WO2004065542A3 - MAT2As AS MODIFIERS OF THE p53 PATHWAY AND METHODS OF USE - Google Patents

MAT2As AS MODIFIERS OF THE p53 PATHWAY AND METHODS OF USE Download PDF

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Publication number
WO2004065542A3
WO2004065542A3 PCT/US2003/041439 US0341439W WO2004065542A3 WO 2004065542 A3 WO2004065542 A3 WO 2004065542A3 US 0341439 W US0341439 W US 0341439W WO 2004065542 A3 WO2004065542 A3 WO 2004065542A3
Authority
WO
WIPO (PCT)
Prior art keywords
pathway
methods
mat2as
modifiers
mat2a
Prior art date
Application number
PCT/US2003/041439
Other languages
French (fr)
Other versions
WO2004065542A2 (en
Inventor
Marcia Belvin
Helen Francis-Lang
Lori Friedman
Gregory D Plowman
Kim Lickteig
Original Assignee
Exelixis Inc
Marcia Belvin
Helen Francis-Lang
Lori Friedman
Gregory D Plowman
Kim Lickteig
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Exelixis Inc, Marcia Belvin, Helen Francis-Lang, Lori Friedman, Gregory D Plowman, Kim Lickteig filed Critical Exelixis Inc
Priority to AU2003303094A priority Critical patent/AU2003303094A1/en
Publication of WO2004065542A2 publication Critical patent/WO2004065542A2/en
Publication of WO2004065542A3 publication Critical patent/WO2004065542A3/en

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/48—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/573—Immunoassay; Biospecific binding assay; Materials therefor for enzymes or isoenzymes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Organic Chemistry (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Wood Science & Technology (AREA)
  • Pathology (AREA)
  • Zoology (AREA)
  • General Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
  • Hospice & Palliative Care (AREA)
  • Biophysics (AREA)
  • Oncology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • General Engineering & Computer Science (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

Human MAT2A genes are identified as modulators of the p53 pathway, and thus are therapeutic targets for disorders associated with defective p53 function. Methods for identifying modulators of p53, comprising screening for agents that modulate the activity of MAT2A are provided.
PCT/US2003/041439 2002-12-30 2003-12-29 MAT2As AS MODIFIERS OF THE p53 PATHWAY AND METHODS OF USE WO2004065542A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2003303094A AU2003303094A1 (en) 2002-12-30 2003-12-29 MAT2As AS MODIFIERS OF THE p53 PATHWAY AND METHODS OF USE

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US43716202P 2002-12-30 2002-12-30
US60/437,162 2002-12-30

Publications (2)

Publication Number Publication Date
WO2004065542A2 WO2004065542A2 (en) 2004-08-05
WO2004065542A3 true WO2004065542A3 (en) 2004-12-29

Family

ID=32771743

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2003/041439 WO2004065542A2 (en) 2002-12-30 2003-12-29 MAT2As AS MODIFIERS OF THE p53 PATHWAY AND METHODS OF USE

Country Status (2)

Country Link
AU (1) AU2003303094A1 (en)
WO (1) WO2004065542A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108601752A (en) 2015-12-03 2018-09-28 安吉奥斯医药品有限公司 MAT2A inhibitor for treating MTAP deletion form cancers
KR102411150B1 (en) 2016-08-31 2022-06-21 아지오스 파마슈티컬스 아이엔씨. inhibitors of cellular metabolic processes

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020142981A1 (en) * 2000-06-14 2002-10-03 Horne Darci T. Gene expression profiles in liver cancer
US20030082511A1 (en) * 2001-09-25 2003-05-01 Brown Steven J. Identification of modulatory molecules using inducible promoters
US20030109690A1 (en) * 1999-09-29 2003-06-12 Human Genome Sciences, Inc. Colon and colon cancer associated polynucleotides and polypeptides
US6596701B1 (en) * 1995-04-25 2003-07-22 Mediquest Therapeutics, Inc. S-adenosyl methionine regulation of metabolic pathways and its use in diagnosis and therapy

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6596701B1 (en) * 1995-04-25 2003-07-22 Mediquest Therapeutics, Inc. S-adenosyl methionine regulation of metabolic pathways and its use in diagnosis and therapy
US20030109690A1 (en) * 1999-09-29 2003-06-12 Human Genome Sciences, Inc. Colon and colon cancer associated polynucleotides and polypeptides
US20020142981A1 (en) * 2000-06-14 2002-10-03 Horne Darci T. Gene expression profiles in liver cancer
US20030082511A1 (en) * 2001-09-25 2003-05-01 Brown Steven J. Identification of modulatory molecules using inducible promoters

Also Published As

Publication number Publication date
AU2003303094A8 (en) 2004-08-13
AU2003303094A1 (en) 2004-08-13
WO2004065542A2 (en) 2004-08-05

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