WO2004087880A3 - Compounds and their use to treat diabetes and related disorders - Google Patents

Compounds and their use to treat diabetes and related disorders Download PDF

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Publication number
WO2004087880A3
WO2004087880A3 PCT/US2004/009342 US2004009342W WO2004087880A3 WO 2004087880 A3 WO2004087880 A3 WO 2004087880A3 US 2004009342 W US2004009342 W US 2004009342W WO 2004087880 A3 WO2004087880 A3 WO 2004087880A3
Authority
WO
WIPO (PCT)
Prior art keywords
compounds
related disorders
treat diabetes
diabetes
relates
Prior art date
Application number
PCT/US2004/009342
Other languages
French (fr)
Other versions
WO2004087880A2 (en
WO2004087880A8 (en
Inventor
William H Bullock
Qingjie Liu
Original Assignee
Bayer Pharmaceuticals Corp
William H Bullock
Qingjie Liu
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Pharmaceuticals Corp, William H Bullock, Qingjie Liu filed Critical Bayer Pharmaceuticals Corp
Priority to US10/543,070 priority Critical patent/US20060094714A1/en
Priority to EP04758414A priority patent/EP1613318A4/en
Priority to JP2006509358A priority patent/JP2006521400A/en
Publication of WO2004087880A2 publication Critical patent/WO2004087880A2/en
Publication of WO2004087880A8 publication Critical patent/WO2004087880A8/en
Publication of WO2004087880A3 publication Critical patent/WO2004087880A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

Abstract

The invention relates generally to compounds described herein. More specifically, the invention relates to compounds and pharmaceutical compositions containing such compounds. Methods of the invention comprise administration of a compound of the invention for the treatment of diabetes and related disorders.
PCT/US2004/009342 2003-03-26 2004-03-26 Compounds and their use to treat diabetes and related disorders WO2004087880A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
US10/543,070 US20060094714A1 (en) 2004-03-26 2004-03-26 Compounds and their use to treat diabetes and related disorders
EP04758414A EP1613318A4 (en) 2003-03-26 2004-03-26 Compounds and their use to treat diabetes and related disorders
JP2006509358A JP2006521400A (en) 2003-03-26 2004-03-26 Compounds for the treatment of diabetes and related disorders and their use

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US45819403P 2003-03-26 2003-03-26
US60/458,194 2003-03-26

Publications (3)

Publication Number Publication Date
WO2004087880A2 WO2004087880A2 (en) 2004-10-14
WO2004087880A8 WO2004087880A8 (en) 2005-01-13
WO2004087880A3 true WO2004087880A3 (en) 2005-03-10

Family

ID=33131765

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2004/009342 WO2004087880A2 (en) 2003-03-26 2004-03-26 Compounds and their use to treat diabetes and related disorders

Country Status (3)

Country Link
EP (1) EP1613318A4 (en)
JP (1) JP2006521400A (en)
WO (1) WO2004087880A2 (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8093236B2 (en) 2007-03-13 2012-01-10 Takeda Pharmaceuticals Company Limited Weekly administration of dipeptidyl peptidase inhibitors
US8324383B2 (en) 2006-09-13 2012-12-04 Takeda Pharmaceutical Company Limited Methods of making polymorphs of benzoate salt of 2-[[6-[(3R)-3-amino-1-piperidinyl]-3,4-dihydro-3-methyl-2,4-dioxo-1(2H)-pyrimidinyl]methyl]-benzonitrile
US8906901B2 (en) 2005-09-14 2014-12-09 Takeda Pharmaceutical Company Limited Administration of dipeptidyl peptidase inhibitors

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1924567B1 (en) 2005-09-16 2012-08-22 Takeda Pharmaceutical Company Limited Process for the preparation of pyrimidinedione derivatives
WO2007112347A1 (en) 2006-03-28 2007-10-04 Takeda Pharmaceutical Company Limited Dipeptidyl peptidase inhibitors
TW200838536A (en) 2006-11-29 2008-10-01 Takeda Pharmaceutical Polymorphs of succinate salt of 2-[6-(3-amino-piperidin-1-yl)-3-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-ylmethy]-4-fluor-benzonitrile and methods of use therefor
EA202190137A1 (en) 2018-06-27 2021-05-17 Бристол-Маерс Сквибб Компани NAPHTHYRIDINE COMPOUNDS FOR USE AS T-CELL ACTIVATORS
LT3814348T (en) 2018-06-27 2023-10-10 Bristol-Myers Squibb Company Substituted naphthyridinone compounds useful as t cell activators
AR119821A1 (en) 2019-08-28 2022-01-12 Bristol Myers Squibb Co SUBSTITUTED PYRIDOPYRIMIDINOL COMPOUNDS USEFUL AS T-CELL ACTIVATORS
AR120823A1 (en) 2019-12-23 2022-03-23 Bristol Myers Squibb Co SUBSTITUTED BICYCLIC COMPOUNDS USEFUL AS T-CELL ACTIVATORS

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4350817A (en) * 1980-02-28 1982-09-21 American Home Products Corporation 4-Cl, Br or I-3-Carboxy or cyano-1,2-dihydro-2-oxo-1,8-naphthyridine derivatives
JPH07126268A (en) * 1993-10-29 1995-05-16 Otsuka Pharmaceut Factory Inc 1,8-naphthyridine derivative

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUT76980A (en) * 1994-08-29 1998-01-28 Yamanouchi Pharmaceutical Co. Ltd. Novel naphthyridine derivative and medicinal composition thereof
ATE452890T1 (en) * 2003-11-04 2010-01-15 Merck & Co Inc SUBSTITUTED NAPHTHYRIDINONE DERIVATIVES

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4350817A (en) * 1980-02-28 1982-09-21 American Home Products Corporation 4-Cl, Br or I-3-Carboxy or cyano-1,2-dihydro-2-oxo-1,8-naphthyridine derivatives
JPH07126268A (en) * 1993-10-29 1995-05-16 Otsuka Pharmaceut Factory Inc 1,8-naphthyridine derivative

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
DATABASE CAPLUS [online] KUGE ET AL.: "A facile synthesis of 5-phenylimidazo[4,5-c][1,8]naphthyridine-4(5H)-one", XP002983823, accession no. STN Database accession no. 1995:257052 *
See also references of EP1613318A4 *
SYNTHETIC COMMUNICATIONS, vol. 24, no. 22, 1994, pages 3289 - 3296 *

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8906901B2 (en) 2005-09-14 2014-12-09 Takeda Pharmaceutical Company Limited Administration of dipeptidyl peptidase inhibitors
US8324383B2 (en) 2006-09-13 2012-12-04 Takeda Pharmaceutical Company Limited Methods of making polymorphs of benzoate salt of 2-[[6-[(3R)-3-amino-1-piperidinyl]-3,4-dihydro-3-methyl-2,4-dioxo-1(2H)-pyrimidinyl]methyl]-benzonitrile
US8093236B2 (en) 2007-03-13 2012-01-10 Takeda Pharmaceuticals Company Limited Weekly administration of dipeptidyl peptidase inhibitors

Also Published As

Publication number Publication date
JP2006521400A (en) 2006-09-21
WO2004087880A2 (en) 2004-10-14
EP1613318A4 (en) 2009-03-11
WO2004087880A8 (en) 2005-01-13
EP1613318A2 (en) 2006-01-11

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