WO2006062909A3 - Methods and compositions for enhancing vascular access - Google Patents

Methods and compositions for enhancing vascular access Download PDF

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Publication number
WO2006062909A3
WO2006062909A3 PCT/US2005/043967 US2005043967W WO2006062909A3 WO 2006062909 A3 WO2006062909 A3 WO 2006062909A3 US 2005043967 W US2005043967 W US 2005043967W WO 2006062909 A3 WO2006062909 A3 WO 2006062909A3
Authority
WO
WIPO (PCT)
Prior art keywords
implantable material
cells
methods
present
functional
Prior art date
Application number
PCT/US2005/043967
Other languages
French (fr)
Other versions
WO2006062909A2 (en
Inventor
Helen Marie Nugent
Elazer Edelman
Anupam Dalal
Steve Bollinger
Scott Epperly
Original Assignee
Pervasis Therapeutics Inc
Helen Marie Nugent
Elazer Edelman
Anupam Dalal
Steve Bollinger
Scott Epperly
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pervasis Therapeutics Inc, Helen Marie Nugent, Elazer Edelman, Anupam Dalal, Steve Bollinger, Scott Epperly filed Critical Pervasis Therapeutics Inc
Priority to CN200580042372XA priority Critical patent/CN101076360B/en
Priority to EP05848586A priority patent/EP1824526B1/en
Priority to DE602005022481T priority patent/DE602005022481D1/en
Priority to CN2005800421993A priority patent/CN101141988B/en
Priority to PCT/US2005/043844 priority patent/WO2006062871A2/en
Priority to CA2589597A priority patent/CA2589597C/en
Priority to US11/792,350 priority patent/US20080119946A1/en
Priority to AU2005314263A priority patent/AU2005314263B2/en
Priority to JP2007545545A priority patent/JP2008522735A/en
Priority to JP2007545539A priority patent/JP5674256B2/en
Priority to AU2005314312A priority patent/AU2005314312B2/en
Priority to AT05853004T priority patent/ATE474608T1/en
Priority to CA2589588A priority patent/CA2589588C/en
Priority to CN201210448869.3A priority patent/CN103055350B/en
Priority to EP05853004A priority patent/EP1824529B1/en
Priority to SG2013075387A priority patent/SG195537A1/en
Priority to CA 2818182 priority patent/CA2818182C/en
Priority to JP2008518189A priority patent/JP5632580B2/en
Priority to CN201210246619.1A priority patent/CN102743792B/en
Priority to EP20060772165 priority patent/EP1901680B1/en
Priority to SG201002482-6A priority patent/SG161258A1/en
Priority to CA 2612751 priority patent/CA2612751A1/en
Priority to PCT/US2006/021755 priority patent/WO2007001744A2/en
Priority to ES06772165.4T priority patent/ES2541684T3/en
Priority to AU2006262682A priority patent/AU2006262682B2/en
Priority to US11/922,729 priority patent/US20090035346A1/en
Priority to CN2010102362140A priority patent/CN101878757A/en
Priority to CN2006800279776A priority patent/CN101257861B/en
Publication of WO2006062909A2 publication Critical patent/WO2006062909A2/en
Publication of WO2006062909A3 publication Critical patent/WO2006062909A3/en
Priority to IL183786A priority patent/IL183786A/en
Priority to IL183784A priority patent/IL183784A/en
Priority to IL188263A priority patent/IL188263A/en
Priority to HK08101925.0A priority patent/HK1112429A1/en
Priority to US12/626,823 priority patent/US20100204783A1/en
Priority to US12/779,223 priority patent/US20100318016A1/en
Priority to IL209574A priority patent/IL209574A/en
Priority to AU2010249280A priority patent/AU2010249280B2/en
Priority to US13/040,650 priority patent/US20110229549A1/en
Priority to IL212764A priority patent/IL212764A0/en
Priority to JP2012110766A priority patent/JP2012148164A/en
Priority to JP2012133043A priority patent/JP2012166084A/en
Priority to IL220806A priority patent/IL220806A/en
Priority to JP2012256581A priority patent/JP2013039431A/en
Priority to JP2014239567A priority patent/JP2015042682A/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3804—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by specific cells or progenitors thereof, e.g. fibroblasts, connective tissue cells, kidney cells
    • A61L27/3808—Endothelial cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3839—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by the site of application in the body

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Cell Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Transplantation (AREA)
  • Botany (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dermatology (AREA)
  • Medicinal Chemistry (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Zoology (AREA)
  • Epidemiology (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Prostheses (AREA)
  • External Artificial Organs (AREA)

Abstract

Disclosed is an implantable material comprising a biocompatible matrix and cells which, when provided to a vascular access structure, can promote functionality generally. For example, implantable material of the present invention can enhance maturation of an arteriovenous native fistula as well as prolong the fistula in a mature, functional state suitable for dialysis. Additionally, the present invention can promote formation of a functional arteriovenous graft suitable for dialysis as well as promote formation of a functional peripheral bypass graft. Implantable material can be configured as a flexible planar form or a flowable composition with shape­retaining properties suitable for implantation at, adjacent or in the vicinity of an anastomoses or arteriovenous graft. According to the methods disclosed herein, the implantable material is provided to an exterior surface of a blood vessel. Certain embodiments of the flexible planar form define a slot. The materials and methods of the present invention comprise cells, preferably endothelial cells or cells having an endothelial-like phenotype.
PCT/US2005/043967 2004-12-08 2005-12-06 Methods and compositions for enhancing vascular access WO2006062909A2 (en)

Priority Applications (43)

Application Number Priority Date Filing Date Title
CN200580042372XA CN101076360B (en) 2004-12-08 2005-12-06 Materials and methods for minimally-invasive administration of a cell-containing flowable composition
EP05848586A EP1824526B1 (en) 2004-12-08 2005-12-06 Materials and methods for minimally-invasive administration of a cell-containing flowable composition
DE602005022481T DE602005022481D1 (en) 2004-12-08 2005-12-06 COMPOSITIONS AND THEIR USE FOR BETTER VESSEL ACCESS
CN2005800421993A CN101141988B (en) 2004-12-08 2005-12-06 Materials and methods for treating and managing plaque disease
PCT/US2005/043844 WO2006062871A2 (en) 2004-12-08 2005-12-06 Materials and methods for minimally-invasive administration of a cell-containing flowable composition
CA2589597A CA2589597C (en) 2004-12-08 2005-12-06 Methods and compositions for enhancing vascular access
US11/792,350 US20080119946A1 (en) 2004-12-08 2005-12-06 Methods And Compositions For Enhacing Vascular Access
AU2005314263A AU2005314263B2 (en) 2004-12-08 2005-12-06 Methods and compositions for enhancing vascular access
JP2007545545A JP2008522735A (en) 2004-12-08 2005-12-06 Methods and compositions for enhancing vascular access
JP2007545539A JP5674256B2 (en) 2004-12-08 2005-12-06 Materials and methods for minimally invasive administration of cell-containing flowable compositions
AU2005314312A AU2005314312B2 (en) 2004-12-08 2005-12-06 Materials and methods for minimally-invasive administration of a cell-containing flowable composition
AT05853004T ATE474608T1 (en) 2004-12-08 2005-12-06 COMPOSITIONS AND THEIR USE FOR BETTER VASCULAR ACCESS
CA2589588A CA2589588C (en) 2004-12-08 2005-12-06 Materials and methods for minimally-invasive administration of a cell-containing flowable composition
CN201210448869.3A CN103055350B (en) 2004-12-08 2005-12-06 Materials and methods for minimally-invasive administration of cell-containing flowable composition
EP05853004A EP1824529B1 (en) 2004-12-08 2005-12-06 Compositions and their use for enhancing vascular access
CA 2612751 CA2612751A1 (en) 2005-06-21 2006-06-05 Vegf-containing transport media composition for storing cells engrafted in a biocompatible matrix
AU2006262682A AU2006262682B2 (en) 2005-06-21 2006-06-05 Methods and compositions for enhancing vascular access
JP2008518189A JP5632580B2 (en) 2005-06-21 2006-06-05 Methods and compositions for improving vascular access
CN201210246619.1A CN102743792B (en) 2005-06-21 2006-06-05 Methods and compositions for enhancing vascular access
EP20060772165 EP1901680B1 (en) 2005-06-21 2006-06-05 Crypreservation of biocompatible material
SG201002482-6A SG161258A1 (en) 2005-06-21 2006-06-05 Methods and compositions for enhancing vascular access
SG2013075387A SG195537A1 (en) 2005-06-21 2006-06-05 Methods and compositions for enhancing vascular access
PCT/US2006/021755 WO2007001744A2 (en) 2005-06-21 2006-06-05 Methods and compositions for enhancing vascular access
ES06772165.4T ES2541684T3 (en) 2005-06-21 2006-06-05 Cryopreservation of biocompatible material
CA 2818182 CA2818182C (en) 2005-06-21 2006-06-05 Methods and compositions for enhancing vascular access
US11/922,729 US20090035346A1 (en) 2005-06-21 2006-06-05 Methods and Compositions for Enhancing Vascular Access
CN2010102362140A CN101878757A (en) 2005-06-21 2006-06-05 Be used to strengthen the method and composition of vascular access
CN2006800279776A CN101257861B (en) 2005-06-21 2006-06-05 Methods and compositions for enhancing vascular access
IL183786A IL183786A (en) 2004-12-08 2007-06-07 Methods and compositions for enhancing vascular access
IL183784A IL183784A (en) 2004-12-08 2007-06-07 Materials for minimally-invasive administration of a cell-containing flowable composition
IL188263A IL188263A (en) 2005-06-21 2007-12-19 Transport media compositions for storing an implantable material and methods for storing an implantable material
HK08101925.0A HK1112429A1 (en) 2004-12-08 2008-02-21 Compositions and their use for enhancing vascular access
US12/626,823 US20100204783A1 (en) 2005-12-06 2009-11-27 Methods and compositions for enhancing vascular access
US12/779,223 US20100318016A1 (en) 2004-12-08 2010-05-13 Methods and Compositions for Enhancing Vascular Access
IL209574A IL209574A (en) 2004-12-08 2010-11-25 Materials for minimally-invasive administration of a cell-containing flowable composition
AU2010249280A AU2010249280B2 (en) 2004-12-08 2010-12-10 Materials and methods for minimally-invasive administration of a cell-containing flowable composition
US13/040,650 US20110229549A1 (en) 2004-12-08 2011-03-04 Methods and Compositions for Enhancing Vascular Access
IL212764A IL212764A0 (en) 2004-12-08 2011-05-08 Methods and compositions for enhancing vascular access
JP2012110766A JP2012148164A (en) 2004-12-08 2012-05-14 Material and method for minimally-invasive administration of cell-containing flowable composition
JP2012133043A JP2012166084A (en) 2005-06-21 2012-06-12 Method and composition for enhancing vascular access
IL220806A IL220806A (en) 2005-06-21 2012-07-05 Method and compositions for enhancing vascular access
JP2012256581A JP2013039431A (en) 2004-12-08 2012-11-22 Material and method for minimally-invasive administration of cell-containing flowable composition
JP2014239567A JP2015042682A (en) 2004-12-08 2014-11-27 Material and method for minimally-invasive administration of cell-containing flowable composition

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US63415504P 2004-12-08 2004-12-08
US60/634,155 2004-12-08
US66385905P 2005-03-21 2005-03-21
US60/663,859 2005-03-21
US68205405P 2005-05-18 2005-05-18
US60/682,054 2005-05-18
US4984405P 2005-12-06 2005-12-06

Related Child Applications (4)

Application Number Title Priority Date Filing Date
US11/922,729 Continuation US20090035346A1 (en) 2005-06-21 2006-06-05 Methods and Compositions for Enhancing Vascular Access
PCT/US2006/021755 Continuation WO2007001744A2 (en) 2005-06-21 2006-06-05 Methods and compositions for enhancing vascular access
US12/626,823 Continuation-In-Part US20100204783A1 (en) 2005-12-06 2009-11-27 Methods and compositions for enhancing vascular access
US12/779,223 Continuation US20100318016A1 (en) 2004-12-08 2010-05-13 Methods and Compositions for Enhancing Vascular Access

Publications (2)

Publication Number Publication Date
WO2006062909A2 WO2006062909A2 (en) 2006-06-15
WO2006062909A3 true WO2006062909A3 (en) 2006-08-31

Family

ID=36570653

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2005/043967 WO2006062909A2 (en) 2004-12-08 2005-12-06 Methods and compositions for enhancing vascular access

Country Status (1)

Country Link
WO (1) WO2006062909A2 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2006238892B2 (en) 2005-04-21 2011-01-27 Massachusetts Institute Of Technology Materials and methods for altering an immune response to exogenous and endogenous immunogens, including syngeneic and non-syngeneic cells, tissues or organs
JP5632580B2 (en) * 2005-06-21 2014-11-26 シャイア リジェネラティブ メディシン， インコーポレイテッド Methods and compositions for improving vascular access
US20100092532A1 (en) * 2006-11-07 2010-04-15 Helen Marie Nugent Materials and Methods for Treating and Managing Angiogenesis-Mediated Diseases
WO2008057590A2 (en) * 2006-11-07 2008-05-15 Pervasis Therapeutics, Inc. Methods and compositions for modulating tissue modeling
JP6356065B2 (en) 2011-08-01 2018-07-11 ラミネート・メディカル・テクノロジーズ・リミテッド External vascular support

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4820626A (en) * 1985-06-06 1989-04-11 Thomas Jefferson University Method of treating a synthetic or naturally occuring surface with microvascular endothelial cells, and the treated surface itself
WO2001062241A1 (en) * 2000-02-23 2001-08-30 Smithkline Beecham Corporation Method for the prevention or reduction of vascular access dysfunction
US6328762B1 (en) * 1999-04-27 2001-12-11 Sulzer Biologics, Inc. Prosthetic grafts
US20020077694A1 (en) * 1999-06-30 2002-06-20 Pharmasonics, Inc. Methods and kits for the inhibition of hyperplasia in vascular fistulas and grafts
WO2002062335A2 (en) * 2001-01-16 2002-08-15 Vascular Therapies, Llc Implantable device containing resorbable matrix material and anti-proliferative drugs for preventing or treating failure of hemodialysis vascular access and other vascular grafts
WO2004002549A1 (en) * 2002-06-28 2004-01-08 Novartis Ag Use of organic compounds

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4820626A (en) * 1985-06-06 1989-04-11 Thomas Jefferson University Method of treating a synthetic or naturally occuring surface with microvascular endothelial cells, and the treated surface itself
US6328762B1 (en) * 1999-04-27 2001-12-11 Sulzer Biologics, Inc. Prosthetic grafts
US20020077694A1 (en) * 1999-06-30 2002-06-20 Pharmasonics, Inc. Methods and kits for the inhibition of hyperplasia in vascular fistulas and grafts
WO2001062241A1 (en) * 2000-02-23 2001-08-30 Smithkline Beecham Corporation Method for the prevention or reduction of vascular access dysfunction
WO2002062335A2 (en) * 2001-01-16 2002-08-15 Vascular Therapies, Llc Implantable device containing resorbable matrix material and anti-proliferative drugs for preventing or treating failure of hemodialysis vascular access and other vascular grafts
WO2004002549A1 (en) * 2002-06-28 2004-01-08 Novartis Ag Use of organic compounds

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
HAZINEDAROGLU S M ET AL: "Immediate postimplant hemodialysis through a new ''self-sealing'' heparin-bonded polycarbonate/urethane graft", TRANSPLANTATION PROCEEDINGS, ORLANDO, FL, US, vol. 36, no. 9, November 2004 (2004-11-01), pages 2599 - 2602, XP004697046, ISSN: 0041-1345 *
HIRIGOYEN M B ET AL: "Periadventitial delivery of heparin in the prevention of microvenous thrombosis", JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY, SAUNDERS, PHILADELPHIA, PA, US, vol. 54, no. 9, September 1996 (1996-09-01), pages 1097 - 1102, XP001097380, ISSN: 0278-2391 *

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