WO2006043582A1 - 治療用カテーテル - Google Patents
治療用カテーテル Download PDFInfo
- Publication number
- WO2006043582A1 WO2006043582A1 PCT/JP2005/019181 JP2005019181W WO2006043582A1 WO 2006043582 A1 WO2006043582 A1 WO 2006043582A1 JP 2005019181 W JP2005019181 W JP 2005019181W WO 2006043582 A1 WO2006043582 A1 WO 2006043582A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- guide wire
- catheter
- lumen
- shaft
- slit
- Prior art date
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/0067—Catheters; Hollow probes characterised by the distal end, e.g. tips
- A61M25/0068—Static characteristics of the catheter tip, e.g. shape, atraumatic tip, curved tip or tip structure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/0021—Catheters; Hollow probes characterised by the form of the tubing
- A61M25/0023—Catheters; Hollow probes characterised by the form of the tubing by the form of the lumen, e.g. cross-section, variable diameter
- A61M25/0026—Multi-lumen catheters with stationary elements
- A61M25/003—Multi-lumen catheters with stationary elements characterized by features relating to least one lumen located at the distal part of the catheter, e.g. filters, plugs or valves
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/0043—Catheters; Hollow probes characterised by structural features
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/0021—Catheters; Hollow probes characterised by the form of the tubing
- A61M25/0023—Catheters; Hollow probes characterised by the form of the tubing by the form of the lumen, e.g. cross-section, variable diameter
- A61M25/0026—Multi-lumen catheters with stationary elements
- A61M2025/0034—Multi-lumen catheters with stationary elements characterized by elements which are assembled, connected or fused, e.g. splittable tubes, outer sheaths creating lumina or separate cores
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/0021—Catheters; Hollow probes characterised by the form of the tubing
- A61M25/0023—Catheters; Hollow probes characterised by the form of the tubing by the form of the lumen, e.g. cross-section, variable diameter
- A61M25/0026—Multi-lumen catheters with stationary elements
- A61M2025/0037—Multi-lumen catheters with stationary elements characterized by lumina being arranged side-by-side
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/10—Balloon catheters
- A61M2025/1043—Balloon catheters with special features or adapted for special applications
- A61M2025/1056—Balloon catheters with special features or adapted for special applications having guide wire lumens outside the main shaft, i.e. the guide wire lumen is within or on the surface of the balloon
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/0067—Catheters; Hollow probes characterised by the distal end, e.g. tips
- A61M25/008—Strength or flexibility characteristics of the catheter tip
Definitions
- the present invention relates to a catheter intended for injecting a drug into the body percutaneously, and a debris (foreign matter) such as a thrombus formed in a blood vessel or an atheromatous released in the blood vessel.
- a therapeutic catheter such as an aspiration catheter that is removed from the body by a negative pressure applied to the proximal end of the catheter.
- Balloon catheters used for PTA and PTCA are mainly used as a set of a guide catheter and a guide wire in order to expand a stenosis site or a blockage site of a blood vessel.
- a balloon catheter In this angioplasty using a balloon catheter, first the guide catheter is inserted into the femoral artery, and the tip is positioned at the entrance of the coronary artery via the aorta, and then the guide wire penetrates the balloon catheter. Is advanced beyond the stenosis or occlusion site of the blood vessel, and then the balloon catheter is advanced along the guide wire, and the balloon is inflated while being positioned at the stenosis or occlusion site.
- This balloon catheter is not limited to the treatment of a stenosis or occlusion site of a blood vessel, but is useful for many medical applications including insertion into a blood vessel and insertion into various body cavities and tubular tissues.
- the occlusion in the blood vessel is caused by a thrombus
- the occlusion site is covered with a balloon catheter.
- the thrombus may be released from the inner wall of the blood vessel and occlude the downstream peripheral blood vessel.
- the stenotic site in the blood vessel is expanded, if the lesion contains a large number of rod-shaped plaques, expansion of the balloon catheter causes the rod-shaped plaque (atheromas) to scatter from the lesion, Peripheral blood vessels may be occluded. In this way, when the peripheral blood vessel is occluded, blood flow does not flow to the periphery even if the occluded portion or stenosis portion is expanded, resulting in a situation of slow flow or no reflow.
- vasodilators such as nitroglycerin may be administered to restore blood flow, or thrombolytic agents such as urokinase may be administered locally to dissolve obstructions. There is still a problem that it takes time to complete. If peripheral occlusion is severe and hemodynamics is poor, auxiliary means such as aortic balloon bobbing (IABP) are also used. In addition to thrombolysis, attempts have been made to remove thrombus from the body by applying negative pressure from the proximal end of the catheter.
- IABP aortic balloon bobbing
- Temporary occlusion balloon catheters are used as a means to temporarily occlude blood vessels.
- the temporary occlusion balloon force Tetel shaft is used as a guide wire, and other treatment catheters, such as a balloon catheter for dilatation of blood vessels, are transmitted through the shaft of the temporary occlusion balloon catheter.
- the lesion is inserted. Thereafter, the temporary occlusion balloon catheter is expanded to the periphery of the lesion, and the lesion is treated with the blood flow blocked.
- the shaft of the temporary occlusion balloon catheter may be positioned inside the guide wire lumen of another treatment catheter, and in this case, the guide wire lumen inner diameter of the treatment catheter is sufficiently longer than the entire length of the shaft. It is necessary to have a diameter equivalent to that of a general guide wire that is thin.
- the temporary occlusion balloon is expanded by an expansion device connected to the proximal end of the catheter, but when the expansion device is connected, other therapeutic catheters are manipulated along the shaft of the temporary occlusion balloon catheter. I can't.
- a seal portion that can maintain the expansion of the balloon even when the expansion device (usually referred to as an adapter since it is used in a form combined with a connection adapter) is removed is provided near the balloon catheter for temporary occlusion.
- the outer diameter of the seal part must be smaller than the guide wire lumen of the treatment catheter.
- Patent Document 1 discloses a catheter that blocks a blood flow using a single inflation balloon and an adapter for inflating or deflating the inflation balloon. This adapter is only described as being removable on the proximal end of the catheter. In addition, the adapter is not provided with a function for operating the extending member. In such a case, it seems that the extension member is directly operated by the operator's hand, but it is quite difficult to directly operate the thin shaft by hand. In Patent Document 1, the fitting between the elongated member and the catheter body and fluid sealing are performed by threading or friction.
- Patent Document 2 discloses a catheter having a rope mouth file valve and an inflation adapter for operating the valve.
- the structure is composed of a housing having a first part and a second part.
- the catheter is fixed in the housing, and the first part and the second part are combined to fix the housing with a lock clip.
- the catheter could not be easily fixed with one operation, and that a smooth procedure could not be performed in an actual clinical site.
- Patent Document 3 discloses an occlusive device incorporating an expandable member used for embolism suppression and an adapter for operating the expandable member.
- the adapter is attached to the proximal side of the occlusive device, and a tension wire (the present invention) is disclosed.
- the relative position of the working part) and the outer shaft member can be adjusted.
- the two halves are joined together in a clamshell shape and fixed with a latch, and the problem remains that the catheter cannot be simply fixed by a single operation like the adapter of Patent Document 2. That is, the problem that the operation time, in particular, the time from the treatment with the therapeutic power tail to the release of the temporary occlusion is very long has not been solved.
- Patent Document 5 tries to insert a guide wire into the catheter by twisting operation.
- the rigidity of the tip portion is significantly different from that of other portions, so that the operability is poor.
- the wire is not tightly held, the operability is poor, and a guide wire is present inside the catheter, which impairs the original function of the catheter.
- the guide wire is placed through the bend. This is unsuitable for reasons such as being difficult to follow, or a suction target such as a blood plug being caught by an internal guide wire, resulting in extremely poor suction capability.
- removal of a thrombus generated in a blood vessel is carried out mainly by a peripheral blood vessel using a thrombectomy catheter having a coil shape for removal or a balloon shape.
- the plug removal catheter has the coil shape control or balloon expansion hub attached to the hand, so it cannot be used together with the suction catheter that sucks and removes it by the negative pressure applied by the proximal end of the catheter. Many methods for removing blood clots were taken.
- Patent Document 1 Japanese Unexamined Patent Application Publication No. 2002-126093
- Patent Document 2 Special Table 2001-523535
- Patent Document 3 Special Table 2004-510524
- Patent Document 4 Japanese Patent Laid-Open No. 63-288167
- Patent Document 5 WOOlZ068177
- the means for solving the above problems is that the new treatment catheter structure, the selected material arrangement, and the assembly method can effectively serve as a guidewire in the guidewire lumen quickly, regardless of adapter attachment / detachment. It is to provide a therapeutic catheter in which a shaft or guide wire of another catheter can be placed. That is, the present invention is a therapeutic catheter having a main shaft having a lumen communicating with the distal end of the hand end force, a guide wire lumen for following the guide wire at the distal end, and a hub at the proximal end.
- the treatment catheter is characterized in that the guide wire lumen has a slit extending over the entire length of the guide wire lumen.
- the present invention provides a main shaft having a lumen communicating from the proximal end to the most advanced portion, a guide wire shaft having a guide wire lumen for following the guide wire at the tip end portion of the main shaft, and the guide wire shaft.
- a therapeutic force catheter having a hub at the proximal end of the main shaft, wherein the guide wire shaft has a slit extending over the entire length of the guide wire lumen.
- the slit portion has a structure in which the material constituting the guide wire lumen overlaps. Furthermore, it is more preferable that a guide for assisting insertion of the guide wire is formed in the vicinity of the slit portion, or that the slit portion has a stopper structure for suppressing the opening of the guide wire lumen.
- X-ray contrast It is also preferable that an X-ray impermeable marker for indicating the position of the distal end portion of the catheter is disposed near the boundary between the guide wire lumen and the main lumen, or near the connection portion between the guide wire shaft and the main shaft.
- the overlapping structure, guide, and stopper structure can be provided alone or in combination.
- the therapeutic catheter of the present invention is an aspiration catheter that is aspirated and removed from the body by negative pressure applied by the proximal end force of the catheter.
- the guidewire lumen of conventional therapeutic catheters has only been passed through the distal or distal inlet to pass through the guidewire and the shaft of other catheters that in effect serve as a guidewire.
- the method of treatment using the shaft of the balloon catheter for temporary occlusion that temporarily occludes the blood vessel as a guide wire compared with the treatment method in which the atheroma generated by the balloon expansion described above is removed by the suction catheter, it is expanded in advance.
- the adapter By setting the balloon catheter through the temporary occlusion balloon catheter, 1) connect the adapter to the temporary occlusion balloon catheter, expand and occlude, and 2) carry the dilatation balloon catheter from that state to the lesion, and expand. 3 ) Remove the balloon catheter for dilatation, 4) Place the temporary occlusion balloon catheter in the guide wire lumen of the suction catheter, which is the treatment catheter of the present invention, and proceed to the lesion, 5) Suction operation, 6) Suction force 7) —When occlusion balloon catheter contraction, and Thus, the adapter can be removed from the temporary occlusion balloon expansion and contraction, so it can be placed in the guide wire lumen of the treatment catheter of the present invention, greatly reducing the time to occlude the blood vessel. It was possible. In addition, since the adapter attachment / detachment operation associated with the expansion and contraction of the temporary occlusion balloon catheter can be omitted, the adapter system can be simplified and omitted.
- FIG. 1 is a side view showing an embodiment of a distal end portion of a treatment catheter according to the present invention.
- FIG. 2 is a cross-sectional view taken along line AA in FIG.
- FIG. 3 is a cross-sectional view of the same portion as FIG. 2, showing another embodiment having a structure in which the material constituting the guide wire lumen is overlapped at the slit portion.
- FIG. 4 shows another embodiment having a structure in which, in addition to the structure in which the material constituting the guide wire lumen overlaps in the slit portion, a guide for assisting insertion of the guide wire is provided in the slit portion.
- FIG. 3 is a cross-sectional view of a portion similar to FIG.
- FIG. 5 shows a structure in which the material constituting the guide wire lumen overlaps in the slit portion, a guide that assists insertion of the guide wire into the slit portion, and a stopper structure that suppresses the opening of the guide wire lumen.
- FIG. 5 is a cross-sectional view of the same portion as FIG.
- the present invention is a therapeutic catheter having a lumen communicating from the proximal end to the most advanced portion, a main shaft having a guide wire lumen for following the guide wire at the distal end, and a hub at the proximal end, the guide wire
- a treatment catheter characterized in that the lumen has a slit extending over the entire length of the guide wire lumen.
- FIG. 1 shows a treatment catheter having a main shaft 101 having a lumen communicating from the proximal end to the most distal portion of the therapeutic catheter according to the present invention, a guide wire lumen for following the guide wire at the distal end, and a hub at the proximal end.
- FIG. 1 shows that a slit 103 extending over the entire length of the guide wire lumen is provided at the tip 102 of the main shaft forming the guide wire lumen.
- the guide wire lumen is the same as the main shaft. Although it may be physically molded, a guide wire shaft with a guide wire lumen for following the guide wire at the tip of the main shaft with a lumen communicating from the proximal end to the most advanced part inside is provided. You may form by the method of connecting.
- a guide wire shaft having a guide wire lumen therein can be represented by 102.
- reference numeral 104 in FIG. 1 denotes an X-ray opaque marker.
- FIG. 2 shows a cross-sectional view corresponding to the line AA in FIG.
- reference numeral 201 denotes a main shaft, 202 ⁇ guide wire shaft, 203 ⁇ slit, 204 ⁇ Xf spring impermeable marker, 205 ⁇ guide wire lumen, and 206 a main shaft lumen.
- the guide wire shaft 202 may be a guide wire lumen formed integrally with the distal end portion of the main shaft 201 as described above.
- Main shaft and guide wire There are no particular restrictions on the material of one shaft, and various thermoplastic elastomers such as polyethylene, polyamide, polyurethane, polyamide elastomer, polyester elastomer, and force S can be used.
- the guide wire shaft is preferably made of a material having a Shore hardness of 55D or more, particularly preferably a Shore hardness of 63D or more, since the holding power of the guide wire is insufficient if the hardness is insufficient.
- the final setting should be set, but a length in the range of 10 to 50 times the nominal diameter of the guidewire used is preferred from 15 times A length in the range of 30 times is more preferable.
- the angle and position of the slit There are no particular restrictions on the angle and position of the slit. It should be set by comprehensively determining the operability, guide wire holding force, and other performance of the entire catheter when placing the wire, but in many cases it is preferable to attach it almost parallel to the catheter axial direction. In some cases, it may be easier to place the guide wire if the slit is oblique in the axial direction. Also, there is no particular restriction on the circumferential position of the slit, but the guide is better positioned on the side of the guide wire shaft with respect to the axis connecting the main shaft and guide wire shaft as shown in Figs. It is preferable from the viewpoints of operability and guide wire holding power when arranging wires.
- slit portion there are no particular restrictions on the shape and structure of the slit portion.
- the structure In order to improve the overall operability and guide wire holding power when the guide wire is placed through the slit, and the overall performance of the catheter, there are various shapes and structures. As shown in Fig. 3, when the structure has a part where the material constituting the guide wire lumen overlaps at the slit part, it is preferable because the holding power of the guide wire can be improved.
- the width of the guide wire the balance between operability and holding force is maintained well within the range of 5% to 30% of the circumferential length of the inner surface of the guide wire lumen.
- reference numeral 301 denotes a main shaft, 302 a guide wire shaft, 303 a slit, 304 a radiopaque marker, 305 a guide wire lumen, and 306 a main shaft lumen.
- the guide wire is arranged through the slit by forming a guide 407 including a convex portion that assists the insertion of the guide wire along the slit outside the overlapping portion in the vicinity of the slit portion. It is also possible to improve the operability.
- As the shape of the guide it is preferable that the guide wire does not escape when the guide wire is pressed against the slit, and that the guide is deformed in the opening direction.
- Other configurations are the same as those shown in FIG. 3, and thus detailed description thereof is omitted.
- reference numerals 401f to main shaft, 402f to guide wire shaft, 403f to slit, 404 to X-ray opaque marker, 405 to guide wire lumen, and 406 to main shaft lumen are shown.
- a guide 507 similar to the above is provided, and a stopper structure 508 for suppressing the opening of the guide wire lumen is provided in the slit portion, whereby the guide It is also possible to improve the dwell holding power.
- a protrusion stopper convex part 508A
- the concave portion stopper concave portion 508B
- reference numeral 501 is the main shaft
- 502 is the guide wire shaft
- 503 is the slit
- 504 is the X-ray opaque marker
- 505 is the guide wire lumen
- 506 is the main shaft lumen
- 507 is the guide wire insertion aid. Show each guide you want to play.
- one or more X-ray impermeable markers for indicating the position of the tip of the catheter on X-ray contrast are connected to the catheter tip.
- the catheter is arranged near the boundary between the guide wire lumen and the main lumen or near the connection portion between the guide wire shaft and the main shaft.
- FIGS. 3 to 5 it is preferable to connect the guide wire lumen to the opposite side of the slit because the balance of the guide wire holding force is excellent.
- the main shaft is composed of three shafts: a proximal shaft, an intermediate shaft, and a distal shaft.
- a polyimide tube having an outer diameter of 1.5 mm, an inner diameter of 1.3 mm, and a length of 1100 mm was produced by date forming using a polyamic acid varnish to form a proximal shaft.
- a tube with an outer diameter of 1.5 mm, an inner diameter of 1.2 mm, and a length of 300 mm was produced by extrusion using low-density polyethylene (LF480M, Nippon Polychem Co., Ltd.), and used as an intermediate shaft.
- L480M low-density polyethylene
- a tube with a major axis of about 1.9 mm, a minor axis of about 1.5 mm, and a length of 10.5 mm is extruded by using low-density polyethylene (LF480M, Nippon Polychem Co., Ltd.) and has two lumens inside. It was produced and used as the tip side shaft.
- a low-density polyethylene is attached to a columnar X-ray opaque marker with an elliptical cross section at a position corresponding to the boundary between the two lumens of the distal shaft.
- each mandrel with an outer diameter of 0.4 mm or 1.15 mm is inserted into each lumen and heated.
- a radiopaque marker was fixed.
- the inner diameter of the lumen of the tip shaft was 0.4mm and 1.15mm, respectively.
- a slit was formed in a lumen having an inner diameter of 0.4 mm on the tip side shaft by an ultrasonic cutter so as to be almost parallel to the axial direction.
- One end of the proximal shaft was heated and stretched to reduce the diameter, and the reduced diameter portion was inserted into the intermediate shaft and bonded and fixed using a two-component mixed curing urethane adhesive.
- a main shaft was obtained by heat-welding a lumen with an inner diameter of 1.15 mm and an intermediate shaft of the tip side shaft.
- a protective mandrel was inserted inside both lumens to secure a guide wire and a lumen communicating from the proximal end to the most advanced part.
- a hub manufactured by injection molding using polycarbonate (Makloron 2658, Bayer Co., Ltd.) was fixed to the proximal end of the main shaft with a two-component mixed curing urethane adhesive.
- a columnar X-ray opaque marker with an elliptical cross section near the boundary between the guide wire lumen and the main lumen is bonded and fixed with a two-component mixed curing urethane adhesive, and the cross section near the tip is shown in Fig. 2.
- a suction catheter for a guide wire with a nominal diameter of 0.014 inches was obtained.
- the main shaft was configured using two shafts, a proximal shaft and a distal shaft.
- a polyimide tube having an outer diameter of 1.5 mm, an inner diameter of 1.3 mm, and a length of 110 cm was produced by date forming using a polyamic acid varnish to form a proximal shaft.
- a polyamide elastomer PEBAX6333, ATOCHEM
- a tube having an outer diameter of 1.5 mm, an inner diameter of 1.2 mm, and a length of 30 cm was prepared by extrusion, and used as the distal shaft.
- One end of the proximal shaft was heated and stretched to reduce the diameter, and the reduced diameter portion was inserted into the distal shaft and bonded and fixed using a two-component mixed curing urethane adhesive to obtain a main shaft.
- the leading end of the main shaft was cut obliquely with a razor.
- a tube with an outer diameter of 0.68 mm, an inner diameter of 0.47 mm, and a length of 5.5 mm was prepared by extrusion molding using a polyamide elastomer with a hardness of 72D (PEBAX7233, ATOCHEM). Make a slit almost parallel to the axial direction with a sonic cutter. After forming, a mandrel having an inner diameter of 0.40 mm was welded and connected so as to be parallel to the tip of the main shaft with the outer surface held down. At this time, a columnar X-ray opaque marker with an elliptical cross section on the opposite side of the slit near the boundary between the guide wire lumen and the main lumen is placed with PEBAX6333 coated beforehand.
- the main shaft was configured using two shafts, a proximal shaft and a distal shaft.
- a polyimide tube having an outer diameter of 1.5 mm, an inner diameter of 1.3 mm, and a length of 110 cm was produced by date forming using a polyamic acid varnish to form a proximal shaft.
- a polyamide elastomer PEBAX6333, ATOCHEM
- a tube having an outer diameter of 1.5 mm, an inner diameter of 1.2 mm, and a length of 30 cm was prepared by extrusion, and used as the distal shaft.
- One end of the proximal shaft was heated and stretched to reduce the diameter, and the reduced diameter portion was inserted into the distal shaft and bonded and fixed using a two-component mixed curing urethane adhesive to obtain a main shaft.
- the leading end of the main shaft was cut obliquely with a razor.
- a tube with an outer diameter of 0.70mm, an inner diameter of 0.47mm, and a length of about 300mm was produced by extrusion molding using a polyamide elastomer with a hardness of 63D (PEBAX6333, ATOCHEM).
- PEBAX6333 polyamide elastomer with a hardness of 63D
- Raw material tube for guide wire lumen by heating while passing through a die with an outer shape of 0.6 mm outer shape that has a concave mold on the inner surface that forms a guide that assists guide wire insertion with a mandrel with an inner diameter of 0.43 mm inserted Adjusted.
- the tube is cut to a length of 10.5 mm, and a slit is formed by making an incision almost parallel to the axial direction on the side of the convex portion with an ultrasonic cutter, and then a mandrel with an inner diameter of 0.40 mm is placed inside. And with the outer surface held down, weld so that it is parallel to the tip of the main shaft. Connected. At this time, a columnar X-ray opaque marker with an elliptical cross section on the opposite side of the slit near the boundary between the guide wire lumen and the main lumen is placed with PEBAX6333 pre-coated, and the guide wire lumen and It was fixed at the same time as the welding of the main nomen.
- the main shaft was composed of two shafts, a proximal shaft and a distal shaft.
- a polyimide tube having an outer diameter of 1.5 mm, an inner diameter of 1.3 mm, and a length of 110 cm was produced by date forming using a polyamic acid varnish to form a proximal shaft.
- a tube with an outer diameter of 1.5 mm, an inner diameter of 1.2 mm, and a length of 30 cm was prepared by extrusion molding using a polyamide elastomer (PEBAX6333, ATOCHEM), and used as a distal shaft.
- PEBAX6333, ATOCHEM polyamide elastomer
- One end of the proximal shaft was heated and stretched to reduce the diameter, and the reduced diameter portion was inserted into the distal shaft and bonded and fixed using a two-component mixed curing urethane adhesive to obtain a main shaft.
- the leading end of the main shaft was cut obliquely with a razor.
- a tube with an outer diameter of 0.75 mm, an inner diameter of 0.53 mm, and a length of about 300 mm was prepared by extrusion molding using a polyamide elastomer with a hardness of 55D (PEBAX5533, ATOCHEM).
- PEBAX5533 polyamide elastomer with a hardness of 55D
- a concave mold that forms a guide that assists in inserting the guide wire and a concave mold that forms a stopper convex part (508A) adjacent to the concave mold on the inner surface.
- the material tube for the guide wire lumen was adjusted by passing it through a die while heating.
- the tube is cut to a length of 10.5 mm, a mandrel having an inner diameter of 0 ⁇ 45 mm and having a convex part for forming a concave part of the stopper is arranged inside, and the stopper concave part (508B) is formed by heating the vicinity of the convex part. Formed.
- a slit is formed by making an incision almost parallel to the axial direction with an ultrasonic cutter between the convex part of the guide and the stopper convex part, and then the mandrel is replaced with an inner diameter of 0 to 40 mm and the outer surface is pushed. In such a state, it was welded and connected so as to be parallel to the tip of the main shaft.
- a columnar X-ray opaque marker having an elliptical cross section on the opposite side of the slit near the boundary between the guidewire lumen and the main lumen is pre-coated with PEBAX6333, and the guidewire lumen and It was fixed at the same time as the welding of the main nomen.
- a portion where the material constituting the guide wire lumen overlaps at the slit portion, and the width was about 0.2 mm (about 16% with respect to the circumferential length of the inner surface of the guide wire lumen).
- a hub made by injection molding using polycarbonate (Makloron 2658, Bayer Co., Ltd.) is fixed to the proximal end of the main shaft with a two-component mixed curing urethane adhesive, and the cross section near the tip is shown in Fig. 5.
- a suction catheter for a nominal diameter 0.014 inch guide wire was obtained, which is a therapeutic catheter as described above.
- a polyamide elastomer (PEBAX7233, ATOCHEM) was used to produce a tube with an outer diameter of 1.7 mm, an inner diameter of 1.4 mm, and a length of 45 cm by extrusion molding.
- the leading end of the main shaft was cut obliquely with a razor.
- extrusion molding using a polyamide elastomer with a hardness of 63D (PEBAX6333, ATOCHEM)
- a tube having an outer diameter of 0.79 mm, an inner diameter of 0.61 mm, and a length of 11 mm was prepared, and a slit was formed in the tube by an incision substantially parallel to the axial direction using an ultrasonic cutter.
- a hub made by injection molding using polycarbonate (Makloron 2658, Bayer Co., Ltd.) is bonded and fixed to the end of the main shaft with a two-component mixed-curing urethane adhesive, and the cross section near the tip is shown in Fig. 3.
- a suction catheter for a nominal diameter of 0.018 inch guidewire was obtained, which was a therapeutic catheter like this.
- Main shaft is near side, outer diameter 1.5mm, inner diameter 1.3mm, length 1100mm polyimide tube, tip side, outer diameter 1.5mm, inner diameter 1.2mm, length 300mm polyethylene tube, guide wire tube is A commercially available suction catheter (Slon Buster 7F manufactured by Kaneka Medix Co., Ltd.) composed of a polyethylene tube having an outer diameter of 0.56 mm, an inner diameter of 0.43 mm, and a length of 10 mm fixed to the tip of the main shaft was used as a comparative example.
- the occlusion catheter is expanded to a diameter of 4 mm, the PTCA catheter is expanded before the occlusion catheter (6 atm – 30 seconds), removed, the suction catheter is inserted, inhaled (30 cc syringe), and removed.
- the occlusion catheter was deflated and the time required to resume blood flow was measured.
- Time required for Example 1 is 174 ⁇ 12 seconds
- Time required for Example 2 is 182 ⁇ 21 seconds
- Time required for Example 3 is 140 ⁇ 17 seconds
- Time required for Example 3 is 155 ⁇ 25 seconds
- Method The comparative example was 207 ⁇ 25 seconds, and the effect of the example was confirmed.
- a blood clot removal force teeter with a Ni_Ti alloy tube with an outer diameter of 0.018 inch (0.45 mm) as the main shaft, a flexible balloon made of polyurethane at the tip, and a hub connected to the hand was prepared. It was inserted into the femoral artery through a sheath inserted from the femoral artery of the pig, and thrombus was collected. The thrombectomy catheter was placed through the slit in the guide wire lumen of the suction catheter of Example 5, and the collected thrombus was sucked into the femoral artery. With existing suction catheters, a balloon-type thrombectomy catheter is used as a guide. There was nothing that could be used as a dwyer.
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- Biomedical Technology (AREA)
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Abstract
Description
Claims
Priority Applications (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP05795617A EP1806160A1 (en) | 2004-10-22 | 2005-10-19 | Catheter for medical treatment |
JP2006543026A JP5040310B2 (ja) | 2004-10-22 | 2005-10-19 | 治療用カテーテル |
US11/577,794 US20090076484A1 (en) | 2004-10-22 | 2005-10-19 | Therapeutic Catheter |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2004-307796 | 2004-10-22 | ||
JP2004307796 | 2004-10-22 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2006043582A1 true WO2006043582A1 (ja) | 2006-04-27 |
Family
ID=36202996
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/JP2005/019181 WO2006043582A1 (ja) | 2004-10-22 | 2005-10-19 | 治療用カテーテル |
Country Status (5)
Country | Link |
---|---|
US (1) | US20090076484A1 (ja) |
EP (1) | EP1806160A1 (ja) |
JP (1) | JP5040310B2 (ja) |
TW (1) | TW200626193A (ja) |
WO (1) | WO2006043582A1 (ja) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2014155489A1 (ja) * | 2013-03-25 | 2014-10-02 | テルモ・クリニカルサプライ株式会社 | 血管内異物吸引用カテーテル |
JP2020528776A (ja) * | 2017-07-19 | 2020-10-01 | Hoya株式会社 | 内視鏡バスケット送達カテーテル |
Families Citing this family (30)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8668737B2 (en) | 1997-10-10 | 2014-03-11 | Senorx, Inc. | Tissue marking implant |
US7637948B2 (en) | 1997-10-10 | 2009-12-29 | Senorx, Inc. | Tissue marking implant |
US8498693B2 (en) | 1999-02-02 | 2013-07-30 | Senorx, Inc. | Intracorporeal marker and marker delivery device |
US8361082B2 (en) | 1999-02-02 | 2013-01-29 | Senorx, Inc. | Marker delivery device with releasable plug |
US9820824B2 (en) | 1999-02-02 | 2017-11-21 | Senorx, Inc. | Deployment of polysaccharide markers for treating a site within a patent |
US20090216118A1 (en) | 2007-07-26 | 2009-08-27 | Senorx, Inc. | Polysaccharide markers |
US7983734B2 (en) | 2003-05-23 | 2011-07-19 | Senorx, Inc. | Fibrous marker and intracorporeal delivery thereof |
US6862470B2 (en) | 1999-02-02 | 2005-03-01 | Senorx, Inc. | Cavity-filling biopsy site markers |
US7651505B2 (en) | 2002-06-17 | 2010-01-26 | Senorx, Inc. | Plugged tip delivery for marker placement |
US6725083B1 (en) | 1999-02-02 | 2004-04-20 | Senorx, Inc. | Tissue site markers for in VIVO imaging |
US6575991B1 (en) | 1999-06-17 | 2003-06-10 | Inrad, Inc. | Apparatus for the percutaneous marking of a lesion |
CA2775170C (en) | 2000-11-20 | 2017-09-05 | Senorx, Inc. | An intracorporeal marker delivery system for marking a tissue site |
US20060036158A1 (en) | 2003-11-17 | 2006-02-16 | Inrad, Inc. | Self-contained, self-piercing, side-expelling marking apparatus |
US7877133B2 (en) | 2003-05-23 | 2011-01-25 | Senorx, Inc. | Marker or filler forming fluid |
US20050273002A1 (en) | 2004-06-04 | 2005-12-08 | Goosen Ryan L | Multi-mode imaging marker |
US10357328B2 (en) | 2005-04-20 | 2019-07-23 | Bard Peripheral Vascular, Inc. and Bard Shannon Limited | Marking device with retractable cannula |
CA2562580C (en) | 2005-10-07 | 2014-04-29 | Inrad, Inc. | Drug-eluting tissue marker |
WO2008051749A2 (en) | 2006-10-23 | 2008-05-02 | C. R. Bard, Inc. | Breast marker |
EP2109409B1 (en) | 2006-12-12 | 2018-09-05 | C.R.Bard, Inc. | Multiple imaging mode tissue marker |
EP2101670B1 (en) | 2006-12-18 | 2013-07-31 | C.R.Bard, Inc. | Biopsy marker with in situ-generated imaging properties |
US8311610B2 (en) | 2008-01-31 | 2012-11-13 | C. R. Bard, Inc. | Biopsy tissue marker |
US9327061B2 (en) | 2008-09-23 | 2016-05-03 | Senorx, Inc. | Porous bioabsorbable implant |
CN102256660B (zh) | 2008-12-30 | 2013-07-03 | C·R·巴德公司 | 用于组织标记物放置的标记物输送装置 |
DE102011050173A1 (de) * | 2011-05-06 | 2012-11-08 | Vilmos Nagy | Dehnbare Einführschleuse und Schleusensystem |
USD715442S1 (en) | 2013-09-24 | 2014-10-14 | C. R. Bard, Inc. | Tissue marker for intracorporeal site identification |
USD715942S1 (en) | 2013-09-24 | 2014-10-21 | C. R. Bard, Inc. | Tissue marker for intracorporeal site identification |
USD716451S1 (en) | 2013-09-24 | 2014-10-28 | C. R. Bard, Inc. | Tissue marker for intracorporeal site identification |
USD716450S1 (en) | 2013-09-24 | 2014-10-28 | C. R. Bard, Inc. | Tissue marker for intracorporeal site identification |
WO2015193047A1 (en) * | 2014-06-17 | 2015-12-23 | Biotronik Se & Co. Kg | Elongated guide sheath |
US10827909B2 (en) * | 2018-02-14 | 2020-11-10 | Marla F. Bashour | Alimentary engagement device |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5267958A (en) * | 1992-03-30 | 1993-12-07 | Medtronic, Inc. | Exchange catheter having exterior guide wire loops |
JP2602938B2 (ja) * | 1986-11-14 | 1997-04-23 | ミラー インスツルメンツ,インコーポレーテッド | 細長く柔軟で操作可能なガイドワイヤーに係合させるための組立体および圧力センサー |
US6007517A (en) * | 1996-08-19 | 1999-12-28 | Anderson; R. David | Rapid exchange/perfusion angioplasty catheter |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5046497A (en) * | 1986-11-14 | 1991-09-10 | Millar Instruments, Inc. | Structure for coupling a guidewire and a catheter |
JPH02221649A (ja) * | 1989-02-22 | 1990-09-04 | Yamaha Motor Co Ltd | 燃料噴射装置 |
US5554118A (en) * | 1991-05-24 | 1996-09-10 | Jang; G. David | Universal mode vascular catheter system |
US6520951B1 (en) * | 1996-09-13 | 2003-02-18 | Scimed Life Systems, Inc. | Rapid exchange catheter with detachable hood |
-
2005
- 2005-10-19 EP EP05795617A patent/EP1806160A1/en not_active Withdrawn
- 2005-10-19 US US11/577,794 patent/US20090076484A1/en not_active Abandoned
- 2005-10-19 WO PCT/JP2005/019181 patent/WO2006043582A1/ja active Application Filing
- 2005-10-19 JP JP2006543026A patent/JP5040310B2/ja not_active Expired - Fee Related
- 2005-10-21 TW TW094136911A patent/TW200626193A/zh unknown
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2602938B2 (ja) * | 1986-11-14 | 1997-04-23 | ミラー インスツルメンツ,インコーポレーテッド | 細長く柔軟で操作可能なガイドワイヤーに係合させるための組立体および圧力センサー |
US5267958A (en) * | 1992-03-30 | 1993-12-07 | Medtronic, Inc. | Exchange catheter having exterior guide wire loops |
US6007517A (en) * | 1996-08-19 | 1999-12-28 | Anderson; R. David | Rapid exchange/perfusion angioplasty catheter |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2014155489A1 (ja) * | 2013-03-25 | 2014-10-02 | テルモ・クリニカルサプライ株式会社 | 血管内異物吸引用カテーテル |
JP2020528776A (ja) * | 2017-07-19 | 2020-10-01 | Hoya株式会社 | 内視鏡バスケット送達カテーテル |
Also Published As
Publication number | Publication date |
---|---|
JPWO2006043582A1 (ja) | 2008-05-22 |
TW200626193A (en) | 2006-08-01 |
JP5040310B2 (ja) | 2012-10-03 |
US20090076484A1 (en) | 2009-03-19 |
EP1806160A1 (en) | 2007-07-11 |
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