WO2006069326A3 - Polyethylene glycolated superoxide dismutase mimetics - Google Patents

Polyethylene glycolated superoxide dismutase mimetics Download PDF

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Publication number
WO2006069326A3
WO2006069326A3 PCT/US2005/046825 US2005046825W WO2006069326A3 WO 2006069326 A3 WO2006069326 A3 WO 2006069326A3 US 2005046825 W US2005046825 W US 2005046825W WO 2006069326 A3 WO2006069326 A3 WO 2006069326A3
Authority
WO
WIPO (PCT)
Prior art keywords
superoxide dismutase
methods
dismutase mimetic
polyethylene glycol
covalently linked
Prior art date
Application number
PCT/US2005/046825
Other languages
French (fr)
Other versions
WO2006069326A2 (en
Inventor
Amruta Reddy Poreddy
William L Neumann
Kishore Udipi
Daniela Salvemini
Samuel TREMONT
Original Assignee
Metaphore Pharmaceuticals Inc
Amruta Reddy Poreddy
William L Neumann
Kishore Udipi
Daniela Salvemini
Samuel TREMONT
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Metaphore Pharmaceuticals Inc, Amruta Reddy Poreddy, William L Neumann, Kishore Udipi, Daniela Salvemini, Samuel TREMONT filed Critical Metaphore Pharmaceuticals Inc
Priority to CA2591970A priority Critical patent/CA2591970C/en
Publication of WO2006069326A2 publication Critical patent/WO2006069326A2/en
Publication of WO2006069326A3 publication Critical patent/WO2006069326A3/en
Priority to US11/766,221 priority patent/US8217166B2/en
Priority to US13/929,222 priority patent/US9150837B2/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/555—Heterocyclic compounds containing heavy metals, e.g. hemin, hematin, melarsoprol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F13/00—Compounds containing elements of Groups 7 or 17 of the Periodic Table
    • C07F13/005—Compounds without a metal-carbon linkage

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

Compounds and methods for utilizing compounds comprising a superoxide dismutase mimetic covalently linked to polyethylene glycol. Methods are also provided for preparing a superoxide dismutase mimetic covalently linked to a polyethylene glycol, the methods comprising reacting an activated polyethylene glycol with a superoxide dismutase mimetic, or alternatively, reacting a superoxide dismutase mimetic with an activated polyethylene glycol. A method is also provided for preventing or treating a disease or disorder in which superoxide anions are implicated, comprising administering to a subject in need thereof, a therapeutically effective amount of a compound comprising a superoxide dismutase mimetic covalently linked to a polythylene glycol. Methods of determining the safety and efficacy of the compounds are also provided. Methods for determining the safety and efficacy can include methods in lab animals and humans.
PCT/US2005/046825 2004-12-21 2005-12-21 Polyethylene glycolated superoxide dismutase mimetics WO2006069326A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
CA2591970A CA2591970C (en) 2004-12-21 2005-12-21 Polyethylene glycolated superoxide dismutase mimetics
US11/766,221 US8217166B2 (en) 2005-05-05 2007-06-21 Polyethylene glycolated superoxide dismutase mimetics
US13/929,222 US9150837B2 (en) 2004-12-21 2013-06-27 Polyethylene glycolated superoxide dismutase mimetics

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US63817304P 2004-12-21 2004-12-21
US60/638,173 2004-12-21
US67799905P 2005-05-05 2005-05-05
US60/677,999 2005-05-05

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US11/766,221 Continuation US8217166B2 (en) 2004-12-21 2007-06-21 Polyethylene glycolated superoxide dismutase mimetics

Publications (2)

Publication Number Publication Date
WO2006069326A2 WO2006069326A2 (en) 2006-06-29
WO2006069326A3 true WO2006069326A3 (en) 2006-12-14

Family

ID=36602350

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2005/046825 WO2006069326A2 (en) 2004-12-21 2005-12-21 Polyethylene glycolated superoxide dismutase mimetics

Country Status (2)

Country Link
CA (1) CA2591970C (en)
WO (1) WO2006069326A2 (en)

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6395725B1 (en) * 1997-06-20 2002-05-28 G.D. Searle & Co. Analgesic methods using synthetic catalysts for the dismutation of superoxide radicals

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6395725B1 (en) * 1997-06-20 2002-05-28 G.D. Searle & Co. Analgesic methods using synthetic catalysts for the dismutation of superoxide radicals

Also Published As

Publication number Publication date
CA2591970C (en) 2014-08-19
WO2006069326A2 (en) 2006-06-29
CA2591970A1 (en) 2006-06-29

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