WO2006013103A3 - Induzierbare genexpression - Google Patents

Induzierbare genexpression Download PDF

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Publication number
WO2006013103A3
WO2006013103A3 PCT/EP2005/008427 EP2005008427W WO2006013103A3 WO 2006013103 A3 WO2006013103 A3 WO 2006013103A3 EP 2005008427 W EP2005008427 W EP 2005008427W WO 2006013103 A3 WO2006013103 A3 WO 2006013103A3
Authority
WO
WIPO (PCT)
Prior art keywords
hiv
gene expression
inducible gene
transgene
expression
Prior art date
Application number
PCT/EP2005/008427
Other languages
English (en)
French (fr)
Other versions
WO2006013103A2 (de
Inventor
Frank Notka
Ralf Wagner
Diana Hammer
Original Assignee
Geneart Gmbh
Frank Notka
Ralf Wagner
Diana Hammer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Geneart Gmbh, Frank Notka, Ralf Wagner, Diana Hammer filed Critical Geneart Gmbh
Priority to EP05768069A priority Critical patent/EP1774008A2/de
Priority to JP2007523036A priority patent/JP2008507290A/ja
Priority to CA002575480A priority patent/CA2575480A1/en
Priority to US11/658,206 priority patent/US8691533B2/en
Publication of WO2006013103A2 publication Critical patent/WO2006013103A2/de
Publication of WO2006013103A3 publication Critical patent/WO2006013103A3/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/16011—Human Immunodeficiency Virus, HIV
    • C12N2740/16311—Human Immunodeficiency Virus, HIV concerning HIV regulatory proteins
    • C12N2740/16322—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Virology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Genetics & Genomics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

Die vorliegende Erfindung betrifft Vektorkonstrukte für eine HIV-spezifische Gentherapie. Die Expression der Transgene ist an eine Infektion der Zelle mit HIV gekoppelt, indem die Transkription des Transgens durch eine von HIV abgeleitete Transkriptionskontrollregion kontrolliert wird. Das Transgen wird außerdem durch Modifikation der Nukleotidsequenz in der RNA­Stabilität und Expressionseffizienz verbessert.
PCT/EP2005/008427 2004-08-03 2005-08-03 Induzierbare genexpression WO2006013103A2 (de)

Priority Applications (4)

Application Number Priority Date Filing Date Title
EP05768069A EP1774008A2 (de) 2004-08-03 2005-08-03 Induzierbare genexpression
JP2007523036A JP2008507290A (ja) 2004-08-03 2005-08-03 誘導性遺伝子発現
CA002575480A CA2575480A1 (en) 2004-08-03 2005-08-03 Inducible gene expression
US11/658,206 US8691533B2 (en) 2004-08-03 2005-08-03 Inducible gene expression

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102004037611A DE102004037611B4 (de) 2004-08-03 2004-08-03 Induzierbare Genexpression
DE102004037611.5 2004-08-03

Publications (2)

Publication Number Publication Date
WO2006013103A2 WO2006013103A2 (de) 2006-02-09
WO2006013103A3 true WO2006013103A3 (de) 2006-06-01

Family

ID=35787483

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2005/008427 WO2006013103A2 (de) 2004-08-03 2005-08-03 Induzierbare genexpression

Country Status (7)

Country Link
US (1) US8691533B2 (de)
EP (1) EP1774008A2 (de)
JP (1) JP2008507290A (de)
CN (1) CN101035899B (de)
CA (1) CA2575480A1 (de)
DE (1) DE102004037611B4 (de)
WO (1) WO2006013103A2 (de)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE502005008794D1 (de) * 2004-08-03 2010-02-11 Geneart Ag Verfahren zur modulation der genexpression durch änderung des cpg gehalts
CN102886052B (zh) * 2006-09-14 2014-07-30 迈德詹尼克斯医疗以色列有限公司 长效药物制剂
US8454948B2 (en) 2006-09-14 2013-06-04 Medgenics Medical Israel Ltd. Long lasting drug formulations
CN102108362B (zh) * 2009-12-24 2014-06-25 上海市农业科学院 一种优化的三苯甲烷还原酶基因及其表达和应用
AU2011268458B2 (en) 2010-06-15 2014-06-12 Medgenics Medical Israel Ltd. Long lasting drug formulations
EP2668282A2 (de) * 2011-01-28 2013-12-04 MedImmune, LLC Expression löslicher viraler fusionsglykoproteine in säugetierzellen
US20130303726A1 (en) 2012-04-17 2013-11-14 Chiesi Farmaceutici S.P.A. Method for the preparation of surfactant peptides
JP6824594B2 (ja) 2014-09-11 2021-02-03 Jnc株式会社 合成遺伝子の設計方法
PE20231949A1 (es) * 2015-10-30 2023-12-05 Spark Therapeutics Inc VARIANTES DEL FACTOR VIII REDUCIDO CON CpG, COMPOSICIONES Y METODOS Y USOS PARA EL TRATAMIENTO DE TRASTORNOS DE LA HEMOSTASIA
EP3988650A4 (de) * 2019-06-21 2022-09-21 Osaka University Verfahren zur herstellung eines künstlichen rekombinanten rna-virus, das ein fremdgen stabil hält
CN116323949A (zh) * 2020-07-21 2023-06-23 方拓生物科技公司 用于治疗眼部疾病的组合物和方法

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998034640A2 (en) * 1997-02-07 1998-08-13 Merck & Co., Inc. Synthetic hiv gag genes
WO2000039304A2 (en) * 1998-12-31 2000-07-06 Chiron Corporation Polynucleotides encoding antigenic hiv type c polypeptides, polypeptides and uses thereof
EP1156112A1 (de) * 2000-05-18 2001-11-21 Geneart GmbH Synthetische Gene für gagpol und deren Verwendungen

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE359372T1 (de) * 1996-07-22 2007-05-15 Us Gov Health & Human Serv Vektoren zur inhibierung von viralem und tumorwachstum
DE10053781B4 (de) * 2000-10-30 2008-07-03 Geneart Ag Kernexportreportersystem
DE10260805A1 (de) 2002-12-23 2004-07-22 Geneart Gmbh Verfahren und Vorrichtung zum Optimieren einer Nucleotidsequenz zur Expression eines Proteins

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998034640A2 (en) * 1997-02-07 1998-08-13 Merck & Co., Inc. Synthetic hiv gag genes
WO2000039304A2 (en) * 1998-12-31 2000-07-06 Chiron Corporation Polynucleotides encoding antigenic hiv type c polypeptides, polypeptides and uses thereof
EP1156112A1 (de) * 2000-05-18 2001-11-21 Geneart GmbH Synthetische Gene für gagpol und deren Verwendungen

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
CARA A ET AL: "INHIBITION OF HIV-1 REPLICATION BY COMBINED EXPRESSION OF GAG DOMINANT NEGATIVE MUTANT AND A HUMAN RIBONUCLEASE IN A TIGHTLY CONTROLLED HIV-1 INDUCIBLE VECTOR", GENE THERAPY, MACMILLAN PRESS LTD., BASINGSTOKE, GB, vol. 5, no. 1, 1998, pages 65 - 75, XP000914885, ISSN: 0969-7128 *
FURUTA R A ET AL: "HIV-1 capsid mutants inhibit the replication of wild-type virus at both early and late infection phases", FEBS LETTERS, ELSEVIER, AMSTERDAM, NL, vol. 415, 1997, pages 231 - 234, XP002159812, ISSN: 0014-5793 *
WAGNER R ET AL: "REV-INDEPENDENT EXPRESSION OF SYNTHETIC GAG-POL GENES OF HUMAN IMMUNODEFICIENCY VIRUS TYPE 1 AND SIMIAN IMMUNODEFICIENCY VIRUS: IMPLICATIONS FOR THE SAFETY OF LENTIVIRAL VECTORS", HUMAN GENE THERAPY, vol. 11, no. 17, 20 November 2000 (2000-11-20), pages 2403 - 2413, XP000974656, ISSN: 1043-0342 *

Also Published As

Publication number Publication date
CN101035899A (zh) 2007-09-12
DE102004037611A1 (de) 2006-03-16
CN101035899B (zh) 2012-05-02
JP2008507290A (ja) 2008-03-13
US20110033429A1 (en) 2011-02-10
CA2575480A1 (en) 2006-02-09
WO2006013103A2 (de) 2006-02-09
US8691533B2 (en) 2014-04-08
DE102004037611B4 (de) 2013-10-02
EP1774008A2 (de) 2007-04-18

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