WO2006000213A3 - Peptide zur inhibition der interaktion von proteinkinase a und proteinkinase a-ankerproteinen - Google Patents

Peptide zur inhibition der interaktion von proteinkinase a und proteinkinase a-ankerproteinen Download PDF

Info

Publication number
WO2006000213A3
WO2006000213A3 PCT/DE2005/001181 DE2005001181W WO2006000213A3 WO 2006000213 A3 WO2006000213 A3 WO 2006000213A3 DE 2005001181 W DE2005001181 W DE 2005001181W WO 2006000213 A3 WO2006000213 A3 WO 2006000213A3
Authority
WO
WIPO (PCT)
Prior art keywords
protein kinase
peptides
interaction
inhibiting
anchor proteins
Prior art date
Application number
PCT/DE2005/001181
Other languages
English (en)
French (fr)
Other versions
WO2006000213A2 (de
WO2006000213A9 (de
Inventor
Enno Klussmann
Walter Rosenthal
Christian Hundsrucker
Original Assignee
Forschungsverbund Berlin Ev
Enno Klussmann
Walter Rosenthal
Christian Hundsrucker
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Forschungsverbund Berlin Ev, Enno Klussmann, Walter Rosenthal, Christian Hundsrucker filed Critical Forschungsverbund Berlin Ev
Priority to US11/571,117 priority Critical patent/US20090104177A1/en
Priority to CA002571350A priority patent/CA2571350A1/en
Priority to EP05763349A priority patent/EP1763537A2/de
Publication of WO2006000213A2 publication Critical patent/WO2006000213A2/de
Publication of WO2006000213A3 publication Critical patent/WO2006000213A3/de
Publication of WO2006000213A9 publication Critical patent/WO2006000213A9/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Die Erfindung betrifft eine Nukleinsäuresequenz, die für Peptide kodiert, die die Interaktion von Proteinkinase A (PKA)und Proteinkinase A-Ankerproteinen (AKAP) inhibiert, einen Wirtsorganismus, der die Nukleinsäuresequenz umfasst und gegebenenfalls die Peptide exprimiert sowie die Verwendung der Peptide sowie des Wirtsorganismus bei der Untersuchung von Krankheiten, die mit der AKAP PKA Interaktion assoziiert sind sowie die Verwendung der Peptide als pharmazeutisches Mittel für die Behandlung solcher Krankheiten.
PCT/DE2005/001181 2004-06-29 2005-06-29 Peptide zur inhibition der interaktion von proteinkinase a und proteinkinase a-ankerproteinen WO2006000213A2 (de)

Priority Applications (3)

Application Number Priority Date Filing Date Title
US11/571,117 US20090104177A1 (en) 2004-06-29 2005-06-29 Peptides for inhibiting the interaction of protein kinase a and protein kinase a anchor proteins
CA002571350A CA2571350A1 (en) 2004-06-29 2005-06-29 Peptides for inhibiting the interaction of protein kinase a and protein kinase a anchor proteins
EP05763349A EP1763537A2 (de) 2004-06-29 2005-06-29 Peptide zur inhibition der interaktion von proteinkinase a und proteinkinase a-ankerproteinen

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102004031579A DE102004031579B4 (de) 2004-06-29 2004-06-29 Peptide zur Inhibition der Interaktion von Proteinkinase A und Proteinkinase A-Ankerproteinen, diese umfassendes Nukleinsäuremolekül, Vektor, Wirtszelle, gegen diese gerichtetes Erkennungsmolekül, diese enthaltende pharmazeutische Zusammensetzung, diese enthaltender Kit und deren Verwendung
DE102004031579.5 2004-06-29

Publications (3)

Publication Number Publication Date
WO2006000213A2 WO2006000213A2 (de) 2006-01-05
WO2006000213A3 true WO2006000213A3 (de) 2006-08-24
WO2006000213A9 WO2006000213A9 (de) 2007-03-08

Family

ID=35612701

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/DE2005/001181 WO2006000213A2 (de) 2004-06-29 2005-06-29 Peptide zur inhibition der interaktion von proteinkinase a und proteinkinase a-ankerproteinen

Country Status (5)

Country Link
US (1) US20090104177A1 (de)
EP (1) EP1763537A2 (de)
CA (1) CA2571350A1 (de)
DE (1) DE102004031579B4 (de)
WO (1) WO2006000213A2 (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8003111B2 (en) * 2005-04-06 2011-08-23 Ibc Pharmaceuticals, Inc. Dimeric alpha interferon pegylated site-specifically shows enhanced and prolonged efficacy in vivo
TW200745163A (en) * 2006-02-17 2007-12-16 Syntonix Pharmaceuticals Inc Peptides that block the binding of IgG to FcRn
US8906844B2 (en) 2007-08-09 2014-12-09 Biogen Idec Hemophilia Inc. Immunomodulatory peptides
WO2013021384A1 (en) * 2011-08-11 2013-02-14 Yeda Research And Development Co. Ltd Compositions and methods for modulating apoptosis
GB201208775D0 (en) 2012-05-18 2012-07-04 Uni I Oslo Chemical compounds
EP2740484A1 (de) * 2012-12-05 2014-06-11 Lipotec, S.A. Verbindungen zur Behandlung und/oder Pflege von Haut, Schleimhautmembranen der Kopfhaut und/oder Haar und deren Verwendung in kosmetischen oder pharmazeutischen Zusammensetzungen
GB201320506D0 (en) 2013-11-26 2014-01-01 Uni I Oslo Cyclic amino compounds for the use in the treatment of cardiac disorders
WO2016172537A1 (en) * 2015-04-23 2016-10-27 The Trustees Of The University Of Pennsylvania Compositions to disrupt protein kinase a anchoring and uses thereof

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10306085A1 (de) * 2002-09-06 2004-03-25 Forschungsverbund Berlin E.V. Neue Spleißvariante eines Proteinkinase A-Ankerproteins und Verwendung dieser

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6872645B2 (en) * 2002-04-02 2005-03-29 Nanosys, Inc. Methods of positioning and/or orienting nanostructures
US20040180379A1 (en) * 2002-08-30 2004-09-16 Northwestern University Surface-enhanced raman nanobiosensor

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10306085A1 (de) * 2002-09-06 2004-03-25 Forschungsverbund Berlin E.V. Neue Spleißvariante eines Proteinkinase A-Ankerproteins und Verwendung dieser

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
I.D.C. FRASER ET AL.: "A NOVEL LIPID-ANCHORED A-KINASE ANCHORING PROTEIN FACILITATES cAMP-RESPONSIVE MEMBRANE EVENTS", EMBO, vol. 17, no. 8, 1998, pages 2261 - 2272, XP002369143 *
L.L. BURNS-HAMURO: "DESIGNING ISOFORM-SPECIFIC PEPTIDE DISRUPTORS OF PROTEIN KINASE A LOCALIZATION", P.N.A.S., vol. 100, no. 7, 1 April 2003 (2003-04-01), pages 4072 - 4077, XP002369142 *
LUTZ VOSSEBEIN: "REGULATION VON SIGNALTRANSDUKTIONSELEMENTEN ÜBER ANKERPROTEINE", 2002, DISSERTATION ZUR ERLANGUNG DES GRADES EINES DOKTORS DER NATURWISSENSCHAFTEN DER FAKULTÄT FÜR BIOLOGIE DER RUHR-UNIVERSITÄT-BOCHUM, XP002369158 *

Also Published As

Publication number Publication date
WO2006000213A2 (de) 2006-01-05
WO2006000213A9 (de) 2007-03-08
DE102004031579A1 (de) 2006-02-09
US20090104177A1 (en) 2009-04-23
CA2571350A1 (en) 2006-01-05
DE102004031579B4 (de) 2012-12-27
EP1763537A2 (de) 2007-03-21

Similar Documents

Publication Publication Date Title
WO2006000213A3 (de) Peptide zur inhibition der interaktion von proteinkinase a und proteinkinase a-ankerproteinen
WO2004024757A3 (en) Modified pna molecules
WO2005003296A3 (en) Albumin fusion proteins
WO2003089456A3 (en) Peptide inhibitors of protein kinase c
WO2007112940A3 (en) Albumin-derived amino acid sequence, use thereof for increasing the half-life of therapeutic proteins and of other therapeutic compounds and entities, and constructs comprising the same
WO2005077042A3 (en) Albumin fusion proteins
IL169367A0 (en) Defensin proteins
WO2006047728A3 (en) Bmp gene and fusion protein
WO2006017355A3 (en) Improved aprotinin variants
WO2005051902A3 (en) Modified mscl protein channel
WO2007000770A3 (en) Protein kinase c inhibitors for prevention of insulin resistance and type 2 diabetes
WO2005059131A3 (en) Protein binding miniature proteins and uses thereof
TW200724679A (en) Treatment of disease using an improved regulated expression system
IL169256A (en) Polypeptide having metalloprotease activity, nucleic acid encoding it and pharmaceutical composition comprising it
WO2006040660A3 (en) Plasmids coding for p185neu protein sequence variants and therapeutic uses thereof
WO2006074914A3 (en) Human rna helicase and therapeutic uses thereof
WO2007039254A3 (en) Use of fusion proteins for the prevention or the treatment of pathologies resulting from ischemia
WO2004053117A3 (en) Serine protease
WO2005079541A3 (en) Terephthalamide peptidomimetic compounds and methods
WO2004009633A8 (en) Serotonin receptor
WO2004050703A8 (en) Splice variant of the human pituitary growth hormone
GB0426960D0 (en) TGR-3 like protein receptor
WO2008012476A3 (fr) Utilisation de carboxypeptidases dans le domaine cosmetique et therapeutique
WO2007134907A3 (en) Gm-csf gene therapy for treatment of crohn's disease using an improved regulated expression system
WO2009071276A3 (de) Allel- und isotyp-spezifische intervention an mit autoimmunerkrankungen assoziierten mhc-klasse-ii-molekülen durch peptide

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BW BY BZ CA CH CN CO CR CU CZ DK DM DZ EC EE EG ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KM KP KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NA NG NI NO NZ OM PG PH PL PT RO SC SD SE SG SK SL SM SY TJ TM TN TR TT TZ UA UG US UZ VC VN YU ZA ZM ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): BW GH GM KE LS MW MZ NA SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LT LU MC NL PL PT RO SE SI SK TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG

WWE Wipo information: entry into national phase

Ref document number: 2571350

Country of ref document: CA

WWE Wipo information: entry into national phase

Ref document number: 2005763349

Country of ref document: EP

121 Ep: the epo has been informed by wipo that ep was designated in this application
WWP Wipo information: published in national office

Ref document number: 2005763349

Country of ref document: EP

WWE Wipo information: entry into national phase

Ref document number: 11571117

Country of ref document: US