WO2004110964A3 - Encoded molecules by translation (emt) - Google Patents
Encoded molecules by translation (emt) Download PDFInfo
- Publication number
- WO2004110964A3 WO2004110964A3 PCT/DK2004/000416 DK2004000416W WO2004110964A3 WO 2004110964 A3 WO2004110964 A3 WO 2004110964A3 DK 2004000416 W DK2004000416 W DK 2004000416W WO 2004110964 A3 WO2004110964 A3 WO 2004110964A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- peptides
- templated molecules
- synthesise
- vinylogous
- emt
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
- C12N15/1062—Isolating an individual clone by screening libraries mRNA-Display, e.g. polypeptide and encoding template are connected covalently
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
- C12N15/1068—Template (nucleic acid) mediated chemical library synthesis, e.g. chemical and enzymatical DNA-templated organic molecule synthesis, libraries prepared by non ribosomal polypeptide synthesis [NRPS], DNA/RNA-polymerase mediated polypeptide synthesis
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/67—General methods for enhancing the expression
Abstract
The present invention is directed to methods for the synthesis, selection, amplification and isolation of templated molecules having desirable properties. The invention makes it possible to synthesise a variety of different templated molecules other than α-peptides and modified α-peptides. In particular, the present invention enables synthesis of templated molecules such as β -, ϒ -, ϖ peptides, carbopeptoids, vinylogous peptides, oligoanthrilamides, oligoureas, azapeptides (azatides), oligocarbamates, PNA, oligopyrrolinones, vinylogous sulfonamidopeptide, peptoids, azapeptoids and hydrazino peptides. It is possible in accordance with the methods of the invention to synthesise templated molecules comprising heterocyclic components, such as coumarins and quinolones, pyrazolone, isoxazolone, pyrimidiones, phtalhydrazides, diketopiperazines, hydantoins, and benzodiazepines.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US47834303P | 2003-06-16 | 2003-06-16 | |
DKPA200300893 | 2003-06-16 | ||
DKPA200300893 | 2003-06-16 | ||
US60/478,343 | 2003-06-16 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2004110964A2 WO2004110964A2 (en) | 2004-12-23 |
WO2004110964A3 true WO2004110964A3 (en) | 2005-03-31 |
Family
ID=33553693
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/DK2004/000416 WO2004110964A2 (en) | 2003-06-16 | 2004-06-15 | Encoded molecules by translation (emt) |
Country Status (1)
Country | Link |
---|---|
WO (1) | WO2004110964A2 (en) |
Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8206901B2 (en) | 2002-10-30 | 2012-06-26 | Nuevolution A/S | Method for the synthesis of a bifunctional complex |
US8808984B2 (en) | 2002-03-15 | 2014-08-19 | Neuvolution A/S | Method for synthesising templated molecules |
US8932992B2 (en) | 2001-06-20 | 2015-01-13 | Nuevolution A/S | Templated molecules and methods for using such molecules |
US9096951B2 (en) | 2003-02-21 | 2015-08-04 | Nuevolution A/S | Method for producing second-generation library |
US9121110B2 (en) | 2002-12-19 | 2015-09-01 | Nuevolution A/S | Quasirandom structure and function guided synthesis methods |
US9574189B2 (en) | 2005-12-01 | 2017-02-21 | Nuevolution A/S | Enzymatic encoding methods for efficient synthesis of large libraries |
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2004013070A2 (en) | 2002-08-01 | 2004-02-12 | Nuevolution A/S | Multi-step synthesis of templated molecules |
ATE424455T1 (en) | 2003-03-20 | 2009-03-15 | Nuevolution As | LIGATION-MEDIATING CODING OF SMALL MOLECULES |
EP1670939B1 (en) | 2003-09-18 | 2009-11-04 | Nuevolution A/S | A method for obtaining structural information concerning an encoded molecule and method for selecting compounds |
WO2005058479A2 (en) | 2003-12-17 | 2005-06-30 | Praecis Pharmaceuticals, Inc. | Methods for synthesis of encoded libraries |
US7972994B2 (en) | 2003-12-17 | 2011-07-05 | Glaxosmithkline Llc | Methods for synthesis of encoded libraries |
ATE447020T1 (en) | 2004-03-22 | 2009-11-15 | Nuevolution As | LIGATION CODING USING OLIGONUCLEOTIDE BUILDING BLOCKS |
US9162005B2 (en) * | 2005-04-25 | 2015-10-20 | Arch Biosurgery, Inc. | Compositions for prevention of adhesions and other barrier applications |
CN101267831B (en) | 2005-04-25 | 2013-04-24 | 麻省理工学院 | Compositions and methods for promoting hemostasis and other physiological activities |
US20090203530A1 (en) * | 2005-06-07 | 2009-08-13 | Liu David R | Polymer evolution via templated synthesis |
ATE461279T1 (en) * | 2005-06-07 | 2010-04-15 | Harvard College | ORDERED MULTI-STEP SYNTHESIS USING NUCLEIC ACID-MEDIATED CHEMISTRY |
EP1940755A2 (en) | 2005-10-28 | 2008-07-09 | Praecis Pharmaceuticals Inc. | Methods for identifying compounds of interest using encoded libraries |
JP2009535338A (en) * | 2006-04-25 | 2009-10-01 | マサチューセッツ・インスティテュート・オブ・テクノロジー | Compositions and methods for influencing the movement of pollutants, body fluids or other entities and / or affecting other physiological conditions |
ES2713873T3 (en) | 2010-04-16 | 2019-05-24 | Nuevolution As | Bifunctional complexes and methods for making and using such complexes |
JP2014527801A (en) | 2011-09-01 | 2014-10-23 | ユニバーシティ オブ サザン カリフォルニア | Method for preparing high-throughput peptidomimetics, oral bioavailable drugs and compositions containing them |
ES2756531T3 (en) | 2013-08-22 | 2020-04-27 | Arch Biosurgery Inc | Implantable meshes to control fluid movement |
JP7283727B2 (en) | 2016-06-16 | 2023-05-30 | ヘイスタック サイエンシィズ コーポレーション | Oligonucleotides Directed and Recorded for Combinatorial Synthesis of Code Probe Molecules |
EP3619340A4 (en) | 2017-05-02 | 2021-01-20 | Haystack Sciences Corporation | Molecules for verifying oligonucleotide directed combinatorial synthesis and methods of making and using the same |
Citations (9)
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---|---|---|---|---|
DE19646372C1 (en) * | 1995-11-11 | 1997-06-19 | Evotec Biosystems Gmbh | Conjugates of polypeptide and encoding nucleic acid |
WO1998031700A1 (en) * | 1997-01-21 | 1998-07-23 | The General Hospital Corporation | Selection of proteins using rna-protein fusions |
EP0962527A1 (en) * | 1996-10-17 | 1999-12-08 | Mitsubishi Chemical Corporation | Molecule that homologizes genotype and phenotype and utilization thereof |
WO2000023458A1 (en) * | 1998-10-19 | 2000-04-27 | The Board Of Trustees Of The Leland Stanford Junior University | Dna-templated combinatorial library chemistry |
WO2001007657A1 (en) * | 1999-07-27 | 2001-02-01 | Phylos, Inc. | Peptide acceptor ligation methods |
WO2002059293A2 (en) * | 2001-01-25 | 2002-08-01 | Forster Anthony C | Process and compositions for peptide, protein and peptidomimetic synthesis |
WO2002074929A2 (en) * | 2001-03-19 | 2002-09-26 | President And Fellows Of Harvard College | Evolving new molecular function |
WO2002085923A2 (en) * | 2001-04-19 | 2002-10-31 | The Scripps Research Institute | In vivo incorporation of unnatural amino acids |
WO2002103008A2 (en) * | 2001-06-20 | 2002-12-27 | Nuevolution A/S | Templated molecules and methods for using such molecules |
-
2004
- 2004-06-15 WO PCT/DK2004/000416 patent/WO2004110964A2/en active Application Filing
Patent Citations (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE19646372C1 (en) * | 1995-11-11 | 1997-06-19 | Evotec Biosystems Gmbh | Conjugates of polypeptide and encoding nucleic acid |
EP0962527A1 (en) * | 1996-10-17 | 1999-12-08 | Mitsubishi Chemical Corporation | Molecule that homologizes genotype and phenotype and utilization thereof |
WO1998031700A1 (en) * | 1997-01-21 | 1998-07-23 | The General Hospital Corporation | Selection of proteins using rna-protein fusions |
WO2000023458A1 (en) * | 1998-10-19 | 2000-04-27 | The Board Of Trustees Of The Leland Stanford Junior University | Dna-templated combinatorial library chemistry |
WO2001007657A1 (en) * | 1999-07-27 | 2001-02-01 | Phylos, Inc. | Peptide acceptor ligation methods |
WO2002059293A2 (en) * | 2001-01-25 | 2002-08-01 | Forster Anthony C | Process and compositions for peptide, protein and peptidomimetic synthesis |
WO2002074929A2 (en) * | 2001-03-19 | 2002-09-26 | President And Fellows Of Harvard College | Evolving new molecular function |
WO2002085923A2 (en) * | 2001-04-19 | 2002-10-31 | The Scripps Research Institute | In vivo incorporation of unnatural amino acids |
WO2002103008A2 (en) * | 2001-06-20 | 2002-12-27 | Nuevolution A/S | Templated molecules and methods for using such molecules |
Non-Patent Citations (1)
Title |
---|
FORSTER ANTHONY C ET AL: "Programming peptidomimetic syntheses by translating genetic codes designed de novo.", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, vol. 100, no. 11, 27 May 2003 (2003-05-27), pages 6353 - 6357, XP002316170, ISSN: 0027-8424 * |
Cited By (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8932992B2 (en) | 2001-06-20 | 2015-01-13 | Nuevolution A/S | Templated molecules and methods for using such molecules |
US8808984B2 (en) | 2002-03-15 | 2014-08-19 | Neuvolution A/S | Method for synthesising templated molecules |
US8206901B2 (en) | 2002-10-30 | 2012-06-26 | Nuevolution A/S | Method for the synthesis of a bifunctional complex |
US8722583B2 (en) | 2002-10-30 | 2014-05-13 | Nuevolution A/S | Method for selecting a chemical entity from a tagged library |
US9109248B2 (en) | 2002-10-30 | 2015-08-18 | Nuevolution A/S | Method for the synthesis of a bifunctional complex |
US9284600B2 (en) | 2002-10-30 | 2016-03-15 | Neuvolution A/S | Method for the synthesis of a bifunctional complex |
US9121110B2 (en) | 2002-12-19 | 2015-09-01 | Nuevolution A/S | Quasirandom structure and function guided synthesis methods |
US9096951B2 (en) | 2003-02-21 | 2015-08-04 | Nuevolution A/S | Method for producing second-generation library |
US9574189B2 (en) | 2005-12-01 | 2017-02-21 | Nuevolution A/S | Enzymatic encoding methods for efficient synthesis of large libraries |
Also Published As
Publication number | Publication date |
---|---|
WO2004110964A2 (en) | 2004-12-23 |
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