WO2006072348A3 - Alkinyl-substituted thiophenes - Google Patents

Alkinyl-substituted thiophenes Download PDF

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Publication number
WO2006072348A3
WO2006072348A3 PCT/EP2005/013218 EP2005013218W WO2006072348A3 WO 2006072348 A3 WO2006072348 A3 WO 2006072348A3 EP 2005013218 W EP2005013218 W EP 2005013218W WO 2006072348 A3 WO2006072348 A3 WO 2006072348A3
Authority
WO
WIPO (PCT)
Prior art keywords
alkinyl
substituted thiophenes
illnesses
prophylaxis
treating
Prior art date
Application number
PCT/EP2005/013218
Other languages
German (de)
French (fr)
Other versions
WO2006072348A2 (en
Inventor
Tobias Wunberg
Judith Baumeister
Dirk Gottschling
Kerstin Henninger
Diana Koletzki
Josef Pernerstorfer
Andreas Urban
Alexander Birkmann
Axel Harrenga
Mario Lobell
Original Assignee
Aicuris Gmbh & Co Kg
Tobias Wunberg
Judith Baumeister
Dirk Gottschling
Kerstin Henninger
Diana Koletzki
Josef Pernerstorfer
Andreas Urban
Alexander Birkmann
Axel Harrenga
Mario Lobell
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aicuris Gmbh & Co Kg, Tobias Wunberg, Judith Baumeister, Dirk Gottschling, Kerstin Henninger, Diana Koletzki, Josef Pernerstorfer, Andreas Urban, Alexander Birkmann, Axel Harrenga, Mario Lobell filed Critical Aicuris Gmbh & Co Kg
Publication of WO2006072348A2 publication Critical patent/WO2006072348A2/en
Publication of WO2006072348A3 publication Critical patent/WO2006072348A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The invention relates to alkinyl-substituted thiophenes and to methods for the production thereof, the use thereof for treating and/or for the prophylaxis of illnesses and to the use thereof for producing medicaments for treating and/or for the prophylaxis of illnesses, in particular for use as antiviral agents, in particular, against the hepatitis C virus.
PCT/EP2005/013218 2004-12-22 2005-12-09 Alkinyl-substituted thiophenes WO2006072348A2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DE102004061745 2004-12-22
DE102004061745.7 2004-12-22
DE102005028077.3 2005-06-17
DE102005028077A DE102005028077A1 (en) 2004-12-22 2005-06-17 Alkynyl-substituted thiophenes

Publications (2)

Publication Number Publication Date
WO2006072348A2 WO2006072348A2 (en) 2006-07-13
WO2006072348A3 true WO2006072348A3 (en) 2006-09-21

Family

ID=36599492

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2005/013218 WO2006072348A2 (en) 2004-12-22 2005-12-09 Alkinyl-substituted thiophenes

Country Status (2)

Country Link
DE (1) DE102005028077A1 (en)
WO (1) WO2006072348A2 (en)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101624391A (en) 2001-06-11 2010-01-13 病毒化学医药公司 Thiophene derivatives as antiviral agents for flavivirus infection
CN100413861C (en) 2002-12-10 2008-08-27 维勒凯姆制药股份有限公司 Compounds and methods for the treatment or prevention of flavivirus infections
KR20080016597A (en) 2005-05-13 2008-02-21 바이로켐 파마 인코포레이티드 Compounds and methods for the treatment or prevention of flavivirus infections
DE102006013957A1 (en) * 2006-03-27 2007-10-04 Bayer Healthcare Aktiengesellschaft Use of new or known N-benzyl N-phenyl benzenesulfonamide derivatives to prepare medicaments for treating or preventing viral diseases
EP2559692A1 (en) * 2006-11-15 2013-02-20 Virochem Pharma Inc. Thiophene analogues for the treatment or prevention of Flavivirus infections
JP5841531B2 (en) 2009-07-21 2016-01-13 ギリアード サイエンシーズ， インコーポレイテッド Inhibitors of Flaviviridae virus
EP2507249B1 (en) 2009-09-09 2015-11-11 Gilead Sciences, Inc. Inhibitors of flaviviridae viruses
WO2011068715A1 (en) 2009-11-25 2011-06-09 Vertex Pharmaceuticals Incorporated 5-alkynyl-thiophene-2-carboxylic acid derivatives and their use for the treatment or prevention of flavivirus infections
CN102712632A (en) * 2010-01-15 2012-10-03 吉里德科学公司 Inhibitors of flaviviridae viruses
PL2523950T3 (en) 2010-01-15 2017-09-29 Gilead Sciences, Inc. Inhibitors of flaviviridae viruses
PT2734515E (en) 2011-07-13 2016-03-11 Gilead Sciences Inc Thiophen-2-carboxylic acid derivatives useful as inhibitors of flaviviridae viruses
US8759544B2 (en) 2012-08-17 2014-06-24 Gilead Sciences, Inc. Synthesis of an antiviral compound
US8927741B2 (en) 2012-08-17 2015-01-06 Gilead Sciences, Inc. Synthesis of an antiviral compound
US8841340B2 (en) 2012-08-17 2014-09-23 Gilead Sciences, Inc. Solid forms of an antiviral compound

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002100851A2 (en) * 2001-06-11 2002-12-19 Shire Biochem Inc. Thiophene derivatives as antiviral agents for flavivirus infection
EP1321463A1 (en) * 2001-12-21 2003-06-25 Shire Biochem Inc. Thiazole derivatives and their use for the treatment or prevention of Flavivirus infections
WO2005063734A2 (en) * 2003-12-19 2005-07-14 Aicuris Gmbh & Co. Kg Substituted thiophenes

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002100851A2 (en) * 2001-06-11 2002-12-19 Shire Biochem Inc. Thiophene derivatives as antiviral agents for flavivirus infection
EP1321463A1 (en) * 2001-12-21 2003-06-25 Shire Biochem Inc. Thiazole derivatives and their use for the treatment or prevention of Flavivirus infections
WO2005063734A2 (en) * 2003-12-19 2005-07-14 Aicuris Gmbh & Co. Kg Substituted thiophenes

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
CHAN L ET AL: "Discovery of thiophene-2-carboxylic acids as potent inhibitors of HCV NS5B polymerase and HCV subgenomic RNA replication. Part 1: Sulfonamides", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, OXFORD, GB, vol. 14, no. 3, 9 February 2004 (2004-02-09), pages 793 - 796, XP002328928, ISSN: 0960-894X *

Also Published As

Publication number Publication date
WO2006072348A2 (en) 2006-07-13
DE102005028077A1 (en) 2006-07-13

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