WO2005046600A3 - Transdermal tulobuterol delivery - Google Patents

Transdermal tulobuterol delivery Download PDF

Info

Publication number
WO2005046600A3
WO2005046600A3 PCT/US2004/037305 US2004037305W WO2005046600A3 WO 2005046600 A3 WO2005046600 A3 WO 2005046600A3 US 2004037305 W US2004037305 W US 2004037305W WO 2005046600 A3 WO2005046600 A3 WO 2005046600A3
Authority
WO
WIPO (PCT)
Prior art keywords
tulobuterol
transdermal
delivery
skin
adhesive
Prior art date
Application number
PCT/US2004/037305
Other languages
French (fr)
Other versions
WO2005046600A2 (en
Inventor
David B Lebo
Juny Lee
Vincent Luisi
Je Phil Ryoo
Oliver J Toigo Iii
Original Assignee
Nexmed Holdings Inc
David B Lebo
Juny Lee
Vincent Luisi
Je Phil Ryoo
Oliver J Toigo Iii
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nexmed Holdings Inc, David B Lebo, Juny Lee, Vincent Luisi, Je Phil Ryoo, Oliver J Toigo Iii filed Critical Nexmed Holdings Inc
Publication of WO2005046600A2 publication Critical patent/WO2005046600A2/en
Publication of WO2005046600A3 publication Critical patent/WO2005046600A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
    • A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
    • A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
    • A61K9/7061—Polyacrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof

Abstract

A transdermal tulobuterol delivery system, preferably in the form of a single-layer, drug-in-adhesive matrix patch, is disclosed comprising a relatively low, (less than five weight percent) concentration of tulobuterol base dissolved in a skin adhesive composition containing at least one skin permeation enhancer. The transdermal delivery system of this invention provides controlled release of the active ingredient, includes a relatively low concentration of tulobuterol within the skin-contacting adhesive formulation of a transdermal patch, and provides acceptable sustained transdermal delivery of the dissolved tulobuterol, as well as acceptable tack and. peel adhesive properties for the delivery device.
PCT/US2004/037305 2003-11-07 2004-11-05 Transdermal tulobuterol delivery WO2005046600A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US51812403P 2003-11-07 2003-11-07
US60/518,124 2003-11-07

Publications (2)

Publication Number Publication Date
WO2005046600A2 WO2005046600A2 (en) 2005-05-26
WO2005046600A3 true WO2005046600A3 (en) 2005-12-22

Family

ID=34590221

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2004/037305 WO2005046600A2 (en) 2003-11-07 2004-11-05 Transdermal tulobuterol delivery

Country Status (1)

Country Link
WO (1) WO2005046600A2 (en)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3816945B2 (en) * 2003-11-21 2006-08-30 積水化学工業株式会社 Patch
WO2006044206A2 (en) 2004-10-08 2006-04-27 Noven Pharmaceuticals, Inc. Transdermal drug delivery device including an occlusive backing
HU227970B1 (en) 2007-07-10 2012-07-30 Egis Gyogyszergyar Nyrt Pharmaceutical compositions containing silicones of high volatility
US20100087768A1 (en) * 2008-10-02 2010-04-08 Forlano Paula Transdermal drug delivery system for liquid active ingredient
WO2012103016A2 (en) * 2011-01-26 2012-08-02 Csi Gmbh Extended-release beta agonist/anticholinergic transdermal patches and methods for using the same
WO2012103015A2 (en) * 2011-01-27 2012-08-02 Csi Gmbh Extended-release beta agonist/steroid transdermal patches and methods for using the same
US11154535B2 (en) 2012-07-31 2021-10-26 Egis Pharmaceuticals Plc Transdermal formulation containing COX inhibitors
US10045935B2 (en) 2012-07-31 2018-08-14 Egis Pharmaceuticals Plc Transdermal formulation containing COX inhibitors
CN110433146B (en) * 2018-05-03 2022-03-15 中国医学科学院药物研究所 Tulobuterol crystal storage type transdermal patch and preparation method thereof
AU2020306028A1 (en) * 2019-06-28 2022-02-03 Passport Technologies, Inc. Transdermal drug delivery patch, drug delivery system and drug delivery method
CN112826809B (en) * 2019-11-22 2023-01-10 北京泰德制药股份有限公司 Stable tulobuterol percutaneous absorption preparation

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5866157A (en) * 1994-11-29 1999-02-02 Hisamitsu Pharmaceutical Co., Ltd. Matrix patch formulation
US20020012695A1 (en) * 2000-06-16 2002-01-31 Lee Wan S. Transdermal preparation containing hydrophilic or salt-form drug

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5866157A (en) * 1994-11-29 1999-02-02 Hisamitsu Pharmaceutical Co., Ltd. Matrix patch formulation
US20020012695A1 (en) * 2000-06-16 2002-01-31 Lee Wan S. Transdermal preparation containing hydrophilic or salt-form drug

Also Published As

Publication number Publication date
WO2005046600A2 (en) 2005-05-26

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