WO2004113387A3 - Tumour necrosis factor receptor molecules with reduced immunogenicity - Google Patents

Tumour necrosis factor receptor molecules with reduced immunogenicity Download PDF

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Publication number
WO2004113387A3
WO2004113387A3 PCT/EP2004/006838 EP2004006838W WO2004113387A3 WO 2004113387 A3 WO2004113387 A3 WO 2004113387A3 EP 2004006838 W EP2004006838 W EP 2004006838W WO 2004113387 A3 WO2004113387 A3 WO 2004113387A3
Authority
WO
WIPO (PCT)
Prior art keywords
necrosis factor
factor receptor
receptor molecules
reduced immunogenicity
tumour necrosis
Prior art date
Application number
PCT/EP2004/006838
Other languages
French (fr)
Other versions
WO2004113387A2 (en
Inventor
Matthew Baker
Koen Hellendoorn
Original Assignee
Merck Patent Gmbh
Matthew Baker
Koen Hellendoorn
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Gmbh, Matthew Baker, Koen Hellendoorn filed Critical Merck Patent Gmbh
Priority to EP04740252A priority Critical patent/EP1636264A2/en
Publication of WO2004113387A2 publication Critical patent/WO2004113387A2/en
Publication of WO2004113387A3 publication Critical patent/WO2004113387A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/42—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins
    • C07K16/4208—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an idiotypic determinant on Ig
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

The invention relates to the modification of human soluble tumor necrosis factor receptor type 1 (sTNFR1) to result in sTNFR1 proteins, preferably fusion proteins comprising an immunoglobulin heavy chain constant region (Fc domain) and modified human sTNFR-I. These molecules are substantially non-immunogenic or less immunogenic than any non-modified counterpart when used in vivo by elimination or deletion of T-cell epitopes. The invention relates furthermore to T-cell epitope peptides derived from non-modified human sTNFR-I.
PCT/EP2004/006838 2003-06-24 2004-06-24 Tumour necrosis factor receptor molecules with reduced immunogenicity WO2004113387A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP04740252A EP1636264A2 (en) 2003-06-24 2004-06-24 Tumour necrosis factor receptor molecules with reduced immunogenicity

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP03014121.2 2003-06-24
EP03014121 2003-06-24

Publications (2)

Publication Number Publication Date
WO2004113387A2 WO2004113387A2 (en) 2004-12-29
WO2004113387A3 true WO2004113387A3 (en) 2005-03-17

Family

ID=33522261

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2004/006838 WO2004113387A2 (en) 2003-06-24 2004-06-24 Tumour necrosis factor receptor molecules with reduced immunogenicity

Country Status (2)

Country Link
EP (1) EP1636264A2 (en)
WO (1) WO2004113387A2 (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9096651B2 (en) 2007-09-26 2015-08-04 Chugai Seiyaku Kabushiki Kaisha Method of modifying isoelectric point of antibody via amino acid substitution in CDR
US9228017B2 (en) 2009-03-19 2016-01-05 Chugai Seiyaku Kabushiki Kaisha Antibody constant region variant
US9399680B2 (en) 2007-12-05 2016-07-26 Chugai Seiyaku Kabushiki Kaisha Nucleic acids encoding anti-NR10 antibodies

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DK3050963T3 (en) 2005-03-31 2019-12-09 Chugai Pharmaceutical Co Ltd Process for producing polypeptide by arrangement control
CN1309740C (en) * 2005-10-20 2007-04-11 高基民 Soluble tumour necrosis factor receptor II-
AU2007232873B2 (en) 2006-03-31 2014-02-20 Chugai Seiyaku Kabushiki Kaisha Methods for controlling blood pharmacokinetics of antibodies
CN105177091A (en) 2006-03-31 2015-12-23 中外制药株式会社 Antibody modification method for purifying bispecific antibody
WO2007137129A2 (en) 2006-05-19 2007-11-29 Alcon Research, Ltd. RNAI-MEDIATED INHIBITION OF TUMOR NECROSIS FACTOR α-RELATED CONDITIONS
KR101680906B1 (en) * 2007-09-26 2016-11-30 추가이 세이야쿠 가부시키가이샤 Modified antibody constant region
AU2014200636B2 (en) * 2007-09-26 2016-02-25 Chugai Seiyaku Kabushiki Kaisha Modified antibody constant region
TWI564021B (en) 2008-04-11 2017-01-01 Chugai Pharmaceutical Co Ltd Repeated binding of antigen to antigen binding molecules
TWI440469B (en) 2008-09-26 2014-06-11 Chugai Pharmaceutical Co Ltd Improved antibody molecules
DK2342220T3 (en) * 2008-10-06 2021-08-09 Univ British Columbia METHODS AND SYSTEMS FOR PREDICTING MISFOLD PROTEIN PITOPES
EP2826789A1 (en) 2009-03-19 2015-01-21 Chugai Seiyaku Kabushiki Kaisha Antibody constant region variant
US10150808B2 (en) 2009-09-24 2018-12-11 Chugai Seiyaku Kabushiki Kaisha Modified antibody constant regions
RU2012127383A (en) 2009-12-02 2014-01-10 Акселерон Фарма Инк. COMPOSITIONS AND METHODS FOR INCREASING THE HALF TIME OF FC-FILLED PROTEINS IN SERUM
EP2543730B1 (en) 2010-03-04 2018-10-31 Chugai Seiyaku Kabushiki Kaisha Antibody constant region variant
EP2647706B1 (en) 2010-11-30 2023-05-17 Chugai Seiyaku Kabushiki Kaisha Antigen-binding molecule capable of binding to plurality of antigen molecules repeatedly
WO2012170938A1 (en) 2011-06-08 2012-12-13 Acceleron Pharma Inc. Compositions and methods for increasing serum half-life
CA2927309A1 (en) 2013-05-24 2014-11-27 Promis Neurosciences Inc. Fasr antibodies for diagnostic and therapeutic use
EP3050896B1 (en) 2013-09-27 2021-07-07 Chugai Seiyaku Kabushiki Kaisha Method for producing polypeptide heteromultimer
AU2016224409B2 (en) 2015-02-27 2021-01-28 Chugai Seiyaku Kabushiki Kaisha Composition for treating IL-6-related diseases
JP7082484B2 (en) 2015-04-01 2022-06-08 中外製薬株式会社 Method for Producing Polypeptide Heterogeneous Multimer
EP3398965A4 (en) 2015-12-28 2019-09-18 Chugai Seiyaku Kabushiki Kaisha Method for promoting efficiency of purification of fc region-containing polypeptide
SG10201607778XA (en) 2016-09-16 2018-04-27 Chugai Pharmaceutical Co Ltd Anti-Dengue Virus Antibodies, Polypeptides Containing Variant Fc Regions, And Methods Of Use
WO2018203545A1 (en) 2017-05-02 2018-11-08 国立研究開発法人国立精神・神経医療研究センター Method for predicting and evaluating therapeutic effect in diseases related to il-6 and neutrophils
KR20200132938A (en) 2018-03-15 2020-11-25 추가이 세이야쿠 가부시키가이샤 Anti-dengue virus antibodies with cross-reactivity against Zika virus and methods of use

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002069232A2 (en) * 2001-02-19 2002-09-06 Merck Patent Gmbh Method for identification of t-cell epitopes and use for preparing molecules with reeduced immunogenicity
WO2003104263A2 (en) * 2002-05-01 2003-12-18 Genencor International, Inc. Cytokines and cytokine receptors with reduced immunogenicity

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002069232A2 (en) * 2001-02-19 2002-09-06 Merck Patent Gmbh Method for identification of t-cell epitopes and use for preparing molecules with reeduced immunogenicity
WO2003104263A2 (en) * 2002-05-01 2003-12-18 Genencor International, Inc. Cytokines and cytokine receptors with reduced immunogenicity

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
CHRISTEN URS ET AL: "Immune response to a recombinant human TNFR55-IgG1 fusion protein: Auto-antibodies in rheumatoid arthritis (RA) and multiple sclerosis (MS) patients have neither neutralizing nor agonist activities", HUMAN IMMUNOLOGY, vol. 60, no. 9, September 1999 (1999-09-01), pages 774 - 790, XP002314027, ISSN: 0198-8859 *
GALON J ET AL: "TNFRSF1A mutations and autoinflammatory syndromes", CURRENT OPINION IN IMMUNOLOGY, CURRENT BIOLOGY LTD, XX, vol. 12, no. 4, 1 August 2000 (2000-08-01), pages 479 - 486, XP004257708, ISSN: 0952-7915 *
ROSENBERG J J ET AL: "Development of a novel, nonimmunogenic, soluble human TNF receptor type I (sTNFR-I) construct in the baboon.", JOURNAL OF APPLIED PHYSIOLOGY (BETHESDA, MD. : 1985) NOV 2001, vol. 91, no. 5, November 2001 (2001-11-01), pages 2213 - 2223, XP002314026, ISSN: 8750-7587 *
TODD IAN ET AL: "Mutant forms of tumour necrosis factor receptor I that occur in TNF-receptor-associated periodic syndrome retain signalling functions but show abnormal behaviour", IMMUNOLOGY, vol. 113, no. 1, September 2004 (2004-09-01), pages 65 - 79, XP002314028, ISSN: 0019-2805 *

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9096651B2 (en) 2007-09-26 2015-08-04 Chugai Seiyaku Kabushiki Kaisha Method of modifying isoelectric point of antibody via amino acid substitution in CDR
US9399680B2 (en) 2007-12-05 2016-07-26 Chugai Seiyaku Kabushiki Kaisha Nucleic acids encoding anti-NR10 antibodies
US9228017B2 (en) 2009-03-19 2016-01-05 Chugai Seiyaku Kabushiki Kaisha Antibody constant region variant

Also Published As

Publication number Publication date
WO2004113387A2 (en) 2004-12-29
EP1636264A2 (en) 2006-03-22

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