WO2006021814A3 - Medicament - Google Patents

Medicament Download PDF

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Publication number
WO2006021814A3
WO2006021814A3 PCT/GB2005/050108 GB2005050108W WO2006021814A3 WO 2006021814 A3 WO2006021814 A3 WO 2006021814A3 GB 2005050108 W GB2005050108 W GB 2005050108W WO 2006021814 A3 WO2006021814 A3 WO 2006021814A3
Authority
WO
WIPO (PCT)
Prior art keywords
peptides
well
product
products
methods
Prior art date
Application number
PCT/GB2005/050108
Other languages
French (fr)
Other versions
WO2006021814A2 (en
Inventor
Deirdre Mcintosh
Original Assignee
Aimsco Ltd
Deirdre Mcintosh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB0415359.9A external-priority patent/GB0415359D0/en
Priority to US11/631,067 priority Critical patent/US20080207500A1/en
Priority to KR1020077002992A priority patent/KR101235723B1/en
Priority to BRPI0513062-0A priority patent/BRPI0513062A/en
Priority to EP05758978A priority patent/EP1765377A2/en
Priority to CA002572777A priority patent/CA2572777A1/en
Priority to MX2007000144A priority patent/MX2007000144A/en
Priority to AU2005276242A priority patent/AU2005276242B2/en
Application filed by Aimsco Ltd, Deirdre Mcintosh filed Critical Aimsco Ltd
Priority to EA200700115A priority patent/EA011389B1/en
Priority to JP2007519893A priority patent/JP2008505878A/en
Priority to NZ552412A priority patent/NZ552412A/en
Publication of WO2006021814A2 publication Critical patent/WO2006021814A2/en
Priority to IL180487A priority patent/IL180487A/en
Publication of WO2006021814A3 publication Critical patent/WO2006021814A3/en
Priority to US13/544,413 priority patent/US20130203669A1/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/33—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans derived from pro-opiomelanocortin, pro-enkephalin or pro-dynorphin
    • A61K38/34—Melanocyte stimulating hormone [MSH], e.g. alpha- or beta-melanotropin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/08—Peptides having 5 to 11 amino acids
    • A61K38/095—Oxytocins; Vasopressins; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/33—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans derived from pro-opiomelanocortin, pro-enkephalin or pro-dynorphin
    • A61K38/35—Corticotropin [ACTH]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/57509—Corticotropin releasing factor [CRF] (Urotensin)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/665—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans derived from pro-opiomelanocortin, pro-enkephalin or pro-dynorphin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pain & Pain Management (AREA)
  • Zoology (AREA)
  • Endocrinology (AREA)
  • Epidemiology (AREA)
  • Psychiatry (AREA)
  • Dermatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Molecular Biology (AREA)
  • Cardiology (AREA)
  • Pulmonology (AREA)
  • Reproductive Health (AREA)
  • Rheumatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Urology & Nephrology (AREA)

Abstract

Analysis of a goat serum product with many therapeutic effects is described. The product is identified as containing proopiomelanocortin (POMC) and Corticotropin releasing factor (CRF) peptides, as well as breakdown products of these peptides. We describe methods of treatment of diseases including cancers, multiple sclerosis, and neural disorders using these peptides and their products, as well as medicaments including such peptides and methods of producing the peptides.
PCT/GB2005/050108 2004-07-08 2005-07-08 Medicament WO2006021814A2 (en)

Priority Applications (12)

Application Number Priority Date Filing Date Title
NZ552412A NZ552412A (en) 2004-07-08 2005-07-08 Use of corticotropin releasing factor in the treatment of neural disorders
AU2005276242A AU2005276242B2 (en) 2004-07-08 2005-07-08 Medicament
BRPI0513062-0A BRPI0513062A (en) 2004-07-08 2005-07-08 pharmaceutical composition, method of stimulating pomc production in a patient, uses of an isolated crf peptide and an isolated pomc peptide, and methods of treating a disease, producing crf and curative, enhancer or prophylactic treatment of a disease
EP05758978A EP1765377A2 (en) 2004-07-08 2005-07-08 Medicament
CA002572777A CA2572777A1 (en) 2004-07-08 2005-07-08 Medicament comprising corticotropin releasing factor and proopiomelanocortin, and uses thereof
MX2007000144A MX2007000144A (en) 2004-07-08 2005-07-08 Medicament.
EA200700115A EA011389B1 (en) 2004-07-08 2005-07-08 Medicament
US11/631,067 US20080207500A1 (en) 2004-07-08 2005-07-08 Medicament
KR1020077002992A KR101235723B1 (en) 2004-07-08 2005-07-08 Medicament
JP2007519893A JP2008505878A (en) 2004-07-08 2005-07-08 Medicine
IL180487A IL180487A (en) 2004-07-08 2007-01-01 Corticotropin releasing factor (crf) for treatment of neural disorders
US13/544,413 US20130203669A1 (en) 2004-07-08 2012-07-09 Medicament

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB0415359.9 2004-07-08
GBGB0415359.9A GB0415359D0 (en) 2004-07-08 2004-07-08 Medicament
GB0423386.2 2004-10-21
GBGB0423386.2A GB0423386D0 (en) 2004-07-08 2004-10-21 Medicament

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US63103708A Continuation 2004-07-08 2008-01-28

Publications (2)

Publication Number Publication Date
WO2006021814A2 WO2006021814A2 (en) 2006-03-02
WO2006021814A3 true WO2006021814A3 (en) 2007-03-29

Family

ID=35967903

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2005/050108 WO2006021814A2 (en) 2004-07-08 2005-07-08 Medicament

Country Status (7)

Country Link
EP (1) EP1765377A2 (en)
JP (1) JP2008505878A (en)
KR (1) KR101235723B1 (en)
AU (1) AU2005276242B2 (en)
BR (1) BRPI0513062A (en)
CA (1) CA2572777A1 (en)
WO (1) WO2006021814A2 (en)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0415359D0 (en) * 2004-07-08 2004-08-11 Aimsco Ltd Medicament
GB0509052D0 (en) * 2005-05-04 2005-06-08 Aimsco Ltd Combination therapy
GB0600202D0 (en) * 2006-01-06 2006-02-15 Aimsco Ltd Treatment of HIV
WO2008049011A2 (en) 2006-10-18 2008-04-24 Research Development Foundation Alpha-msh therapies for treatment of autoimmune disease
KR20100056523A (en) * 2007-09-11 2010-05-27 몬도바이오테크 래보래토리즈 아게 Use of grf-1 (1-29) and corticotropin-releasing factor as therapeutic agents
EP2197465A2 (en) * 2007-09-11 2010-06-23 Mondobiotech Laboratories AG Use of angiotensin ii as a therapeutic agent in the treatment of eg s. pneumoniae infection
JP5395794B2 (en) * 2007-09-11 2014-01-22 モンドバイオテック ラボラトリーズ アクチエンゲゼルシャフト Use of galanin peptides as therapeutic agents
NZ588877A (en) * 2008-04-30 2012-08-31 Neutron Row Methods of using corticotropin-releasing factor for the treatment of cancer
US20100203048A1 (en) 2008-04-30 2010-08-12 Stephen Evans-Freke Methods of using corticotropin-releasing factor for the use of the treatment of cancer
GB0910032D0 (en) * 2009-06-11 2009-07-22 Aimsco Ltd Use of serum composition to reduce the levels of TNF and/or VEGF in mammals
US20130259875A1 (en) * 2010-05-11 2013-10-03 Questcor Pharmaceuticals, Inc. Acth for treatment of amyotrophic lateral sclerosis
EP2701728B1 (en) * 2012-06-25 2015-05-06 Aimsco Limited Formulation comprising crh and alpha-2-macroglobulin
WO2015033175A1 (en) * 2013-09-06 2015-03-12 Zlatko Ademovic Combination of pro-opiomelanocortin endogenous peptides in autoimmune disease treatment
GB201322948D0 (en) * 2013-12-23 2014-02-12 Aimsco Ltd Improved formulation
WO2015143245A1 (en) 2014-03-19 2015-09-24 Isis Pharmaceuticals, Inc. Methods for modulating ataxin 2 expression
CN116970607A (en) 2014-03-19 2023-10-31 Ionis制药公司 Compositions for modulating ataxin 2 expression
GB201617175D0 (en) 2016-10-10 2016-11-23 Iconic Intellectual Property Limited Assay
KR20210038589A (en) 2018-07-25 2021-04-07 아이오니스 파마수티컬즈, 인코포레이티드 Compounds and methods for reducing ATXN2 expression
GB201911063D0 (en) 2019-08-02 2019-09-18 Tarian Biologics Ltd Formulations
GB201911064D0 (en) 2019-08-02 2019-09-18 Tarian Biologics Ltd Therapy
KR102551880B1 (en) * 2020-11-13 2023-07-05 성균관대학교산학협력단 Composition for promoting the formation of neurosphere comprising Corticotropin-releasing hormone as an active ingredient

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US5306710A (en) * 1989-07-28 1994-04-26 Regents Of The University Of California Method for treating endotoxin shock with CRF
WO1995023214A1 (en) * 1994-02-28 1995-08-31 Ludwig Institute For Cancer Research Method for stimulating profileration of colon cells using pomc¿76-103?
WO2002067996A2 (en) * 2001-02-24 2002-09-06 Mologen Forschungs-, Entwicklungs- Und Vertriebs Gmbh Beta-endorphin/crf gene therapy for locally combating pain

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