WO2006070861A1 - Composition contenant un agent favorisant la pousse des cheveux et lotion tonifiante favorisant la pousse des cheveux - Google Patents

Composition contenant un agent favorisant la pousse des cheveux et lotion tonifiante favorisant la pousse des cheveux Download PDF

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Publication number
WO2006070861A1
WO2006070861A1 PCT/JP2005/024047 JP2005024047W WO2006070861A1 WO 2006070861 A1 WO2006070861 A1 WO 2006070861A1 JP 2005024047 W JP2005024047 W JP 2005024047W WO 2006070861 A1 WO2006070861 A1 WO 2006070861A1
Authority
WO
WIPO (PCT)
Prior art keywords
hair
growth
fullerene
hinokitiol
hair growing
Prior art date
Application number
PCT/JP2005/024047
Other languages
English (en)
Japanese (ja)
Inventor
Kenji Matsubayashi
Nobuhiko Miwa
Original Assignee
Vitamin C60 Bioresearch Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vitamin C60 Bioresearch Corporation filed Critical Vitamin C60 Bioresearch Corporation
Publication of WO2006070861A1 publication Critical patent/WO2006070861A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q7/00—Preparations for affecting hair growth
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/31—Hydrocarbons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/63—Steroids; Derivatives thereof

Definitions

  • Hair growth composition and hair growth enhancer are hair growth enhancer
  • the present invention relates to a hair restorer composition or a hair growth enhancer that promotes hair growth.
  • Patent Document 1 discloses a hair restorer containing hinokitiol having a bactericidal action and a hair follicle function activating action.
  • Patent Document 1 Japanese Patent Laid-Open No. 2-91014
  • the present invention has been made in view of these problems, and an object thereof is to provide a technique for improving the hair-growth effect of the hair-growth composition.
  • the hair restorer composition of the present invention is characterized by containing fullerenes.
  • fullerenes include fullerenes and fullerene derivatives.
  • the hair-growth component contained in the hair-growth composition one or more selected from the group consisting of hinokitiol, hinokitiol derivatives, glycyrrhizic acid, glycyrrhizic acid derivatives, glycyrrhetinic acid and glycyrrhetinic acid derivatives are effective.
  • the hair restorer composition of the present invention the hair growth or hair growth effect is improved.
  • FIG. 1 is a table showing the components of Examples 1 and 2 and Comparative Examples 1 and 2.
  • FIG. 2 is a photograph showing the hair growth state after applying the hair-growing composition of Example 1 to the shaved portion of a C3H mouse.
  • FIG. 3 is a photograph showing the hair growth state after applying the hair-growing composition of Example 2 to the shaved portion of a C3H mouse.
  • FIG. 4 is a photograph showing the hair growth state after applying the hair-restoring agent and composition of Comparative Example 1 to the shaved portion of C3H mice.
  • FIG. 5 is a photograph showing the hair growth state after applying the hair-restoring agent and composition of Comparative Example 2 to the shaved portion of C3H mice.
  • FIG. 6 is a photograph showing the hair growth state when nothing is applied to the shaved part of a C3H mouse and force is applied.
  • FIG. 7 is a table showing changes with time in hair growth of each sample and control.
  • the present inventors have found that by adding fullerenes to the hair-growing agent composition, the hair-growth effect by the hair-growth component is enhanced and the hair-growth is further promoted. It has never been anticipated that fullerenes can be used as a hair-growth enhancer that enhances the hair-growth effect of the hair-growth ingredients.
  • fullerenes contained in the hair-growing composition according to the present invention include fullerenes, fullerene derivatives, fullerenes and fullerene derivative mixtures.
  • Fullerene is a spherical shell-like molecule composed of carbon, and various types are known. In the present invention, there is no limitation as long as the purpose is satisfied. For example, c, c, c, c, c, c
  • a trimer or the like can be used.
  • C 1, C 2 1, C 3
  • C and C have a simple structure and are generally used
  • the production rate in the arc discharge method and combustion method that can be used is high, so it is easy to secure the industrially required amount.
  • C has the advantage that the structure is symmetrical.
  • the fullerene derivative refers to a compound in which an atomic group composed of an inorganic element is bonded to an atomic group forming a part of an organic compound on at least one carbon constituting the fullerene.
  • the fullerene used for obtaining the fullerene derivative is not limited as long as the object of the present invention is satisfied, and any of the fullerenes specifically shown above may be used.
  • fullerene derivative for example, hydrogenated fullerene, acid fullerene, hydroxylated fullerene, halogenated (F, Cl, Br, I) fullerene, fulleroid, methanofullerene and the like can be used.
  • hydrogenated fullerene, hydroxy-fullerene, and acid-fullerene it is preferable to use hydrogenated fullerene, hydroxy-fullerene, and acid-fullerene. This is because hydrogenated fullerene, hydroxy-fullerene, and acid-fullerene are not only more polar and more compatible with compounds than fullerenes, but are also obtained by basic reactions from fullerenes. It is a force that is expected to be widely used industrially.
  • These fullerene derivatives may also be used in combination.
  • Fullerenes can be obtained by extraction and separation from fullerene-containing soot obtained by, for example, a resistance heating method, a laser heating method, an arc discharge method, or a combustion method.
  • the fullerene content can be adjusted within a range that does not necessarily impair the performance that is not necessarily completely separated.
  • the fullerene derivative can be synthesized by applying a conventionally known method to fullerene. For example, reaction with nucleophiles (nucleophilic addition reaction), cycloaddition reaction, light-added caro
  • the desired fullerene derivative can be obtained by utilizing (cyclization) reaction, oxidation reaction, reduction reaction, radical reaction, and the like.
  • the blending amount of fullerenes is preferably 0.01 to 30% by mass and more preferably 0.1 to 10% by mass with respect to the total mass of the hair-restoring agent composition.
  • the blending amount of fullerenes is less than 0.01% by mass or more than 30% by mass, the effect of promoting hair growth or the effect of enhancing hair growth decreases.
  • Substances that are recognized as having significant effects as hair-restoring ingredients contained in hair-recovery compositions containing fullerenes include hinokitiol, hinokitiol derivatives, glycyrrhizic acid, glycyrrhizic acid derivatives, glycyrrhetinic acid, glycyrrhetinic acid derivatives.
  • hinokitiol hinokitiol derivatives
  • glycyrrhizic acid glycyrrhizic acid derivatives
  • glycyrrhetinic acid glycyrrhetinic acid derivatives.
  • the hinokitiol derivative is not particularly limited as long as hinokitiol is derived by general chemical conversion or the like, but the hydrogen atom of the hydroxyl group of hinokitiol is a functional group such as an acyl group, an alkyl group, or a hydroxyalkyl group. And organic derivatives, metal salts or metal complex derivatives of hinokitiol.
  • Examples of the glycyrrhizic acid derivatives include glycyrrhizic acid salts such as dipotassium glycyrrhizinate and ammonium glycyrrhizinate.
  • the solvent for the hair restorer composition may be water, an aqueous solution containing water as a main component, or an organic solvent as long as the fullerenes and the hair restoring component are appropriately dissolved.
  • an organic solvent as long as the fullerenes and the hair restoring component are appropriately dissolved.
  • hinokitiol is hardly soluble in water, it is desirable to use ethanol as a solvent.
  • hair restorer composition Do reduces the effect of the present invention, as long as it is within the range, fragrances, surface active agents, disinfectants, antioxidants, ultraviolet absorbers, P H adjusting agent, a preservative , And one or more moisturizers.
  • the addition of fullerenes to the hair restorer composition enhances the hair growth effect and shortens the period required for hair growth. This reduces the cost and labor required for hair growth.
  • FIG. 1 shows the components of Examples 1 and 2 and Comparative Examples 1 and 2.
  • Example 1 contains hinokitiol as a hair-growth component and contains fullerene in addition to this. Comparative Example 1 does not contain force fullerene containing hinokitiol for comparison with Example 1.
  • Example 2 contains glycyrrhizic acid as a hair-growth component and in addition to this fullerene. Comparative Example 2 does not contain force fullerene containing glycyrrhizic acid for comparison with Example 2.
  • ethanol was used as a solvent.
  • the fullerene used is C60.
  • the mass% of the hair-growth component and fullerene indicates a ratio with respect to the total mass including the solvent.
  • the hair growth promoting effect was confirmed by the mouse hair growth promoting effect test method.
  • the mouse hair growth promoting effect test method was performed as follows.
  • mice The body hair at the center of the back of C3H mice (male, 7 weeks old) was shaved, and 0.2 ⁇ per mouse was applied to the right side of the shaved portion once a day. Ten mice were used per sample. Immediately after sample application, 5 days, 10 days, and 15 days, mice were photographed on the back of the mouse, and the hair cutting area and hair growth area were calculated to determine the hair growth rate (%). For each sample, the average value of the hair growth rate of 10 mice was calculated, and the hair growth promoting effect was judged. As a control
  • a mouse that did not apply the sample to the shaved part was prepared and it was confirmed that no hair growth occurred.
  • FIG. 2-5 shows the hair growth state after each sample of the components shown in Fig. 1 was applied to the shaved portion of a C3H mouse.
  • FIG. 6 shows the hair growth state when nothing is applied to the shaved part of the C3H mouse.
  • FIG. 7 shows the time course of the hair growth rate of each sample and control.
  • the sample containing fullerene in addition to hinokitiol as in Example 1 has a significantly higher hair growth rate on the 15th day after the sample application than Comparative Example 1 containing no fullerene. Increase was confirmed.
  • the sample containing fullerene in addition to glycyrrhizic acid as in Example 2 has a significantly increased hair growth rate on the 15th day after application of the sample compared to Comparative Example 2 containing no fullerene. confirmed.
  • the hair restorer composition of the present invention the hair growth or hair growth effect is improved.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Birds (AREA)
  • Epidemiology (AREA)
  • Chemical & Material Sciences (AREA)
  • Inorganic Chemistry (AREA)
  • Dermatology (AREA)
  • Cosmetics (AREA)

Abstract

L’invention concerne une composition contenant un agent favorisant la pousse des cheveux présentant un effet bénéfique de production de cheveux ou de pousse de cheveux. On fournit une composition contenant un agent favorisant la pousse des cheveux caractérisée en ce qu’elle contient un fullerène. En tant que composants efficaces favorisant la pousse des cheveux contenus dans la composition contenant un agent favorisant la pousse des cheveux, on peut mentionner au moins un élément choisi dans le groupe constitué par l’hinokitiol, des dérivés d’hinokitiol, l'acide glycyrrhizinique, des dérivés de l’acide glycyrrhizinique, l'acide glycyrrhétinique et des dérivés de l’acide glycyrrhétinique.
PCT/JP2005/024047 2004-12-28 2005-12-28 Composition contenant un agent favorisant la pousse des cheveux et lotion tonifiante favorisant la pousse des cheveux WO2006070861A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2004382060A JP4685441B2 (ja) 2004-12-28 2004-12-28 育毛剤組成物および育毛増強剤
JP2004-382060 2004-12-28

Publications (1)

Publication Number Publication Date
WO2006070861A1 true WO2006070861A1 (fr) 2006-07-06

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JP (1) JP4685441B2 (fr)
WO (1) WO2006070861A1 (fr)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2016169215A (ja) * 2015-03-13 2016-09-23 国立大学法人大阪大学 毛髪処理用組成物とそれを用いた毛髪のキューティクル損傷を抑制する方法
WO2018064985A1 (fr) * 2016-10-09 2018-04-12 北京福纳康生物技术有限公司 Fullerène et application d'un dérivé de fullerène utilisés dans la préparation d'un produit pour favoriser la pousse des cheveux

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106474016A (zh) * 2016-12-16 2017-03-08 深圳市聚华太科技有限公司 一种头皮外用组合物及头皮滋养液
CN108201513B (zh) * 2016-12-16 2021-04-06 北京福纳康生物技术有限公司 一种发用组合物及生发液

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003039596A1 (fr) * 2001-11-09 2003-05-15 Qlt Inc. Therapie photodynamique destinee a traiter la chute des cheveux
WO2004067678A1 (fr) * 2003-01-27 2004-08-12 Mitsubishi Corporation Composition antioxydante et composition a usage externe
EP1447076A1 (fr) * 2003-02-12 2004-08-18 L'oreal Utilisation de solutions de fullerènes pour le conditionnement des cheveux
JP2004231553A (ja) * 2003-01-29 2004-08-19 Kao Corp エアゾール育毛製品
JP2004238302A (ja) * 2003-02-04 2004-08-26 Yukitoshi Kubota 珪素体含有アルカリイオン化粧料
JP2004250435A (ja) * 2002-11-21 2004-09-09 Dai Ichi Seiyaku Co Ltd 育毛用組成物

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003039596A1 (fr) * 2001-11-09 2003-05-15 Qlt Inc. Therapie photodynamique destinee a traiter la chute des cheveux
JP2004250435A (ja) * 2002-11-21 2004-09-09 Dai Ichi Seiyaku Co Ltd 育毛用組成物
WO2004067678A1 (fr) * 2003-01-27 2004-08-12 Mitsubishi Corporation Composition antioxydante et composition a usage externe
JP2004231553A (ja) * 2003-01-29 2004-08-19 Kao Corp エアゾール育毛製品
JP2004238302A (ja) * 2003-02-04 2004-08-26 Yukitoshi Kubota 珪素体含有アルカリイオン化粧料
EP1447076A1 (fr) * 2003-02-12 2004-08-18 L'oreal Utilisation de solutions de fullerènes pour le conditionnement des cheveux

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2016169215A (ja) * 2015-03-13 2016-09-23 国立大学法人大阪大学 毛髪処理用組成物とそれを用いた毛髪のキューティクル損傷を抑制する方法
WO2018064985A1 (fr) * 2016-10-09 2018-04-12 北京福纳康生物技术有限公司 Fullerène et application d'un dérivé de fullerène utilisés dans la préparation d'un produit pour favoriser la pousse des cheveux

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JP4685441B2 (ja) 2011-05-18
JP2006188438A (ja) 2006-07-20

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