WO2006002646A2 - Novel carbamylated epo and method for its production - Google Patents
Novel carbamylated epo and method for its production Download PDFInfo
- Publication number
- WO2006002646A2 WO2006002646A2 PCT/DK2005/000477 DK2005000477W WO2006002646A2 WO 2006002646 A2 WO2006002646 A2 WO 2006002646A2 DK 2005000477 W DK2005000477 W DK 2005000477W WO 2006002646 A2 WO2006002646 A2 WO 2006002646A2
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- protein
- carbamylated
- less
- erythropoietin
- over
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/505—Erythropoietin [EPO]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A61K38/1816—Erythropoietin [EPO]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Definitions
- An active agent intended for oral administration may be coated with or admixed with a material that delays disintegration and/or absorption of the active agent in the gastrointestinal tract ⁇ e.g., glyceryl monostearate or glyceryl distearate may be used).
- a material that delays disintegration and/or absorption of the active agent in the gastrointestinal tract e.g., glyceryl monostearate or glyceryl distearate may be used.
- glyceryl monostearate or glyceryl distearate may be used.
- Pharmaceutical compositions for oral administration may be formulated to facilitate release of an active agent at a particular gastrointestinal location due to specific pH or enzymatic conditions.
- Suppositories generally contain active ingredient in the range of 0.5% to 10% by weight; oral formulations preferably contain 10% to 95% active ingredient.
- CEPO and EPO were purified on a POROS Rl column (POROS Rl reverse phase column material, PerSeptive Biosystems (1-1259-06)). The column material was stored in
- the peptide patterns of the CEPO samples were different from the unmodified EPO. Trypsin normally cleaves at lysine and arginine, thus it would be expected that in the case of fully carbamylated EPO only fragmentation would occur by cleavage of the arginines. Thus, after the peptide pattern is obtained with trypsin, the specific carbamylation sites and unspecifically carbamylated peptides could be identified.
- the peptides expected from a tryptic digestion of CEPO molecules assuming cleavage at the arginines (R) only is set forth in Table 6.
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Genetics & Genomics (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Urology & Nephrology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Psychology (AREA)
- Molecular Biology (AREA)
- Vascular Medicine (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
Description
Claims
Priority Applications (18)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
NZ551594A NZ551594A (en) | 2004-07-07 | 2005-07-07 | Novel carbamylated epo and method for its production |
BRPI0513029-8A BRPI0513029A (en) | 2004-07-07 | 2005-07-07 | method for producing a carbamylated erythropoietin protein, carbamylated erythropoietin protein, compound, pharmaceutical composition, methods of treating a chronic, sub-chronic and acute disease or condition and treating a disease of the central nervous system or peripheral nervous system, and , use of a compound |
EP05755533A EP1781697B1 (en) | 2004-07-07 | 2005-07-07 | Novel carbamylated epo and method for its production |
RSP-2009/0262A RS50851B (en) | 2004-07-07 | 2005-07-07 | Novel carbaylated epo and method for its production |
PL05755533T PL1781697T3 (en) | 2004-07-07 | 2005-07-07 | Novel carbamylated epo and method for its production |
JP2007519619A JP5025470B2 (en) | 2004-07-07 | 2005-07-07 | Novel carbamylated EPO and process for producing the same |
CA002572643A CA2572643A1 (en) | 2004-07-07 | 2005-07-07 | Novel carbamylated epo and method for its production |
DK05755533T DK1781697T3 (en) | 2004-07-07 | 2005-07-07 | New carbamylated erythropoietin protein as well as method of preparation |
AU2005259689A AU2005259689B2 (en) | 2004-07-07 | 2005-07-07 | Novel carbamylated EPO and method for its production |
CN2005800227404A CN1997665B (en) | 2004-07-07 | 2005-07-07 | Novel carbamylated EPO and method for its production |
DE602005014117T DE602005014117D1 (en) | 2004-07-07 | 2005-07-07 | NEW CARBAMYLATED EPO AND METHOD FOR THE PRODUCTION THEREOF |
MXPA06014742A MXPA06014742A (en) | 2004-07-07 | 2005-07-07 | Novel carbamylated epo and method for its production. |
EA200700255A EA011586B1 (en) | 2004-07-07 | 2005-07-07 | Novel carbamylated epo and method for its production |
AT05755533T ATE429444T1 (en) | 2004-07-07 | 2005-07-07 | NEW CARBAMYLATED EPO AND METHOD FOR THE PRODUCTION THEREOF |
IL180518A IL180518A0 (en) | 2004-07-07 | 2007-01-02 | Novel carbamylated epo and method for its production |
NO20070687A NO20070687L (en) | 2004-07-07 | 2007-02-06 | New carbamylated EPO and process for their preparation |
HK08100325.8A HK1109631A1 (en) | 2004-07-07 | 2008-01-10 | Novel carbamylated epo and method for its production |
HR20090343T HRP20090343T1 (en) | 2004-07-07 | 2009-06-15 | Novel carbamylated epo and method for its production |
Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US58637004P | 2004-07-07 | 2004-07-07 | |
US60/586,370 | 2004-07-07 | ||
DKPA200401075 | 2004-07-07 | ||
DKPA200401075 | 2004-07-07 | ||
US69387005P | 2005-06-23 | 2005-06-23 | |
US60/693,870 | 2005-06-23 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2006002646A2 true WO2006002646A2 (en) | 2006-01-12 |
WO2006002646A3 WO2006002646A3 (en) | 2006-04-13 |
Family
ID=34979159
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/DK2005/000477 WO2006002646A2 (en) | 2004-07-07 | 2005-07-07 | Novel carbamylated epo and method for its production |
Country Status (20)
Country | Link |
---|---|
EP (1) | EP1781697B1 (en) |
JP (1) | JP5025470B2 (en) |
AT (1) | ATE429444T1 (en) |
AU (1) | AU2005259689B2 (en) |
BR (1) | BRPI0513029A (en) |
CA (1) | CA2572643A1 (en) |
CY (1) | CY1109232T1 (en) |
DE (1) | DE602005014117D1 (en) |
DK (1) | DK1781697T3 (en) |
EA (1) | EA011586B1 (en) |
ES (1) | ES2325034T3 (en) |
HK (1) | HK1109631A1 (en) |
HR (1) | HRP20090343T1 (en) |
IL (1) | IL180518A0 (en) |
MX (1) | MXPA06014742A (en) |
NO (1) | NO20070687L (en) |
PL (1) | PL1781697T3 (en) |
PT (1) | PT1781697E (en) |
SI (1) | SI1781697T1 (en) |
WO (1) | WO2006002646A2 (en) |
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WO2008111503A1 (en) * | 2007-03-09 | 2008-09-18 | National University Corporation Obihiro University Of Agriculture And Veterinary Medicine | Protective agent for transplanted organ |
WO2009094551A1 (en) | 2008-01-25 | 2009-07-30 | Amgen Inc. | Ferroportin antibodies and methods of use |
US7718363B2 (en) | 2003-04-25 | 2010-05-18 | The Kenneth S. Warren Institute, Inc. | Tissue protective cytokine receptor complex and assays for identifying tissue protective compounds |
WO2010056981A2 (en) | 2008-11-13 | 2010-05-20 | Massachusetts General Hospital | Methods and compositions for regulating iron homeostasis by modulation bmp-6 |
JP2010520859A (en) * | 2007-02-22 | 2010-06-17 | ポリマン サイエンティフィック イミューンバイオロジッシュ フォーシュング ゲゼルシャフト ミット ベシュレンクテル ファフツング | Erythropoietin fusion protein |
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WO2011050808A1 (en) | 2009-10-26 | 2011-05-05 | H. Lundbeck A/S | Use of carbamylated erythropoietin for the treatment of friedreich's ataxia |
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WO2012069474A2 (en) | 2010-11-24 | 2012-05-31 | H. Lundbeck A/S | A method for reducing potential virus burden in a sample by cyanate treatment |
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RU2215748C2 (en) * | 1999-04-09 | 2003-11-10 | Сентро Де Инмунология Молекулар | Method for preparing recombinant human erythropoietin and prepared erythropoietin, pharmaceutical composition |
PA8536201A1 (en) * | 2000-12-29 | 2002-08-29 | Kenneth S Warren Inst Inc | PROTECTION AND IMPROVEMENT OF CELLS, FABRICS AND ORGANS RESPONDING TO Erythropoietin |
US20030072737A1 (en) * | 2000-12-29 | 2003-04-17 | Michael Brines | Tissue protective cytokines for the protection, restoration, and enhancement of responsive cells, tissues and organs |
WO2004112693A2 (en) * | 2003-05-19 | 2004-12-29 | The Kenneth S. Warren Institute, Inc. | Tissue protective cytokines with an extended therapeutic window |
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- 2005-07-07 AU AU2005259689A patent/AU2005259689B2/en not_active Ceased
- 2005-07-07 ES ES05755533T patent/ES2325034T3/en active Active
- 2005-07-07 DK DK05755533T patent/DK1781697T3/en active
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2007
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2008
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2009
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Also Published As
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DE602005014117D1 (en) | 2009-06-04 |
JP2008505133A (en) | 2008-02-21 |
ATE429444T1 (en) | 2009-05-15 |
IL180518A0 (en) | 2007-06-03 |
EP1781697B1 (en) | 2009-04-22 |
EP1781697A2 (en) | 2007-05-09 |
WO2006002646A3 (en) | 2006-04-13 |
JP5025470B2 (en) | 2012-09-12 |
AU2005259689A1 (en) | 2006-01-12 |
PT1781697E (en) | 2009-06-25 |
DK1781697T3 (en) | 2009-07-06 |
ES2325034T3 (en) | 2009-08-24 |
CA2572643A1 (en) | 2006-01-12 |
EA011586B1 (en) | 2009-04-28 |
CY1109232T1 (en) | 2014-07-02 |
AU2005259689B2 (en) | 2011-10-06 |
NO20070687L (en) | 2007-03-27 |
SI1781697T1 (en) | 2009-08-31 |
HK1109631A1 (en) | 2008-06-13 |
EA200700255A1 (en) | 2007-06-29 |
BRPI0513029A (en) | 2008-04-22 |
MXPA06014742A (en) | 2007-02-16 |
HRP20090343T1 (en) | 2009-07-31 |
PL1781697T3 (en) | 2009-10-30 |
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