WO2005113030A1 - 組織閉鎖剤 - Google Patents
組織閉鎖剤 Download PDFInfo
- Publication number
- WO2005113030A1 WO2005113030A1 PCT/JP2005/009065 JP2005009065W WO2005113030A1 WO 2005113030 A1 WO2005113030 A1 WO 2005113030A1 JP 2005009065 W JP2005009065 W JP 2005009065W WO 2005113030 A1 WO2005113030 A1 WO 2005113030A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- tissue
- nonwoven fabric
- thrombin
- fibrinogen
- bioabsorbable synthetic
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/36—Blood coagulation or fibrinolysis factors
- A61K38/363—Fibrinogen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
- A61K38/482—Serine endopeptidases (3.4.21)
- A61K38/4833—Thrombin (3.4.21.5)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/001—Use of materials characterised by their function or physical properties
- A61L24/0042—Materials resorbable by the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
- A61L24/10—Polypeptides; Proteins
- A61L24/106—Fibrin; Fibrinogen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
Definitions
- the present invention relates to a tissue closing agent containing a thrombin component and a fibrinogen component as active ingredients, and a tissue closing agent using a bioabsorbable synthetic nonwoven fabric as a reinforcing material.
- tissue closure is an operation that is required in many cases. For example, there is a defective part or a cut surface of an organ or a tissue! It is necessary to close the joints of the materials.
- the heart of the pericardium and the intestinal tract of the peritoneum may cause adhesion with the surrounding tissue or incarceration with the surrounding tissue. May cause functional impairment. Therefore, the closure may be performed by artificial prosthesis and prosthetic material.
- reports of adverse events such as adhesions, chronic inflammation or infections with these materials are not uncommon.
- a reinforcing material / fibrin glue may be used in combination.
- pericardial closure after cardiac surgery One of the issues to be solved regarding tissue closure in the field of cardiovascular surgery is pericardial closure after cardiac surgery. Pericardial defects often occur after heart surgery. How a closed pericardial defect is closed has a significant effect, especially during reoperation.
- the main cause of the above-mentioned postoperative adhesion and scar formation of the epicardium is a method of treating the pericardium at the time of surgery.
- the pericardium may not be closed when the heart is compressed by pericardial suturing, as in coronary artery vinos surgery or surgery using extracardiac conduit.
- pericardial closure is not performed, adhesions will occur and the risk of reoperation will increase, so in patients with a high possibility of reoperation, the pericardial defect is often replaced with an EPTFE sheet.
- Tissue closure in the field of respiratory surgery includes a pulmonary pleura detachment plane and a lung resection plane! ⁇ is represented by closure of air leak from the bronchial stump.
- air leakage is closed by applying a fibrin glue after suturing, or by using a fibrin glue alone or in combination with a reinforcing material.
- 80% of surgical patients who frequently relapse after surgery In some facilities the leaks recur.
- Recurrence of postoperative leaky leaks prevents early drainage removal, early discharge, and postoperative complications such as empyema. Occasionally, a remarkable leak may worsen the respiratory condition and require reoperation.
- the fibrin glue adhesive is used for tissue adhesion closure, hemostasis, etc. by applying a fibrinogen solution and a thrombin solution ⁇ iij by applying a force or a spraying device overlying the wound site.
- the fibrinogen solution and the thrombin solution often flow down, especially on a surface having a strong inclination.
- the formed fibrin gel is also non-uniform.
- the autologous It is considered that the inability of the fibrinogen solution of the preparation to invade the tissue is caused by the formation of a thrombus and a clogged state of the fibrinogen, which is considered to be the cause of the insufficient closing effect.
- a fibrinogen solution is first rubbed, and a fibrin glue adhesive is spray-coated thereon.
- high pressure resistance was obtained by this method, the use of the fibrin glue alone did not provide a sufficient effect on emphysema due to insufficient strength or remaining in the affected area. Helped.
- the fibrin glue is used by dissolving each of freeze-dried fibrinogen and thrombin at the time of use. Therefore, it is time-consuming to dissolve, and it is not a satisfactory dosage form in terms of simplicity and ease of responding to emergency surgery!
- this sheet formulation is equine collagen and thrombin is derived from cattle, and animal components other than humans are used, when humans are applied, the appearance of antibodies against heterologous proteins will occur. It is not ideal because there is a risk of zoonotic diseases such as prion disease and prion disease.
- the fibrin glue is a component of the same kind when applied to humans, it is a coagulation factor that does not have an infectious agent, and in addition, it has a sheet-shaped dosage form in order to sufficiently exert the closing effect.
- the sheets are made of carefully selected materials, and the materials must also be safe for living organisms.
- Patent Document 1 Japanese Patent Publication No. 61-34830
- Non-Patent Document 1 Toshiaki Morikawa et al., 1994, Journal of the Japanese Society of Respiratory Surgery, 8 volumes, p.288 Disclosure of the invention
- tissue closing agents or methods have been applied in various surgical fields, but there has been no effective tissue closing agent having both safety, efficacy and simplicity.
- tissue-closing agents containing a thrombin component and a fibrinogen component as active ingredients are particularly nonwoven fabrics among bioabsorbable materials.
- the present inventors have found that a tissue closing agent characterized by using a bioabsorbable synthetic nonwoven fabric processed as a reinforcing material has an extremely excellent tissue closing effect, and have completed the present invention.
- the present invention has the following configuration.
- a tissue closing agent characterized by using a bioabsorbable synthetic nonwoven fabric as a reinforcing material for a tissue closing agent containing a thrombin component and a fibrinogen component as active ingredients;
- tissue closing agent kit comprising: a bioabsorbable synthetic nonwoven fabric having thrombin immobilized thereon as an active ingredient; and a container containing fibrinogen as an active ingredient;
- Tissue closure agent kit including a bioabsorbable synthetic nonwoven fabric as a base material, a container containing a thrombin component as an active ingredient, and a container containing a fibrinogen component as an active ingredient
- the tissue closing agent according to the present invention comprises:
- tissue closing agent made of a bioabsorbable synthetic nonwoven fabric which can safely, quickly and surely close tissue in various medical fields including surgical operations in various fields. It has become possible.
- FIG. 1 is a diagram showing epicardial responses one month after treatment in a closure effect evaluation test using a canine pericardial defect model.
- positive values (diagonal lines) indicate clinically acceptable levels (less than mild), and negative values (grids) indicate clinically undesirable levels (more than moderate).
- FIG. 2 is a diagram showing epicardial responses two months after treatment in a closure effect evaluation test using a canine pericardial defect model.
- positive values (diagonal lines) indicate clinically acceptable levels (less than mild), and negative values (grids) indicate clinically undesirable levels (more than moderate).
- the bioabsorbable synthetic nonwoven fabric used in the present invention is not particularly limited as long as it is a nonwoven fabric made of bioabsorbable synthetic fibers.
- a bioabsorbable synthetic fiber is a substance that is absorbed into a living body as a foreign substance with a low inflammation-inducing property with respect to the living body over time.
- the nonwoven fabric preferably has appropriate flexibility and elasticity so that any affected part can be surely covered.
- a synthetic fiber capable of forming such a nonwoven fabric a nonwoven fabric formed of polydalicholic acid, polylactic acid, or a copolymer of glycolic acid and lactic acid can be used.
- bioabsorbable synthetic nonwoven fabric obtained by processing polyglycolic acid into nonwoven fabric is a very preferable material for this purpose. It is.
- the shape of the nonwoven fabric is not particularly limited, but a sheet shape is one of preferable shapes from the viewpoint of application to various applications and the ease of use.
- additives and stabilizers include, for example, blood coagulation factor XIII (preferably derived from human blood or obtained by genetic recombination techniques), calcium salt calcium, proteinase inhibitors (eg, aprotune) ), Albumin, aminoaminoacetic acid, polyethylene glycol, arginine, sodium hyaluronate, glycerin, and mannitol.
- blood coagulation factor XIII preferably derived from human blood or obtained by genetic recombination techniques
- calcium salt calcium e.g, calcium salt calcium
- proteinase inhibitors eg, aprotune
- Albumin eg, aminoaminoacetic acid
- polyethylene glycol arginine
- arginine sodium hyaluronate
- glycerin glycerin
- mannitol mannitol
- tissue closing agent of the present invention is not particularly limited as long as the bioabsorbable synthetic nonwoven fabric finally contains thrombin and fibrinogen as active ingredients.
- the bioabsorbable synthetic nonwoven fabric to which thrombin has been fixed in advance retains flexibility, and is easy to handle and has a favorable viewpoint of the tissue closing effect.
- kits configurations of the adhesive / closing material of the present invention include:
- the fibrinogen component is spray-coated or dip-coated on the thrombin-fixed bioabsorbable synthetic nonwoven fabric or the thrombin-fixed bioabsorbable synthetic nonwoven fabric.
- the thrombin-fixed bioabsorbable synthetic nonwoven fabric comprises: 1) dissolving thrombin in a physiological saline solution or a buffer solution; and, optionally, optionally adding calcium chloride as an additive to the thrombin solution. Immerse the bioabsorbable synthetic nonwoven fabric in the thrombin solution, freeze at -80 ° C for 2 hours, and dry It is manufactured by drying.
- the prepared fibrinogen component is applied to the affected area according to the preparation method of a commercially available fibrin glue adhesive (for example, Bolhir (product name: manufactured by Chemistry and Serological Therapy Laboratory)).
- a bioabsorbable synthetic nonwoven fabric immersed in a solution containing a thrombin component is attached thereto, or each solution is simultaneously applied to the nonwoven fabric using a spray or the like.
- a blood coagulation factor XIII or a protease inhibitor may be added to the solution containing the fibrinogen component.
- the tissue closing agent obtained by the present invention has high adhesiveness, moderate strength, flexibility, and extensibility. Adhesive coating is possible even on a defective part, a cut surface or a joint part of the weave. Furthermore, the biocompatibility is good, and the tissue can be closed without suturing or performing suturing due to its own adhesiveness.
- the polyglycolic acid-based bioabsorbable nonwoven fabric used as the base material of the closure material of the present invention has already been used for medical use, and is absorbed by the living body and decomposed into water and carbon dioxide. Has also been proven.
- the tissue closing agent of the present invention can easily and promptly cope with a defective portion of an in-vivo membrane-like tissue and a defective portion, a dissected surface or a junction of various organs and tissues.
- the coagulation reaction enables effective tissue closure.
- all components must be safe for the body!
- the production of the thrombin-fixed sheet of the present invention was performed according to the following method.
- thrombin prepared by a gene recombination technique was used (see WO03Z004641). Briefly, animal cells into which the human prethrombin gene has been introduced are cultured, and the culture fluid also purifies the prethrombin. On the other hand, ecarin, a culture solution of animal cells into which the ecarin gene has been introduced, can be purified, and the ecarin can activate prethrombin to purify thrombin.
- This example was performed according to the following procedures 1 to 7.
- EPTFE pericardium sheet Product name: Gore-tex EPTFE patch II (pericardium sheet) Z Japango Tex Co., Ltd., 15mm X 15mm
- EPTFE suture Product name: Goatex Ichiyaichi Z Japango
- Neoveal product name, 15mm x 15mm
- a fibrin glue adhesive product name: Bolhir Z (Ltd.) Yi Liao and Serological Therapy Research Institute, Fibrinogen
- Spray the solution containing each and the solution containing thrombin approximately 0.25 mL each on one side to make a sheet.
- a fibrinogen solution (approximately 0.2 mL) is dropped around the pericardial defect and rubbed manually, and the sheet is adhered to the above sheet, and the upper sheet is applied with a fibrin glue adhesive (a fibrinogen-containing solution and a thrombin-containing solution are applied to each solution). (0.5mL).
- a fibrinogen solution (Volheal (product name)) is applied to the thrombin-immobilized sheet (15 mm x 15 mm) prepared in Example 1 within a range of 12 mm x 12 mm on both sides (the outer 3 mm is left as a margin). Spray-coated about 0.5mL per side to make a sheet.
- a fibrinogen solution (approximately 0.2 mL) is dropped around the pericardial defect and rubbed manually, and the above sheet is attached and the upper surface is spray-coated with the fibrinogen solution.
- tissue closing agent of the present invention allows quick replacement with living tissue and regeneration of the pericardium.
- Rating 1 Judge; Very slight adhesion (can be easily peeled off manually) Rating 2: +; Mild adhesion (can be bluntly peeled)
- This example was performed according to the following procedures 1 to 7.
- Nembutal 25-30 mg / kg
- Anesthetize Nembutal 25-30 mg / kg to a beagle dog, intubate the trachea, and connect to an artificial respirator.
- 8% fibrinogen solution (approximately 0.7 mL) is applied to the air leak site, the thrombin immobilization sheet (10 mm x 25 mm) prepared in Example 1 is overlaid, 8% fibrinogen solution is dropped on it, and left for 5 minutes .
- Example 2 An 8% fibrinogen solution was applied to the air leak site, and neoveil (product name, 10 mm X 25 mm) used as a base material in Example 1 was overlaid, and a 250 U / mL thrombin-containing solution (Volheel ( After dropping 0.7 mL of the solution (included in the product name), spray about 0.7 mL each of the fibrinogen-containing solution and thrombin-containing solution included in the Bolheel (product name), and leave for 5 minutes.
- neoveil product name, 10 mm X 25 mm
- a 250 U / mL thrombin-containing solution Volheel ( After dropping 0.7 mL of the solution (included in the product name), spray about 0.7 mL each of the fibrinogen-containing solution and thrombin-containing solution included in the Bolheel (product name), and leave for 5 minutes.
- Collagen sheet preparation with immobilized components of fibrin adhesive (Product name: Takocombu Z Torii Pharmaceutical Co., Ltd.): Components such as fibrinogen and thrombin are supported on a sponge-like macolagen sheet, and a vacuum is applied to one side of the sheet. (20mm X 30mm) fixed by drying is immersed in physiological saline, then applied to the air leak site and left for 5 minutes.
- the first group and the second group using the polyglycolic acid-based nonwoven fabric as the base material exhibited a higher pressure-resistant effect than the third group using the collagen sheet.
- the first group using the thrombin-fixed sheet showed a particularly excellent pressure-resistant effect.
- coughing is often forced to prevent infection, and the instantaneous airway pressure at this time is considered to be 40 to 50 cm'H0.
- Third group collage
- the average withstand pressure was 34.6 cm ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ in the group using
- the tissue closing agent of the present invention has good biocompatibility and can close tissues without suturing or performing suturing due to its own adhesiveness. Therefore, it is used as a closing agent for deficient parts of in-vivo membrane-like tissues such as pleura, pericardium, and serosa, and deficient parts, cut surfaces or junctions of various organs' tissues.
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
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Abstract
Description
Claims
Priority Applications (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US11/597,321 US20070231372A1 (en) | 2004-05-21 | 2005-05-18 | Tissue Sealant |
CA002567297A CA2567297A1 (en) | 2004-05-21 | 2005-05-18 | Tissue sealant |
JP2006513706A JPWO2005113030A1 (ja) | 2004-05-21 | 2005-05-18 | 組織閉鎖剤 |
EP05741543A EP1759718A4 (en) | 2004-05-21 | 2005-05-18 | PREPARATION OF TISSUE COLLAGE |
AU2005244692A AU2005244692B2 (en) | 2004-05-21 | 2005-05-18 | Tissue closing preparation |
IL179399A IL179399A0 (en) | 2004-05-21 | 2006-11-20 | Tissue closing preparation |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2004-152474 | 2004-05-21 | ||
JP2004152474 | 2004-05-21 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2005113030A1 true WO2005113030A1 (ja) | 2005-12-01 |
Family
ID=35428263
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/JP2005/009065 WO2005113030A1 (ja) | 2004-05-21 | 2005-05-18 | 組織閉鎖剤 |
Country Status (8)
Country | Link |
---|---|
US (1) | US20070231372A1 (ja) |
EP (1) | EP1759718A4 (ja) |
JP (1) | JPWO2005113030A1 (ja) |
KR (1) | KR20070026578A (ja) |
AU (1) | AU2005244692B2 (ja) |
CA (1) | CA2567297A1 (ja) |
IL (1) | IL179399A0 (ja) |
WO (1) | WO2005113030A1 (ja) |
Cited By (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2009183649A (ja) * | 2008-02-08 | 2009-08-20 | Chemo Sero Therapeut Res Inst | シート状組織接着剤 |
JP2009534063A (ja) * | 2006-04-20 | 2009-09-24 | アエスクラップ アクチェンゲゼルシャフト | 層状創傷包帯 |
JP2010069031A (ja) * | 2008-09-19 | 2010-04-02 | Chemo Sero Therapeut Res Inst | シート状フィブリン糊接着剤 |
WO2011138974A1 (ja) * | 2010-05-07 | 2011-11-10 | 帝人株式会社 | 生体糊用補強材及びその製造方法 |
WO2012011429A1 (ja) | 2010-07-20 | 2012-01-26 | 一般財団法人化学及血清療法研究所 | 組織接着用シート製剤 |
WO2013172472A1 (ja) | 2012-05-14 | 2013-11-21 | 帝人株式会社 | シート成形体および止血材 |
JP5393447B2 (ja) * | 2007-03-22 | 2014-01-22 | 一般財団法人化学及血清療法研究所 | 固体状フィブリノゲン製剤 |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20120177718A1 (en) * | 2009-06-11 | 2012-07-12 | The Chemo-Sero-Therapeutic Research Institute | Wound-covering material |
WO2010146582A2 (en) * | 2009-06-15 | 2010-12-23 | Technion- Research And Development Foundation Ltd. | Reinforced surgical adhesives and sealants and their in-situ application |
WO2023222770A1 (en) | 2022-05-17 | 2023-11-23 | Julius-Maximilians-Universitaet Wuerzburg | Novel recombinant fibrinogen variants for fibrin sealants for surgical wound care |
KR102602497B1 (ko) | 2023-05-08 | 2023-11-14 | 강병환 | 액화천연가스 냉열의 재활용을 통한 폐기물 처리 시스템 |
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JPS57153645A (en) * | 1981-02-16 | 1982-09-22 | Horumosoohiemii Miyunhen Gmbh | Material for closing and treating injured part and production thereof |
JPH11502431A (ja) * | 1995-01-16 | 1999-03-02 | バクスター インターナショナル インコーポレイテッド | 手術後の癒着を防止するための架橋化フィブリンの自己支持シート様材料 |
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-
2005
- 2005-05-18 EP EP05741543A patent/EP1759718A4/en not_active Withdrawn
- 2005-05-18 WO PCT/JP2005/009065 patent/WO2005113030A1/ja active Application Filing
- 2005-05-18 JP JP2006513706A patent/JPWO2005113030A1/ja active Pending
- 2005-05-18 US US11/597,321 patent/US20070231372A1/en not_active Abandoned
- 2005-05-18 AU AU2005244692A patent/AU2005244692B2/en not_active Ceased
- 2005-05-18 CA CA002567297A patent/CA2567297A1/en not_active Abandoned
- 2005-05-18 KR KR1020067026158A patent/KR20070026578A/ko not_active Application Discontinuation
-
2006
- 2006-11-20 IL IL179399A patent/IL179399A0/en unknown
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JPH11502431A (ja) * | 1995-01-16 | 1999-03-02 | バクスター インターナショナル インコーポレイテッド | 手術後の癒着を防止するための架橋化フィブリンの自己支持シート様材料 |
JPH11309151A (ja) * | 1998-04-30 | 1999-11-09 | Nippon Waisuredarii Kk | 手術用縫合デバイス |
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JP2009534063A (ja) * | 2006-04-20 | 2009-09-24 | アエスクラップ アクチェンゲゼルシャフト | 層状創傷包帯 |
JP5393447B2 (ja) * | 2007-03-22 | 2014-01-22 | 一般財団法人化学及血清療法研究所 | 固体状フィブリノゲン製剤 |
US9775884B2 (en) | 2007-03-22 | 2017-10-03 | The Chemo-Sero-Therapeutic Research Institute | Solid fibrinogen preparation |
JP2009183649A (ja) * | 2008-02-08 | 2009-08-20 | Chemo Sero Therapeut Res Inst | シート状組織接着剤 |
JP2010069031A (ja) * | 2008-09-19 | 2010-04-02 | Chemo Sero Therapeut Res Inst | シート状フィブリン糊接着剤 |
WO2011138974A1 (ja) * | 2010-05-07 | 2011-11-10 | 帝人株式会社 | 生体糊用補強材及びその製造方法 |
WO2012011429A1 (ja) | 2010-07-20 | 2012-01-26 | 一般財団法人化学及血清療法研究所 | 組織接着用シート製剤 |
KR20130090882A (ko) | 2010-07-20 | 2013-08-14 | 잇빤 자이단호진 가가쿠오요비겟세이료호겐쿠쇼 | 조직 접착용 시트 제제 |
JP5889188B2 (ja) * | 2010-07-20 | 2016-03-22 | 一般財団法人化学及血清療法研究所 | 組織接着用シート製剤 |
WO2013172472A1 (ja) | 2012-05-14 | 2013-11-21 | 帝人株式会社 | シート成形体および止血材 |
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US11433160B2 (en) | 2012-05-14 | 2022-09-06 | Teijin Limited | Formed sheet product and hemostatic material |
Also Published As
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JPWO2005113030A1 (ja) | 2008-07-31 |
EP1759718A1 (en) | 2007-03-07 |
KR20070026578A (ko) | 2007-03-08 |
AU2005244692A1 (en) | 2005-12-01 |
US20070231372A1 (en) | 2007-10-04 |
EP1759718A4 (en) | 2011-03-02 |
AU2005244692B2 (en) | 2011-06-23 |
CA2567297A1 (en) | 2005-12-01 |
IL179399A0 (en) | 2007-05-15 |
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