WO2005032414A2 - Modular stent - Google Patents

Modular stent Download PDF

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Publication number
WO2005032414A2
WO2005032414A2 PCT/US2004/031899 US2004031899W WO2005032414A2 WO 2005032414 A2 WO2005032414 A2 WO 2005032414A2 US 2004031899 W US2004031899 W US 2004031899W WO 2005032414 A2 WO2005032414 A2 WO 2005032414A2
Authority
WO
WIPO (PCT)
Prior art keywords
deflection
stent
support frame
thread
annular segment
Prior art date
Application number
PCT/US2004/031899
Other languages
French (fr)
Other versions
WO2005032414A3 (en
Inventor
Thomas Nissl
Eric Mangiardi
Original Assignee
Alveolus Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alveolus Inc. filed Critical Alveolus Inc.
Publication of WO2005032414A2 publication Critical patent/WO2005032414A2/en
Publication of WO2005032414A3 publication Critical patent/WO2005032414A3/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/86—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure
    • A61F2/90—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure
    • A61F2/91—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes
    • A61F2/915—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes with bands having a meander structure, adjacent bands being connected to each other
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/86—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure
    • A61F2/90—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure
    • A61F2/91—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
    • A61F2002/30316—The prosthesis having different structural features at different locations within the same prosthesis; Connections between prosthetic parts; Special structural features of bone or joint prostheses not otherwise provided for
    • A61F2002/30329—Connections or couplings between prosthetic parts, e.g. between modular parts; Connecting elements
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2002/826—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents more than one stent being applied sequentially
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/86—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure
    • A61F2/90—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure
    • A61F2/91—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes
    • A61F2/915—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes with bands having a meander structure, adjacent bands being connected to each other
    • A61F2002/91516—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes with bands having a meander structure, adjacent bands being connected to each other the meander having a change in frequency along the band
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/86—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure
    • A61F2/90—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure
    • A61F2/91—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes
    • A61F2/915—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes with bands having a meander structure, adjacent bands being connected to each other
    • A61F2002/91525—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes with bands having a meander structure, adjacent bands being connected to each other within the whole structure different bands showing different meander characteristics, e.g. frequency or amplitude
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/86—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure
    • A61F2/90—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure
    • A61F2/91—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes
    • A61F2/915—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes with bands having a meander structure, adjacent bands being connected to each other
    • A61F2002/91533—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes with bands having a meander structure, adjacent bands being connected to each other characterised by the phase between adjacent bands
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/86—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure
    • A61F2/90—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure
    • A61F2/91—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes
    • A61F2/915—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes with bands having a meander structure, adjacent bands being connected to each other
    • A61F2002/9155—Adjacent bands being connected to each other
    • A61F2002/91566—Adjacent bands being connected to each other connected trough to trough
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/86—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure
    • A61F2/90—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure
    • A61F2/91—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes
    • A61F2/915—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes with bands having a meander structure, adjacent bands being connected to each other
    • A61F2002/9155—Adjacent bands being connected to each other
    • A61F2002/91575—Adjacent bands being connected to each other connected peak to trough
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/86—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure
    • A61F2/90—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure
    • A61F2/91—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes
    • A61F2/915—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes with bands having a meander structure, adjacent bands being connected to each other
    • A61F2002/9155—Adjacent bands being connected to each other
    • A61F2002/91591—Locking connectors, e.g. using male-female connections
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2220/00—Fixations or connections for prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2220/0025—Connections or couplings between prosthetic parts, e.g. between modular parts; Connecting elements
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    • A61F2250/00—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
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    • A61F2250/006—Additional features; Implant or prostheses properties not otherwise provided for modular

Definitions

  • the invention is relative to a stent with suture mediated removability features.
  • Stents are used to treat stenoses.
  • Stenoses are closures and constrictions of tubular body canals acquired congenitally or conditioned by disease. Tumors that press on the body canals or deposits that close the body canals are frequently causes for stenoses.
  • Stenoses can be opened by operative and non-operative measures.
  • stents are introduced by catheter techniques or introducing aids into the intracorporal vessel in the area of the stenosis. Stents function as prosthesis for supporting the inner walls of lumens.
  • a stent taught by DE 101 18 944 Al belongs to the state of the art whose support frame is surrounded on the outside by a thread or wire.
  • the support frame can be radially constricted by pulling on the thread ends, that are each provided with a loop or the like, which makes it possible for the frame to be removed.
  • the invention solves this problem in a stent in accordance with the features of protective Claim 1 in which the support frame is formed by several axially successive annular segments and in which at least two adjacent annular segments can be connected by positively intermeshing coupling elements.
  • the stent in accordance with the invention and the annular segments used to build the stent are constructed in a modular building- block system and can be individually composed.
  • the stent can be used wherever different lengths and/or different properties, e.g., different degrees of radial forces or different geometries should be used or must be used.
  • a stent can be constructed or composed of individual annular segments or of annular segments combined in groups adapted to the particular requirements of use of the stenosis to be treated. A rapid reaction time for specific and specially adapted stents for a patient is possible.
  • the stent of the invention is adapted functionally by means of the combination of annular segments with different properties, in particular with radial forces that differ from each other. This can take place by the combination of annular segments with a differing design and/or consisting of different materials.
  • the suggested stent also has manufacturing and economical advantages.
  • the rejection rate can be reduced by using short, individual annular segments.
  • An individual annular segment is, e.g., 20 mm long.
  • a complete stent can then be composed of 6 individual ⁇ nnul ⁇ r segments with ⁇ total length of 120 mm. If an annular segment is defective, only this single short annular segment needs to be replaced, whereas, in the case of a support frame with a one-piece construction the entire stent would be unusable.
  • the connection of the annular segments via the coupling elements is positive, but articulated in a limited manner. This measure is advantageous for the direction of the curves of the stent.
  • the annular segments are connected via positively intermeshing coupling elements.
  • the coupling elements are preferably designed as complementary claw connectors, as provided in protective Claim 2.
  • both coupling elements project axially relative to the annular segments in the direction of the longitudinal axis of the stent (protective Claim 3) .
  • one of the coupling elements is designed inside the annular segment so that only one corresponding coupling element projects in the axial direction of the stent.
  • special terminal annular segments on the free ends of a stent of the invention which segments comprise coupling elements only on one side in the direction of the middle of the stent.
  • the annular segments are positively connected by the coupling elements.
  • the coupling elements have undercut areas for producing a stable connection.
  • the undercut areas can be curved (protective Claim 4).
  • Straight-line undercut areas are also advantageous (protective Claim 5).
  • a combination of curved undercut areas and of straight-line undercut areas on the coupling elements is also possible.
  • the coupling elements are supported on each other by the undercut areas so that a reliable, positive coupling of the annular segments among themselves is assured.
  • a number of annular segments can be advantageously interlocked to stent sections by connector struts, as provided in protective Claim 6. According to this claim a number of annular segments are firmly connected by connector struts.
  • the individual sections again comprise coupling elements that make possible a positive connection of the annular segments or of the stent sections to each other in accordance with the invention.
  • the annular segments are formed by corrugated struts that endlessly follow each other.
  • All deformable, medically possible metals or metal alloys can be used in this instance, e.g., high-grade steel, cobalt alloys, technical pure iron or nickel-titanium alloys or other medical implant materials.
  • the invention is described in detail in the following using exemplary embodiments. Further objectives, features and advantages of the invention will be apparent from the following detailed description taken in conjunction with the accompanying drawings.
  • Figure 1 shows a three-dimensional view of a stent in accordance with the invention.
  • Figures 2 to 5 and 7 each show a section of a stent with the representation of five different configurations of the support frame.
  • Figure 6 shows a section of the support frame with the representation of a guide eyelet.
  • components corresponding to each other have the same reference numerals.
  • the invention is therefore based on the problem of creating a functionally improved, removable stent.
  • the invention solves this problem with ⁇ stent in accordance with the features of Claim 1 .
  • the core of the invention is constituted by the measure that the support frame of the stent is surrounded on the outside by a thread and that the thread ends are guided via a deflection from the outside into the support frame where they are coupled by a connector. In this manner the friction is distinctly reduced in contrast to a threaded thread, which substantially improves the explantation process of a stent.
  • the ends coupled in the interior of the support frame by the connection can be readily grasped with a suitable instrument.
  • the support frame can be drawn together, preferably partially in the area of the first annular segment, by pulling the thread.
  • the stent constricted in this manner can then be removed from the body canal.
  • a biocompatible, non-dissolvable thread can be used as thread.
  • the term " thread" can also denote a wire.
  • the deflection for the thread ends can basically be realized by differently designed deflection elements. Eyelet-shaped, loop-shaped or hook-like deflection elements are considered to be especially advantageous.
  • the deflection elements should reliably hold and guide the thread.
  • the deflection is realized by at least one deflection element provided on an annular segment.
  • the deflection is preferably formed by two deflection elements, e.g., eyelets, arranged on the circumference of the support frame at an interval from one another (Claim 3).
  • the explantation process can already be distinctly simplified if one or two end-side annular segments of a stent can be drawn together.
  • Claim 4 consequently provide that the deflection is provided on the end-side annular segment (viewed in the direction of the longitudinal axis of the stent).
  • Claim 5 Another advantageous embodiment of the stent of the invention provides according to Claim 5 that the deflection is arranged on the inner side, facing the middle of the stent, of the end-side annular segment.
  • An alternative embodiment forms subject matter of Claim 6. According to it the deflection is formed by two deflection elements of which a first deflection element is arranged on the inner side, facing the middle of the stent, of an annular segment and the second deflection element is arranged on the outer side of the annular segment.
  • the two deflection elements are spaced relative to one another over the circumference of the support frame as well as viewed in the direction of the longitudinal axis of the stent.
  • An entire annular segment is drawn together when the thread ends are pulled by the diagonal course of the thread achieved in this manner via the annular segment and the connector struts.
  • the deflection can also be formed by two deflection elements of which a first deflection element is provided on the end-side annular segment, viewed in the direction of the longitudinal axis of the stent, and the second deflection element is provided on the adjacent, inner annular segment (Claim 7).
  • the connector consists of a material visible in x-rays.
  • the coupling site on the thread ends can be detected by x-rays in this manner, which facilitates the medical intervention for explanting a stent.
  • other guide elements for the thread can be provided in the support frame in order to support the purposeful position of the yarn on the support frame, as is provided in Claim 9.
  • the annular segments themselves are formed by struts following each other in an endless manner in a corrugated manner.
  • adjacent annular segments are coupled by connector struts.
  • Each connector strut has a longitudinal section running substantially parallel to the longitudinal axis of the stent and has a strut section aligned transversely to the latter and configured in a U or V shape (Claim 1 1 ).
  • FIG. 1 shows a stent in accordance with the invention in a three-dimensional representation.
  • Stent 1 comprises a tubular support frame 2 on axially sequential, interconnected annular segments 3, 4, 5.
  • Each annular segment 3, 4, 5 is formed by struts 6, 7 following each other in an endless manner in a corrugated or zigzag pattern.
  • Adjacent annular segments 3, 4 and 4, 5 are coupled by connector struts 8.
  • Connector struts 8 have a longitudinal section 9 running substantially parallel to longitudinal axis L of the stent and have a strut section 10 aligned transversely to the latter and configured in a U or V shape (refer also to figure 2 in this regard).
  • the illustration according to figure 1 shows stent 1 in its widened out supporting state.
  • Support frame 2 is surrounded on the outside by thread 1 1 .
  • thread 1 1 is shown in figure 1 at an interval from support frame 2.
  • Thread 1 1 surrounds support frame 2 in an annular fashion between annular segments 3, 4.
  • the two thread ends 12, 13 of thread 1 1 are guided into the interior of support frame 2 via deflection 14 in the form of two deflection elements 15, 1 6 formed by eyelets.
  • Thread ends 12, 13 are firmly connected to one another by connector 17 consisting of a material visible to x-rays.
  • Figure 1 shows connector 17 in a simplified manner.
  • Connector 17 couples the two thread ends 12, 13 firmly and quasi inseparably to one another.
  • Figure 2 shows a section of support frame 2 corresponding to figure 1 .
  • Deflection 14 is provided on end-side (viewed in the direction of longitudinal axis L of the stent) annular segment 3.
  • the two deflection elements 15, 16 are arranged on the inner side, facing the middle of the stent, of annular segment 3 and in transitional area 18 between two struts 6, 7.
  • Deflection elements 15, 16 are located on the circumference of support frame 2 at distance A from one another.
  • Thread 1 1 runs between annular segments 3, 4 and loops around connector struts 8 with the exception of connector strut 8' between the two deflection elements 15, 1 6.
  • thread 1 1 is grasped in the interior of support frame 2 on connector 17.
  • the two annular segments 3, 4 are drawn together via connector struts 8 by the traction applied from the outside .and are reduced in diameter.
  • Stent 1 can subsequently be removed without problems.
  • Thread 1 1 can also overlap or cross itself on the end side before thread ends 12, 13 are guided via deflection elements 15, 1 6 of deflection 14 into the interior of support frame 2. Such a situation is shown in figure 7. Otherwise, the construction of the stent corresponds to the one previously described using figures 1 , 2.
  • deflection 14 is formed by two deflection elements 19, 20 in the form of eyelets of which ⁇ first deflection element 19 is arranged on the inner side, facing the middle of the stent, of annular segment 3 and the second deflection element 20 is arranged on the outer side of annular segment 3.
  • the first deflection element 19 is located in transitional area 18 between struts 6, 7 and in contrast thereto second deflection element 20 is arranged in transitional area 21 between struts 6, 7 and connector strut 8 on the side facing away from connector strut 8.
  • Thread 1 1 looping around support frame 2 on its outside is again guided via deflection 14 into support frame 2.
  • thread ends 12, 13 of thread 1 1 are threaded through deflection elements 19, 20 and coupled in support frame 2 by connector 17.
  • this second end is totally constricted during the drawing together by thread 1 1 .
  • Figure 4 shows a comparable configuration.
  • first deflection element 22 in the form of an eyelet arranged on the inner side, facing middle M of the stent, of annular segment 3 and has a second deflection element 23 on the outer side of annular segment 3.
  • First deflection element 22 is located on transitional area 24 between struts 6, 7 of the inner side of annular segment 3 and second deflection element 23 is located on transitional area 25 between struts 6, 7 on the outer side of annular segment 3.
  • Interval A between deflection elements 22, 23 is greater over the circumference than that in the embodiment of support frame 2 according to figure 3.
  • deflection 14 is formed by two deflection elements 26, 27 of which the first deflection element 26 is provided on the end-side ⁇ nnul ⁇ r segment 3, viewed in longitudinal axis L of the stent and the second deflection element 27 is provided on adjacent, inner annular segment 4.
  • deflection elements 26, 27 are preferably formed by eyelets. According to the invention thread 1 1 is guided via deflection elements 26, 27 from the outside into the interior of support frame 2, where it is coupled by connector 17.
  • Both annular segments 3, 4 are contracted when thread 1 1 is pulled as a result of the connecting of deflection elements 26, 27 to the first, inner segment area and to the second, outer segment area of annular segments 3, 4, whereupon stent 1 can be removed from the body canal.

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  • Physics & Mathematics (AREA)
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Abstract

The invention is relative to a stent 1 with a tubular support frame 2 consisting of axially successively following, interconnected annular segments 3, 4, 5, which support frame 2 is surrounded on its outside by a thread 11. The thread ends 12, 13 are guided via a deflection 14 from the outside into support frame 2, where they are coupled by a connector consisting of a material visible in x-rays. Deflection 14 is realized by two deflection elements 15, 16 in the form of eyelets provided on annular segment 3. Deflection elements 15, 16 are arranged on the circumference of support frame 2 at an interval from one another and are provided on end-side annular segment 3, viewed in longitudinal direction L of the stent.

Description

MODULAR STENT
FIELD OF INVENTION The invention is relative to a stent with suture mediated removability features. BACKGROUND OF THE INVENTION Stents are used to treat stenoses. Stenoses are closures and constrictions of tubular body canals acquired congenitally or conditioned by disease. Tumors that press on the body canals or deposits that close the body canals are frequently causes for stenoses. Stenoses can be opened by operative and non-operative measures. In the case of non-operative measures, stents are introduced by catheter techniques or introducing aids into the intracorporal vessel in the area of the stenosis. Stents function as prosthesis for supporting the inner walls of lumens. In various areas of application, e.g., bronchus, biliary, trachea or esophagus the stents must be able to removed out of the body as a function of the course of the disease or treatment. This can be problematic since newly formed tissue can grow on the support frame and even grow through it, which can result in complications when removing a stent. In this connection a stent taught by DE 101 18 944 Al belongs to the state of the art whose support frame is surrounded on the outside by a thread or wire. The support frame can be radially constricted by pulling on the thread ends, that are each provided with a loop or the like, which makes it possible for the frame to be removed. In particular when the wire or thread is guided or braided in multiple windings around the support frame, a high degree of friction results between the two stent components, which has a disadvantageous effect on the explantation process. Even the grasping of the thread ends can be complex at times. SUMMARY OF EXEMPLARY EMBODIMENTS The invention solves this problem in a stent in accordance with the features of protective Claim 1 in which the support frame is formed by several axially successive annular segments and in which at least two adjacent annular segments can be connected by positively intermeshing coupling elements. The stent in accordance with the invention and the annular segments used to build the stent are constructed in a modular building- block system and can be individually composed. The stent can be used wherever different lengths and/or different properties, e.g., different degrees of radial forces or different geometries should be used or must be used. A stent can be constructed or composed of individual annular segments or of annular segments combined in groups adapted to the particular requirements of use of the stenosis to be treated. A rapid reaction time for specific and specially adapted stents for a patient is possible. The stent of the invention is adapted functionally by means of the combination of annular segments with different properties, in particular with radial forces that differ from each other. This can take place by the combination of annular segments with a differing design and/or consisting of different materials. The suggested stent also has manufacturing and economical advantages. Thus, the rejection rate can be reduced by using short, individual annular segments. An individual annular segment is, e.g., 20 mm long. A complete stent can then be composed of 6 individual αnnulαr segments with α total length of 120 mm. If an annular segment is defective, only this single short annular segment needs to be replaced, whereas, in the case of a support frame with a one-piece construction the entire stent would be unusable. The connection of the annular segments via the coupling elements is positive, but articulated in a limited manner. This measure is advantageous for the direction of the curves of the stent. The annular segments are connected via positively intermeshing coupling elements. The coupling elements are preferably designed as complementary claw connectors, as provided in protective Claim 2. It is advantageous if both coupling elements project axially relative to the annular segments in the direction of the longitudinal axis of the stent (protective Claim 3) . However, it is also conceivable that one of the coupling elements is designed inside the annular segment so that only one corresponding coupling element projects in the axial direction of the stent. It can be advantageous in practice to use special terminal annular segments on the free ends of a stent of the invention which segments comprise coupling elements only on one side in the direction of the middle of the stent. The annular segments are positively connected by the coupling elements. To this end the coupling elements have undercut areas for producing a stable connection. The undercut areas can be curved (protective Claim 4). Straight-line undercut areas are also advantageous (protective Claim 5). In addition, a combination of curved undercut areas and of straight-line undercut areas on the coupling elements is also possible. The coupling elements are supported on each other by the undercut areas so that a reliable, positive coupling of the annular segments among themselves is assured. A number of annular segments can be advantageously interlocked to stent sections by connector struts, as provided in protective Claim 6. According to this claim a number of annular segments are firmly connected by connector struts. The individual sections again comprise coupling elements that make possible a positive connection of the annular segments or of the stent sections to each other in accordance with the invention. According to the features of protective Claim 7 the annular segments are formed by corrugated struts that endlessly follow each other. All deformable, medically possible metals or metal alloys can be used in this instance, e.g., high-grade steel, cobalt alloys, technical pure iron or nickel-titanium alloys or other medical implant materials. The invention is described in detail in the following using exemplary embodiments. Further objectives, features and advantages of the invention will be apparent from the following detailed description taken in conjunction with the accompanying drawings.
BRIEF DESCRIPTION OF THE FIGURES Figure 1 shows a three-dimensional view of a stent in accordance with the invention. Figures 2 to 5 and 7 each show a section of a stent with the representation of five different configurations of the support frame. Figure 6 shows a section of the support frame with the representation of a guide eyelet. In all figures components corresponding to each other have the same reference numerals.
DETAILED DESCRIPTION OF AN EMBODIMENT The invention is therefore based on the problem of creating a functionally improved, removable stent. The invention solves this problem with α stent in accordance with the features of Claim 1 . The core of the invention is constituted by the measure that the support frame of the stent is surrounded on the outside by a thread and that the thread ends are guided via a deflection from the outside into the support frame where they are coupled by a connector. In this manner the friction is distinctly reduced in contrast to a threaded thread, which substantially improves the explantation process of a stent. The ends coupled in the interior of the support frame by the connection can be readily grasped with a suitable instrument. If the edges of the stent should be granulated or grown in, the support frame can be drawn together, preferably partially in the area of the first annular segment, by pulling the thread. The stent constricted in this manner can then be removed from the body canal. A biocompatible, non-dissolvable thread can be used as thread.
The term " thread" can also denote a wire. The deflection for the thread ends can basically be realized by differently designed deflection elements. Eyelet-shaped, loop-shaped or hook-like deflection elements are considered to be especially advantageous. The deflection elements should reliably hold and guide the thread. According to .the features of Claim 2 the deflection is realized by at least one deflection element provided on an annular segment. The deflection is preferably formed by two deflection elements, e.g., eyelets, arranged on the circumference of the support frame at an interval from one another (Claim 3). The explantation process can already be distinctly simplified if one or two end-side annular segments of a stent can be drawn together. The features of Claim 4 consequently provide that the deflection is provided on the end-side annular segment (viewed in the direction of the longitudinal axis of the stent). Another advantageous embodiment of the stent of the invention provides according to Claim 5 that the deflection is arranged on the inner side, facing the middle of the stent, of the end-side annular segment. An alternative embodiment forms subject matter of Claim 6. According to it the deflection is formed by two deflection elements of which a first deflection element is arranged on the inner side, facing the middle of the stent, of an annular segment and the second deflection element is arranged on the outer side of the annular segment. Accordingly, the two deflection elements are spaced relative to one another over the circumference of the support frame as well as viewed in the direction of the longitudinal axis of the stent. An entire annular segment is drawn together when the thread ends are pulled by the diagonal course of the thread achieved in this manner via the annular segment and the connector struts. Furthermore, the deflection can also be formed by two deflection elements of which a first deflection element is provided on the end-side annular segment, viewed in the direction of the longitudinal axis of the stent, and the second deflection element is provided on the adjacent, inner annular segment (Claim 7). According to the features of Claim 8 the connector consists of a material visible in x-rays. The coupling site on the thread ends can be detected by x-rays in this manner, which facilitates the medical intervention for explanting a stent. In addition, other guide elements for the thread can be provided in the support frame in order to support the purposeful position of the yarn on the support frame, as is provided in Claim 9. The annular segments themselves are formed by struts following each other in an endless manner in a corrugated manner. According to Claim 10 adjacent annular segments are coupled by connector struts. Each connector strut has a longitudinal section running substantially parallel to the longitudinal axis of the stent and has a strut section aligned transversely to the latter and configured in a U or V shape (Claim 1 1 ). This embodiment of the support frame assures a high and anatomically flexible support force and is stable in length even given external compression. The invention is described in detail in the following with reference made to the exemplary embodiments shown in the drawings. Figure 1 shows a stent in accordance with the invention in a three-dimensional representation. Stent 1 comprises a tubular support frame 2 on axially sequential, interconnected annular segments 3, 4, 5. Each annular segment 3, 4, 5 is formed by struts 6, 7 following each other in an endless manner in a corrugated or zigzag pattern. Adjacent annular segments 3, 4 and 4, 5 are coupled by connector struts 8. Connector struts 8 have a longitudinal section 9 running substantially parallel to longitudinal axis L of the stent and have a strut section 10 aligned transversely to the latter and configured in a U or V shape (refer also to figure 2 in this regard). The illustration according to figure 1 shows stent 1 in its widened out supporting state. Support frame 2 is surrounded on the outside by thread 1 1 . For the sake of a better understanding thread 1 1 is shown in figure 1 at an interval from support frame 2. Thread 1 1 surrounds support frame 2 in an annular fashion between annular segments 3, 4. The two thread ends 12, 13 of thread 1 1 are guided into the interior of support frame 2 via deflection 14 in the form of two deflection elements 15, 1 6 formed by eyelets. Thread ends 12, 13 are firmly connected to one another by connector 17 consisting of a material visible to x-rays. Figure 1 shows connector 17 in a simplified manner. Connector 17 couples the two thread ends 12, 13 firmly and quasi inseparably to one another. Figure 2 shows a section of support frame 2 corresponding to figure 1 . Deflection 14 is provided on end-side (viewed in the direction of longitudinal axis L of the stent) annular segment 3. The two deflection elements 15, 16 are arranged on the inner side, facing the middle of the stent, of annular segment 3 and in transitional area 18 between two struts 6, 7. Deflection elements 15, 16 are located on the circumference of support frame 2 at distance A from one another. Thread 1 1 runs between annular segments 3, 4 and loops around connector struts 8 with the exception of connector strut 8' between the two deflection elements 15, 1 6. In order to remove an implanted strut 1 from a body canal thread 1 1 is grasped in the interior of support frame 2 on connector 17. The two annular segments 3, 4 are drawn together via connector struts 8 by the traction applied from the outside .and are reduced in diameter. Stent 1 can subsequently be removed without problems.. Thread 1 1 can also overlap or cross itself on the end side before thread ends 12, 13 are guided via deflection elements 15, 1 6 of deflection 14 into the interior of support frame 2. Such a situation is shown in figure 7. Otherwise, the construction of the stent corresponds to the one previously described using figures 1 , 2. In this configuration struts 6, 7 are drawn onto connector 8' with deflection elements 15, 16 and all connectors 8, 8' and annular segments 3, 4 are radially constricted therewith by traction on thread ends 12, 13 via thread 1 1 . In the embodiment of a support frame 2 according to figure 3 deflection 14 is formed by two deflection elements 19, 20 in the form of eyelets of which α first deflection element 19 is arranged on the inner side, facing the middle of the stent, of annular segment 3 and the second deflection element 20 is arranged on the outer side of annular segment 3. The first deflection element 19 is located in transitional area 18 between struts 6, 7 and in contrast thereto second deflection element 20 is arranged in transitional area 21 between struts 6, 7 and connector strut 8 on the side facing away from connector strut 8. Thread 1 1 looping around support frame 2 on its outside is again guided via deflection 14 into support frame 2. To this end thread ends 12, 13 of thread 1 1 are threaded through deflection elements 19, 20 and coupled in support frame 2 by connector 17. As a consequence of the diagonal course of thread 1 1 via annular segment 3 achieved in this configuration, this second end is totally constricted during the drawing together by thread 1 1 . Figure 4 shows a comparable configuration. It also has a first deflection element 22 in the form of an eyelet arranged on the inner side, facing middle M of the stent, of annular segment 3 and has a second deflection element 23 on the outer side of annular segment 3. First deflection element 22 is located on transitional area 24 between struts 6, 7 of the inner side of annular segment 3 and second deflection element 23 is located on transitional area 25 between struts 6, 7 on the outer side of annular segment 3. Interval A between deflection elements 22, 23 is greater over the circumference than that in the embodiment of support frame 2 according to figure 3. Here too, a diagonal thread course is achieved on the outside of support frame 2 via struts 6, 7 and connector struts 8 so that when thread 1 1 is pulled the entire annular segment 3 is contracted. In the case of a stent 1 with a support frame 2 according to figure 5 deflection 14 is formed by two deflection elements 26, 27 of which the first deflection element 26 is provided on the end-side αnnulαr segment 3, viewed in longitudinal axis L of the stent and the second deflection element 27 is provided on adjacent, inner annular segment 4. In this instance too deflection elements 26, 27 are preferably formed by eyelets. According to the invention thread 1 1 is guided via deflection elements 26, 27 from the outside into the interior of support frame 2, where it is coupled by connector 17. Both annular segments 3, 4 are contracted when thread 1 1 is pulled as a result of the connecting of deflection elements 26, 27 to the first, inner segment area and to the second, outer segment area of annular segments 3, 4, whereupon stent 1 can be removed from the body canal.
List of reference numerals 1 - stent 2 - support frame 3 - annular segment 4 - annular segment 5 - annular segment 6 - strut 7 - strut 8 - connector strut 8' - connector strut 9 - longitudinal section 10 - strut section 1 1 - thread 12 - thread end 13 - thread end 14 - deflection 15 - deflection element 1 6 - deflection element 1 7 - connector 18 - transitional area 19 - deflection element 20 - deflection element 21 - transitional area 22 - deflection element 23 - deflection element 24 - transitional area 25 - transitional area 26 - deflection element 27 - deflection element 28 - guide element L - longitudinal axis of stent A - interval M - middle of stent The present invention may be embodied in other specific forms without departing from its spirit or essential characteristics. The described embodiments are to be considered in all respects only as illustrative, and not restrictive. The scope of the invention is, therefore, indicated by the appended claims, rather than by the foregoing description. All changes, which come within the meaning and range of equivalency of the claims, are to be embraced within their scope.

Claims

What is claimed is: 1 . A stent with a tubular support frame (2) consisting of axially successively following, interconnected annular segments (3, 4, 5), which support frame (2) is surrounded on its outside by a thread (1 1 ), characterized in that the thread ends (12, 13) are guided via a deflection (14) from the outside into the support frame (2), where they are coupled by a connector (17). 2. The stent according to Claim 1 , characterized in that the deflection (14) is realized at least one deflection element (15, 16; 19, 20; 22, 23; 26, 27) provided on an annular segment (3, 4). 3. The stent according to Claim 1 or 2, characterized in that the deflection (14) is formed by two deflection elements (15, 16; 19, 20; 22, 23; 26, 27) arranged on the circumference of the support frame (2) with an interval (A) from one another. 4. The stent according to one of Claims 1 to 3, characterized in that the deflection (14) is provided on the end-side annular segment (3), viewed in the direction of the longitudinal axis (L) of the stent. 5. The stent according to one of Claims 1 to 4, characterized in that the deflection (14) is arranged on the inner side, facing the middle of the stent, of the annular segment (3). 6. The stent according to one of Claims 1 to 4, characterized in that the deflection (14) is formed by two deflection elements (19, 20; 22, 23) of which a first deflection element (19; 22) is arranged on the inner side, facing the middle of the stent, of an annular segment (3) and that the second deflection element (20; 23) is arranged on the outer side of the annular segment (3). 7. The stent according to one of Claims 1 to 3, characterized in that the deflection (14) is formed by two deflection elements (26, 27) of which a first deflection element (26) is provided on the end-side annular segment (3), viewed in the direction of the longitudinal axis (L) of the stent, and a second deflection element (27) is provided on the adjacent annular segment (4). 8. The stent according to one of Claims 1 to 7, characterized in that the connector (17) consists of a material visible in x-rays. 9. The stent according to one of Claims 1 to 8, characterized in that additional guide elements (28) are provided in the support frame (2). 10. The stent according to one of Claims 1 to 9, characterized in that the annular segments (3, 4, 5) are formed by struts (6, 7) that follow one another in an endless, corrugated manner and that adjacent annular segments (3, 4, 9) are coupled by connector struts (8, 8' ) . 1 1 . The stent according to one of Claims 1 to 10, characterized in that each connector strut (8, 8') comprises a longitudinal section (9) running substantially parallel to the longitudinal axis (L) of the stent and comprises a strut section (10) aligned transversely to the latter and configured in a U shape or V shape.
PCT/US2004/031899 2003-09-30 2004-09-29 Modular stent WO2005032414A2 (en)

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Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2469296A (en) * 2009-04-07 2010-10-13 Cook Inc Modular stent assembly
US10779965B2 (en) 2013-11-06 2020-09-22 Enopace Biomedical Ltd. Posts with compliant junctions
US10828181B2 (en) 2011-09-09 2020-11-10 Enopace Biomedical Ltd. Annular antenna
US11400299B1 (en) 2021-09-14 2022-08-02 Rainbow Medical Ltd. Flexible antenna for stimulator
CN116929673A (en) * 2023-09-15 2023-10-24 武汉天运汽车电器有限公司 Valve part detection device for vehicle

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US6540777B2 (en) * 2001-02-15 2003-04-01 Scimed Life Systems, Inc. Locking stent

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6540777B2 (en) * 2001-02-15 2003-04-01 Scimed Life Systems, Inc. Locking stent

Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2469296A (en) * 2009-04-07 2010-10-13 Cook Inc Modular stent assembly
WO2010118126A1 (en) 2009-04-07 2010-10-14 William Cook Europe Aps Modular stent assembly
GB2469296B (en) * 2009-04-07 2011-03-09 Cook Inc Modular stent assembly
US8361141B2 (en) 2009-04-07 2013-01-29 Cook Medical Technologies Llc Modular stent assembly
US10828181B2 (en) 2011-09-09 2020-11-10 Enopace Biomedical Ltd. Annular antenna
US10779965B2 (en) 2013-11-06 2020-09-22 Enopace Biomedical Ltd. Posts with compliant junctions
US11432949B2 (en) 2013-11-06 2022-09-06 Enopace Biomedical Ltd. Antenna posts
US11400299B1 (en) 2021-09-14 2022-08-02 Rainbow Medical Ltd. Flexible antenna for stimulator
CN116929673A (en) * 2023-09-15 2023-10-24 武汉天运汽车电器有限公司 Valve part detection device for vehicle
CN116929673B (en) * 2023-09-15 2023-12-12 武汉天运汽车电器有限公司 Valve part detection device for vehicle

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