invention relates to an injection device for administering multiple doses of a medication liquid and provides a fast and simple way to check that the volume of the dose that one is preparing to administer to oneself or to another person corresponds to the programmed volume of the dose .
  • Injection devices of the above kind are known in the art .
  • One such device conventionally comprises a generally elongate housing adapted to be held by a user and to a distal end of which is fixed an cartridge containing the liquid to be administered.
  • the cartridge has an internal wall adapted to be moved by a plunger mobile axially inside the housing to expel a dose of liquid. Forward movement of the plunger inside the housing is driven by an actuator at a proximal end of the housing that can be operated by the user .
  • the inj ection device further comprises a knurled knob carrying a graduated scale by means of which the user may adjust the volume of the dose to be injected in accordance with the medical prescription.
  • the user must turn the knob to bring the appropriate graduation on the scale against a mark on the housing of the injection device .
  • the user programmes the movement of the plunger and therefore the volume of the dose to be injected.
  • the user When he wishes to administer an injection, the user must first arm the injection device by pulling out the actuator . During this rearward movement, the actuator moves partly out of the housing of the device and uncovers a second graduated scale formed of regularly spaced axial lines of varying length. As a function of the distance to which the actuator is pulled out , the lines are progressively concealed by the housing of the device, the last line visible indicating the volume of the dose that is ready to be injected.
  • the user is able to check that the volume of the dose he is preparing to administer corresponds to the programmed volume .
  • the major drawback of the above device is that the user finds it difficult to read the indications of the second graduated scale . This is because it is not easy to distinguish accurately between the last line that is still visible and the first line that is concealed by the housing of said device . Furthermore, it may be necessary to rotate the injection device on itself to uncover the line indicating the volume of the dose ready to be injected, which is inconvenient .
  • An object of the present invention is to remedy the problems mentioned above and other problems by providing an inj ection device providing a clear and accurate way of checking that the volume of the dose that is ready to be inj ected corresponds to the volume of the prescribed dose .
  • the present invention provides an inj ection device for administering multiple doses of a medication liquid, said device comprising a housing, a cartridge containing a preparation or precursor component for the preparation and having a front part and a rear part, the rear part being closed by a movable wall , a displacement of which wall causes the preparation to be moved forward the other end of the cartridge, through which the liquid exits , and actuating means for actuating the wall via a plunger whose forward movement inside the housing is driven by an actuator at the proximal end of the housing and adapted to be actuated by the user, said injection device being characterised in that it further comprises means moving concomitantly with the plunger and co-operating with a graduated scale on the device that is oblique to the axis of general forward movement of said plunger .
  • the injection device provides a clear, legible and accurate indication of the volume of the dose that is ready to be injected.
  • This result is achieved because the graduated scale indicating the volume of the dose is oblique rather than parallel to the axis of general forward movement of the plunger .
  • the plunger moves forward too small a distance to be represented directly on a graduated scale parallel to its direction of forward movement .
  • the graduated scale is oblique to the direction of forward movement of the plunger, so that the movement of the means representing the forward movement of the plunger is projected onto said scale in accordance with its angle of inclination and is therefore demultiplied and thus easier to read.
  • the injection device comprises a dosing ring carrying a dosing scale that is visible from the outside through an observation window in the housing of said injection device .
  • the user can therefore check before each inj ection that the indication provided by the dosing ring, which corresponds to his initial setting of the volume of the dose to be injected, coincides with the indication provided by the oblique graduated scale, which corresponds to the volume of the dose that is ready to be inj ected.
  • This makes the device much safer to use , especially when preparing to inject the final dose of medication liquid, the volume of which usually does not correspond to the prescribed volume . Because the user is able to determine accurately the volume of liquid remaining in the cartridge, he can tell what dose to prepare with the injection device .
  • FIG. 1 is a general plan view of the injection device of the invention, partly in section at the level of the cartridge containing the liquid to be administered;
  • - figure 2 is a view to a larger scale of the ringed area in figure 1;
  • figure 3 is a partially cutaway perspective view of the device of the invention; and figure 4 is a view to a larger scale of the ringed area in figure 3.
  • the present invention stems from the general inventive concept of projecting onto an oblique graduated scale the small linear displacements of the plunger of an inj ection device that causes the expulsion of a dose of medication liquid from an cartridge . Projected onto an oblique axis in this way, the movements of the plunger are demultiplied and are therefore very easy to read, which makes this kind of device much safer and much more convenient to use .
  • FIG 1 is a general plan view of the injection device 1 of the invention preferably adapted to be held by a user .
  • the device 1 comprises a generally elongate housing 2.
  • a cartridge 6 protected by a plastic cap 8 and containing the medication liquid to be administered.
  • the cartridge 6 has one end closed by a sealed wall 10 and adapted to be moved toward the other end of the cartridge 6 , which is terminated by a needle 12 through which the liquid exits .
  • the wall 10 is moved by a plunger 14 (see Figures 3 and 4 ) whose forward movement inside the housing 2 is driven by an actuator 16 at a proximal end 18 of the housing 2 and adapted to be operated by the user .
  • a first dosing scale 20 is visible from the outside through a first observation window 22 in the housing 2.
  • This first dosing scale 20 enables the user to adjust the volume of the dose to be injected as a function of the medical prescription .
  • On the housing 2 is a second graduated scale 24 oblique to the general axis of symmetry X-X of the injection device 1.
  • the scale 24 is rectilinear and is formed of a succession of parallel and regularly spaced segments or graduations 26.
  • the scale 24 extends along a second observation window 28 in the housing 2 through which can be seen at least part of means 30 representative of the forward movement of the plunger 14 , to be described in more detail below.
  • the scale 24 enables the user to check that the volume of the dose he is preparing to inject corresponds to the volume of the dose that he programmed before using the device 1 , and this makes the device extremely safe to use .
  • Figure 3 is a perspective view of the device 1 with the housing 2 partly cutaway and figure 4 is a view to a larger scale of the ringed area in figure 3.
  • the wall 10 (which can be seen in figures 1 and 3 ) is moved by the plunger 14 , whose general direction of forward movement coincides with the axis of longitudinal symmetry X-X of the device 1.
  • the forward movement of the plunger is driven by the actuator 16 via the means 30 representative of the forward movement of said plunger 14.
  • the means 30 take the form of a forward movement bush 34 fastened to the actuator 16.
  • the device 1 operates in the following manner .
  • To arm said device 1 and prepare it to dispense a new dose of liquid the user pulls out the actuator 16 until it stops moving .
  • the bush 34 is withdrawn concomitantly and remains partly visible from the outside through the second observation window 28 , the intersection of the circular edge 36 of its front face 38 with one of the graduations 26 of the oblique scale 24 enabling the user to determine the volume of the dose he is preparing to administer .
  • this reading could be effected by determining the intersection of a marker on the bush with the oblique scale 24 or on a part connected directly or indirectly to the plunger 14.
  • the user administers the inj ection by pushing on the actuator 16 , which moves forward the bush 34 and therefore the plunger 14 , which applies pressure to the wall 10 to expel a dose of medication liquid.
  • the plunger 14 and therefore the bush 34 move forward in small increments , and it would be difficult or even impossible to represent those increments on a scale parallel to the direction of movement of those elements .
  • the benefit of the invention is that, by projecting these distances onto a scale oblique to the general direction of forward movement of the plunger 14 , the linear movements of the component 14 are amplified and made easy to read. The user can therefore check at any time that the volume of the dose ready to be injected corresponds to the volume that he programmed before using the device 1 , which increases his confidence that the product is safe to use .

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  • Health & Medical Sciences (AREA)
  • Vascular Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)

Abstract

Injection device for administering multiple doses of a medication liquid, said device (1) comprising a housing (2), a cartridge (6) containing a preparation or precursor component for the preparation and having a front part and a rear part, the rear part being closed by a movable wall (10), a displacement of which wall causes the preparation to be moved forward the other end of the cartridge (6), through which the liquid exits, and actuating means (16) for actuating the wall (10) via a plunger (14) whose forward movement inside the housing (2) is driven by an actuator (16) at the proximal end of the housing (2) and adapted to be actuated by the user, said injection device (1) further comprises means (30) moving concomitantly with the plunger (14) and co­operating with a graduated scale (24) on the device (1) that is oblique to the axis of general forward movement of said plunger (14).

Description

INJECTION DEVICE FOR ADMINISTERING A MEDICATION
LIQUID
The present invention relates to an injection device for administering multiple doses of a medication liquid and provides a fast and simple way to check that the volume of the dose that one is preparing to administer to oneself or to another person corresponds to the programmed volume of the dose .
Background of the invention
Injection devices of the above kind are known in the art . One such device conventionally comprises a generally elongate housing adapted to be held by a user and to a distal end of which is fixed an cartridge containing the liquid to be administered. The cartridge has an internal wall adapted to be moved by a plunger mobile axially inside the housing to expel a dose of liquid. Forward movement of the plunger inside the housing is driven by an actuator at a proximal end of the housing that can be operated by the user . The inj ection device further comprises a knurled knob carrying a graduated scale by means of which the user may adjust the volume of the dose to be injected in accordance with the medical prescription. To this end, the user must turn the knob to bring the appropriate graduation on the scale against a mark on the housing of the injection device . By doing this , the user programmes the movement of the plunger and therefore the volume of the dose to be injected. When he wishes to administer an injection, the user must first arm the injection device by pulling out the actuator . During this rearward movement, the actuator moves partly out of the housing of the device and uncovers a second graduated scale formed of regularly spaced axial lines of varying length. As a function of the distance to which the actuator is pulled out , the lines are progressively concealed by the housing of the device, the last line visible indicating the volume of the dose that is ready to be injected. Thus by comparing the indications provided by the two graduations , the user is able to check that the volume of the dose he is preparing to administer corresponds to the programmed volume . The major drawback of the above device is that the user finds it difficult to read the indications of the second graduated scale . This is because it is not easy to distinguish accurately between the last line that is still visible and the first line that is concealed by the housing of said device . Furthermore, it may be necessary to rotate the injection device on itself to uncover the line indicating the volume of the dose ready to be injected, which is inconvenient .
Summary of the Invention
An object of the present invention is to remedy the problems mentioned above and other problems by providing an inj ection device providing a clear and accurate way of checking that the volume of the dose that is ready to be inj ected corresponds to the volume of the prescribed dose .
To this end, the present invention provides an inj ection device for administering multiple doses of a medication liquid, said device comprising a housing, a cartridge containing a preparation or precursor component for the preparation and having a front part and a rear part, the rear part being closed by a movable wall , a displacement of which wall causes the preparation to be moved forward the other end of the cartridge, through which the liquid exits , and actuating means for actuating the wall via a plunger whose forward movement inside the housing is driven by an actuator at the proximal end of the housing and adapted to be actuated by the user, said injection device being characterised in that it further comprises means moving concomitantly with the plunger and co-operating with a graduated scale on the device that is oblique to the axis of general forward movement of said plunger . Thanks to these features , the injection device provides a clear, legible and accurate indication of the volume of the dose that is ready to be injected. This result is achieved because the graduated scale indicating the volume of the dose is oblique rather than parallel to the axis of general forward movement of the plunger . On each inj ection of a dose of medication liquid, the plunger moves forward too small a distance to be represented directly on a graduated scale parallel to its direction of forward movement . For this reason, the graduated scale is oblique to the direction of forward movement of the plunger, so that the movement of the means representing the forward movement of the plunger is projected onto said scale in accordance with its angle of inclination and is therefore demultiplied and thus easier to read. In one embodiment of the invention, the injection device comprises a dosing ring carrying a dosing scale that is visible from the outside through an observation window in the housing of said injection device .
The user can therefore check before each inj ection that the indication provided by the dosing ring, which corresponds to his initial setting of the volume of the dose to be injected, coincides with the indication provided by the oblique graduated scale, which corresponds to the volume of the dose that is ready to be inj ected. This makes the device much safer to use , especially when preparing to inject the final dose of medication liquid, the volume of which usually does not correspond to the prescribed volume . Because the user is able to determine accurately the volume of liquid remaining in the cartridge, he can tell what dose to prepare with the injection device .
Brief description of the drawings
Other features and advantages of the present invention will emerge more clearly from the following detailed description of one embodiment of an inj ection device of the invention, given by way of purely illustrative and non-limiting example and with reference to the appended drawings , in which: - figure 1 is a general plan view of the injection device of the invention, partly in section at the level of the cartridge containing the liquid to be administered; - figure 2 is a view to a larger scale of the ringed area in figure 1;
- figure 3 is a partially cutaway perspective view of the device of the invention; and figure 4 is a view to a larger scale of the ringed area in figure 3.
Detailed description of the preferred embodiments
The present invention stems from the general inventive concept of projecting onto an oblique graduated scale the small linear displacements of the plunger of an inj ection device that causes the expulsion of a dose of medication liquid from an cartridge . Projected onto an oblique axis in this way, the movements of the plunger are demultiplied and are therefore very easy to read, which makes this kind of device much safer and much more convenient to use .
Figure 1 is a general plan view of the injection device 1 of the invention preferably adapted to be held by a user . The device 1 comprises a generally elongate housing 2. To a distal end 4 of the housing 2 is fixed a cartridge 6 protected by a plastic cap 8 and containing the medication liquid to be administered. The cartridge 6 has one end closed by a sealed wall 10 and adapted to be moved toward the other end of the cartridge 6 , which is terminated by a needle 12 through which the liquid exits . The wall 10 is moved by a plunger 14 (see Figures 3 and 4 ) whose forward movement inside the housing 2 is driven by an actuator 16 at a proximal end 18 of the housing 2 and adapted to be operated by the user . A first dosing scale 20 is visible from the outside through a first observation window 22 in the housing 2. This first dosing scale 20 enables the user to adjust the volume of the dose to be injected as a function of the medical prescription . On the housing 2 is a second graduated scale 24 oblique to the general axis of symmetry X-X of the injection device 1. The scale 24 is rectilinear and is formed of a succession of parallel and regularly spaced segments or graduations 26. The scale 24 extends along a second observation window 28 in the housing 2 through which can be seen at least part of means 30 representative of the forward movement of the plunger 14 , to be described in more detail below. The scale 24 enables the user to check that the volume of the dose he is preparing to inject corresponds to the volume of the dose that he programmed before using the device 1 , and this makes the device extremely safe to use .
Figure 3 is a perspective view of the device 1 with the housing 2 partly cutaway and figure 4 is a view to a larger scale of the ringed area in figure 3. These two figures show that the first dosing scale 20 is on a dosing ring 32 that is prevented from moving in translation but mobile in rotation, to enable the user to move into the observation window 22 the indication corresponding to the volume of the dose prescribed for him. The wall 10 (which can be seen in figures 1 and 3 ) is moved by the plunger 14 , whose general direction of forward movement coincides with the axis of longitudinal symmetry X-X of the device 1. The forward movement of the plunger is driven by the actuator 16 via the means 30 representative of the forward movement of said plunger 14. The means 30 take the form of a forward movement bush 34 fastened to the actuator 16.
The device 1 operates in the following manner . To arm said device 1 and prepare it to dispense a new dose of liquid, the user pulls out the actuator 16 until it stops moving . The bush 34 is withdrawn concomitantly and remains partly visible from the outside through the second observation window 28 , the intersection of the circular edge 36 of its front face 38 with one of the graduations 26 of the oblique scale 24 enabling the user to determine the volume of the dose he is preparing to administer . In a different embodiment, this reading could be effected by determining the intersection of a marker on the bush with the oblique scale 24 or on a part connected directly or indirectly to the plunger 14.
After arming the device 1 , the user administers the inj ection by pushing on the actuator 16 , which moves forward the bush 34 and therefore the plunger 14 , which applies pressure to the wall 10 to expel a dose of medication liquid. The plunger 14 and therefore the bush 34 move forward in small increments , and it would be difficult or even impossible to represent those increments on a scale parallel to the direction of movement of those elements . The benefit of the invention is that, by projecting these distances onto a scale oblique to the general direction of forward movement of the plunger 14 , the linear movements of the component 14 are amplified and made easy to read. The user can therefore check at any time that the volume of the dose ready to be injected corresponds to the volume that he programmed before using the device 1 , which increases his confidence that the product is safe to use .
It goes without saying that the present invention is not limited to the embodiments that have just been described and that the person skilled in the art may envisage various simple modifications and variations that lie within the scope of the invention as defined by the appended claims .

Claims

1. An injection device for administering multiple doses of a medication liquid, said device (1 ) comprising a housing (2 ) , a cartridge ( 6) containing a preparation or precursor component for the preparation and having a front part and a rear part, the rear part being closed by a movable wall ( 10 ) , a displacement of which wall causes the preparation to be moved forward the other end of the cartridge ( 6 ) , through which the liquid exits , and actuating means ( 16 ) for actuating the wall (10 ) via a plunger ( 14 ) whose forward movement inside the housing is driven by an actuator (16 ) at the proximal end ( 18 ) of the housing (2 ) and adapted to be actuated by the user, said injection device (1) being characterised in that it further comprises means (30 ) moving concomitantly with the plunger (14) and co-operating with a graduated scale (24 ) on the device (1) that is oblique to the axis of general forward movement of said plunger ( 14) .
2. An injection device according to claim 1 , characterised in that the means (30 ) moving concomitantly with the plunger ( 14 ) comprise a forward movement bush (34 ) adapted to move forward and backward inside the housing (2 ) and through which forward movement of the actuator ( 16 ) is transmitted to the plunger ( 14) .
3. An injection device according to claim 2 , characterised in that the graduated scale ( 24 ) extends along an observation window (28 ) in the housing (2 ) through which the forward movement bush (34 ) is visible .
4. An injection device according to any of claims 1 to 3 , characterised in that it comprises a dosing ring (32 ) carrying a dosing scale ( 20 ) that is visible from the outside through an observation window ( 22 ) in the housing (2 ) of said injection device ( 1) .
5. An injection device according to claim 4 , characterised in that the dosing ring (32 ) is prevented from moving in translation inside the housing (2 ) but free to rotate before selection of the dose to be injected.
PCT/IB2006/000176 2005-01-25 2006-01-12 Injection device for administering a medication liquid WO2006079918A1 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
EP05100449A EP1700613A1 (en) 2005-01-25 2005-01-25 Injection device for administering a medication liquid
EP05100449.7 2005-01-25
US65997405P 2005-03-08 2005-03-08
US60/659,974 2005-03-08

Publications (1)

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WO2006079918A1 true WO2006079918A1 (en) 2006-08-03

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PCT/IB2006/000176 WO2006079918A1 (en) 2005-01-25 2006-01-12 Injection device for administering a medication liquid

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Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2397174A2 (en) * 2010-06-18 2011-12-21 Becton, Dickinson and Company Adjustable plunger dose stop
WO2016025316A1 (en) * 2014-08-15 2016-02-18 Eli Lilly And Company Automatic medication injection device with visible indication of injecting progress
CN110382022A (en) * 2017-03-15 2019-10-25 诺和诺德股份有限公司 Dosage capture component with secondary image analysis feature

Citations (3)

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Publication number Priority date Publication date Assignee Title
EP0295075A1 (en) * 1987-06-12 1988-12-14 Hypoguard (Uk) Limited Measured dose syringe
DE4013769A1 (en) * 1990-04-28 1991-10-31 Adamaszek Franz Heinz Automatic insulin injection device - includes rotating knob to allow vol. of insulin to be accurately chosen
EP0943349A1 (en) * 1998-03-19 1999-09-22 NIHON CHEMICAL RESEARCH KABUSHIKI KAISHA also known as JAPAN CHEMICAL RESEARCH CO., LTD Injection syringe including device for preparation of injection

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0295075A1 (en) * 1987-06-12 1988-12-14 Hypoguard (Uk) Limited Measured dose syringe
DE4013769A1 (en) * 1990-04-28 1991-10-31 Adamaszek Franz Heinz Automatic insulin injection device - includes rotating knob to allow vol. of insulin to be accurately chosen
EP0943349A1 (en) * 1998-03-19 1999-09-22 NIHON CHEMICAL RESEARCH KABUSHIKI KAISHA also known as JAPAN CHEMICAL RESEARCH CO., LTD Injection syringe including device for preparation of injection

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2397174A2 (en) * 2010-06-18 2011-12-21 Becton, Dickinson and Company Adjustable plunger dose stop
EP2397174A3 (en) * 2010-06-18 2012-12-19 Becton, Dickinson and Company Adjustable plunger dose stop
WO2016025316A1 (en) * 2014-08-15 2016-02-18 Eli Lilly And Company Automatic medication injection device with visible indication of injecting progress
AU2015302043B2 (en) * 2014-08-15 2018-07-12 Eli Lilly And Company Automatic medication injection device with visible indication of injecting progress
US10350362B2 (en) 2014-08-15 2019-07-16 Eli Lilly And Company Automatic medication injection device with visible indication of injecting progress
CN110382022A (en) * 2017-03-15 2019-10-25 诺和诺德股份有限公司 Dosage capture component with secondary image analysis feature
US11623049B2 (en) 2017-03-15 2023-04-11 Novo Nordisk A/S Dose capturing assembly with secondary image analysis feature

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