WO2005044178A3 - Methods of using and compositions comprising immunomodulatory compounds for treatment, modification and management of pain - Google Patents

Methods of using and compositions comprising immunomodulatory compounds for treatment, modification and management of pain Download PDF

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Publication number
WO2005044178A3
WO2005044178A3 PCT/US2004/012721 US2004012721W WO2005044178A3 WO 2005044178 A3 WO2005044178 A3 WO 2005044178A3 US 2004012721 W US2004012721 W US 2004012721W WO 2005044178 A3 WO2005044178 A3 WO 2005044178A3
Authority
WO
WIPO (PCT)
Prior art keywords
methods
pain
compositions
management
modification
Prior art date
Application number
PCT/US2004/012721
Other languages
French (fr)
Other versions
WO2005044178A2 (en
Inventor
Jerome B Zeldis
Herbert Faleck
Donald C Manning
Original Assignee
Celgene Corp
Jerome B Zeldis
Herbert Faleck
Donald C Manning
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to EA200600820A priority Critical patent/EA200600820A1/en
Application filed by Celgene Corp, Jerome B Zeldis, Herbert Faleck, Donald C Manning filed Critical Celgene Corp
Priority to NZ547129A priority patent/NZ547129A/en
Priority to EP04750612A priority patent/EP1680111A4/en
Priority to AU2004286818A priority patent/AU2004286818A1/en
Priority to BRPI0415007-4A priority patent/BRPI0415007A/en
Priority to CA002543160A priority patent/CA2543160A1/en
Priority to JP2006536542A priority patent/JP2007525484A/en
Priority to MXPA06004427A priority patent/MXPA06004427A/en
Priority to AP2006003621A priority patent/AP2006003621A0/en
Priority to US10/576,152 priority patent/US7612096B2/en
Publication of WO2005044178A2 publication Critical patent/WO2005044178A2/en
Publication of WO2005044178A3 publication Critical patent/WO2005044178A3/en
Priority to IL175100A priority patent/IL175100A0/en

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/4035—Isoindoles, e.g. phthalimide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/60—Salicylic acid; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Immunology (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Diabetes (AREA)
  • Pain & Pain Management (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Obesity (AREA)
  • Dermatology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Methods of treating, preventing, modifying and managing various types of pain are disclosed. Specific methods comprise the administration of an immunomodulatory compound, or a pharmaceutically acceptable salt, solvate, hydrate, stereoisomer, clathrate, or prodrug thereof, alone or in combination with a second active agent and/or surgery, psychological or physical therapy. Pharmaceutical compositions, single unit dosage forms, and kits suitable for use in methods of the invention are also disclosed.
PCT/US2004/012721 2003-10-23 2004-04-23 Methods of using and compositions comprising immunomodulatory compounds for treatment, modification and management of pain WO2005044178A2 (en)

Priority Applications (11)

Application Number Priority Date Filing Date Title
CA002543160A CA2543160A1 (en) 2003-10-23 2004-04-23 Methods of using and compositions comprising immunomodulatory compounds for treatment, modification and management of pain
NZ547129A NZ547129A (en) 2003-10-23 2004-04-23 Methods of using and compositions comprising immunomodulatory compounds such as 1-oxo-2-(2,6-dioxopiperidin-3-yl)4-methylisoindoline for treatment, modification and management of pain
EP04750612A EP1680111A4 (en) 2003-10-23 2004-04-23 Methods of using and compositions comprising immunomodulatory compounds for treatment, modification and management of pain
AU2004286818A AU2004286818A1 (en) 2003-10-23 2004-04-23 Methods for treatment, modification and management of pain using 1-oxo-2-(2,-6-Dioxopiperidin-3-YL)-4-Methylisoindoline
BRPI0415007-4A BRPI0415007A (en) 2003-10-23 2004-04-23 method for treating, preventing, modifying or administering pain and pharmaceutical composition
EA200600820A EA200600820A1 (en) 2003-10-23 2004-04-23 METHODS OF TREATMENT, MODIFICATION AND ELIMINATION OF PATIENTS USING 1-OXO-2- (2,6-DIOXOPYPERIDIN-3-IL) -4-METHYLISYNDOLINE
JP2006536542A JP2007525484A (en) 2003-10-23 2004-04-23 Method for treatment, modification and management of pain using 1-oxo-2- (2,6-dioxopiperidin-3-yl) -4-methylisoindoline
US10/576,152 US7612096B2 (en) 2003-10-23 2004-04-23 Methods for treatment, modification and management of radiculopathy using 1-oxo-2-(2,6-dioxopiperidin-3yl)-4-aminoisoindoline
AP2006003621A AP2006003621A0 (en) 2003-10-23 2004-04-23 Methods for treatment modification and management of pains using 1-oxo-2-(2,6-dioxopiperidin-3-yl)-4-methylisoin-doleline
MXPA06004427A MXPA06004427A (en) 2003-10-23 2004-04-23 Methods of using and compositions comprising immunomodulatory compounds for treatment, modification and management of pain.
IL175100A IL175100A0 (en) 2003-10-23 2006-04-23 Methods for treatment, modification and management of pain using 1-oxo-2-(2,6-dioxopiperidin-3-yl)-4-methylisoindoline

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10/693,794 2003-10-23
US10/693,794 US20050203142A1 (en) 2002-10-24 2003-10-23 Methods of using and compositions comprising immunomodulatory compounds for treatment, modification and management of pain

Publications (2)

Publication Number Publication Date
WO2005044178A2 WO2005044178A2 (en) 2005-05-19
WO2005044178A3 true WO2005044178A3 (en) 2005-10-27

Family

ID=34573202

Family Applications (2)

Application Number Title Priority Date Filing Date
PCT/US2004/012721 WO2005044178A2 (en) 2003-10-23 2004-04-23 Methods of using and compositions comprising immunomodulatory compounds for treatment, modification and management of pain
PCT/US2004/012722 WO2005043971A2 (en) 2003-10-23 2004-04-23 Methods of using and compositions comprising selective cytokine inhibitory drugs for treatment, modification and management of pain

Family Applications After (1)

Application Number Title Priority Date Filing Date
PCT/US2004/012722 WO2005043971A2 (en) 2003-10-23 2004-04-23 Methods of using and compositions comprising selective cytokine inhibitory drugs for treatment, modification and management of pain

Country Status (16)

Country Link
US (1) US20050203142A1 (en)
EP (2) EP1679967A4 (en)
JP (1) JP2007525484A (en)
KR (2) KR20060125763A (en)
CN (2) CN1897945A (en)
AP (1) AP2006003621A0 (en)
AU (2) AU2004286819A1 (en)
BR (2) BRPI0415007A (en)
CA (1) CA2543160A1 (en)
EA (1) EA200600820A1 (en)
IL (2) IL175074A0 (en)
MX (2) MXPA06004381A (en)
NZ (1) NZ547129A (en)
OA (1) OA13274A (en)
WO (2) WO2005044178A2 (en)
ZA (2) ZA200603401B (en)

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