WO2005003065A3 - Sulfonamide substituted imidazoquinolines - Google Patents

Sulfonamide substituted imidazoquinolines Download PDF

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Publication number
WO2005003065A3
WO2005003065A3 PCT/US2004/020607 US2004020607W WO2005003065A3 WO 2005003065 A3 WO2005003065 A3 WO 2005003065A3 US 2004020607 W US2004020607 W US 2004020607W WO 2005003065 A3 WO2005003065 A3 WO 2005003065A3
Authority
WO
WIPO (PCT)
Prior art keywords
sulfonamide substituted
useful
substituted imidazoquinolines
compounds
imidazoquinolines
Prior art date
Application number
PCT/US2004/020607
Other languages
French (fr)
Other versions
WO2005003065A2 (en
Inventor
George W Griesgraber
Original Assignee
3M Innovative Properties Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 3M Innovative Properties Co filed Critical 3M Innovative Properties Co
Priority to JP2006517711A priority Critical patent/JP2007521280A/en
Priority to AU2004253929A priority patent/AU2004253929A1/en
Priority to CN2004800181459A priority patent/CN1812789B/en
Priority to BRPI0411916-9A priority patent/BRPI0411916A/en
Priority to MXPA06000144A priority patent/MXPA06000144A/en
Priority to NZ544330A priority patent/NZ544330A/en
Priority to CA002529322A priority patent/CA2529322A1/en
Priority to EP04756208A priority patent/EP1638566A4/en
Publication of WO2005003065A2 publication Critical patent/WO2005003065A2/en
Publication of WO2005003065A3 publication Critical patent/WO2005003065A3/en
Priority to IL172427A priority patent/IL172427A0/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Imidazoquinoline and tetrahydroimidazoquinoline compounds that contain sulfonamide functionality at the 1-position are useful as immune response modifiers. The compounds and compositions of the invention can induce the biosynthesis of various cytokines and are useful in the treatment of a variety of conditions including viral diseases and neoplastic diseases.
PCT/US2004/020607 2003-06-27 2004-06-25 Sulfonamide substituted imidazoquinolines WO2005003065A2 (en)

Priority Applications (9)

Application Number Priority Date Filing Date Title
JP2006517711A JP2007521280A (en) 2003-06-27 2004-06-25 Sulfonamide substituted imidazoquinolines
AU2004253929A AU2004253929A1 (en) 2003-06-27 2004-06-25 Sulfonamide substituted imidazoquinolines
CN2004800181459A CN1812789B (en) 2003-06-27 2004-06-25 Sulfonamide substituted imidazoquinolines
BRPI0411916-9A BRPI0411916A (en) 2003-06-27 2004-06-25 sulfonamide-substituted imidazoquinolines
MXPA06000144A MXPA06000144A (en) 2003-06-27 2004-06-25 Sulfonamide substituted imidazoquinolines.
NZ544330A NZ544330A (en) 2003-06-27 2004-06-25 Sulfonamide substituted imidazoquinolines
CA002529322A CA2529322A1 (en) 2003-06-27 2004-06-25 Sulfonamide substituted imidazoquinolines
EP04756208A EP1638566A4 (en) 2003-06-27 2004-06-25 Sulfonamide substituted imidazoquinolines
IL172427A IL172427A0 (en) 2003-06-27 2005-12-07 Sulfonamide substituted imidazoquinolines

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US48320003P 2003-06-27 2003-06-27
US60/483,200 2003-06-27

Publications (2)

Publication Number Publication Date
WO2005003065A2 WO2005003065A2 (en) 2005-01-13
WO2005003065A3 true WO2005003065A3 (en) 2005-03-10

Family

ID=33563911

Family Applications (2)

Application Number Title Priority Date Filing Date
PCT/US2004/020607 WO2005003065A2 (en) 2003-06-27 2004-06-25 Sulfonamide substituted imidazoquinolines
PCT/US2004/020606 WO2005003064A2 (en) 2003-06-27 2004-06-25 Sulfonamide substituted imidazoquinolines

Family Applications After (1)

Application Number Title Priority Date Filing Date
PCT/US2004/020606 WO2005003064A2 (en) 2003-06-27 2004-06-25 Sulfonamide substituted imidazoquinolines

Country Status (16)

Country Link
EP (1) EP1638566A4 (en)
JP (1) JP2007521280A (en)
KR (1) KR20060035637A (en)
CN (1) CN1812789B (en)
AR (2) AR044923A1 (en)
AU (1) AU2004253929A1 (en)
BR (1) BRPI0411916A (en)
CA (1) CA2529322A1 (en)
IL (1) IL172427A0 (en)
MX (1) MXPA06000144A (en)
MY (1) MY157827A (en)
NZ (1) NZ544330A (en)
RU (1) RU2374246C2 (en)
TW (2) TW200514784A (en)
WO (2) WO2005003065A2 (en)
ZA (1) ZA200600769B (en)

Families Citing this family (44)

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US20040265351A1 (en) 2003-04-10 2004-12-30 Miller Richard L. Methods and compositions for enhancing immune response
US7648997B2 (en) 2003-08-12 2010-01-19 Coley Pharmaceutical Group, Inc. Hydroxylamine substituted imidazoquinolines
NZ545412A (en) 2003-08-27 2008-12-24 Coley Pharm Group Inc Aryloxy and arylalkyleneoxy substituted imidazoquinolines
US20050054665A1 (en) 2003-09-05 2005-03-10 3M Innovative Properties Company Treatment for CD5+ B cell lymphoma
AR046172A1 (en) 2003-10-03 2005-11-30 3M Innovative Properties Co PIRAZOLOPIRIDINAS AND ITS ANALOGS; PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM AND THEIR USE IN THE INHIBITION OF THE BIOSYNTHESIS OF CITOCINES
BRPI0414856A (en) 2003-10-03 2006-11-21 3M Innovative Properties Co alkoxy-substituted imidazoquinolines
US7544697B2 (en) 2003-10-03 2009-06-09 Coley Pharmaceutical Group, Inc. Pyrazolopyridines and analogs thereof
US7897767B2 (en) 2003-11-14 2011-03-01 3M Innovative Properties Company Oxime substituted imidazoquinolines
CN1906192A (en) 2003-11-14 2007-01-31 3M创新有限公司 Hydroxylamine substituted imidazo ring compounds
KR101130928B1 (en) 2003-11-25 2012-04-12 쓰리엠 이노베이티브 프로퍼티즈 컴파니 Substituted imidazo ring systems and methods
US8940755B2 (en) * 2003-12-02 2015-01-27 3M Innovative Properties Company Therapeutic combinations and methods including IRM compounds
EP1701955A1 (en) 2003-12-29 2006-09-20 3M Innovative Properties Company Arylalkenyl and arylalkynyl substituted imidazoquinolines
WO2005066169A2 (en) 2003-12-30 2005-07-21 3M Innovative Properties Company Imidazoquinolinyl, imidazopyridinyl, and imidazonaphthyridinyl sulfonamides
US8697873B2 (en) 2004-03-24 2014-04-15 3M Innovative Properties Company Amide substituted imidazopyridines, imidazoquinolines, and imidazonaphthyridines
US8017779B2 (en) 2004-06-15 2011-09-13 3M Innovative Properties Company Nitrogen containing heterocyclyl substituted imidazoquinolines and imidazonaphthyridines
US8026366B2 (en) 2004-06-18 2011-09-27 3M Innovative Properties Company Aryloxy and arylalkyleneoxy substituted thiazoloquinolines and thiazolonaphthyridines
WO2006038923A2 (en) 2004-06-18 2006-04-13 3M Innovative Properties Company Aryl substituted imidazonaphthyridines
WO2006065280A2 (en) 2004-06-18 2006-06-22 3M Innovative Properties Company Isoxazole, dihydroisoxazole, and oxadiazole substituted imidazo ring compounds and methods
US8541438B2 (en) 2004-06-18 2013-09-24 3M Innovative Properties Company Substituted imidazoquinolines, imidazopyridines, and imidazonaphthyridines
ZA200706251B (en) * 2004-12-30 2008-11-26 Coley Pharm Group Inc Immune response modifier formulations and methods
ES2392648T3 (en) 2004-12-30 2012-12-12 3M Innovative Properties Company Substituted chiral compounds containing a condensed 1,2-imidazo-4,5-c core
JP5543068B2 (en) 2004-12-30 2014-07-09 スリーエム イノベイティブ プロパティズ カンパニー Chiral fused [1,2] imidazo [4,5-c] cyclic compound
JP2008530022A (en) 2005-02-04 2008-08-07 コーリー ファーマシューティカル グループ，インコーポレイテッド Aqueous gel formulation containing immune response modifier
JP5122980B2 (en) 2005-02-09 2013-01-16 スリーエム イノベイティブ プロパティズ カンパニー Alkyloxy-substituted thiazoloquinolines and alkyloxy-substituted thiazolonaphthylidenes
WO2006086634A2 (en) 2005-02-11 2006-08-17 Coley Pharmaceutical Group, Inc. Oxime and hydroxylamine substituted imidazo[4,5-c] ring compounds and methods
EP1869043A2 (en) 2005-04-01 2007-12-26 Coley Pharmaceutical Group, Inc. Pyrazolopyridine-1,4-diamines and analogs thereof
JP2008538550A (en) 2005-04-01 2008-10-30 コーリー ファーマシューティカル グループ，インコーポレイテッド 1-Substituted pyrazolo (3,4-c) cyclic compounds as modulators of cytokine biosynthesis for treating viral infections and neoplastic diseases
ZA200803029B (en) * 2005-09-09 2009-02-25 Coley Pharm Group Inc Amide and carbamate derivatives of alkyl substituted /V-[4-(4-amino-1H-imidazo[4,5-c] quinolin-1-yl)butyl] methane-sulfonamides and methods
EA200800782A1 (en) * 2005-09-09 2008-08-29 Коли Фармасьютикал Груп, Инк. AMIDA AND CARBAMATE DERIVATIVES N- {2- [4-AMINO-2- (ETOXIMETHYL) -1H-IMIDAZOLO [4,5-c] QUINOLIN-1-IL] -1,1-DIMETHYLETHYL} METHANE SULFONAMIDE AND METHODS
EA014244B1 (en) * 2005-09-23 2010-10-29 Коли Фармасьютикал Груп, Инк. METHOD FOR1H-IMIDAZO[4,5-c]PYRIDINES AND ANALOGS THEREOF
WO2007100634A2 (en) 2006-02-22 2007-09-07 3M Innovative Properties Company Immune response modifier conjugates
WO2008008432A2 (en) 2006-07-12 2008-01-17 Coley Pharmaceutical Group, Inc. Substituted chiral fused( 1,2) imidazo (4,5-c) ring compounds and methods
EP2386557B1 (en) * 2008-03-24 2018-01-10 4SC Discovery GmbH Novel substituted imidazoquinolines
EP3222621B1 (en) 2010-08-17 2023-03-08 3M Innovative Properties Company Lipidated immune response modifier compound and its medical use
BR112013031039B1 (en) 2011-06-03 2020-04-28 3M Innovative Properties Co hydrazine compounds 1h-imidazoquinoline-4-amines, conjugates made from these compounds, composition and pharmaceutical composition comprising said compounds and conjugates, uses thereof and method of manufacturing the conjugate
JP6460789B2 (en) 2011-06-03 2019-01-30 スリーエム イノベイティブ プロパティズ カンパニー Heterobifunctional linker having polyethylene glycol segment and immune response modulating complex prepared from the linker
WO2015092592A1 (en) 2013-12-17 2015-06-25 Pfizer Inc. Novel 3,4-disubstituted-1h-pyrrolo[2,3-b]pyridines and 4,5-disubstituted-7h-pyrrolo[2,3-c]pyridazines as lrrk2 inhibitors
MX2018003215A (en) 2015-09-14 2018-06-08 Pfizer Novel imidazo [4,5-c] quinoline and imidazo [4,5-c][1,5] naphthyridine derivatives as lrrk2 inhibitors.
CN115317603A (en) 2016-07-07 2022-11-11 小利兰·斯坦福大学托管委员会 Antibody adjuvant conjugates
WO2018163066A1 (en) 2017-03-10 2018-09-13 Pfizer Inc. Novel imidazo[4,5-c]quinoline derivatives as lrrk2 inhibitors
LT3679025T (en) 2017-09-06 2022-06-27 BioNTech SE Substituted imidazoquinolines as agonists of tlr7
WO2019123178A1 (en) 2017-12-20 2019-06-27 3M Innovative Properties Company Amide substitued imidazo[4,5-c]quinoline compounds with a branched chain linking group for use as an immune response modifier
KR20220004634A (en) 2019-03-15 2022-01-11 볼트 바이오테라퓨틱스 인코퍼레이티드 Immunoconjugates targeting HER2
CA3161668A1 (en) * 2019-12-20 2021-06-24 Nammi Therapeutics, Inc. Formulated and/or co-formulated liposome compositions containing toll-like receptor ("tlr") agonist prodrugs useful in the treatment of cancer and methods thereof

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6331539B1 (en) * 1999-06-10 2001-12-18 3M Innovative Properties Company Sulfonamide and sulfamide substituted imidazoquinolines
US6677349B1 (en) * 2001-12-21 2004-01-13 3M Innovative Properties Company Sulfonamide and sulfamide substituted imidazoquinolines

Family Cites Families (1)

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DE60230340D1 (en) * 2001-11-16 2009-01-22 3M Innovative Properties Co N-Ä4- (4-amino-2-ethyl-1H-imidazoÄ4,5-quinolin-1-yl) -butyl-methanesulfonamide, pharmaceutical composition containing the same and their use

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6331539B1 (en) * 1999-06-10 2001-12-18 3M Innovative Properties Company Sulfonamide and sulfamide substituted imidazoquinolines
US6677349B1 (en) * 2001-12-21 2004-01-13 3M Innovative Properties Company Sulfonamide and sulfamide substituted imidazoquinolines

Also Published As

Publication number Publication date
EP1638566A4 (en) 2009-03-25
CA2529322A1 (en) 2005-01-13
AU2004253929A1 (en) 2005-01-13
RU2374246C2 (en) 2009-11-27
TW200514784A (en) 2005-05-01
CN1812789B (en) 2010-07-14
ZA200600769B (en) 2007-05-30
WO2005003065A2 (en) 2005-01-13
CN1812789A (en) 2006-08-02
KR20060035637A (en) 2006-04-26
WO2005003064A2 (en) 2005-01-13
WO2005003064A3 (en) 2005-03-31
TW200511992A (en) 2005-04-01
MY157827A (en) 2016-07-29
IL172427A0 (en) 2006-04-10
JP2007521280A (en) 2007-08-02
RU2005138915A (en) 2006-06-27
NZ544330A (en) 2009-06-26
BRPI0411916A (en) 2006-08-15
MXPA06000144A (en) 2006-04-07
AR044922A1 (en) 2005-10-12
EP1638566A2 (en) 2006-03-29
AR044923A1 (en) 2005-10-12

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