WO2004065569A3 - Anticorps multifonctionnels - Google Patents
Anticorps multifonctionnels Download PDFInfo
- Publication number
- WO2004065569A3 WO2004065569A3 PCT/US2004/001808 US2004001808W WO2004065569A3 WO 2004065569 A3 WO2004065569 A3 WO 2004065569A3 US 2004001808 W US2004001808 W US 2004001808W WO 2004065569 A3 WO2004065569 A3 WO 2004065569A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- antibodies
- functional antibodies
- present
- antigen recognition
- reactive site
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/44—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material not provided for elsewhere, e.g. haptens, metals, DNA, RNA, amino acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
- C07K16/1267—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria
- C07K16/1282—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria from Clostridium (G)
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
Abstract
La présente invention concerne des anticorps comprenant un domaine de reconnaissance d'antigène qui se lient spécifiquement à un chelate métallique. Des anticorps mutant comprenant un site réactif non présent dans le type sauvage de cet anticorps, le site réactif étant dans une position proche du domaine de reconnaissance d'antigène ou à l'intérieur de celui-ci. Cette invention concerne aussi des procédés d'utilisation de ces anticorps pour diagnostiquer ou traiter une maladie.
Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US10/350,555 US7528235B2 (en) | 2003-01-23 | 2003-01-23 | Multi-functional antibodies |
US10/350,555 | 2003-01-23 | ||
US10/625,047 US7820787B2 (en) | 2003-01-23 | 2003-07-22 | Multi-functional antibodies |
US10/625,047 | 2003-07-22 | ||
US10/631,258 | 2003-07-31 | ||
US10/631,258 US20050026263A1 (en) | 2003-07-31 | 2003-07-31 | Multi-functional antibodies |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2004065569A2 WO2004065569A2 (fr) | 2004-08-05 |
WO2004065569A3 true WO2004065569A3 (fr) | 2005-03-24 |
Family
ID=32776952
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2004/001808 WO2004065569A2 (fr) | 2003-01-23 | 2004-01-23 | Anticorps multifonctionnels |
Country Status (1)
Country | Link |
---|---|
WO (1) | WO2004065569A2 (fr) |
Cited By (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8877190B2 (en) | 2006-11-30 | 2014-11-04 | Abbvie Inc. | Aβ conformer selective anti-Aβ globulomer monoclonal antibodies |
US8895004B2 (en) | 2007-02-27 | 2014-11-25 | AbbVie Deutschland GmbH & Co. KG | Method for the treatment of amyloidoses |
US8987419B2 (en) | 2010-04-15 | 2015-03-24 | AbbVie Deutschland GmbH & Co. KG | Amyloid-beta binding proteins |
US9146244B2 (en) | 2007-06-12 | 2015-09-29 | Ac Immune S.A. | Polynucleotides encoding an anti-beta-amyloid monoclonal antibody |
US9176150B2 (en) | 2003-01-31 | 2015-11-03 | AbbVie Deutschland GmbH & Co. KG | Amyloid beta(1-42) oligomers, derivatives thereof and antibodies thereto, methods of preparation thereof and use thereof |
US9221900B2 (en) | 2010-07-30 | 2015-12-29 | Ac Immune S.A. | Methods for identifying safe and functional humanized antibodies |
US9403902B2 (en) | 2007-10-05 | 2016-08-02 | Ac Immune S.A. | Methods of treating ocular disease associated with amyloid-beta-related pathology using an anti-amyloid-beta antibody |
US9540432B2 (en) | 2005-11-30 | 2017-01-10 | AbbVie Deutschland GmbH & Co. KG | Anti-Aβ globulomer 7C6 antibodies |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2577815A1 (fr) * | 2004-08-20 | 2006-03-30 | The Regents Of The University Of California | Fragment d'anticorps genetiquement modifie qui se lie a un antigene de maniere irreversible |
CN101506236B (zh) | 2005-11-30 | 2012-12-12 | 雅培制药有限公司 | 抗淀粉样β蛋白的单克隆抗体及其用途 |
WO2007131242A2 (fr) * | 2006-05-05 | 2007-11-15 | The Regents Of The University Of California | Systeme anticorps-haptene a liaison streptavidine-biotine |
AR062065A1 (es) | 2006-07-14 | 2008-10-15 | Ac Immune Sa | Anticuerpo humanizado |
US8613923B2 (en) | 2007-06-12 | 2013-12-24 | Ac Immune S.A. | Monoclonal antibody |
KR20160017126A (ko) * | 2007-06-12 | 2016-02-15 | 에이씨 이뮨 에스.에이. | 모노클로널 항 베타 아밀로이드 항체 |
JP6147665B2 (ja) | 2010-08-14 | 2017-06-14 | アッヴィ・インコーポレイテッド | アミロイドベータ結合タンパク質 |
CN104411725B (zh) | 2012-07-04 | 2018-09-28 | 弗·哈夫曼-拉罗切有限公司 | 抗生物素抗体及使用方法 |
CN104428006B (zh) * | 2012-07-04 | 2017-09-08 | 弗·哈夫曼-拉罗切有限公司 | 共价连接的抗原‑抗体缀合物 |
EP3138578B1 (fr) | 2012-07-04 | 2022-01-12 | F. Hoffmann-La Roche AG | Anticorps anti-théophylline et procédés d'utilisation |
US10561737B2 (en) * | 2014-01-03 | 2020-02-18 | Hoffmann-La Roche Inc. | Bispecific anti-hapten/anti-blood brain barrier receptor antibodies, complexes thereof and their use as blood brain barrier shuttles |
WO2015101587A1 (fr) | 2014-01-03 | 2015-07-09 | F. Hoffmann-La Roche Ag | Conjugués hélicar-anticorps anti-hélicar liés de façon covalente et utilisations associées |
CA2930046A1 (fr) * | 2014-01-03 | 2015-07-09 | F. Hoffmann-La Roche Ag | Conjugues toxine polypeptidique-anticorps a laison covalente |
BR112016029935A2 (pt) | 2014-06-26 | 2017-10-31 | Hoffmann La Roche | ?anticorpos anti-brdu, complexo, formulação farmacêutica e uso de anticorpo? |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5958374A (en) * | 1994-03-28 | 1999-09-28 | The Regents Of The University Of California | Method for preparing radionuclide-labeled chelating agent-ligand complexes |
WO2001022922A2 (fr) * | 1999-09-27 | 2001-04-05 | The Regents Of The University Of California | Manipulations d'anticorps a liaison irreversible |
US20030124057A1 (en) * | 2001-11-28 | 2003-07-03 | Immunomedics, Inc. | Anti-DOTA antibody |
-
2004
- 2004-01-23 WO PCT/US2004/001808 patent/WO2004065569A2/fr active Application Filing
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5958374A (en) * | 1994-03-28 | 1999-09-28 | The Regents Of The University Of California | Method for preparing radionuclide-labeled chelating agent-ligand complexes |
WO2001022922A2 (fr) * | 1999-09-27 | 2001-04-05 | The Regents Of The University Of California | Manipulations d'anticorps a liaison irreversible |
US20030124057A1 (en) * | 2001-11-28 | 2003-07-03 | Immunomedics, Inc. | Anti-DOTA antibody |
Non-Patent Citations (6)
Cited By (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9176150B2 (en) | 2003-01-31 | 2015-11-03 | AbbVie Deutschland GmbH & Co. KG | Amyloid beta(1-42) oligomers, derivatives thereof and antibodies thereto, methods of preparation thereof and use thereof |
US9540432B2 (en) | 2005-11-30 | 2017-01-10 | AbbVie Deutschland GmbH & Co. KG | Anti-Aβ globulomer 7C6 antibodies |
US8877190B2 (en) | 2006-11-30 | 2014-11-04 | Abbvie Inc. | Aβ conformer selective anti-Aβ globulomer monoclonal antibodies |
US9359430B2 (en) | 2006-11-30 | 2016-06-07 | Abbvie Inc. | Abeta conformer selective anti-Abeta globulomer monoclonal antibodies |
US8895004B2 (en) | 2007-02-27 | 2014-11-25 | AbbVie Deutschland GmbH & Co. KG | Method for the treatment of amyloidoses |
US9146244B2 (en) | 2007-06-12 | 2015-09-29 | Ac Immune S.A. | Polynucleotides encoding an anti-beta-amyloid monoclonal antibody |
US9403902B2 (en) | 2007-10-05 | 2016-08-02 | Ac Immune S.A. | Methods of treating ocular disease associated with amyloid-beta-related pathology using an anti-amyloid-beta antibody |
US8987419B2 (en) | 2010-04-15 | 2015-03-24 | AbbVie Deutschland GmbH & Co. KG | Amyloid-beta binding proteins |
US9221900B2 (en) | 2010-07-30 | 2015-12-29 | Ac Immune S.A. | Methods for identifying safe and functional humanized antibodies |
Also Published As
Publication number | Publication date |
---|---|
WO2004065569A2 (fr) | 2004-08-05 |
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