WO2005080565A8 - Ｄｎａメチル化分析用ｄｎａアレイ及びその製造方法並びにｄｎａメチル化分析方法 - Google Patents

Ｄｎａメチル化分析用ｄｎａアレイ及びその製造方法並びにｄｎａメチル化分析方法

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Publication number
WO2005080565A8
WO2005080565A8 PCT/JP2005/002490 JP2005002490W WO2005080565A8 WO 2005080565 A8 WO2005080565 A8 WO 2005080565A8 JP 2005002490 W JP2005002490 W JP 2005002490W WO 2005080565 A8 WO2005080565 A8 WO 2005080565A8
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Prior art keywords
dna
dna fragments
analyzing
constructing
cytosine
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PCT/JP2005/002490
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English (en)
French (fr)
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WO2005080565A1 (ja
Inventor
Naomi Yamakawa
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Japan Science & Tech Agency
Tokyo Metropolitan Foundation
Naomi Yamakawa
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Application filed by Japan Science & Tech Agency, Tokyo Metropolitan Foundation, Naomi Yamakawa filed Critical Japan Science & Tech Agency
Priority to US10/590,122 priority Critical patent/US20080227652A1/en
Priority to EP05710340A priority patent/EP1717312B1/en
Priority to DE602005023710T priority patent/DE602005023710D1/de
Priority to JP2006510228A priority patent/JP4688792B2/ja
Publication of WO2005080565A1 publication Critical patent/WO2005080565A1/ja
Publication of WO2005080565A8 publication Critical patent/WO2005080565A8/ja

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Abstract

　（１）修飾塩基（例えば、メチル化シトシン）又は塩基（例えば、シトシン）が露出しているＤＮＡ断片混合物を調製する工程、（２）前記ＤＮＡ断片混合物を、抗修飾塩基（例えば、メチル化シトシン）抗体又は抗塩基（例えば、シトシン）抗体と接触させ、免疫複合体形成ＤＮＡ断片群と未反応ＤＮＡ断片群とに分離するか、あるいは、前記抗体に対して高親和性を示すＤＮＡ断片群と、前記抗体に対して低親和性を示すＤＮＡ断片群とに分離する工程、（３）前記の各ＤＮＡ断片群に含まれるＤＮＡ断片の全部又は一部を同定する工程、及び（４）同定ＤＮＡ断片とそれぞれハイブリダイズ可能な核酸を基板上に配置する工程を含む、ＤＮＡ修飾化（例えば、メチル化）分析用ＤＮＡアレイの製造方法を開示する。
PCT/JP2005/002490 2004-02-20 2005-02-17 Ｄｎａメチル化分析用ｄｎａアレイ及びその製造方法並びにｄｎａメチル化分析方法 WO2005080565A1 (ja)

Priority Applications (4)

Application Number Priority Date Filing Date Title
US10/590,122 US20080227652A1 (en) 2004-02-20 2005-02-17 Dna Array for Analyzing Dna Methylation, Method of Producing the Same and Method of Analyzing Dna Methylation
EP05710340A EP1717312B1 (en) 2004-02-20 2005-02-17 Dna array for analyzing dna methylation, method of constructing the same and mehtod of analyzing dna methylaion
DE602005023710T DE602005023710D1 (de) 2004-02-20 2005-02-17 Dna-array zur analyse der dna-methylierung, konstruktionsverfahren dafür sowie verfahren zur analyse der dna-methylierung
JP2006510228A JP4688792B2 (ja) 2004-02-20 2005-02-17 Ｄｎａメチル化分析用ｄｎａアレイ及びその製造方法並びにｄｎａメチル化分析方法

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2004044759 2004-02-20
JP2004-044759 2004-02-20

Publications (2)

Publication Number Publication Date
WO2005080565A1 WO2005080565A1 (ja) 2005-09-01
WO2005080565A8 true WO2005080565A8 (ja) 2006-01-26

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Country Status (5)

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US (1) US20080227652A1 (ja)
EP (1) EP1717312B1 (ja)
JP (1) JP4688792B2 (ja)
DE (1) DE602005023710D1 (ja)
WO (1) WO2005080565A1 (ja)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
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GB0413688D0 (en) * 2004-06-18 2004-07-21 Novartis Forschungsstiftung Analysis of methylated nucleic acid
AU2005308916B2 (en) * 2004-11-29 2011-07-21 Sequenom, Inc. Kits and methods for detecting methylated DNA
US7794939B2 (en) * 2007-02-26 2010-09-14 University Of Idaho Methods of DNA methylation detection
JP5211790B2 (ja) * 2007-03-26 2013-06-12 住友化学株式会社 Ｄｎａメチル化測定方法
WO2009131223A1 (ja) * 2008-04-25 2009-10-29 地方独立行政法人東京都健康長寿医療センター Ｄｎａメチル化分析方法
JP2010017178A (ja) * 2008-06-11 2010-01-28 Sumitomo Chemical Co Ltd Ｄｎａを定量又は検出する方法
JP2010017179A (ja) * 2008-06-11 2010-01-28 Sumitomo Chemical Co Ltd Ｄｎａを定量又は検出する方法
EP2443459B1 (en) * 2009-06-19 2018-12-26 The Arizona Board of Regents, A Body Corporate Of the State of Arizona acting for and on behalf Of Arizona State University Compound arrays for sample profiling
JP6095058B2 (ja) 2013-03-14 2017-03-15 国立研究開発法人産業技術総合研究所 メチルシトシン検出法
US20200399678A1 (en) * 2017-10-30 2020-12-24 Naomi Yamakawa Method for analyzing dna methylation using next generation sequencer and method for concentrating specific dna fragments

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JPH0322981A (ja) * 1989-06-21 1991-01-31 Akita Pref Gov ｐｏｌｙ（Ａ）と反応するモノクローン抗体を用いたｐｏｌｙ（Ａ）↑＋ｍＲＮＡの精製法
US6506594B1 (en) * 1999-03-19 2003-01-14 Cornell Res Foundation Inc Detection of nucleic acid sequence differences using the ligase detection reaction with addressable arrays
US6610489B2 (en) * 2000-04-28 2003-08-26 Sangamo Biosciences, Inc. Pharmacogenomics and identification of drug targets by reconstruction of signal transduction pathways based on sequences of accessible regions
US6649347B2 (en) * 2000-06-23 2003-11-18 Chromatin, Inc. Use of methylated nucleic acid segments for isolating centromere DNA
AUPR142500A0 (en) * 2000-11-13 2000-12-07 Human Genetic Signatures Pty Ltd A peptide nucleic acid-based assay for the detection of specific nucleic acid sequences
WO2002086169A1 (en) * 2001-04-23 2002-10-31 Dana-Farber Cancer Institute, Inc. Methods for rapid screening of polymorphisms, mutations and methylation
JP2003038183A (ja) * 2001-06-22 2003-02-12 Dna Chip Kenkyusho:Kk ゲノムｄｎａ中のメチレーションサイトのメチル化検出用バイオチップ及びメチル化検出方法
CA2489360C (en) * 2002-06-26 2013-01-29 Cold Spring Harbor Laboratory Methods and compositions for determining methylation profiles
WO2004059007A2 (en) * 2002-12-25 2004-07-15 National Institute Of Advanced Industrial Science And Technology Nucleic acid methylation detection process using an internal reference sample
JP3854943B2 (ja) * 2003-05-23 2006-12-06 独立行政法人科学技術振興機構 Ｄｎａメチル化率の測定方法

Also Published As

Publication number Publication date
DE602005023710D1 (de) 2010-11-04
EP1717312B1 (en) 2010-09-22
EP1717312A1 (en) 2006-11-02
US20080227652A1 (en) 2008-09-18
WO2005080565A1 (ja) 2005-09-01
JP4688792B2 (ja) 2011-05-25
JPWO2005080565A1 (ja) 2007-10-25
EP1717312A4 (en) 2008-05-14

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