WO2005055984A1 - Method for preparation of salt aerosol with predefined concentration - Google Patents
Method for preparation of salt aerosol with predefined concentration Download PDFInfo
- Publication number
- WO2005055984A1 WO2005055984A1 PCT/EE2004/000008 EE2004000008W WO2005055984A1 WO 2005055984 A1 WO2005055984 A1 WO 2005055984A1 EE 2004000008 W EE2004000008 W EE 2004000008W WO 2005055984 A1 WO2005055984 A1 WO 2005055984A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- salt
- aerosol
- preparation
- kinetic energy
- particles
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/14—Alkali metal chlorides; Alkaline earth metal chlorides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0065—Inhalators with dosage or measuring devices
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/02—Inhalators with activated or ionised fluids, e.g. electrohydrodynamic [EHD] or electrostatic devices; Ozone-inhalators with radioactive tagged particles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2202/00—Special media to be introduced, removed or treated
- A61M2202/06—Solids
- A61M2202/064—Powder
- A61M2202/066—Powder made from a compacted product by abrading
Definitions
- the present invention the method for preparation of salt aerosol with predefined concentration belongs to the field of medical techniques and can be used for treating respiratory tract problems and for preventive purposes, both in salt chambers of in-patient and out-patient clinics.
- a known method for preparation of salt aerosol is described in the patent SU 1793932, where the aerosol is obtained by using a salt crusher.
- the salt crusher works periodically by switching on and off, depending on the signals received from the aerosol concentration sensors.
- the object of the invention is the method of obtaining a spray, which is based on affecting the material being crushed by ultrasound vibrations.
- the source of vibrations comprising a piezo element, has been produced in such a way that by changing the parameters of vibrations it is possible to change the size of aerosol particles.
- the patent RU 2025139 discloses a device for preparation of salt aerosol.
- the upper part of the case of the device has a spiral-shaped horizontal air channel; the air that gets into the device, by moving spirally, creates rarefied air.
- the grinded salt particles are expelled from the mill due to centrifugal forces and partially due to rarefaction for example into the chamber with an artificial microclimate.
- the author's certificate SU 1741809 discloses the invention which is directed to a device for preparation of common salt aerosol for treatment of patients, who have bronchial asthma.
- the dispersity of the aerosol is controlled by help of pneumatic throttle, which is connected to grinding chamber and enables control of air flow.
- the patent application PCT/US96/03528 (WO 96/31221) and the patent US 5747002 are directed to a method for preparation of sodium chloride formulations having a substantially uniform particle size suitable to ensure the dispersible properties for inhalation into the lungs of a subject.
- the method involves jet milling coarse sodium chloride in one or preferably two or more procedures using air pressure suitable to produce particles having a significant fraction that are less than about 7 microns in size. Immediately following the milling, the particles are vacuum dried to prevent substantial aggregation over time.
- the invention disclosed in the patent RU 2062120 is directed to a device for individual threatment of respiratory diseases, which comprises case with grinded salt rock, air duct, diffuser, and is equipped with connection element for the patient.
- a device for individual threatment of respiratory diseases which comprises case with grinded salt rock, air duct, diffuser, and is equipped with connection element for the patient.
- Such construction enables inhalation of curative salt aerosol as a result of normal breathing process.
- the invention disclosed in the patent RU 2058768 is directed to a salt chamber which walls are made from salt blocks and which comprises a saturation filter, pressure fan and, in opposite wall, a diffuser and sucking fan. Such system prepares the salt aerosol.
- the aim of the present invention is to develop method for preparation of salt aerosol with predefined concentration and size of salt particles activated with kinetic energy, by which dry coarse salt is directed by help of determined dosage process onto intensively operating salt-grinding instrument.
- the crystal structure of coarse salt is broken due to impacts with grinding instrument, the salt particles are activated with kinetic energy and an aerosol with required quality and primary concentration is prepared in the grinding chamber by mixing of salt particles with primary compressed air with controlled flow. Compressed air is directed into grinding chamber and mixed with grinded salt particles directly during process of breaking the crystal structure of coarse salt.
- the produced salt aerosol is directed into the salt chamber by help of controlled secondary airflow.
- the salt aerosol received using the present method is of maximum homogeneous quality; the salt particles are activated with kinetic energy; the sizes of particles are 2 to 5 microns with a fraction of such particles of at least 90% in the aerosol; the concentration of the salt aerosol is 0.5 - 60.00 mg/m 3 .
- FIG. 1 depicts a salt aerosol generator with doser which uses the method being described.
- the coarse grained salt is poured into the salt depository 1, from which, by means of the dosing rotor 2, the coarse salt is directed from the doser 3 through the channel 4 into the mill 6, where the crystal structure of the coarse salt is broken by help of salt-grinding instrument 7.
- the grinding instrument 7 of the mill 6 is operating with continuous intensivity, which provides homogeneously crushed salt crystal powder.
- the required aerosol appears by mixing salt particles and compressed air in the grinding device.
- the compressed air is directed into the mill 6 through the air channels 8 and 10. The compressed air forces the aerosol from the mill 6 through the upper part 5 of the mill into the salt chamber.
- the method being described enables the salt chamber to provide a salt treatment (halotherapy) process of new higher quality, which is created by the salt aerosol activated with kinetic energy.
Abstract
Description
Claims
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EEU200300066U EE00431U1 (en) | 2003-12-09 | 2003-12-09 | Method for obtaining a salt aerosol at a predetermined concentration |
EEU200300066 | 2003-12-09 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2005055984A1 true WO2005055984A1 (en) | 2005-06-23 |
WO2005055984B1 WO2005055984B1 (en) | 2005-08-11 |
Family
ID=34639210
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/EE2004/000008 WO2005055984A1 (en) | 2003-12-09 | 2004-12-07 | Method for preparation of salt aerosol with predefined concentration |
Country Status (3)
Country | Link |
---|---|
DE (1) | DE102004059530A1 (en) |
EE (1) | EE00431U1 (en) |
WO (1) | WO2005055984A1 (en) |
Cited By (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1941926A2 (en) * | 2007-01-08 | 2008-07-09 | Asthma Rehabilitációs Centrum KFT. | Apparatus and Method for producing salt, preferably NaCl aerosol suitable for treating respiratory diseases |
WO2008084269A2 (en) * | 2007-01-12 | 2008-07-17 | Janos Feher | Device for producing rich in nacl, high dispersity and low moisture aerosol |
WO2008092465A1 (en) * | 2007-01-30 | 2008-08-07 | Vladimir Budarin | Method and device for obtaining a salt aerosol of adjustable concentration and personal halotheraphy assembly |
WO2008060173A3 (en) * | 2006-11-14 | 2008-12-04 | Constantin Pascu | Procedure and devices for the controlled obtaining of dry saline aerosols with therapeutic effect |
DE102012111431A1 (en) | 2012-11-26 | 2014-05-28 | Klafs Gmbh & Co. Kg | micronizer |
WO2016108055A2 (en) | 2014-12-30 | 2016-07-07 | Kokai Tamás | Unit for the micronization and dosage of solid active agents |
US11497593B2 (en) | 2014-04-13 | 2022-11-15 | R & M Butterworth Pty Ltd. | Livestock treatment method and apparatus |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FI20051141L (en) * | 2005-11-10 | 2007-05-11 | Kari Viherlahti | Spreading device |
EE00941U1 (en) | 2010-02-17 | 2010-07-15 | Budarin Vladimir | Dry salt aerosol generation system |
DE102010038163A1 (en) | 2010-10-13 | 2012-04-19 | Alina Chervinskaya | Device for production of salt aerosol, has chamber opened for outputting salt aerosol and surrounded by upper and lower parts, which hold crushing mill during separation of upper and lower parts from each other |
DE102016106358B3 (en) | 2016-04-07 | 2017-09-28 | Klafs Gmbh & Co. Kg | micronizer |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE4003989A1 (en) * | 1990-02-09 | 1991-08-14 | Uzgorodskij Od Nii Kurortologi | Forming therapeutic atmos. with sodium chloride crystals - by grinding for entrainment in rising hot air stream |
SU1793932A3 (en) * | 1991-05-28 | 1993-02-07 | Meдиko-Texhичeckий Цehtp "Aэpomeд" | Device for production of aerosols |
RU2025139C1 (en) * | 1991-09-17 | 1994-12-30 | Родин Леонид Васильевич | Plant for production of salt aerosol |
US5747002A (en) * | 1995-04-05 | 1998-05-05 | Genentech, Inc. | Preparation of sodium chloride aerosol formulations |
WO2001062264A2 (en) * | 2000-02-23 | 2001-08-30 | The Procter & Gamble Company | Halotherapy method by inhalation of sodium chloride |
-
2003
- 2003-12-09 EE EEU200300066U patent/EE00431U1/en not_active IP Right Cessation
-
2004
- 2004-12-07 WO PCT/EE2004/000008 patent/WO2005055984A1/en active Application Filing
- 2004-12-09 DE DE102004059530A patent/DE102004059530A1/en not_active Withdrawn
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE4003989A1 (en) * | 1990-02-09 | 1991-08-14 | Uzgorodskij Od Nii Kurortologi | Forming therapeutic atmos. with sodium chloride crystals - by grinding for entrainment in rising hot air stream |
SU1793932A3 (en) * | 1991-05-28 | 1993-02-07 | Meдиko-Texhичeckий Цehtp "Aэpomeд" | Device for production of aerosols |
RU2025139C1 (en) * | 1991-09-17 | 1994-12-30 | Родин Леонид Васильевич | Plant for production of salt aerosol |
US5747002A (en) * | 1995-04-05 | 1998-05-05 | Genentech, Inc. | Preparation of sodium chloride aerosol formulations |
WO2001062264A2 (en) * | 2000-02-23 | 2001-08-30 | The Procter & Gamble Company | Halotherapy method by inhalation of sodium chloride |
Non-Patent Citations (2)
Title |
---|
DATABASE WPI Section Ch Week 199415, Derwent World Patents Index; Class B07, AN 1994-125505, XP002323522 * |
DATABASE WPI Section Ch Week 199531, Derwent World Patents Index; Class B07, AN 1995-238729, XP002323521 * |
Cited By (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2008060173A3 (en) * | 2006-11-14 | 2008-12-04 | Constantin Pascu | Procedure and devices for the controlled obtaining of dry saline aerosols with therapeutic effect |
US20090232895A1 (en) * | 2006-11-14 | 2009-09-17 | Costantin Pascu | Procedure and devices for the controlled obtaining of dry saline aerosols with therapeutic effect |
EP1941926A2 (en) * | 2007-01-08 | 2008-07-09 | Asthma Rehabilitációs Centrum KFT. | Apparatus and Method for producing salt, preferably NaCl aerosol suitable for treating respiratory diseases |
EP1941926A3 (en) * | 2007-01-08 | 2009-03-04 | Asthma Rehabilitációs Centrum KFT. | Apparatus and Method for producing salt, preferably NaCl aerosol suitable for treating respiratory diseases |
WO2008084269A2 (en) * | 2007-01-12 | 2008-07-17 | Janos Feher | Device for producing rich in nacl, high dispersity and low moisture aerosol |
WO2008084269A3 (en) * | 2007-01-12 | 2009-02-12 | Janos Feher | Device for producing rich in nacl, high dispersity and low moisture aerosol |
WO2008092465A1 (en) * | 2007-01-30 | 2008-08-07 | Vladimir Budarin | Method and device for obtaining a salt aerosol of adjustable concentration and personal halotheraphy assembly |
DE102012111431A1 (en) | 2012-11-26 | 2014-05-28 | Klafs Gmbh & Co. Kg | micronizer |
US11497593B2 (en) | 2014-04-13 | 2022-11-15 | R & M Butterworth Pty Ltd. | Livestock treatment method and apparatus |
WO2016108055A2 (en) | 2014-12-30 | 2016-07-07 | Kokai Tamás | Unit for the micronization and dosage of solid active agents |
US20180021527A1 (en) * | 2014-12-30 | 2018-01-25 | Tamas KOKAI | Unit for the micronization and dosage of solid active agents |
EP3650007A1 (en) | 2014-12-30 | 2020-05-13 | Kókai, Tamás | Unit for the micronization and dosage of solid active agents |
Also Published As
Publication number | Publication date |
---|---|
WO2005055984B1 (en) | 2005-08-11 |
DE102004059530A1 (en) | 2005-07-07 |
EE00431U1 (en) | 2004-04-15 |
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