WO2006063189A3 - Multi-layered chewing gum tablet with quick disintegration layer - Google Patents

Multi-layered chewing gum tablet with quick disintegration layer Download PDF

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Publication number
WO2006063189A3
WO2006063189A3 PCT/US2005/044523 US2005044523W WO2006063189A3 WO 2006063189 A3 WO2006063189 A3 WO 2006063189A3 US 2005044523 W US2005044523 W US 2005044523W WO 2006063189 A3 WO2006063189 A3 WO 2006063189A3
Authority
WO
WIPO (PCT)
Prior art keywords
chewing gum
gum tablet
layer
quick disintegration
disintegration layer
Prior art date
Application number
PCT/US2005/044523
Other languages
French (fr)
Other versions
WO2006063189A2 (en
Inventor
Christopher Edward Fankhauser
Alexander Mark Schobel
Original Assignee
Novartis Ag
Novartis Pharma Gmbh
Christopher Edward Fankhauser
Alexander Mark Schobel
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag, Novartis Pharma Gmbh, Christopher Edward Fankhauser, Alexander Mark Schobel filed Critical Novartis Ag
Publication of WO2006063189A2 publication Critical patent/WO2006063189A2/en
Publication of WO2006063189A3 publication Critical patent/WO2006063189A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/465—Nicotine; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
    • A61K9/0058—Chewing gums
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
    • A61K9/209—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat containing drug in at least two layers or in the core and in at least one outer layer

Abstract

A multi-layered drug delivery system contains at least one gum layer and at least one rapidly dissolving tablet layer. The tablet layer contains a therapeutically effective amount of a medicament which is susceptible to rupture upon chewing, thereby causing the release of the drug. The invention is especially useful as a delivery system for oral hygienic agents, pharmaceuticals, and nutritive and dietary supplements. Useful delivery systems include those for nicotine, and cough, cold, allergy and/or sinus medicaments.
PCT/US2005/044523 2004-12-10 2005-12-08 Multi-layered chewing gum tablet with quick disintegration layer WO2006063189A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US63493104P 2004-12-10 2004-12-10
US60/634,931 2004-12-10

Publications (2)

Publication Number Publication Date
WO2006063189A2 WO2006063189A2 (en) 2006-06-15
WO2006063189A3 true WO2006063189A3 (en) 2006-09-21

Family

ID=36578595

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2005/044523 WO2006063189A2 (en) 2004-12-10 2005-12-08 Multi-layered chewing gum tablet with quick disintegration layer

Country Status (1)

Country Link
WO (1) WO2006063189A2 (en)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8920856B2 (en) 2009-10-08 2014-12-30 Intercontinental Great Brands Llc Co-extruded layered candy and gum apparatus and methods
US9060526B2 (en) 2009-01-22 2015-06-23 Intercontinental Great Brands Llc Confectionery processing
US9220284B2 (en) 2008-05-02 2015-12-29 Intercontinental Great Brands Llc Multilayered sugar free mannitol confectionery and methods of making same
US9247761B2 (en) 2009-10-30 2016-02-02 Intercontinental Great Brands Llc Sugar free confectionery; methods of making same; and use in preparing multilayered confectionery
JP7214755B2 (en) 2018-05-17 2023-01-30 フェルティン ファルマ アー／エス Tableted chewing gum suitable for pharmaceutical active ingredients

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2635678C (en) 2005-12-29 2011-07-12 Wm. Wrigley Jr. Company Chewing gum containing styrene-diene block copolymers
CA2678876C (en) * 2007-03-07 2015-11-24 Novartis Ag Orally administrable films
WO2009007768A1 (en) * 2007-07-06 2009-01-15 Gumlink A/S Compressed tablet comprising polyol
EP3093010A1 (en) * 2007-10-19 2016-11-16 Reckitt Benckiser Healthcare (UK) Limited Oral composition comprising a cooling agent
GB2453770A (en) * 2007-10-19 2009-04-22 Reckitt Benckiser Healthcare Oral composition comprising a cooling agent
CN101215455B (en) * 2007-12-26 2011-04-06 解兵 Flute film glue and processing technique thereof
EP2233134A1 (en) * 2009-03-27 2010-09-29 McNeil AB Multi-portion intra-oral dosage form with organoleptic properties
US20100247586A1 (en) * 2009-03-27 2010-09-30 Andreas Hugerth Multi-Portion Intra-Oral Dosage Form With Organoleptic Properties
US10548839B2 (en) 2010-03-16 2020-02-04 Wei Tian Process of manufacturing a lyophilized fast dissolving, multi-phasic dosage form
WO2016090389A1 (en) * 2014-12-01 2016-06-09 Rathogwa Michael T Decongestant gum
US10441535B2 (en) * 2014-12-29 2019-10-15 NeuroGum, LLC Nutraceutical confectionary composition containing caffeine and L-theanine
US11517533B2 (en) 2016-10-25 2022-12-06 Catalent U.K. Swindon Zydis Limited Compositions of different densities for fast disintegrating multi-layer tablet
US10632076B2 (en) 2016-11-18 2020-04-28 Fertin Pharma A/S Tablet comprising separate binder and erythritol
US10543205B2 (en) 2016-11-18 2020-01-28 Fertin Pharma A/S Oral delivery vehicle containing nicotine
CN110464691B (en) * 2018-05-10 2021-04-20 北京东方淼森生物科技有限公司 Peach gum composition and application thereof
US11096895B2 (en) 2018-05-17 2021-08-24 Fertin Pharma A/S Oral tablet suitable for active pharmaceutical ingredients
US11090263B2 (en) 2018-05-22 2021-08-17 Fertin Pharma A/S Tableted chewing gum suitable for active pharmaceutical ingredients
US20190350858A1 (en) 2018-05-17 2019-11-21 Fertin Pharma A/S Oral tablet for delivery of active ingredients to the gastrointestinal tract
US11058633B2 (en) 2018-05-17 2021-07-13 Fertin Pharma A/S Disintegrating oral tablet suitable for active pharmaceutical ingredients
US11058641B2 (en) 2018-05-17 2021-07-13 Fertin Pharma A/S Oral tablet for taste masking of active ingredients
US11135157B2 (en) 2018-05-17 2021-10-05 Fertin Pharma A/S Oral tablet for delivery of active ingredients to the throat
US11052047B2 (en) 2018-05-17 2021-07-06 Fertin Pharma A/S Oral tablet suitable for fast release of active pharmaceutical ingredients
US11154496B2 (en) 2019-01-25 2021-10-26 Nordiccan A/S Cannabinoid chewing gum with polyvinyl acetate elastomer plasticizers
US11191720B2 (en) 2019-01-25 2021-12-07 Nordiccan A/S Chewing gum with improved delivery of cannabinoids
US11013685B2 (en) 2019-01-25 2021-05-25 Nordiccan A/S Cannabinoid chewing gum with improved release of cannabinoids
US11406593B2 (en) 2019-01-25 2022-08-09 Nordiccan A/S Cannabinoid chewing gum with high intensity sweeteners
US11166910B2 (en) 2019-01-25 2021-11-09 Nordiccan A/S Cannabinoid chewing gum with sugar alcohols
US11471405B2 (en) 2019-03-01 2022-10-18 Nordiccan A/S Tableted chewing gum with enhanced delivery of cannabinoids
US10799450B2 (en) 2019-03-01 2020-10-13 Medcan Pharma A/S Tableted cannabinoid chewing gum with layered structure
US10933017B2 (en) 2019-03-01 2021-03-02 Nordiccan A/S Tableted cannabinoid chewing gum with polyvinyl acetate elastomer plasticizers
JP2022521711A (en) * 2019-03-01 2022-04-12 ノルディックカン・アー／エス Cannabinoid chewing gum with a layered structure
US11253473B2 (en) 2019-03-01 2022-02-22 Nordiccan A/S Method of producing tableted cannabinoid chewing gum

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4139589A (en) * 1975-02-26 1979-02-13 Monique Beringer Process for the manufacture of a multi-zone tablet and tablet manufactured by this process
WO2004006686A2 (en) * 2002-07-15 2004-01-22 Bagger-Sørensen & Co. A/S Tabletted chewing gum sweet and method for manufacturing the same
WO2004073691A1 (en) * 2003-02-20 2004-09-02 Jagotec Ag Chewing gum in the form of multi-layer tablets
EP1554935A1 (en) * 2004-01-19 2005-07-20 Gumlink A/S Layered chewing gum tablet

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4139589A (en) * 1975-02-26 1979-02-13 Monique Beringer Process for the manufacture of a multi-zone tablet and tablet manufactured by this process
WO2004006686A2 (en) * 2002-07-15 2004-01-22 Bagger-Sørensen & Co. A/S Tabletted chewing gum sweet and method for manufacturing the same
WO2004073691A1 (en) * 2003-02-20 2004-09-02 Jagotec Ag Chewing gum in the form of multi-layer tablets
EP1554935A1 (en) * 2004-01-19 2005-07-20 Gumlink A/S Layered chewing gum tablet

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9220284B2 (en) 2008-05-02 2015-12-29 Intercontinental Great Brands Llc Multilayered sugar free mannitol confectionery and methods of making same
US9237758B2 (en) 2008-05-02 2016-01-19 Intercontinental Great Brands Llc Multilayered sugar free isomalt confectionery and methods of making same
US9060526B2 (en) 2009-01-22 2015-06-23 Intercontinental Great Brands Llc Confectionery processing
US8920856B2 (en) 2009-10-08 2014-12-30 Intercontinental Great Brands Llc Co-extruded layered candy and gum apparatus and methods
US9247761B2 (en) 2009-10-30 2016-02-02 Intercontinental Great Brands Llc Sugar free confectionery; methods of making same; and use in preparing multilayered confectionery
JP7214755B2 (en) 2018-05-17 2023-01-30 フェルティン ファルマ アー／エス Tableted chewing gum suitable for pharmaceutical active ingredients

Also Published As

Publication number Publication date
WO2006063189A2 (en) 2006-06-15

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