WO2005079164A1 - 5α-REDUCTASE INHIBITORS - Google Patents
5α-REDUCTASE INHIBITORSInfo
- Publication number
- WO2005079164A1 WO2005079164A1 PCT/JP2005/002013 JP2005002013W WO2005079164A1 WO 2005079164 A1 WO2005079164 A1 WO 2005079164A1 JP 2005002013 W JP2005002013 W JP 2005002013W WO 2005079164 A1 WO2005079164 A1 WO 2005079164A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- acid
- reductase inhibitors
- lanosta
- trien
- efficacious
- Prior art date
Links
- 239000002677 5-alpha reductase inhibitor Substances 0.000 title abstract 2
- ZTKZZRIVAYGFSF-PIPDTRPPSA-N (E,6R)-2-methyl-6-[(5R,10S,13R,14R,17R)-4,4,10,13,14-pentamethyl-3,7-dioxo-2,5,6,11,12,15,16,17-octahydro-1H-cyclopenta[a]phenanthren-17-yl]hept-2-enoic acid Chemical compound C([C@@]12C)CC(=O)C(C)(C)[C@@H]1CC(=O)C1=C2CC[C@]2(C)[C@@H]([C@@H](CC\C=C(/C)C(O)=O)C)CC[C@]21C ZTKZZRIVAYGFSF-PIPDTRPPSA-N 0.000 abstract 2
- 206010004446 Benign prostatic hyperplasia Diseases 0.000 abstract 2
- AQUHIKXTCOSRFY-GOEVOFJGSA-N Ganoderic acid S Natural products CC1(C)C(=O)CC[C@]2(C)C3=CC[C@]4(C)[C@@H]([C@@H](CC\C=C(\C)C(O)=O)C)CC[C@@]4(C)C3=CC[C@H]21 AQUHIKXTCOSRFY-GOEVOFJGSA-N 0.000 abstract 2
- 201000004240 prostatic hypertrophy Diseases 0.000 abstract 2
- 206010000496 Acne Diseases 0.000 abstract 1
- 108010066551 Cholestenone 5 alpha-Reductase Proteins 0.000 abstract 1
- 206010060862 Prostate cancer Diseases 0.000 abstract 1
- 208000008742 Seborrheic Dermatitis Diseases 0.000 abstract 1
- 206010039792 Seborrhoea Diseases 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 201000004384 alopecia Diseases 0.000 abstract 1
- 231100000360 alopecia Toxicity 0.000 abstract 1
- 239000003098 androgen Substances 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 230000003449 preventive Effects 0.000 abstract 1
- 150000003648 triterpenes Chemical class 0.000 abstract 1
Abstract
It is intended to provide 5α-reductase inhibitors efficacious in preventing and treating diseases in which androgen participates, for example, prostatic cancer, prostatic hypertrophy, male pattern alopecia, simple acne, seborrhea and so on. Because of having a high 5α-reductase inhibitory activity, lanosta type triterpenes (in particular, ganoderic acid DM, 15α-hydroxy-3-oxolanosta-7,9(11),24-trien-26-oic acid), 5-lanosta-7,9(11),24-trien-15α,26-dihydroxy-3-one) or tyromycic acid) are efficacious as preventives/remedies for prostatic hypertrophy.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2006510188A JP5008973B2 (en) | 2004-02-10 | 2005-02-10 | 5α-reductase inhibitor |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2004033283 | 2004-02-10 | ||
| JP2004-033283 | 2004-02-10 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| WO2005079164A2 WO2005079164A2 (en) | 2005-09-01 |
| WO2005079164A1 true WO2005079164A1 (en) | 2005-09-01 |
| WO2005079164A3 WO2005079164A3 (en) | 2005-10-27 |
Family
ID=
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