WO2004094465A3 - Synthetic molecules that mimic chemokines - Google Patents
Synthetic molecules that mimic chemokines Download PDFInfo
- Publication number
- WO2004094465A3 WO2004094465A3 PCT/US2004/012708 US2004012708W WO2004094465A3 WO 2004094465 A3 WO2004094465 A3 WO 2004094465A3 US 2004012708 W US2004012708 W US 2004012708W WO 2004094465 A3 WO2004094465 A3 WO 2004094465A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- mimic
- chemokines
- synthetic molecules
- polypeptides
- treatment
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/521—Chemokines
- C07K14/522—Alpha-chemokines, e.g. NAP-2, ENA-78, GRO-alpha/MGSA/NAP-3, GRO-beta/MIP-2alpha, GRO-gamma/MIP-2beta, IP-10, GCP-2, MIG, PBSF, PF-4, KC
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/502—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
- G01N33/5047—Cells of the immune system
- G01N33/505—Cells of the immune system involving T-cells
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5091—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing the pathological state of an organism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
- G01N2500/10—Screening for compounds of potential therapeutic value involving cells
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Cell Biology (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Pathology (AREA)
- Food Science & Technology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Toxicology (AREA)
- Microbiology (AREA)
- General Physics & Mathematics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Physiology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Abstract
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US46471403P | 2003-04-23 | 2003-04-23 | |
US60/464,714 | 2003-04-23 |
Publications (3)
Publication Number | Publication Date |
---|---|
WO2004094465A2 WO2004094465A2 (en) | 2004-11-04 |
WO2004094465A8 WO2004094465A8 (en) | 2004-12-23 |
WO2004094465A3 true WO2004094465A3 (en) | 2006-03-02 |
Family
ID=33310942
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2004/012708 WO2004094465A2 (en) | 2003-04-23 | 2004-04-23 | Synthetic molecules that mimic chemokines |
Country Status (1)
Country | Link |
---|---|
WO (1) | WO2004094465A2 (en) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DK1869066T3 (en) * | 2005-04-08 | 2010-03-29 | Lonza Ag | Peptide synthesis of alpha coils on PEG resin |
US8628750B2 (en) | 2006-02-27 | 2014-01-14 | Technische Universitat Munchen | Cancer imaging and treatment |
US7696309B2 (en) | 2006-10-23 | 2010-04-13 | The Brigham And Women's Hospital, Inc. | Protease resistant mutants of stromal cell derived factor-1 in the repair of tissue damage |
EP2053060A1 (en) * | 2007-10-24 | 2009-04-29 | Protaffin Biotechnologie AG | SDF-1-based glyocosaminoglycan antagonists and methods of using same |
US8921415B2 (en) | 2009-01-29 | 2014-12-30 | Mapi Pharma Ltd. | Polymorphs of darunavir |
WO2011092687A1 (en) * | 2010-01-28 | 2011-08-04 | Mapi Pharma Hk Limited | Process for the preparation of darunavir and darunavir intermediates |
WO2011106234A1 (en) | 2010-02-25 | 2011-09-01 | Provasculon, Inc. | Protease-resistant mutants of stromal cell derived factor-1 in the repair of tissue damage |
US10662234B2 (en) | 2011-06-07 | 2020-05-26 | Mesoblast International Sàrl | Methods for repairing tissue damage using protease-resistant mutants of stromal cell derived factor-1 |
ES2699576T3 (en) * | 2013-06-12 | 2019-02-11 | Pharis Biotec Gmbh | Peptides with antagonistic activities against natural CXCR4 |
CN107325187B (en) * | 2017-07-19 | 2021-11-09 | 黄子为 | Polypeptide with CXCR4 protein agonistic activity and application and pharmaceutical composition thereof |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2751658A1 (en) * | 1996-07-26 | 1998-01-30 | Pasteur Institut | USE OF A LESTR / FUSIN / CXCR4 RECEIVER CHEMOKINE (SDF-1) LIGAND TO PREVENT OR TREAT HIV-TYPE INFECTION |
WO1999020759A1 (en) * | 1997-10-22 | 1999-04-29 | Genetics Institute, Inc. | Chemokines with amino-terminal modifications |
WO1999047158A2 (en) * | 1998-03-13 | 1999-09-23 | The University Of British Columbia | Therapeutic chemokine receptor antagonists |
-
2004
- 2004-04-23 WO PCT/US2004/012708 patent/WO2004094465A2/en active Application Filing
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2751658A1 (en) * | 1996-07-26 | 1998-01-30 | Pasteur Institut | USE OF A LESTR / FUSIN / CXCR4 RECEIVER CHEMOKINE (SDF-1) LIGAND TO PREVENT OR TREAT HIV-TYPE INFECTION |
WO1999020759A1 (en) * | 1997-10-22 | 1999-04-29 | Genetics Institute, Inc. | Chemokines with amino-terminal modifications |
WO1999047158A2 (en) * | 1998-03-13 | 1999-09-23 | The University Of British Columbia | Therapeutic chemokine receptor antagonists |
Non-Patent Citations (4)
Title |
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CHEN WEN-JI ET AL: "Recombinant human CXC-chemokine receptor-4 in melanophores are linked to Gi protein: Seven transmembrane coreceptors for human immunodeficiency virus entry into cells", MOLECULAR PHARMACOLOGY, vol. 53, no. 2, February 1998 (1998-02-01), pages 177 - 181, XP002325707, ISSN: 0026-895X * |
LOETSCHER ET AL: "N-TERMINAL PEPTIDES OF STROMAL CELL-DERIVED FACTOR WITH CXC CHEMOKINE RECEPTOR 4 AGONIST AND ANTAGONIST ACTIVITIES", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY OF BIOLOGICAL CHEMISTS, BALTIMORE, MD, US, vol. 273, no. 35, 28 August 1998 (1998-08-28), pages 22279 - 22283, XP002115696, ISSN: 0021-9258 * |
MERZOUK A ET AL: "RATIONAL DESIGNING OF CXCR-4 AGONISTS AND ANTAGONISTS: SYNTHESIS OF NOVEL CYCLAM DERIVATIVES OF STROMAL CELL-DERIVED FACTOR (SDF-1)", PEPTIDES: THE WAVE OF THE FUTURE: PROCEEDINGS OF THE INTERNATIONAL AND THE AMERICAN PEPTIDE SYMPOSIUM, 9 June 2001 (2001-06-09), pages 789 - 790, XP009046707 * |
THIERRY ANNE-CHRISTINE ET AL: "Long synthetic peptides as biologically active proteins: The example of the chemokines", BIOLOGICALS, ACADEMIC PRESS LTD., LONDON, GB, vol. 29, no. 3-4, September 2001 (2001-09-01), pages 259 - 263, XP002274174, ISSN: 1045-1056 * |
Also Published As
Publication number | Publication date |
---|---|
WO2004094465A2 (en) | 2004-11-04 |
WO2004094465A8 (en) | 2004-12-23 |
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