WO2005077976A3 - Coiled-coil domains from c4b-binding protein - Google Patents

Coiled-coil domains from c4b-binding protein Download PDF

Info

Publication number
WO2005077976A3
WO2005077976A3 PCT/IB2005/000550 IB2005000550W WO2005077976A3 WO 2005077976 A3 WO2005077976 A3 WO 2005077976A3 IB 2005000550 W IB2005000550 W IB 2005000550W WO 2005077976 A3 WO2005077976 A3 WO 2005077976A3
Authority
WO
WIPO (PCT)
Prior art keywords
coiled
binding protein
coil domains
fragments
c4bp
Prior art date
Application number
PCT/IB2005/000550
Other languages
French (fr)
Other versions
WO2005077976A2 (en
Inventor
Fergal Hill
Jean-Baptiste Marchand
Original Assignee
Avidis Sa
Fergal Hill
Jean-Baptiste Marchand
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Avidis Sa, Fergal Hill, Jean-Baptiste Marchand filed Critical Avidis Sa
Publication of WO2005077976A2 publication Critical patent/WO2005077976A2/en
Publication of WO2005077976A3 publication Critical patent/WO2005077976A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Peptides Or Proteins (AREA)

Abstract

The present invention provides novel coiled coils including fragments of C4bp which are capable of forming oligomers. These fragments can be used to oligomerise other components, such as polypeptide and non-polypeptide antigens. Also provided are C4bp fragments which are modified by substitution of one or more amino acids or by conjugation to PEG.
PCT/IB2005/000550 2004-02-13 2005-02-14 Coiled-coil domains from c4b-binding protein WO2005077976A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP04290397.1 2004-02-13
EP04290397 2004-02-13

Publications (2)

Publication Number Publication Date
WO2005077976A2 WO2005077976A2 (en) 2005-08-25
WO2005077976A3 true WO2005077976A3 (en) 2006-03-09

Family

ID=34854720

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2005/000550 WO2005077976A2 (en) 2004-02-13 2005-02-14 Coiled-coil domains from c4b-binding protein

Country Status (1)

Country Link
WO (1) WO2005077976A2 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1790358A1 (en) 2005-11-23 2007-05-30 Université de Reims Champagne-Ardennes Protein constructs designed for targeting and lysis of cells
EP1795540A1 (en) 2005-11-30 2007-06-13 Imaxio Multimeric complexes of antigens and an adjuvant
EP2397547A4 (en) * 2009-02-10 2012-09-05 Univ Ryukyus Drug transporter, and adjuvant and vaccine each utilizing same
MX363443B (en) 2012-12-11 2019-03-21 Osivax Sas Modified coiled coil type proteins having improved properties.
WO2023281120A1 (en) * 2021-07-09 2023-01-12 Luxembourg Institute Of Health (Lih) Dimeric protein complexes and uses thereof

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991011461A1 (en) * 1990-01-26 1991-08-08 Biogen, Inc. C4 binding protein fusion proteins
WO1997004109A1 (en) * 1995-07-21 1997-02-06 Universite Pierre Et Marie Curie (Paris Vi) α-β C4BP-TYPE RECOMBINANT HETEROMULTIMERIC PROTEINS
WO2003086444A1 (en) * 2002-04-04 2003-10-23 Amgen Inc. Use of transthyretin peptide/protein fusions to increase the serum half-life of pharmacologically active peptides/proteins
WO2004016283A2 (en) * 2002-08-14 2004-02-26 Avidis Sa Heteropolymeric compound comprising a scaffold, an adjuvant and an antigen, and its use
WO2004020639A2 (en) * 2002-08-14 2004-03-11 Avidis Sa Production of multimeric fusion proteins using a c4bp scaffold
WO2005014654A2 (en) * 2003-08-12 2005-02-17 Avidis Sa Product comprising a c4bp core protein and a monomeric antigen, and its use

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991011461A1 (en) * 1990-01-26 1991-08-08 Biogen, Inc. C4 binding protein fusion proteins
WO1997004109A1 (en) * 1995-07-21 1997-02-06 Universite Pierre Et Marie Curie (Paris Vi) α-β C4BP-TYPE RECOMBINANT HETEROMULTIMERIC PROTEINS
WO2003086444A1 (en) * 2002-04-04 2003-10-23 Amgen Inc. Use of transthyretin peptide/protein fusions to increase the serum half-life of pharmacologically active peptides/proteins
WO2004016283A2 (en) * 2002-08-14 2004-02-26 Avidis Sa Heteropolymeric compound comprising a scaffold, an adjuvant and an antigen, and its use
WO2004020639A2 (en) * 2002-08-14 2004-03-11 Avidis Sa Production of multimeric fusion proteins using a c4bp scaffold
WO2005014654A2 (en) * 2003-08-12 2005-02-17 Avidis Sa Product comprising a c4bp core protein and a monomeric antigen, and its use

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
HILLARP A ET AL: "Molecular cloning of rat C4b binding protein alpha- and beta-chains: structural and functional relationships among human, bovine, rabbit, mouse, and rat proteins.", JOURNAL OF IMMUNOLOGY (BALTIMORE, MD. : 1950) 1 FEB 1997, vol. 158, no. 3, 1 February 1997 (1997-02-01), pages 1315 - 1323, XP002335885, ISSN: 0022-1767 *
LUPAS A ET AL: "PREDICTING COILED COILS FROM PROTEIN SEQUENCES", SCIENCE (WASHINGTON D C), vol. 252, no. 5009, 1991, pages 1162 - 1164, XP001206937, ISSN: 0036-8075 *
SKERRA A: "ENGINEERED PROTEIN SCAFFOLDS FOR MOLECULAR RECOGNITION", JOURNAL OF MOLECULAR RECOGNITION, HEYDEN & SON LTD., LONDON, GB, vol. 13, no. 4, July 2000 (2000-07-01), pages 167 - 187, XP009019725, ISSN: 0952-3499 *
VILLOUTREIX BRUNO O ET AL: "Structural investigation of C4b-binding protein by molecular modeling: Localization of putative binding sites", PROTEINS, vol. 31, no. 4, 1 June 1998 (1998-06-01), pages 391 - 405, XP002335886, ISSN: 0887-3585 *

Also Published As

Publication number Publication date
WO2005077976A2 (en) 2005-08-25

Similar Documents

Publication Publication Date Title
WO2007002261A3 (en) IL-1β BINDING ANTIBODIES AND FRAGMENTS THEREOF
WO2010011947A3 (en) AMYLOID ß PEPTIDE ANALOGUES, OLIGOMERS THEREOF, PROCESSES FOR PREPARING AND COMPOSITIONS COMPRISING SAID ANALOGUES OR OLIGOMERS, AND THEIR USES
NO20063026L (en) antibodies
WO2006122825A3 (en) Single domain vhh antibodies against von willebrand factor
WO2017085172A3 (en) Improved serum albumin binders
WO2009004315A8 (en) Isolated peptides and uses thereof
DK1888761T3 (en) Recombinant N-glycosylated proteins from prokaryotic cells
WO2009018126A3 (en) Collagen-related peptides and uses thereof
WO2008140812A3 (en) Compositions and methods comprising klk3, psca, or folh1 antigen
WO2007064917A3 (en) Methods of preparation of recombinant forms of human beta-amyloid protein and uses of these proteins
WO2010136549A3 (en) Modified aav capsid polypeptides
ES2379283T3 (en) Serum albumin binding proteins
EP3670536A3 (en) Recombinant tnf ligand family member polypeptides with antibody binding domain and uses thereof
WO2009023300A3 (en) Mutants of cholesterol-dependent cytolysins and uses thereof
WO2004108765A3 (en) Extracellular aspergillus polypeptides
WO2008020335A8 (en) Immunogenic compositions for streptococcus agalactiae
EA201100071A1 (en) NEW COMPOSITIONS AND METHODS
WO2005077976A3 (en) Coiled-coil domains from c4b-binding protein
WO2003033658A3 (en) Neutrokine-alpha and neutrokine-alpha splice variant
WO2008003707A3 (en) Minimized small peptides with high affinity for factor viii and factor viii-like proteins
WO2006097432A3 (en) Keratin-binding desmoplakin polypeptide sequences
ATE466876T1 (en) IMMUNOGENIC CONSTRUCTS
WO2010103515A3 (en) Compositions and methods for prevention and treatment of neurodegenerative diseases
ATE441865T1 (en) NEW POLYPEPTIDES FOR IN VINTRO ISOLATION AND PREVENTION OF LEGIONELLA PNEUMOPHILA INFECTIONS
WO2006086330A3 (en) Pharmaceutical compositions

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BW BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE EG ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NA NI NO NZ OM PG PH PL PT RO RU SC SD SE SG SK SL SY TJ TM TN TR TT TZ UA UG US UZ VC VN YU ZA ZM ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): BW GH GM KE LS MW MZ NA SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LT LU MC NL PL PT RO SE SI SK TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
NENP Non-entry into the national phase

Ref country code: DE

WWW Wipo information: withdrawn in national office

Country of ref document: DE

122 Ep: pct application non-entry in european phase