WO2004110269A1 - 脳磁計用センサとそれを使用した超多チャンネル脳磁計システム - Google Patents
脳磁計用センサとそれを使用した超多チャンネル脳磁計システム Download PDFInfo
- Publication number
- WO2004110269A1 WO2004110269A1 PCT/JP2003/007419 JP0307419W WO2004110269A1 WO 2004110269 A1 WO2004110269 A1 WO 2004110269A1 JP 0307419 W JP0307419 W JP 0307419W WO 2004110269 A1 WO2004110269 A1 WO 2004110269A1
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- WO
- WIPO (PCT)
- Prior art keywords
- sensor
- magnetoencephalography
- coil
- coils
- stacked
- Prior art date
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/24—Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
- A61B5/242—Detecting biomagnetic fields, e.g. magnetic fields produced by bioelectric currents
- A61B5/245—Detecting biomagnetic fields, e.g. magnetic fields produced by bioelectric currents specially adapted for magnetoencephalographic [MEG] signals
Definitions
- the present invention relates to a super multi-channel magnetoencephalography system for measuring a magnetic field generated by a subject's brain, and more particularly to a super multi-channel magnetoencephalography system characterized by the structure of a sensor surrounding a subject's head. It is.
- the human brain generates electrical signals. These electrical signals are very weak, but they can be measured non-invasively by various methods.
- the biomagnetometry which is an example of such a method, measures a magnetic field generated outside the head by a brain current.
- the magnetoencephalography (MEG) system is a specially improved high-sensitivity device for magnetic field detection that has a magnetic field sensor, a current detector in the sensor, and associated electronics, and has excellent time and spatial resolution. There is great expectation as a noninvasive brain function measurement device, and its use is gradually being promoted.
- the planar type magnetic field sensor used in such a system is typically a multi-loop coil-shaped electric wire that generates a small current when penetrated by a magnetic flux. It consists of a meter coil (a) and a total of two directionally differentiating coils (Daradiometer) (b) and (c) for the magnetic field. Further, there is also often used one that does not have the above (a) but measures only with the coils of (b) and (c). At the same time, only (a) coils are available.
- the area of the sensor coil needs to be several square centimeters in order to secure sufficient sensitivity, and when the sensor coil having such an area is densely arranged on the surface of the head, FIG. As shown, the number of arrangements is limited, and at most several hundred channels is the upper limit.
- the present invention is to shift the sensor coil printed on the thin film by exactly a / n (where a is the length of one side of the thin film coil and n is a natural number) in the vertical and horizontal directions, and n
- a is the length of one side of the thin film coil and n is a natural number
- n is a natural number
- An object of the present invention is to provide a magnetoencephalograph sensor capable of measuring the first-order and higher-order derivatives of an axial direction of a magnetic field so as to obtain a difference in current generated in a coil, and an ultra-high-resolution system using the sensor. . Disclosure of the invention
- the sensor is precisely a Z n (provided that a is the length of the thin film Koi Le side, n is a natural number) vertically and horizontally shifted by, and preferably formed by laminating two n 2.
- a plurality of sensors formed by laminating the above sensor coils are arranged vertically one above the other while accurately facing each other. It is a sensor for magnetoencephalography that can measure differential and higher order derivatives.
- any one of the above sensors, high-speed switching means corresponding to each coil in the sensor, and a squid arranged corresponding to the high-speed switching means is provided.
- This is a multi-channel magnetoencephalography system.
- FIG. 1 is a diagram illustrating the configuration of a sensor unit according to the present invention.
- FIG. 2 is a diagram showing a state where the sensor unit is arranged on the head.
- FIG. 3 is a diagram showing an example of a conventional planar-type sensor coil. BEST MODE FOR CARRYING OUT THE INVENTION
- FIG. 1 is an explanatory diagram of a sensor coil unit used in the system.
- reference numeral 1 denotes a sensor, and this sensor 1 is composed of two thin film coils having the same function as a conventionally known planar type sensor coil, which are accurately shifted by a / n in the vertical and horizontal directions, and stacked two in number. (Where a is the length of one side of the thin-film coil and n is a natural number). If a coil is printed on a thin film, if the thickness of one sheet is several meters, even if hundreds to thousands of sheets are stacked, it will be only several mm at most. Accurate lamination can also be easily achieved with current technology.
- a plurality of sensors 1 are arranged on the surface of the head, and the sensor coil 2 in each sensor 1 is connected to the corresponding switch 4 via the corresponding switching means 3 such as a multiplexer. It is connected. Therefore, the multiplexer is 1 ⁇ ! Sequentially switching the Sukuitsu de to I 2, amplifiers etc. can be configured measurement system with the channels also up to several thousand times the conventional number. The configuration after the squirt uses the conventional system as it is. By arranging the sensors vertically and measuring the difference between the currents generated in the corresponding coils, and measuring the first-order and higher-order derivatives of the magnetic field in the axial direction, an axial Dalladometer can be constructed. In this way, it is possible to create a system that can obtain ultra-high resolution simply by multiplexing sensors using thin-film technology with the same configuration as existing electronic systems.
- the information to be detected by one sensor is determined by the number of stacked layers, so when the number of stacked layers increases, the number of sensor coils increases significantly by the number of stacked layers compared to the number of sensors arranged on the head.
- the conventional sensor coil The amount of information collected is much higher than that of a conventional system, and it is possible to obtain an ultra-high-resolution system with a resolution hundreds to tens of thousands times higher than that of a conventional system.
- the embodiment of the sensor according to the present invention has been described.
- the above-described embodiment is merely described using an example of a method and an apparatus which are most easily realized at present.
- the output obtained from the stacked sensor coils by the above method is processed using appropriate software, the same result can be obtained, so the amount of displacement of the sensor coil (a / n) Is not necessarily required to be constant, and the number of layers is not necessarily required to be n 2 .
- the planar shape of the sensor coil is not limited to a square, but may be another shape. In the above-described embodiment, the planar type sensor has been described.
- a plurality of sensors are arranged one above the other, and a conventionally known Dalladio sensor or a higher-order differential sensor is used. They can be configured, and they can be connected to a squid via switching means to construct a magnetoencephalography system.
- the sensor does not need to be placed parallel to the object to be measured (for example, the head), and can be used to measure a magnetic field component perpendicular to the head and parallel to the head.
- the switching means conventionally known appropriate means can be adopted.
- a sensor is formed by laminating thin films on which sensor coils are printed by shifting them by a certain direction in the left, right, up and down directions, and inputting signals from a plurality of corresponding thin film sensor coils in parallel to input of multi-channel squid.
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- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Medical Informatics (AREA)
- Biophysics (AREA)
- Pathology (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Physics & Mathematics (AREA)
- Molecular Biology (AREA)
- Surgery (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Measurement And Recording Of Electrical Phenomena And Electrical Characteristics Of The Living Body (AREA)
- Measuring Magnetic Variables (AREA)
Abstract
Description
Claims
Priority Applications (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CA2494167A CA2494167C (en) | 2003-06-11 | 2003-06-11 | Sensors for use in magnetoencephalometers and a super-multichannel magnetoencephalography system using these sensors |
PCT/JP2003/007419 WO2004110269A1 (ja) | 2003-06-11 | 2003-06-11 | 脳磁計用センサとそれを使用した超多チャンネル脳磁計システム |
US10/516,106 US7672707B2 (en) | 2003-06-11 | 2003-06-11 | Sensor for magnetoencephalography meter and supermultichannel magnetoencephalography meter system using the same |
EP03816837A EP1632176B1 (en) | 2003-06-11 | 2003-06-11 | Sensor for magnetoencephalography meter and supermultichannel magnetoencephalography meter system using the same |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/JP2003/007419 WO2004110269A1 (ja) | 2003-06-11 | 2003-06-11 | 脳磁計用センサとそれを使用した超多チャンネル脳磁計システム |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2004110269A1 true WO2004110269A1 (ja) | 2004-12-23 |
Family
ID=33548992
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/JP2003/007419 WO2004110269A1 (ja) | 2003-06-11 | 2003-06-11 | 脳磁計用センサとそれを使用した超多チャンネル脳磁計システム |
Country Status (4)
Country | Link |
---|---|
US (1) | US7672707B2 (ja) |
EP (1) | EP1632176B1 (ja) |
CA (1) | CA2494167C (ja) |
WO (1) | WO2004110269A1 (ja) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9026194B2 (en) | 2011-03-03 | 2015-05-05 | Moment Technologies, Llc | Current diverter for magnetic stimulation of biological systems |
US8483795B2 (en) | 2011-03-03 | 2013-07-09 | Moment Technologies, Llc | Primary source mirror for biomagnetometry |
US8527029B2 (en) | 2011-08-09 | 2013-09-03 | Moment Technologies, Llc | Modular arrays of primary source mirrors for biomagnetometry |
US8907668B2 (en) | 2011-10-14 | 2014-12-09 | Moment Technologies, Llc | High-resolution scanning prism magnetometry |
WO2019060298A1 (en) | 2017-09-19 | 2019-03-28 | Neuroenhancement Lab, LLC | METHOD AND APPARATUS FOR NEURO-ACTIVATION |
US11717686B2 (en) | 2017-12-04 | 2023-08-08 | Neuroenhancement Lab, LLC | Method and apparatus for neuroenhancement to facilitate learning and performance |
EP3731749A4 (en) | 2017-12-31 | 2022-07-27 | Neuroenhancement Lab, LLC | NEURO-ACTIVATION SYSTEM AND METHOD FOR ENHANCING EMOTIONAL RESPONSE |
US11364361B2 (en) | 2018-04-20 | 2022-06-21 | Neuroenhancement Lab, LLC | System and method for inducing sleep by transplanting mental states |
CN113382683A (zh) | 2018-09-14 | 2021-09-10 | 纽罗因恒思蒙特实验有限责任公司 | 改善睡眠的***和方法 |
US11786694B2 (en) | 2019-05-24 | 2023-10-17 | NeuroLight, Inc. | Device, method, and app for facilitating sleep |
Citations (2)
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JPH02116766A (ja) * | 1988-09-22 | 1990-05-01 | Siemens Ag | 多チヤネル測定装置の超電導磁界勾配計ループシステム |
JPH09164123A (ja) * | 1995-12-14 | 1997-06-24 | Shimadzu Corp | 生体磁気計測装置 |
Family Cites Families (13)
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EP0246419B1 (de) * | 1986-05-21 | 1991-04-10 | Siemens Aktiengesellschaft | SQUID-Magnetometer für eine Vorrichtung zur Messung schwacher Magnetfelder |
US4913152A (en) * | 1988-04-28 | 1990-04-03 | The Johns Hopkins University | Magnetoencephalograph (MEG) using a multi-axis magnetic gradiometer for localization and tracking of neuromagnetic signals |
US5122744A (en) * | 1990-10-09 | 1992-06-16 | Ibm Corporation | Gradiometer having a magnetometer which cancels background magnetic field from other magnetometers |
FI89130C (fi) * | 1990-11-01 | 1993-08-25 | Neuromag Oy | Lokaliseringsspolar och anordning foer deras faestning vid huvudet foer anvaendning i magnetoenkefalografiska maetningar |
JPH078467A (ja) * | 1992-02-06 | 1995-01-13 | Biomagnetic Technol Inc | 生体磁力計及び磁気データの収集方法 |
JPH0817251B2 (ja) * | 1993-01-07 | 1996-02-21 | 株式会社超伝導センサ研究所 | Squid磁束計 |
JP3139372B2 (ja) * | 1995-07-10 | 2001-02-26 | 住友電気工業株式会社 | 磁気センサ |
CA2319227C (en) * | 1998-01-23 | 2003-09-30 | Ctf Systems Inc. | System and method for measuring, estimating and displaying rms current density maps |
JP2002243817A (ja) * | 2001-02-21 | 2002-08-28 | Hitachi Ltd | 検出コイル一体型グラジオメータ及び磁場計測装置 |
JP3757815B2 (ja) * | 2001-04-27 | 2006-03-22 | 株式会社日立製作所 | 生体磁場計測装置 |
US20030141868A1 (en) * | 2001-08-23 | 2003-07-31 | Bakharev Alexander A. | High balance gradiometer |
JP3566258B2 (ja) * | 2002-02-13 | 2004-09-15 | 独立行政法人 科学技術振興機構 | 脳磁計用センサとそれを使用した超多チャンネル脳磁計システム |
US7130675B2 (en) * | 2002-06-28 | 2006-10-31 | Tristan Technologies, Inc. | High-resolution magnetoencephalography system and method |
-
2003
- 2003-06-11 EP EP03816837A patent/EP1632176B1/en not_active Expired - Fee Related
- 2003-06-11 CA CA2494167A patent/CA2494167C/en not_active Expired - Fee Related
- 2003-06-11 US US10/516,106 patent/US7672707B2/en not_active Expired - Fee Related
- 2003-06-11 WO PCT/JP2003/007419 patent/WO2004110269A1/ja active Application Filing
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
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JPH02116766A (ja) * | 1988-09-22 | 1990-05-01 | Siemens Ag | 多チヤネル測定装置の超電導磁界勾配計ループシステム |
JPH09164123A (ja) * | 1995-12-14 | 1997-06-24 | Shimadzu Corp | 生体磁気計測装置 |
Non-Patent Citations (1)
Title |
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See also references of EP1632176A4 * |
Also Published As
Publication number | Publication date |
---|---|
CA2494167A1 (en) | 2005-02-02 |
EP1632176B1 (en) | 2010-07-21 |
EP1632176A4 (en) | 2008-11-05 |
CA2494167C (en) | 2011-04-26 |
US20050234328A1 (en) | 2005-10-20 |
US7672707B2 (en) | 2010-03-02 |
EP1632176A1 (en) | 2006-03-08 |
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