WO2006071603A3 - Phosphodiesterase 4d in the ryanodine receptor complex protects against heart failure - Google Patents

Phosphodiesterase 4d in the ryanodine receptor complex protects against heart failure Download PDF

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Publication number
WO2006071603A3
WO2006071603A3 PCT/US2005/045914 US2005045914W WO2006071603A3 WO 2006071603 A3 WO2006071603 A3 WO 2006071603A3 US 2005045914 W US2005045914 W US 2005045914W WO 2006071603 A3 WO2006071603 A3 WO 2006071603A3
Authority
WO
WIPO (PCT)
Prior art keywords
ryanodine receptor
disorders
present
diseases
phosphodiesterase
Prior art date
Application number
PCT/US2005/045914
Other languages
French (fr)
Other versions
WO2006071603A2 (en
WO2006071603A9 (en
Inventor
Andrew R Marks
Stephan E Lehnart
Xander H T Wehrens
Steven Reiken
Marco Conti
Catherine S L Jin
Original Assignee
Univ Columbia
Andrew R Marks
Stephan E Lehnart
Xander H T Wehrens
Steven Reiken
Marco Conti
Catherine S L Jin
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Columbia, Andrew R Marks, Stephan E Lehnart, Xander H T Wehrens, Steven Reiken, Marco Conti, Catherine S L Jin filed Critical Univ Columbia
Priority to CA002591924A priority Critical patent/CA2591924A1/en
Publication of WO2006071603A2 publication Critical patent/WO2006071603A2/en
Publication of WO2006071603A3 publication Critical patent/WO2006071603A3/en
Publication of WO2006071603A9 publication Critical patent/WO2006071603A9/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y301/00—Hydrolases acting on ester bonds (3.1)
    • C12Y301/04—Phosphoric diester hydrolases (3.1.4)
    • C12Y301/04053—3',5'-Cyclic-AMP phosphodiesterase (3.1.4.53)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

The present invention provides compositions useful for treating and preventing ryanodine receptor associated disorders comprising a PDE-associated agent and a pharmaceutically acceptable carrier. The present invention also provides methods for treating or preventing ryanodine receptor associated disorders including cardiac disorders and diseases, skeletal muscular disorders and diseases, cognitive disorders and diseases malignant hyperthermia, diabetes and sudden infant death syndrome. The present invention further provides methods for regulating PKA phosphorylation of a ryanodine receptor as well as methods for regulating Ca+2 release and reuptake in cells. Also provided are kits for use in delivering a PDE-associated agent to cardiac cells in a subject, comprising the composition of the present invention and a catheter.
PCT/US2005/045914 2004-12-16 2005-12-15 Phosphodiesterase 4d in the ryanodine receptor complex protects against heart failure WO2006071603A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CA002591924A CA2591924A1 (en) 2004-12-16 2005-12-15 Phosphodiesterase 4d in the ryanodine receptor complex protects against heart failure

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US63695904P 2004-12-16 2004-12-16
US60/636,959 2004-12-16

Publications (3)

Publication Number Publication Date
WO2006071603A2 WO2006071603A2 (en) 2006-07-06
WO2006071603A3 true WO2006071603A3 (en) 2006-10-12
WO2006071603A9 WO2006071603A9 (en) 2007-03-29

Family

ID=36615403

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2005/045914 WO2006071603A2 (en) 2004-12-16 2005-12-15 Phosphodiesterase 4d in the ryanodine receptor complex protects against heart failure

Country Status (2)

Country Link
CA (1) CA2591924A1 (en)
WO (1) WO2006071603A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8710045B2 (en) 2004-01-22 2014-04-29 The Trustees Of Columbia University In The City Of New York Agents for preventing and treating disorders involving modulation of the ryanodine receptors

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030054531A1 (en) * 2001-03-19 2003-03-20 Decode Genetics Ehf, Human stroke gene
US20040048780A1 (en) * 2000-05-10 2004-03-11 The Trustees Of Columbia University In The City Of New York Method for treating and preventing cardiac arrhythmia
WO2004042389A2 (en) * 2002-11-08 2004-05-21 Bayer Healthcare Ag Diagnostics and therapeutics for diseases associated with human phosphodiesterase 4d (pde4d)
EP1439221A1 (en) * 2002-12-17 2004-07-21 F. Hoffmann-La Roche Ag PDE core construct
US20040224368A1 (en) * 2003-03-07 2004-11-11 Marks Andrew R. Type 1 ryanodine receptor-based methods

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040048780A1 (en) * 2000-05-10 2004-03-11 The Trustees Of Columbia University In The City Of New York Method for treating and preventing cardiac arrhythmia
US20030054531A1 (en) * 2001-03-19 2003-03-20 Decode Genetics Ehf, Human stroke gene
WO2004042389A2 (en) * 2002-11-08 2004-05-21 Bayer Healthcare Ag Diagnostics and therapeutics for diseases associated with human phosphodiesterase 4d (pde4d)
EP1439221A1 (en) * 2002-12-17 2004-07-21 F. Hoffmann-La Roche Ag PDE core construct
US20040224368A1 (en) * 2003-03-07 2004-11-11 Marks Andrew R. Type 1 ryanodine receptor-based methods

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
KAPILOFF MICHAEL S; JACKSON NICOLE; AIRHART NATHAN: "mAKAP and the ryanodine receptor are part of a multi-component signaling complex on the cardiomyocyte nuclear envelope", JOURNAL OF CELL SCIENCE, vol. 114, no. 17, September 2001 (2001-09-01), pages 3167 - 3176, XP002390984 *
LEHNART STEPHAN E; WEHRENS XANDER H; REIKEN STEVEN R; JIN S -I C; VEST JOHN A; MARKS ANDREW R: "Phosphodiesterase 4D associates with the cardiac calcium release channel (Ryanodine receptor) and protects from hypertrophy and heart failure", CIRCULATION, vol. 110, no. 17SupplS, 26 October 2004 (2004-10-26), pages 227 - 228, XP009069565 *

Also Published As

Publication number Publication date
WO2006071603A2 (en) 2006-07-06
WO2006071603A9 (en) 2007-03-29
CA2591924A1 (en) 2006-07-06

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