WO2005124359A3 - Methods of diagnosing and treating diabetes and insulin resistance - Google Patents

Methods of diagnosing and treating diabetes and insulin resistance Download PDF

Info

Publication number
WO2005124359A3
WO2005124359A3 PCT/US2005/021296 US2005021296W WO2005124359A3 WO 2005124359 A3 WO2005124359 A3 WO 2005124359A3 US 2005021296 W US2005021296 W US 2005021296W WO 2005124359 A3 WO2005124359 A3 WO 2005124359A3
Authority
WO
WIPO (PCT)
Prior art keywords
methods
diagnosing
insulin resistance
treating diabetes
diabetes
Prior art date
Application number
PCT/US2005/021296
Other languages
French (fr)
Other versions
WO2005124359A2 (en
Inventor
Shonna A Moodie
Brian E Lavan
Thomas A Gustafson
Original Assignee
Metabolex Inc
Shonna A Moodie
Brian E Lavan
Thomas A Gustafson
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Metabolex Inc, Shonna A Moodie, Brian E Lavan, Thomas A Gustafson filed Critical Metabolex Inc
Priority to JP2007516736A priority Critical patent/JP2008502909A/en
Publication of WO2005124359A2 publication Critical patent/WO2005124359A2/en
Publication of WO2005124359A3 publication Critical patent/WO2005124359A3/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/66—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood sugars, e.g. galactose
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/04—Endocrine or metabolic disorders
    • G01N2800/042—Disorders of carbohydrate metabolism, e.g. diabetes, glucose metabolism

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Immunology (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • Cell Biology (AREA)
  • Diabetes (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

The present invention provides compositions and methods for diagnosing and treating diabetes and insulin resistance. In particular, the invention provides methods of identifying modulators of the polynucleotides or polypeptides of the invention and using those modulators to treat diabetes, as well as methods of diagnosing diabetes by measuring the levels of the polynucleotides or polypeptides of the invention in a patient.
PCT/US2005/021296 2004-06-15 2005-06-15 Methods of diagnosing and treating diabetes and insulin resistance WO2005124359A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2007516736A JP2008502909A (en) 2004-06-15 2005-06-15 Methods for diagnosis and treatment of diabetes and insulin resistance

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US58029004P 2004-06-15 2004-06-15
US60/580,290 2004-06-15

Publications (2)

Publication Number Publication Date
WO2005124359A2 WO2005124359A2 (en) 2005-12-29
WO2005124359A3 true WO2005124359A3 (en) 2006-02-16

Family

ID=35510374

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2005/021296 WO2005124359A2 (en) 2004-06-15 2005-06-15 Methods of diagnosing and treating diabetes and insulin resistance

Country Status (2)

Country Link
JP (1) JP2008502909A (en)
WO (1) WO2005124359A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11976282B2 (en) 2020-06-23 2024-05-07 Qatar University GATA3 inhibitors for the promotion of subcutaneous fat deposition
WO2024026454A1 (en) * 2022-07-28 2024-02-01 University Of Maryland, Baltimore Inhibitors of pde11a4 and methods of using same

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003077949A2 (en) * 2002-03-14 2003-09-25 Bayer Pharmaceuticals Corporation Methods of treating diabetes using pde 11a inhibitors

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003077949A2 (en) * 2002-03-14 2003-09-25 Bayer Pharmaceuticals Corporation Methods of treating diabetes using pde 11a inhibitors

Also Published As

Publication number Publication date
WO2005124359A2 (en) 2005-12-29
JP2008502909A (en) 2008-01-31

Similar Documents

Publication Publication Date Title
WO2006017171A3 (en) Methods of diagnosing & treating obesity, diabetes and insulin resistance
WO2008030273A3 (en) Compositions and methods for diagnosis and treatment of type 2 diabetes
WO2009038689A3 (en) Compositions and methods for diagnosis and treatment of type 2 diabetes
WO2007067341A3 (en) Compositions and methods for increasing insulin sensitivity
WO2007079171A3 (en) Treatment for hodgkin's lymphoma
IL198922A0 (en) Chemical compounds and uses
WO2006044531A3 (en) Antisense modulation of ptp1b expression
WO2008008286A3 (en) Substituted pyrazoles as ghrelin receptor antagonists
WO2006097793A3 (en) Compositions capable of facilitating penetration across a biological barrier
WO2008065372A3 (en) Modified erythropoietin polypeptides and uses thereof for treatment
WO2008055491A3 (en) Diagnosis and risk assessment of pancreatic diabetes using mr-proadm
WO2007056457A3 (en) Methods, compositions, and kits for the treatment of medical conditions
WO2006063042A3 (en) Selecting patients for therapy with a her inhibitor
WO2008027687A3 (en) Use of tenecteplase for treating acute ischemic stroke
WO2010005982A3 (en) Multiplexed biomarkers of insulin resistance
WO2009023048A3 (en) Markers for metabolic syndrome
WO2006128041A3 (en) Compositions and methods for the treatment or prevention of chemoresistant neoplasia
WO2006007400A9 (en) Methods of diagnosing and treating obesity, diabetes and insulin resistance
WO2003101284A3 (en) Methods of diagnosing and treating diabetes and insulin resistance
WO2007079312A3 (en) Compositions and methods for treating actin-mediated medical conditions
WO2008065682A3 (en) Genetic susceptibility variants of type 2 diabetes mellitus
WO2005034737A3 (en) Methods for diagnosing and treating endoplasmic reticulum (er) stress diseases
WO2008059041A3 (en) Complementation of factor xi deficiency by factor v mutants
WO2003103597A3 (en) Methods of diagnosing & treating diabetes and insulin resistance
WO2005124359A3 (en) Methods of diagnosing and treating diabetes and insulin resistance

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BW BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE EG ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KM KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NA NG NI NO NZ OM PG PH PL PT RO RU SC SD SE SG SK SL SM SY TJ TM TN TR TT TZ UA UG US UZ VC VN YU ZA ZM ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GM KE LS MW MZ NA SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LT LU MC NL PL PT RO SE SI SK TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
WWE Wipo information: entry into national phase

Ref document number: 2007516736

Country of ref document: JP

NENP Non-entry into the national phase

Ref country code: DE

WWW Wipo information: withdrawn in national office

Country of ref document: DE

122 Ep: pct application non-entry in european phase