WO2006042370A1 - Méthodes et préparations pour cheveux et ongles - Google Patents
Méthodes et préparations pour cheveux et ongles Download PDFInfo
- Publication number
- WO2006042370A1 WO2006042370A1 PCT/AU2005/001628 AU2005001628W WO2006042370A1 WO 2006042370 A1 WO2006042370 A1 WO 2006042370A1 AU 2005001628 W AU2005001628 W AU 2005001628W WO 2006042370 A1 WO2006042370 A1 WO 2006042370A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- hair
- isoflavone
- genistein
- daidzein
- isoflavones
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q3/00—Manicure or pedicure preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
- A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7008—Compounds having an amino group directly attached to a carbon atom of the saccharide radical, e.g. D-galactosamine, ranimustine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
- A61K8/498—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom having 6-membered rings or their condensed derivatives, e.g. coumarin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
- A61K8/602—Glycosides, e.g. rutin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/14—Drugs for dermatological disorders for baldness or alopecia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q5/00—Preparations for care of the hair
Definitions
- isoflavones occur principally as glycosides. Following ingestion by man and animals, the glycoside moiety is hydrolysed free by a combination of gastric acid hydrolysis and fermentation by intestinal bacteria. Some of the isoflavones in the aglycone form are absorbed directly and circulate in the blood, while the remainder are metabolised by intestinal fermentation to a variety of compounds which are also absorbed. The absorbed isoflavones and their metabolites appear to undergo little or no further metabolism in the body, being readily transported in the bloodstream, and ultimately being excreted in the urine.
- compositions comprising phytoestrogen isoflavones, especially when taken orally are effective for improving nail strength by, for example, reducing delamination, splitting and breakage and/or improving nail smoothness and evenness of the nail surface and/or improving hair condition, for example, reducing dryness, split ends, improving lustre, colour and/or body and/or reducing hair loss.
- the present invention provides a method of maintaining or improving nails and/or hair comprising administering to a subject in need of said improvement an effective amount of a composition comprising an isoflavone, for example, any two or more members of the group consisting of genistein, daidzein, biochanin A, formononetin or the natural glycosides thereof.
- a composition comprising an isoflavone, for example, any two or more members of the group consisting of genistein, daidzein, biochanin A, formononetin or the natural glycosides thereof.
- the composition has a higher content of daidzein or daidzein and formononetin than genistein or genistein and biochanin A .
- the invention also provides the use of an isoflavone or a mixture thereof, for example as described above, for maintaining or improving nails and/or hair.
- the invention provides a method of treatment comprising administering an effective amount of an isoflavone, particularly a combination of isoflavones as described above or a composition containing same, to a person in need thereof.
- the invention extends to use of the isoflavones compounds or compositions containing same for the treatment of deficiencies in nail strength and/or hair strength.
- Certain clovers such as red clover (T. pratense) and subterranean clover (T. subterranean) are the preferred sources. On a dry weight basis, these clovers contain the highest amounts of oestro genie isoflavones of all legumes tested to date with levels of 3-5 g % (T. subterranean) and 1-3 g % (T. pratense). In comparison, soya flour has a level of 0.15-0.30 g %, lentils (0.08-0.12 g %), chick peas (0.07-0.13 g %), and garden peas (0.02-0.03 g %).
- An additional feature of clovers is that there are wide varieties of cultivars. with widely differing isoflavone levels and ' types. This allows blending of different cultivars to achieve the desired ratio of the different isoflavones, although it is equally possible to use a single cultivar which provides the desired ratio.
- the oestrogenic isoflavones are restricted principally to the leaf, fruit and root; the stem and petiole contain very little.
- the leaves are rarely regarded as foodstuff, indeed with these crops, the plants normally are allowed to die and dry out before the seed crop is harvested. Nevertheless, the fresh leaves of these crops could be regarded as a source of phytoestrogens for the invention although the much lower isoflavone content of the leaves of these crops compared to clovers, plus their generally slow growth compared to clovers, suggests that they would not be a preferred source of large-scale isoflavone enrichment.
- the composition has a higher content of daidzein or daidzein and formononetin than genistein or genistein and biochanin A .
- the composition has a higher content of biochanin A or formononetin than genistein or daidzein.
- a typical tablet having an isoflavone content of 40 mg tablet was found to contain an average relative content of about 0.68 genistein, 25.5 biochanin. A, 0.12 daidzein and 13.7 formononetin in a ratio of about 1.89:1 of genistein and biochanin A to daidzein and formononetin.
- the temperature of the mix can range between ambient temperature and boiling temperature.
- the exposure time can be between 1 hour and 4 week or even longer. It has been determined that the adequate times for maximal recovery of isoflavones are 2 weeks at 50oC and 24 hours at 90oC.
- the supernatant is separated from the undissolved plant material and the organic solvent removed by distillation. The aqueous supernatant is then concentrated, by typically by distillation.
- Additional processing steps can be used, if desired, to convert the extracted natural product to capsule, tablet, or other convenient form for ingestion, using normal techniques for doing this. Otherwise the product can be packaged as a convenient food additive.
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Dermatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Birds (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Cosmetics (AREA)
Abstract
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU2004906043 | 2004-10-20 | ||
AU2004906043A AU2004906043A0 (en) | 2004-10-20 | Composition |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2006042370A1 true WO2006042370A1 (fr) | 2006-04-27 |
Family
ID=36202618
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/AU2005/001628 WO2006042370A1 (fr) | 2004-10-20 | 2005-10-20 | Méthodes et préparations pour cheveux et ongles |
Country Status (1)
Country | Link |
---|---|
WO (1) | WO2006042370A1 (fr) |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2008120105A3 (fr) * | 2007-03-30 | 2009-02-05 | 9898 Ltd | Technologie de plate-forme pharmaceutique pour le développement de produits naturels |
WO2009064245A1 (fr) | 2007-11-12 | 2009-05-22 | Mip Technologies Ab | Polymères imprimés présentant une affinité pour les protéines et les peptides phosphorylés |
KR101393369B1 (ko) * | 2012-03-23 | 2014-05-09 | 충남대학교산학협력단 | 고삼의 에틸아세테이트 분획 성분을 유효성분으로 함유하는 모발 성장 촉진용 약학적 조성물 |
KR20140102558A (ko) * | 2013-02-14 | 2014-08-22 | 경희대학교 산학협력단 | 포모노네틴 또는 이의 약학적으로 허용가능한 염을 유효성분으로 포함하는 탈모방지 및 발모촉진용 조성물 |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6017893A (en) * | 1997-08-29 | 2000-01-25 | Natures Sunshine Products, Inc. | Use of isoflavones to prevent hair loss and preserve the integrity of existing hair |
WO2002011675A2 (fr) * | 2000-08-10 | 2002-02-14 | Zelickson M D Brian D | Element nutritif organique destine au traitement de la calvitie |
WO2002067878A2 (fr) * | 2001-02-21 | 2002-09-06 | Skinceuticals, Inc. | Utilisations d'extrait de lait de notre-dame dans des compositions pour le soin de la peau |
US20030027772A1 (en) * | 2001-05-30 | 2003-02-06 | L'oreal | Composition containing at least one inhibitor of the enzyme 3-beta-HSD |
-
2005
- 2005-10-20 WO PCT/AU2005/001628 patent/WO2006042370A1/fr active Application Filing
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6017893A (en) * | 1997-08-29 | 2000-01-25 | Natures Sunshine Products, Inc. | Use of isoflavones to prevent hair loss and preserve the integrity of existing hair |
WO2002011675A2 (fr) * | 2000-08-10 | 2002-02-14 | Zelickson M D Brian D | Element nutritif organique destine au traitement de la calvitie |
WO2002067878A2 (fr) * | 2001-02-21 | 2002-09-06 | Skinceuticals, Inc. | Utilisations d'extrait de lait de notre-dame dans des compositions pour le soin de la peau |
US20030027772A1 (en) * | 2001-05-30 | 2003-02-06 | L'oreal | Composition containing at least one inhibitor of the enzyme 3-beta-HSD |
Cited By (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2008120105A3 (fr) * | 2007-03-30 | 2009-02-05 | 9898 Ltd | Technologie de plate-forme pharmaceutique pour le développement de produits naturels |
CN101790682A (zh) * | 2007-03-30 | 2010-07-28 | 9898有限公司 | 发展自然产物的药用平台的技术 |
AU2008234619B2 (en) * | 2007-03-30 | 2013-04-04 | Sinoveda Canada Inc. | Pharmaceutical platform technology for the development of natural products |
WO2009064245A1 (fr) | 2007-11-12 | 2009-05-22 | Mip Technologies Ab | Polymères imprimés présentant une affinité pour les protéines et les peptides phosphorylés |
KR101393369B1 (ko) * | 2012-03-23 | 2014-05-09 | 충남대학교산학협력단 | 고삼의 에틸아세테이트 분획 성분을 유효성분으로 함유하는 모발 성장 촉진용 약학적 조성물 |
KR20140102558A (ko) * | 2013-02-14 | 2014-08-22 | 경희대학교 산학협력단 | 포모노네틴 또는 이의 약학적으로 허용가능한 염을 유효성분으로 포함하는 탈모방지 및 발모촉진용 조성물 |
KR101664531B1 (ko) * | 2013-02-14 | 2016-10-11 | 경희대학교 산학협력단 | 포모노네틴 또는 이의 약학적으로 허용가능한 염을 유효성분으로 포함하는 탈모방지 및 발모촉진용 조성물 |
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