WO2005097672A3 - Method for the production of carbon nanotubes that are ferromagnetically filled in part and carry biomolecules, and use thereof in diagnosis and therapy - Google Patents

Method for the production of carbon nanotubes that are ferromagnetically filled in part and carry biomolecules, and use thereof in diagnosis and therapy Download PDF

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Publication number
WO2005097672A3
WO2005097672A3 PCT/EP2005/003790 EP2005003790W WO2005097672A3 WO 2005097672 A3 WO2005097672 A3 WO 2005097672A3 EP 2005003790 W EP2005003790 W EP 2005003790W WO 2005097672 A3 WO2005097672 A3 WO 2005097672A3
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WO
WIPO (PCT)
Prior art keywords
carbon nanotubes
diagnosis
therapy
production
tube
Prior art date
Application number
PCT/EP2005/003790
Other languages
German (de)
French (fr)
Other versions
WO2005097672A2 (en
Inventor
Jens Ingolf Moench
Axel Meye
Albrecht Leonhardt
Gerd Hammermann
Manfred P Wirth
Bernd Buechner
Kai Kraemer
Original Assignee
Chung Dresden Leibniz Inst Fue
Univ Dresden Tech
Hamstein Consult Gmbh
Jens Ingolf Moench
Axel Meye
Albrecht Leonhardt
Gerd Hammermann
Manfred P Wirth
Bernd Buechner
Kai Kraemer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chung Dresden Leibniz Inst Fue, Univ Dresden Tech, Hamstein Consult Gmbh, Jens Ingolf Moench, Axel Meye, Albrecht Leonhardt, Gerd Hammermann, Manfred P Wirth, Bernd Buechner, Kai Kraemer filed Critical Chung Dresden Leibniz Inst Fue
Priority to EP05731324A priority Critical patent/EP1747018A2/en
Publication of WO2005097672A2 publication Critical patent/WO2005097672A2/en
Publication of WO2005097672A3 publication Critical patent/WO2005097672A3/en

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0092—Hollow drug-filled fibres, tubes of the core-shell type, coated fibres, coated rods, microtubules or nanotubes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0052—Thermotherapy; Hyperthermia; Magnetic induction; Induction heating therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6949—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/12—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules
    • A61K51/1268—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules host-guest, closed hollow molecules, inclusion complexes, e.g. with cyclodextrins, clathrates, cavitates, fullerenes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0097—Micromachined devices; Microelectromechanical systems [MEMS]; Devices obtained by lithographic treatment of silicon; Devices comprising chips
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/5115—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5192—Processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
    • A61K9/0009—Galenical forms characterised by the drug release technique; Application systems commanded by energy involving or responsive to electricity, magnetism or acoustic waves; Galenical aspects of sonophoresis, iontophoresis, electroporation or electroosmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5094—Microcapsules containing magnetic carrier material, e.g. ferrite for drug targeting

Abstract

The invention relates to a method for producing single-wall or multiple-wall carbon nanotubes (CNTs) that are ferromagnetically filled in part with iron, cobalt, nickel, an alloy thereof, or an alloy of said elements and platinum while carrying biomolecules which are enclosed within the tube and/or are associated with the outer surface of the tube. In a preferred embodiment of the invention, the disclosed nanotubes can contain two or several active substances in the tube which are released one after another when used in the body. The invention further relates to the use of the inventive carbon nanotubes that are ferromagnetically filled in part for diagnostic and therapeutic purposes, especially for the diagnosis and treatment of tumors.
PCT/EP2005/003790 2004-04-07 2005-04-07 Method for the production of carbon nanotubes that are ferromagnetically filled in part and carry biomolecules, and use thereof in diagnosis and therapy WO2005097672A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP05731324A EP1747018A2 (en) 2004-04-07 2005-04-07 Method for the production of carbon nanotubes that are ferromagnetically filled in part and carry biomolecules, and use thereof in diagnosis and therapy

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102004017705A DE102004017705A1 (en) 2004-04-07 2004-04-07 Ferromagnetic carbon nanotubes carrying biomolecules, methods of making them, and their use in diagnosis and therapy
DE102004017705.8 2004-04-07

Publications (2)

Publication Number Publication Date
WO2005097672A2 WO2005097672A2 (en) 2005-10-20
WO2005097672A3 true WO2005097672A3 (en) 2006-05-18

Family

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Country Status (3)

Country Link
EP (1) EP1747018A2 (en)
DE (1) DE102004017705A1 (en)
WO (1) WO2005097672A2 (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8993346B2 (en) 2009-08-07 2015-03-31 Nanomix, Inc. Magnetic carbon nanotube based biodetection
US9103775B2 (en) 2002-01-16 2015-08-11 Nanomix, Inc. Nano-electronic sensors for chemical and biological analytes, including capacitance and bio-membrane devices
US9291613B2 (en) 2002-06-21 2016-03-22 Nanomix, Inc. Sensor having a thin-film inhibition layer

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DE102005005704B4 (en) * 2005-02-03 2010-08-12 Leibniz-Institut Für Festkörper- Und Werkstoffforschung Dresden E.V. Use of particles for the determination of the local temperature in organic and non-organic bodies
ATE524197T1 (en) 2006-05-25 2011-09-15 Univ Wake Forest Health Sciences HYPERTHERMAL TECHNIQUES AND THEIR THERAPEUTIC APPLICATIONS
US8501233B2 (en) 2007-03-13 2013-08-06 Wake Forest University Compositions and methods for treating cancer
WO2008118960A2 (en) * 2007-03-26 2008-10-02 William Marsh Rice University Radiation protection using carbon nanotube derivatives
US8784866B2 (en) 2007-03-26 2014-07-22 William Marsh Rice University Water-soluble carbon nanotube compositions for drug delivery and medicinal applications
WO2009070380A2 (en) * 2007-10-03 2009-06-04 William Marsh Rice University Water-soluble carbon nanotube compositions for drug delivery and medical applications
CN102000349B (en) * 2010-10-27 2013-11-27 上海师范大学 Carbon nano tube/polymer/magnetic ferrate nano composite material and preparation method thereof
CN102134732B (en) * 2010-12-21 2013-03-06 北京化工大学 Method for preparing nickel and nickel alloy one-dimensional superstructure nanometer functional materials by adopting hydrogen separation template method
CN114522242B (en) * 2022-02-28 2023-02-03 深圳大学 Magnetic drive spiral micro-nano motor and preparation method and application thereof

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Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9103775B2 (en) 2002-01-16 2015-08-11 Nanomix, Inc. Nano-electronic sensors for chemical and biological analytes, including capacitance and bio-membrane devices
US9291613B2 (en) 2002-06-21 2016-03-22 Nanomix, Inc. Sensor having a thin-film inhibition layer
US8993346B2 (en) 2009-08-07 2015-03-31 Nanomix, Inc. Magnetic carbon nanotube based biodetection

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Publication number Publication date
EP1747018A2 (en) 2007-01-31
DE102004017705A1 (en) 2005-11-03
WO2005097672A2 (en) 2005-10-20

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