WO2006064530A3 - Dermorphin analogs with analgesic activity - Google Patents

Dermorphin analogs with analgesic activity Download PDF

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Publication number
WO2006064530A3
WO2006064530A3 PCT/IT2005/000733 IT2005000733W WO2006064530A3 WO 2006064530 A3 WO2006064530 A3 WO 2006064530A3 IT 2005000733 W IT2005000733 W IT 2005000733W WO 2006064530 A3 WO2006064530 A3 WO 2006064530A3
Authority
WO
WIPO (PCT)
Prior art keywords
dermorphin
analgesic activity
aminoacid
fact
analogs
Prior art date
Application number
PCT/IT2005/000733
Other languages
French (fr)
Other versions
WO2006064530A2 (en
Inventor
Pietro Melchiorri
Lucia Negri
Raniero Rocchi
Luigi Ciocca
Original Assignee
Biogen S R L
Pietro Melchiorri
Lucia Negri
Raniero Rocchi
Luigi Ciocca
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biogen S R L, Pietro Melchiorri, Lucia Negri, Raniero Rocchi, Luigi Ciocca filed Critical Biogen S R L
Priority to EP05823581A priority Critical patent/EP1831244A2/en
Publication of WO2006064530A2 publication Critical patent/WO2006064530A2/en
Publication of WO2006064530A3 publication Critical patent/WO2006064530A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

New opioid heptapeptide analogs of dermorphin characterised by the fact that, like dermorphin, they maintain a tyrosine residue in position 1 and a D-α-aminoacid, preferably D-Ala, in position 2, and by the fact that in position 7 they have the aminoacid of maximum basicity, i.e. arginine. The preferred peptide of the invention, Arg7-dermorphin, referred to as arginorphin, has a potent analgesic activity. This activity largely comes about at the peripheral opiod nociceptor level, without involving the more serious central side effects typical of opiates.
PCT/IT2005/000733 2004-12-15 2005-12-14 Dermorphin analogs with analgesic activity WO2006064530A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP05823581A EP1831244A2 (en) 2004-12-15 2005-12-14 Dermorphin analogs with analgesic activity

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ITRM2004A000607 2004-12-15
ITRM20040607 ITRM20040607A1 (en) 2004-12-15 2004-12-15 ANALOGUES OF THE DERMORFINA WITH ANALGESIC ACTIVITY.

Publications (2)

Publication Number Publication Date
WO2006064530A2 WO2006064530A2 (en) 2006-06-22
WO2006064530A3 true WO2006064530A3 (en) 2007-02-08

Family

ID=36358951

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IT2005/000733 WO2006064530A2 (en) 2004-12-15 2005-12-14 Dermorphin analogs with analgesic activity

Country Status (3)

Country Link
EP (1) EP1831244A2 (en)
IT (1) ITRM20040607A1 (en)
WO (1) WO2006064530A2 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111701028A (en) 2011-05-18 2020-09-25 梅德瑞斯糖尿病有限责任公司 Improved peptide medicine for insulin resistance
CA2836573C (en) * 2011-05-18 2022-06-07 Eumederis Pharmaceuticals, Inc. Improved peptide pharmaceuticals
BR112015011478B1 (en) 2012-11-20 2022-10-25 Mederis Diabetes, Llc PEPTIDE PRODUCTS, THEIR USES AND PHARMACEUTICAL COMPOSITION
DK3444281T3 (en) 2012-11-20 2022-02-07 Eumederis Pharmaceuticals Inc IMPROVED PEPTID MEDICINES
IL285613B1 (en) 2014-05-28 2024-07-01 Mederis Diabetes Llc Improved peptide pharmaceuticals for insulin resistance
MX2020006999A (en) 2018-01-03 2020-12-10 Mederis Diabetes Llc Improved peptide pharmaceuticals for treatment of nash and other disorders.
PL439243A1 (en) * 2021-10-18 2023-04-24 Instytut Medycyny Doświadczalnej I Klinicznej Im. Mirosława Mossakowskiego Polskiej Akademii Nauk New dermorphine analogue as an analgesic for treatment of chronic pain

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5602100A (en) * 1988-06-30 1997-02-11 Astra Ab Dermorphin analogs having pharmacological activity

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5602100A (en) * 1988-06-30 1997-02-11 Astra Ab Dermorphin analogs having pharmacological activity

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
NEGRI, LUCIA ET AL: "Dermorphin-related peptides from the skin of Phyllomedusa bicolor and their amidated analogs activate two .mu. opioid receptor subtypes that modulate antinociception and catalepsy in the rat", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA , 89(15), 7203-7 CODEN: PNASA6; ISSN: 0027-8424, 1992, XP002382460 *

Also Published As

Publication number Publication date
WO2006064530A2 (en) 2006-06-22
EP1831244A2 (en) 2007-09-12
ITRM20040607A1 (en) 2005-03-15

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