WO2005089509A3 - Systemes d'essai a haut debit et procedes pour identifier des agents qui modifient l'expression de proteines cellulaires - Google Patents

Systemes d'essai a haut debit et procedes pour identifier des agents qui modifient l'expression de proteines cellulaires Download PDF

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Publication number
WO2005089509A3
WO2005089509A3 PCT/US2005/009298 US2005009298W WO2005089509A3 WO 2005089509 A3 WO2005089509 A3 WO 2005089509A3 US 2005009298 W US2005009298 W US 2005009298W WO 2005089509 A3 WO2005089509 A3 WO 2005089509A3
Authority
WO
WIPO (PCT)
Prior art keywords
methods
high throughput
assay systems
identifying agents
throughput assay
Prior art date
Application number
PCT/US2005/009298
Other languages
English (en)
Other versions
WO2005089509A2 (fr
Inventor
Arthur M M D Brown
Eckhard Ficker
Barbara A Wible
Original Assignee
Chantest Inc
Arthur M M D Brown
Eckhard Ficker
Barbara A Wible
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chantest Inc, Arthur M M D Brown, Eckhard Ficker, Barbara A Wible filed Critical Chantest Inc
Priority to EP05733189A priority Critical patent/EP1735624A4/fr
Priority to JP2007504174A priority patent/JP5284637B2/ja
Priority to AU2005223851A priority patent/AU2005223851A1/en
Priority to CA002562474A priority patent/CA2562474A1/fr
Publication of WO2005089509A2 publication Critical patent/WO2005089509A2/fr
Publication of WO2005089509A3 publication Critical patent/WO2005089509A3/fr

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
    • G01N33/5061—Muscle cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/502—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
    • G01N33/5023—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects on expression patterns
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56966—Animal cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/10—Screening for compounds of potential therapeutic value involving cells
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/10—Composition for standardization, calibration, simulation, stabilization, preparation or preservation; processes of use in preparation for chemical testing
    • Y10T436/105831—Protein or peptide standard or control [e.g., hemoglobin, etc.]
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/12—Condition responsive control
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/13—Tracers or tags

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Cell Biology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Virology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)

Abstract

La présente invention concerne des systèmes d'essai à haut débit et des procédés pour identifier des agents qui modifient le niveau d'expression de protéines dans des cellules mammifères, en particulier des protéines membranaires intégrales.
PCT/US2005/009298 2004-03-19 2005-03-17 Systemes d'essai a haut debit et procedes pour identifier des agents qui modifient l'expression de proteines cellulaires WO2005089509A2 (fr)

Priority Applications (4)

Application Number Priority Date Filing Date Title
EP05733189A EP1735624A4 (fr) 2004-03-19 2005-03-17 Systemes d'essai a haut debit et procedes pour identifier des agents qui modifient l'expression de proteines cellulaires
JP2007504174A JP5284637B2 (ja) 2004-03-19 2005-03-17 細胞タンパク質の発現を変化させる薬剤を同定するためのハイスループットアッセイ系および方法
AU2005223851A AU2005223851A1 (en) 2004-03-19 2005-03-17 High throughput assay systems and methods for identifying agents that alter expression of cellular proteins
CA002562474A CA2562474A1 (fr) 2004-03-19 2005-03-17 Systemes d'essai a haut debit et procedes pour identifier des agents qui modifient l'expression de proteines cellulaires

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10/804,214 US20050208595A1 (en) 2004-03-19 2004-03-19 High throughput assay systems and methods for identifying agents that alter expression of cellular proteins
US10/804,214 2004-03-19

Publications (2)

Publication Number Publication Date
WO2005089509A2 WO2005089509A2 (fr) 2005-09-29
WO2005089509A3 true WO2005089509A3 (fr) 2005-12-22

Family

ID=34986830

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2005/009298 WO2005089509A2 (fr) 2004-03-19 2005-03-17 Systemes d'essai a haut debit et procedes pour identifier des agents qui modifient l'expression de proteines cellulaires

Country Status (8)

Country Link
US (2) US20050208595A1 (fr)
EP (1) EP1735624A4 (fr)
JP (1) JP5284637B2 (fr)
CN (1) CN1973203A (fr)
AU (1) AU2005223851A1 (fr)
CA (1) CA2562474A1 (fr)
NZ (1) NZ595791A (fr)
WO (1) WO2005089509A2 (fr)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008066525A2 (fr) * 2006-11-30 2008-06-05 Dancu Michael B Système et procédé pour produire des conditions dynamiques, y compris des conditions hémodynamiques in vivo, dans une structure tubulaire tridimensionnelle
WO2009009718A1 (fr) 2007-07-11 2009-01-15 Sru Biosystems, Inc. Procédés d'identification de modulateurs de canaux ioniques
US9134307B2 (en) 2007-07-11 2015-09-15 X-Body, Inc. Method for determining ion channel modulating properties of a test reagent
AU2011305249B2 (en) 2010-09-26 2015-07-23 Da Yu Enterprises, L.L.C. Method of recombinant macromolecular production

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020150912A1 (en) * 2000-09-07 2002-10-17 Owman Christer S. O. Reporter system for cell surface receptor-ligand binding
US6831154B1 (en) * 2001-05-16 2004-12-14 Myriad Genetics, Inc. Membrane-associated protein 17KD (MAP17)-interacting protein and use thereof

Family Cites Families (18)

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Publication number Priority date Publication date Assignee Title
GB1545094A (en) * 1976-12-14 1979-05-02 Gist Brocades Nv Piperazine derivatives
NL8202636A (nl) * 1982-06-29 1984-01-16 Gist Brocades Nv Piperazinederivaten, werkwijzen ter bereiding daarvan en farmaceutische preparaten die deze verbindingen bevatten.
HU196194B (en) 1986-04-28 1988-10-28 Richter Gedeon Vegyeszet Process for producing new 1-4 disubstituted piperazines and pharmaceuticals comprising the compounds
CA2064574A1 (fr) 1989-08-03 1991-02-04 Richard B. Rothman Produit et traitement pour soigner l'intoxication a la ***e et empecher la recidive pendant et apres le traitement, grace a un antagoniste de la ***e, de l'amphetamine et dela phencyclidine
SE510795C2 (sv) 1996-10-29 1999-06-21 Sca Packaging Display Ab Skyddshuv med integrerat bildat exponeringsställ
GB9705428D0 (en) * 1997-03-15 1997-04-30 Knoll Ag Therapeutic agents
AU5477500A (en) * 1999-06-09 2000-12-28 General Hospital Corporation, The Method of measuring plasma membrane targeting of glut4
JP4754143B2 (ja) * 1999-10-12 2011-08-24 ケモセントリックス， インコーポレイテッド ケモカインレセプター
US7179462B2 (en) * 2000-06-02 2007-02-20 University Of Connecticut Health Center α (2) macroglobulin receptor as a heat shock protein receptor and uses thereof
FR2812945B1 (fr) * 2000-08-10 2002-10-04 Aventis Pharma Sa Utilisation de la proteine grf1 et cellules exprimant la proteine grf1 pour le criblage de molecules
US6846643B2 (en) * 2000-08-14 2005-01-25 Boehringer Ingelheim Pharmaceuticals, Inc. Methods and molecules useful for identifying molecules that bind LFA-1 and for determining receptor occupancy
WO2002036733A2 (fr) * 2000-10-06 2002-05-10 Antigenics Inc. Cd36 en tant que recepteur de la proteine de choc thermique et ses utilisations
AU2002230820A1 (en) * 2000-12-18 2002-07-01 Gene Logic, Inc. Gene expression profiles associated with osteoblast differentiation
JP2003024088A (ja) * 2001-04-27 2003-01-28 Takeda Chem Ind Ltd 新規ｇタンパク質共役型レセプタータンパク質およびそのｄｎａ
EP1258495A1 (fr) * 2001-05-09 2002-11-20 Millennium Pharmaceuticals, Inc. 98359, Sous unité beta 4 du canal sodique, et ses applications
US6929923B2 (en) * 2002-07-23 2005-08-16 Rigel Pharmaceuticals, Inc. Modulators of leukocyte activation, BIC compositions and methods of use
US8071321B2 (en) * 2002-08-29 2011-12-06 Cytocure Llc Methods for up-regulating antigen expression in tumors
US7211407B2 (en) * 2003-07-15 2007-05-01 Chan Test, Inc. High throughput assay systems and methods for identifying agents that alter surface expression of integral membrane proteins

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020150912A1 (en) * 2000-09-07 2002-10-17 Owman Christer S. O. Reporter system for cell surface receptor-ligand binding
US6831154B1 (en) * 2001-05-16 2004-12-14 Myriad Genetics, Inc. Membrane-associated protein 17KD (MAP17)-interacting protein and use thereof

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of EP1735624A4 *

Also Published As

Publication number Publication date
NZ595791A (en) 2013-05-31
CA2562474A1 (fr) 2005-09-29
CN1973203A (zh) 2007-05-30
US20050208595A1 (en) 2005-09-22
JP5284637B2 (ja) 2013-09-11
WO2005089509A2 (fr) 2005-09-29
EP1735624A2 (fr) 2006-12-27
US7678548B2 (en) 2010-03-16
EP1735624A4 (fr) 2008-05-21
US20080268472A1 (en) 2008-10-30
AU2005223851A1 (en) 2005-09-29
JP2007529756A (ja) 2007-10-25

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