WO2004074438A3 - Antagonistes de ccr8 - Google Patents
Antagonistes de ccr8 Download PDFInfo
- Publication number
- WO2004074438A3 WO2004074438A3 PCT/US2004/004394 US2004004394W WO2004074438A3 WO 2004074438 A3 WO2004074438 A3 WO 2004074438A3 US 2004004394 W US2004004394 W US 2004004394W WO 2004074438 A3 WO2004074438 A3 WO 2004074438A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- ccr8
- benzenesulfonamide
- ccr8 antagonists
- antagonists
- bicyclicaryl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
- C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
- C07D243/08—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 not condensed with other rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
L'invention concerne certains aryl-benzènesulfonamides bicycliques substitués et leur utilisation pour l'inhibition du récepteur de chimiokine dénommé CCR8. La structure générique des composés décrits est celle d'un benzène sulfonamide de formule (I). (I)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US44745003P | 2003-02-14 | 2003-02-14 | |
US60/447,450 | 2003-02-14 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2004074438A2 WO2004074438A2 (fr) | 2004-09-02 |
WO2004074438A3 true WO2004074438A3 (fr) | 2005-02-24 |
Family
ID=32908441
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2004/004394 WO2004074438A2 (fr) | 2003-02-14 | 2004-02-13 | Antagonistes de ccr8 |
Country Status (1)
Country | Link |
---|---|
WO (1) | WO2004074438A2 (fr) |
Families Citing this family (38)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2687931C (fr) | 2007-05-31 | 2016-05-24 | Boehringer Ingelheim International Gmbh | Antagonistes des recepteurs ccr2 et utilisations de ceux-ci |
EP2379525B1 (fr) | 2008-12-19 | 2015-07-29 | Boehringer Ingelheim International GmbH | Pyrimidine-4 carboxamides cycliques en tant qu'antagonistes du récepteur ccr2 pour le traitement d'inflammations, de l'asthme et des broncho-pneumopathies chroniques obstructives |
WO2010105243A1 (fr) | 2009-03-13 | 2010-09-16 | Agios Pharmaceuticals, Inc. | Procédés et compositions pour des troubles liés à la prolifération cellulaire |
CA2758071C (fr) | 2009-04-06 | 2018-01-09 | Agios Pharmaceuticals, Inc. | Modulateurs de pyruvate kinase m2, compositions therapeutiques et methodes d'utilisation associees |
JP5764555B2 (ja) | 2009-06-29 | 2015-08-19 | アジオス ファーマシューティカルズ, インコーポレイテッド | 治療組成物および関連する使用方法 |
IN2012DN00471A (fr) | 2009-06-29 | 2015-06-05 | Agios Pharmaceuticals Inc | |
EP2525790B1 (fr) | 2009-10-21 | 2020-05-27 | Agios Pharmaceuticals, Inc. | Procédés et compositions pour troubles associés à la prolifération cellulaire |
EP2491145B1 (fr) | 2009-10-21 | 2016-03-09 | Agios Pharmaceuticals, Inc. | Procédés et compositions pour des troubles relatifs à la prolifération cellulaire |
WO2011072174A1 (fr) * | 2009-12-09 | 2011-06-16 | Agios Pharmaceuticals, Inc. | Composés thérapeutiquement actifs destinés au traitement d'un cancer caractérisé par une mutation idh |
ES2524829T3 (es) | 2009-12-17 | 2014-12-12 | Boehringer Ingelheim International Gmbh | Nuevos antagonistas del receptor CCR2 y usos de los mismos |
JP5658272B2 (ja) * | 2009-12-17 | 2015-01-21 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | Ccr2の新規アンタゴニスト及びこれらの使用 |
JP2013526507A (ja) | 2010-05-12 | 2013-06-24 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 新規ccr2受容体アンタゴニスト、その製造方法及び薬物としてのその使用 |
WO2011141477A1 (fr) | 2010-05-12 | 2011-11-17 | Boehringer Ingelheim International Gmbh | Nouveaux antagonistes du récepteur ccr2, leur procédé de production et leur utilisation en tant que médicaments |
EP2571870B1 (fr) | 2010-05-17 | 2015-01-21 | Boehringer Ingelheim International GmbH | Antagonistes de ccr2 et leurs utilisations |
US9018212B2 (en) | 2010-05-25 | 2015-04-28 | Boehringer Ingelheim International Gmbh | Pyridazine carboxamides as CCR2 receptor antagonists |
US8962656B2 (en) | 2010-06-01 | 2015-02-24 | Boehringer Ingelheim International Gmbh | CCR2 antagonists |
JP5837091B2 (ja) | 2010-12-17 | 2015-12-24 | アジオス ファーマシューティカルズ, インコーポレイテッド | ピルビン酸キナーゼm2(pkm2)調節剤としての新規n−(4−(アゼチジン−1−カルボニル)フェニル)−(ヘテロ−)アリールスルホンアミド誘導体 |
ES2569712T3 (es) | 2010-12-21 | 2016-05-12 | Agios Pharmaceuticals, Inc. | Activadores de PKM2 bicíclicos |
TWI549947B (zh) | 2010-12-29 | 2016-09-21 | 阿吉歐斯製藥公司 | 治療化合物及組成物 |
RU2675656C2 (ru) | 2011-05-03 | 2018-12-21 | Аджиос Фармасьютикалз, Инк. | Способы применения активаторов пируваткиназы |
CN102827170A (zh) | 2011-06-17 | 2012-12-19 | 安吉奥斯医药品有限公司 | 治疗活性组合物和它们的使用方法 |
CN102827073A (zh) | 2011-06-17 | 2012-12-19 | 安吉奥斯医药品有限公司 | 治疗活性组合物和它们的使用方法 |
EP2731941B1 (fr) | 2011-07-15 | 2019-05-08 | Boehringer Ingelheim International GmbH | Antagonistes ccr2, nouveaux et sélectifs |
CN115536635A (zh) | 2012-01-06 | 2022-12-30 | 法国施维雅药厂 | 治疗活性化合物及其使用方法 |
US9474779B2 (en) | 2012-01-19 | 2016-10-25 | Agios Pharmaceuticals, Inc. | Therapeutically active compositions and their methods of use |
NZ706999A (en) | 2012-10-15 | 2018-12-21 | Agios Pharmaceuticals Inc | Inhibitors of mutant isocitrate dehydrogenase and therapeutical uses thereof |
WO2015003355A2 (fr) | 2013-07-11 | 2015-01-15 | Agios Pharmaceuticals, Inc. | Composés thérapeutiquement actifs et leurs méthodes d'utilisation |
WO2015003360A2 (fr) | 2013-07-11 | 2015-01-15 | Agios Pharmaceuticals, Inc. | Composés thérapeutiquement actifs et leurs méthodes d'utilisation |
EP3019480B1 (fr) | 2013-07-11 | 2020-05-06 | Agios Pharmaceuticals, Inc. | Composés 2,4- ou 4,6-diaminopyrimidine comme inhibiteurs d'idh2 mutantes pour le traitement du cancer |
US9579324B2 (en) | 2013-07-11 | 2017-02-28 | Agios Pharmaceuticals, Inc | Therapeutically active compounds and their methods of use |
US20150031627A1 (en) | 2013-07-25 | 2015-01-29 | Agios Pharmaceuticals, Inc | Therapeutically active compounds and their methods of use |
NZ723859A (en) | 2014-03-14 | 2023-01-27 | Servier Lab | Pharmaceutical compositions of therapeutically active compounds and their uses |
DK3307271T3 (da) | 2015-06-11 | 2023-10-09 | Agios Pharmaceuticals Inc | Fremgangsmåder til anvendelse af pyruvatkinase-aktivatorer |
AU2016287584B2 (en) | 2015-07-02 | 2020-03-26 | Centrexion Therapeutics Corporation | (4-((3R,4R)-3-methoxytetrahydro-pyran-4-ylamino)piperidin-1-yl)(5-methyl-6-(((2R,6S)-6-(p-tolyl)tetrahydro-2H-pyran-2-yl)methylamino)pyrimidin-4yl)methanone citrate |
PT3362066T (pt) | 2015-10-15 | 2021-11-16 | Celgene Corp | Terapia de combinação para tratar malignidades |
WO2017066566A1 (fr) | 2015-10-15 | 2017-04-20 | Agios Pharmaceuticals, Inc | Polythérapie pour le traitement de malignités |
US10980788B2 (en) | 2018-06-08 | 2021-04-20 | Agios Pharmaceuticals, Inc. | Therapy for treating malignancies |
JP2023540661A (ja) * | 2020-07-03 | 2023-09-26 | ナンキン イムノファージ バイオテック カンパニー リミテッド | CCR8阻害剤を使用してTregsを標的とする方法および組成物 |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1990009787A1 (fr) * | 1989-02-27 | 1990-09-07 | The Du Pont Merck Pharmaceutical Company | Nouveaux sulfamides servant de radiosensibilisateurs |
US6133442A (en) * | 1994-12-20 | 2000-10-17 | Hoffmann-La Roche Inc. | Aryl- and hetaryl-sulfonamide derivatives, their preparation and their use as endothelin antagonists |
-
2004
- 2004-02-13 WO PCT/US2004/004394 patent/WO2004074438A2/fr active Application Filing
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1990009787A1 (fr) * | 1989-02-27 | 1990-09-07 | The Du Pont Merck Pharmaceutical Company | Nouveaux sulfamides servant de radiosensibilisateurs |
US6133442A (en) * | 1994-12-20 | 2000-10-17 | Hoffmann-La Roche Inc. | Aryl- and hetaryl-sulfonamide derivatives, their preparation and their use as endothelin antagonists |
Also Published As
Publication number | Publication date |
---|---|
WO2004074438A2 (fr) | 2004-09-02 |
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