WO2005034954A3 - Pharmaceutical compositions of paroxetine containing microcrystalline cellulose, prepared by wet granulation - Google Patents

Pharmaceutical compositions of paroxetine containing microcrystalline cellulose, prepared by wet granulation Download PDF

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Publication number
WO2005034954A3
WO2005034954A3 PCT/IB2004/003295 IB2004003295W WO2005034954A3 WO 2005034954 A3 WO2005034954 A3 WO 2005034954A3 IB 2004003295 W IB2004003295 W IB 2004003295W WO 2005034954 A3 WO2005034954 A3 WO 2005034954A3
Authority
WO
WIPO (PCT)
Prior art keywords
prepared
microcrystalline cellulose
pharmaceutical compositions
wet granulation
paroxetine
Prior art date
Application number
PCT/IB2004/003295
Other languages
French (fr)
Other versions
WO2005034954A2 (en
Inventor
Pratik Kumar
Girish Kumar Jain
Ashok Kumar Rampal
Original Assignee
Ranbaxy Lab Ltd
Pratik Kumar
Girish Kumar Jain
Ashok Kumar Rampal
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ranbaxy Lab Ltd, Pratik Kumar, Girish Kumar Jain, Ashok Kumar Rampal filed Critical Ranbaxy Lab Ltd
Priority to EP04769597A priority Critical patent/EP1675574A2/en
Publication of WO2005034954A2 publication Critical patent/WO2005034954A2/en
Publication of WO2005034954A3 publication Critical patent/WO2005034954A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2886—Dragees; Coated pills or tablets, e.g. with film or compression coating having two or more different drug-free coatings; Tablets of the type inert core-drug layer-inactive layer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes

Landscapes

  • Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The present invention relates to stable pharmaceutical compositions of paroxetine and process for preparation thereof. The pharmaceutical composition includes paroxetine, microcrystalline cellulose, and one or more additional pharmaceutically acceptable inert excipients. The pharmaceutical composition is prepared by a wet granulation technique.
PCT/IB2004/003295 2003-10-08 2004-10-08 Pharmaceutical compositions of paroxetine containing microcrystalline cellulose, prepared by wet granulation WO2005034954A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP04769597A EP1675574A2 (en) 2003-10-08 2004-10-08 Pharmaceutical compositions of paroxetine containing microcrystalline cellulose, prepared by wet granulation

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN1247DE2003 2003-10-08
IN1247/DEL/2003 2003-10-08

Publications (2)

Publication Number Publication Date
WO2005034954A2 WO2005034954A2 (en) 2005-04-21
WO2005034954A3 true WO2005034954A3 (en) 2005-06-02

Family

ID=34430679

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2004/003295 WO2005034954A2 (en) 2003-10-08 2004-10-08 Pharmaceutical compositions of paroxetine containing microcrystalline cellulose, prepared by wet granulation

Country Status (2)

Country Link
EP (1) EP1675574A2 (en)
WO (1) WO2005034954A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007012968A2 (en) * 2005-07-29 2007-02-01 Aurobindo Pharma Ltd Stable dosage form of an antidepressant
CA2620108A1 (en) * 2005-08-26 2007-03-01 Bpsi Holdings Llc Drug compositions containing controlled release hypromellose matrices
US20090130206A1 (en) * 2006-05-09 2009-05-21 Umesh Nandkumar Khatavkar Controlled Release Compositions of an Antidepressant Agent
CN102525966B (en) * 2010-12-13 2016-06-29 江苏万全特创医药生物技术有限公司 A kind of tablet containing paroxetine and preparation method thereof

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002055062A2 (en) * 2001-01-11 2002-07-18 Synthon B.V. Pharmaceutical tablet comprising paroxetine mesylate
WO2002069969A1 (en) * 2001-03-02 2002-09-12 A/S Gea Farmaceutisk Fabrik A process for the manufacture of pharmaceutical tablets containing paroxetine hydrochloride anhydrate
WO2003057150A2 (en) * 2001-12-28 2003-07-17 Teva Pharmaceutical Industries Ltd. A stable pharmaceutical formulation of paroxetine hydrochloride and a process for preparation thereof
WO2004058229A1 (en) * 2002-12-24 2004-07-15 Biovail Laboratories Inc. Modified release formulations of selective serotonin re-uptake inhibitors

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002055062A2 (en) * 2001-01-11 2002-07-18 Synthon B.V. Pharmaceutical tablet comprising paroxetine mesylate
WO2002069969A1 (en) * 2001-03-02 2002-09-12 A/S Gea Farmaceutisk Fabrik A process for the manufacture of pharmaceutical tablets containing paroxetine hydrochloride anhydrate
WO2003057150A2 (en) * 2001-12-28 2003-07-17 Teva Pharmaceutical Industries Ltd. A stable pharmaceutical formulation of paroxetine hydrochloride and a process for preparation thereof
WO2003057151A2 (en) * 2001-12-28 2003-07-17 Teva Pharmaceutical Industries Ltd. A stable pharmaceutical formulation of paroxetine hydrochloride anhydrous and a process for preparation thereof
WO2004058229A1 (en) * 2002-12-24 2004-07-15 Biovail Laboratories Inc. Modified release formulations of selective serotonin re-uptake inhibitors

Also Published As

Publication number Publication date
WO2005034954A2 (en) 2005-04-21
EP1675574A2 (en) 2006-07-05

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