WO2005066158A3 - An improved process for the synthesis of losartan potassium - Google Patents

An improved process for the synthesis of losartan potassium Download PDF

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Publication number
WO2005066158A3
WO2005066158A3 PCT/IN2004/000169 IN2004000169W WO2005066158A3 WO 2005066158 A3 WO2005066158 A3 WO 2005066158A3 IN 2004000169 W IN2004000169 W IN 2004000169W WO 2005066158 A3 WO2005066158 A3 WO 2005066158A3
Authority
WO
WIPO (PCT)
Prior art keywords
synthesis
losartan potassium
improved process
potassium
disclosed
Prior art date
Application number
PCT/IN2004/000169
Other languages
French (fr)
Other versions
WO2005066158A2 (en
Inventor
Ashok Kumar
Rajesh Kumar Keshava Pra Singh
Nalinakshya Balaram Panda
Abhay Atmaram Upare
Manmohan Madhavrao Nimbalkar
Satish Rajanikant Soudagar
Ashvini Kumar Nand Kish Saxena
Original Assignee
Ipca Lab Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ipca Lab Ltd filed Critical Ipca Lab Ltd
Priority to EP04785921A priority Critical patent/EP1709034A2/en
Publication of WO2005066158A2 publication Critical patent/WO2005066158A2/en
Publication of WO2005066158A3 publication Critical patent/WO2005066158A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Improved processes using primary, secondary and tertiary alcohols and with safer mode of introduction of the reagent and reaction conditions are described. Further, the process of manufacture of Losaratan potassium by use of alkali metal salt such as Potassium carbonate is disclosed. A process for preparation of the polymorphic Form I of Losartan potassium is also disclosed herein.
PCT/IN2004/000169 2004-01-06 2004-06-15 An improved process for the synthesis of losartan potassium WO2005066158A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP04785921A EP1709034A2 (en) 2004-01-06 2004-06-15 An improved process for the synthesis of losartan potassium

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN14MU2004 2004-01-06
IN14/MUM/2004 2004-01-06

Publications (2)

Publication Number Publication Date
WO2005066158A2 WO2005066158A2 (en) 2005-07-21
WO2005066158A3 true WO2005066158A3 (en) 2005-08-25

Family

ID=34746662

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IN2004/000169 WO2005066158A2 (en) 2004-01-06 2004-06-15 An improved process for the synthesis of losartan potassium

Country Status (2)

Country Link
EP (1) EP1709034A2 (en)
WO (1) WO2005066158A2 (en)

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995017396A1 (en) * 1993-12-23 1995-06-29 Merck & Co., Inc. Polymorphs of losartan and the process for the preparation of form ii of losartan
WO1998018787A1 (en) * 1996-10-29 1998-05-07 Merck & Co., Inc. Process for the crystallization of losartan
WO2001081336A1 (en) * 2000-04-21 2001-11-01 Richter Gedeon Vegyészeti Gyár Rt. Process for the synthesis of a known tetrazol derivative
WO2002094816A1 (en) * 2001-05-18 2002-11-28 Aurobindo Pharma Limited Process for the crystallization of losartan potassium
WO2003048135A1 (en) * 2001-11-14 2003-06-12 Teva Pharmaceutical Industries Ltd. Amorphous and crystalline forms of losartan potassium and process for their preparation
WO2003093262A2 (en) * 2002-04-29 2003-11-13 Teva Pharmaceutical Industries Ltd. Processes for preparing losartan and losartan potassium

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995017396A1 (en) * 1993-12-23 1995-06-29 Merck & Co., Inc. Polymorphs of losartan and the process for the preparation of form ii of losartan
US5608075A (en) * 1993-12-23 1997-03-04 Merck & Co., Inc. Polymorphs of losartan and the process for the preparation of form II of losartan
WO1998018787A1 (en) * 1996-10-29 1998-05-07 Merck & Co., Inc. Process for the crystallization of losartan
WO2001081336A1 (en) * 2000-04-21 2001-11-01 Richter Gedeon Vegyészeti Gyár Rt. Process for the synthesis of a known tetrazol derivative
EP1274702A1 (en) * 2000-04-21 2003-01-15 Richter Gedeon Vegyeszeti Gyar R.T. Process for the synthesis of a known tetrazol derivative
WO2002094816A1 (en) * 2001-05-18 2002-11-28 Aurobindo Pharma Limited Process for the crystallization of losartan potassium
WO2003048135A1 (en) * 2001-11-14 2003-06-12 Teva Pharmaceutical Industries Ltd. Amorphous and crystalline forms of losartan potassium and process for their preparation
WO2003093262A2 (en) * 2002-04-29 2003-11-13 Teva Pharmaceutical Industries Ltd. Processes for preparing losartan and losartan potassium

Also Published As

Publication number Publication date
WO2005066158A2 (en) 2005-07-21
EP1709034A2 (en) 2006-10-11

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