WO2005087193A3 - Chemoembolisation involving an anthracycline compound - Google Patents

Chemoembolisation involving an anthracycline compound Download PDF

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Publication number
WO2005087193A3
WO2005087193A3 PCT/GB2005/000958 GB2005000958W WO2005087193A3 WO 2005087193 A3 WO2005087193 A3 WO 2005087193A3 GB 2005000958 W GB2005000958 W GB 2005000958W WO 2005087193 A3 WO2005087193 A3 WO 2005087193A3
Authority
WO
WIPO (PCT)
Prior art keywords
chemoembolisation
involving
polymer
anthracycline compound
anthracycline
Prior art date
Application number
PCT/GB2005/000958
Other languages
French (fr)
Other versions
WO2005087193A2 (en
Inventor
Andrew Lennard Lewis
Peter William Stratford
Simon William Leppard
Original Assignee
Biocompatibles Uk Ltd
Andrew Lennard Lewis
Peter William Stratford
Simon William Leppard
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0405538A external-priority patent/GB0405538D0/en
Application filed by Biocompatibles Uk Ltd, Andrew Lennard Lewis, Peter William Stratford, Simon William Leppard filed Critical Biocompatibles Uk Ltd
Publication of WO2005087193A2 publication Critical patent/WO2005087193A2/en
Publication of WO2005087193A3 publication Critical patent/WO2005087193A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates

Abstract

A composition for chemoembolotherapy of colorectal metastases in liver preferably comprises particles of a water-insoluble water-swellable polymer and, absorbed therein an anthracycline in high dose. Suitably the polymer is a synthetic anionic polymer, preferably a poly (vinyl alcohol) based polymer and the drug is doxorubicin.
PCT/GB2005/000958 2004-03-11 2005-03-11 Chemoembolisation involving an anthracycline compound WO2005087193A2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB0405538A GB0405538D0 (en) 2004-03-11 2004-03-11 Chemoembolisation
GB0405538.0 2004-03-11
EP04254832.1 2004-08-11
EP04254832 2004-08-11

Publications (2)

Publication Number Publication Date
WO2005087193A2 WO2005087193A2 (en) 2005-09-22
WO2005087193A3 true WO2005087193A3 (en) 2006-06-08

Family

ID=34961857

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2005/000958 WO2005087193A2 (en) 2004-03-11 2005-03-11 Chemoembolisation involving an anthracycline compound

Country Status (1)

Country Link
WO (1) WO2005087193A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9040022B2 (en) 2005-05-09 2015-05-26 Biosphere Medical, S.A. Compositions and methods using microspheres and non-ionic contrast agents

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8697137B2 (en) 2000-03-24 2014-04-15 Biosphere Medical, Inc. Methods of using microspheres for active embolization
ES2403645T5 (en) * 2006-06-22 2020-11-16 Biocompatibles Uk Ltd Rehydratable pharmaceutical product
EP1985286A1 (en) * 2007-04-24 2008-10-29 Biocompatibles UK Limited Microspheres for treatment of brain tumours
EP2152236B1 (en) 2007-05-11 2015-09-02 Nerviano Medical Sciences S.r.l. Pharmaceutical composition of an anthracycline
EP2367535B1 (en) * 2008-12-02 2017-02-22 Biocompatibles Uk Ltd. Pancreatic tumour treatment

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995013798A1 (en) * 1993-11-18 1995-05-26 Cancer Research Institute Inc. Controlled release preparation
WO2000028920A1 (en) * 1998-11-13 2000-05-25 Biocompatibles Limited Therapeutic use of polymers
WO2001068720A1 (en) * 2000-03-13 2001-09-20 Biocure, Inc. Embolic compositions
WO2001072281A2 (en) * 2000-03-24 2001-10-04 Biosphere Medical Inc. Microspheres for active embolization
WO2004071495A1 (en) * 2003-02-12 2004-08-26 Biocompatibles Uk Limited Composition for chemoembolotherapy of solid tumors

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995013798A1 (en) * 1993-11-18 1995-05-26 Cancer Research Institute Inc. Controlled release preparation
WO2000028920A1 (en) * 1998-11-13 2000-05-25 Biocompatibles Limited Therapeutic use of polymers
WO2001068720A1 (en) * 2000-03-13 2001-09-20 Biocure, Inc. Embolic compositions
WO2001072281A2 (en) * 2000-03-24 2001-10-04 Biosphere Medical Inc. Microspheres for active embolization
WO2004071495A1 (en) * 2003-02-12 2004-08-26 Biocompatibles Uk Limited Composition for chemoembolotherapy of solid tumors

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
BALL DAVID S ET AL: "In vitro stability of tris-acryl gelatin microspheres in a multipharmaceutical chemoembolization solution.", JOURNAL OF VASCULAR AND INTERVENTIONAL RADIOLOGY : JVIR. JAN 2003, vol. 14, no. 1, January 2003 (2003-01-01), pages 83 - 88, XP008039810, ISSN: 1051-0443 *
WINGARD L B JR ET AL: "CELL SURFACE EFFECTS OF ADRIAMYCIN AND CARMINOMYCIN IMMOBILIZED ON CROSS-LINKED POLYVINYL ALCOHOL", CANCER RESEARCH, vol. 45, no. 8, 1985, pages 3529 - 3536, XP008039824, ISSN: 0008-5472 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9040022B2 (en) 2005-05-09 2015-05-26 Biosphere Medical, S.A. Compositions and methods using microspheres and non-ionic contrast agents

Also Published As

Publication number Publication date
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