WO2005045037A3 - RNA INTERFERENCE MEDIATED INHIBITION OF 5-ALPHA REDUCTASE AND ANDROGEN RECEPTOR GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA) - Google Patents
RNA INTERFERENCE MEDIATED INHIBITION OF 5-ALPHA REDUCTASE AND ANDROGEN RECEPTOR GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA) Download PDFInfo
- Publication number
- WO2005045037A3 WO2005045037A3 PCT/US2004/027169 US2004027169W WO2005045037A3 WO 2005045037 A3 WO2005045037 A3 WO 2005045037A3 US 2004027169 W US2004027169 W US 2004027169W WO 2005045037 A3 WO2005045037 A3 WO 2005045037A3
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- WIPO (PCT)
- Prior art keywords
- nucleic acid
- androgen receptor
- short interfering
- sina
- alpha reductase
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1138—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against receptors or cell surface proteins
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- C12Y—ENZYMES
- C12Y103/00—Oxidoreductases acting on the CH-CH group of donors (1.3)
- C12Y103/01—Oxidoreductases acting on the CH-CH group of donors (1.3) with NAD+ or NADP+ as acceptor (1.3.1)
- C12Y103/01022—3-Oxo-5alpha-steroid 4-dehydrogenase (NADP+) (1.3.1.22), i.e. cortisone alpha-reductase
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/11—Antisense
- C12N2310/111—Antisense spanning the whole gene, or a large part of it
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- C12N2310/12—Type of nucleic acid catalytic nucleic acids, e.g. ribozymes
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- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/12—Type of nucleic acid catalytic nucleic acids, e.g. ribozymes
- C12N2310/121—Hammerhead
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- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/14—Type of nucleic acid interfering N.A.
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- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/31—Chemical structure of the backbone
- C12N2310/315—Phosphorothioates
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- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/31—Chemical structure of the backbone
- C12N2310/317—Chemical structure of the backbone with an inverted bond, e.g. a cap structure
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- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/31—Chemical structure of the backbone
- C12N2310/318—Chemical structure of the backbone where the PO2 is completely replaced, e.g. MMI or formacetal
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- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/32—Chemical structure of the sugar
- C12N2310/321—2'-O-R Modification
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- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/32—Chemical structure of the sugar
- C12N2310/322—2'-R Modification
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- C12N2310/00—Structure or type of the nucleic acid
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- C12N2310/33—Chemical structure of the base
- C12N2310/332—Abasic residue
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- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/34—Spatial arrangement of the modifications
- C12N2310/346—Spatial arrangement of the modifications having a combination of backbone and sugar modifications
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- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/50—Physical structure
- C12N2310/53—Physical structure partially self-complementary or closed
Abstract
Applications Claiming Priority (20)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US10/693,059 | 2003-10-23 | ||
US10/693,059 US20080039414A1 (en) | 2002-02-20 | 2003-10-23 | RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA) |
US10/720,448 | 2003-11-24 | ||
US10/720,448 US8273866B2 (en) | 2002-02-20 | 2003-11-24 | RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (SINA) |
US10/727,780 US20050233329A1 (en) | 2002-02-20 | 2003-12-03 | Inhibition of gene expression using duplex forming oligonucleotides |
US10/727,780 | 2003-12-03 | ||
US10/757,803 | 2004-01-14 | ||
US10/757,803 US20050020525A1 (en) | 2002-02-20 | 2004-01-14 | RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA) |
US54348004P | 2004-02-10 | 2004-02-10 | |
US60/543,480 | 2004-02-10 | ||
US10/780,447 US7491805B2 (en) | 2001-05-18 | 2004-02-13 | Conjugates and compositions for cellular delivery |
US10/780.447 | 2004-02-13 | ||
US10/826,966 | 2004-04-16 | ||
US10/826,966 US20050032733A1 (en) | 2001-05-18 | 2004-04-16 | RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (SiNA) |
USPCT/US04/13456 | 2004-04-30 | ||
PCT/US2004/013456 WO2005041859A2 (en) | 2003-04-30 | 2004-04-30 | Conjugates and compositions for cellular delivery. |
US10/844,072 US20050159376A1 (en) | 2002-02-20 | 2004-05-12 | RNA interference mediated inhibition 5-alpha reductase and androgen receptor gene expression using short interfering nucleic acid (siNA) |
US10/844,072 | 2004-05-12 | ||
USPCT/US04/16390 | 2004-05-24 | ||
PCT/US2004/016390 WO2005019453A2 (en) | 2001-05-18 | 2004-05-24 | RNA INTERFERENCE MEDIATED INHIBITION OF GENE EXPRESSION USING CHEMICALLY MODIFIED SHORT INTERFERING NUCLEIC ACID (siNA) |
Publications (3)
Publication Number | Publication Date |
---|---|
WO2005045037A2 WO2005045037A2 (en) | 2005-05-19 |
WO2005045037A3 true WO2005045037A3 (en) | 2005-11-03 |
WO2005045037B1 WO2005045037B1 (en) | 2005-12-29 |
Family
ID=56290595
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2004/027169 WO2005045037A2 (en) | 2003-10-23 | 2004-08-20 | RNA INTERFERENCE MEDIATED INHIBITION OF 5-ALPHA REDUCTASE AND ANDROGEN RECEPTOR GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA) |
Country Status (1)
Country | Link |
---|---|
WO (1) | WO2005045037A2 (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN110536965B (en) * | 2017-02-21 | 2023-08-18 | 奥利克斯医药有限公司 | Asymmetric siRNA for inhibiting expression of male pattern alopecia target gene |
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PL1781787T3 (en) | 2004-08-23 | 2018-01-31 | Sylentis Sau | Treatment of eye disorders characterized by an elevated intraocular pressure by sirnas |
WO2006024880A2 (en) | 2004-08-31 | 2006-03-09 | Sylentis S.A.U. | Methods and compositions to inhibit p2x7 receptor expression |
GB0505081D0 (en) | 2005-03-14 | 2005-04-20 | Genomica Sau | Downregulation of interleukin-12 expression by means of rnai technology |
GB0521351D0 (en) | 2005-10-20 | 2005-11-30 | Genomica Sau | Modulation of TRPV expression levels |
GB0521716D0 (en) | 2005-10-25 | 2005-11-30 | Genomica Sau | Modulation of 11beta-hydroxysteriod dehydrogenase 1 expression for the treatment of ocular diseases |
GB0605337D0 (en) | 2006-03-17 | 2006-04-26 | Genomica Sau | Treatment of CNS conditions |
US20100292090A1 (en) | 2006-08-25 | 2010-11-18 | Oncotherapy Science, Inc. | Prognostic markers and therapeutic targets for lung cancer |
TW200831673A (en) | 2006-12-13 | 2008-08-01 | Oncotherapy Science Inc | TTK as tumor marker and therapeutic target for lung cancer |
WO2008109355A1 (en) * | 2007-03-02 | 2008-09-12 | Mdrna, Inc. | Nucleic acid compounds for inhibiting srd5a2 gene expression and uses thereof |
KR20100075858A (en) | 2007-08-24 | 2010-07-05 | 온코세라피 사이언스 가부시키가이샤 | Cancer-related genes, cdca5, epha7, stk31 and wdhd1 |
KR20100075452A (en) | 2007-08-24 | 2010-07-02 | 온코세라피 사이언스 가부시키가이샤 | Pkib and naaladl2 for target genes of prostate cancer therapy and diagnosis |
WO2010023877A1 (en) | 2008-08-27 | 2010-03-04 | Oncotherapy Science, Inc. | Prmt1 for target genes of cancer therapy and diagnosis |
WO2013036879A1 (en) * | 2011-09-08 | 2013-03-14 | Gradalis, Inc. | Compositions and methods for treating prostate cancer |
GB201215857D0 (en) | 2012-09-05 | 2012-10-24 | Sylentis Sau | siRNA and their use in methods and compositions for the treatment and/or prevention of eye conditions |
CN104781402A (en) | 2012-09-05 | 2015-07-15 | 西伦蒂斯私人股份公司 | siRNA and their use in methods and compositions for the treatment and/or prevention of eye conditions |
LT2929031T (en) | 2012-12-05 | 2018-02-12 | Alnylam Pharmaceuticals, Inc. | Pcsk9 irna compositions and methods of use thereof |
WO2015132303A1 (en) | 2014-03-04 | 2015-09-11 | Sylentis Sau | Sirnas and their use in methods and compositions for the treatment and/or prevention of eye conditions |
MX2018002158A (en) | 2015-08-25 | 2018-07-06 | Alnylam Pharmaceuticals Inc | Methods and compositions for treating a proprotein convertase subtilisin kexin (pcsk9) gene-associated disorder. |
KR102473989B1 (en) | 2018-11-28 | 2022-12-07 | (주)바이오니아 | Double-stranded oligo nucleotide structure comprising androgen receptor specific sequences and composition comprising the same for preventing hair loss and hair growth |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1996002256A1 (en) * | 1994-07-15 | 1996-02-01 | City Of Hope | CLEAVAGE OF 5α-REDUCTASE MRNA |
WO1997038728A1 (en) * | 1996-04-15 | 1997-10-23 | Dyad Pharmaceutical Corporation | Combination therapy for androgenic alopecia with antisense oligonucleotides and minoxidil |
WO2000044895A1 (en) * | 1999-01-30 | 2000-08-03 | Roland Kreutzer | Method and medicament for inhibiting the expression of a defined gene |
WO2003070918A2 (en) * | 2002-02-20 | 2003-08-28 | Ribozyme Pharmaceuticals, Incorporated | Rna interference by modified short interfering nucleic acid |
WO2004063331A2 (en) * | 2003-01-03 | 2004-07-29 | Gencia Corporation | SiRNA MEDIATED POST-TRANSRIPTIONAL GENE SILENCING OF GENES INVOLVED IN ALOPECIA |
-
2004
- 2004-08-20 WO PCT/US2004/027169 patent/WO2005045037A2/en active Application Filing
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1996002256A1 (en) * | 1994-07-15 | 1996-02-01 | City Of Hope | CLEAVAGE OF 5α-REDUCTASE MRNA |
WO1997038728A1 (en) * | 1996-04-15 | 1997-10-23 | Dyad Pharmaceutical Corporation | Combination therapy for androgenic alopecia with antisense oligonucleotides and minoxidil |
WO2000044895A1 (en) * | 1999-01-30 | 2000-08-03 | Roland Kreutzer | Method and medicament for inhibiting the expression of a defined gene |
WO2003070918A2 (en) * | 2002-02-20 | 2003-08-28 | Ribozyme Pharmaceuticals, Incorporated | Rna interference by modified short interfering nucleic acid |
WO2004063331A2 (en) * | 2003-01-03 | 2004-07-29 | Gencia Corporation | SiRNA MEDIATED POST-TRANSRIPTIONAL GENE SILENCING OF GENES INVOLVED IN ALOPECIA |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN110536965B (en) * | 2017-02-21 | 2023-08-18 | 奥利克斯医药有限公司 | Asymmetric siRNA for inhibiting expression of male pattern alopecia target gene |
Also Published As
Publication number | Publication date |
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WO2005045037A2 (en) | 2005-05-19 |
WO2005045037B1 (en) | 2005-12-29 |
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