WO2004056861A3 - Glycoisoforms of adiponectin and uses thereof - Google Patents

Glycoisoforms of adiponectin and uses thereof Download PDF

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Publication number
WO2004056861A3
WO2004056861A3 PCT/IB2003/006187 IB0306187W WO2004056861A3 WO 2004056861 A3 WO2004056861 A3 WO 2004056861A3 IB 0306187 W IB0306187 W IB 0306187W WO 2004056861 A3 WO2004056861 A3 WO 2004056861A3
Authority
WO
WIPO (PCT)
Prior art keywords
adiponectin
reagents
glycoisoforms
methods
provides
Prior art date
Application number
PCT/IB2003/006187
Other languages
French (fr)
Other versions
WO2004056861A2 (en
Inventor
Garth J S Cooper
Aimin Xu
Yu Wang
Original Assignee
Protemix Corp Ltd
Garth J S Cooper
Aimin Xu
Yu Wang
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/NZ2003/000002 external-priority patent/WO2003062275A1/en
Application filed by Protemix Corp Ltd, Garth J S Cooper, Aimin Xu, Yu Wang filed Critical Protemix Corp Ltd
Priority to AU2003285686A priority Critical patent/AU2003285686A1/en
Publication of WO2004056861A2 publication Critical patent/WO2004056861A2/en
Publication of WO2004056861A3 publication Critical patent/WO2004056861A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/5759—Products of obesity genes, e.g. leptin, obese (OB), tub, fat
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • Endocrinology (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Obesity (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

The invention provides methods and reagents for regulation of metabolic events, such as those mediated by adiponectin and adiponectin agonists. The invention also provides screening assays for identification of biologically active agents, diagnostic and therapeutic agents, and other methods and reagents.
PCT/IB2003/006187 2002-12-23 2003-01-21 Glycoisoforms of adiponectin and uses thereof WO2004056861A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2003285686A AU2003285686A1 (en) 2002-12-23 2003-01-21 Glycoisoforms of adiponectin and uses thereof

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US43614802P 2002-12-23 2002-12-23
US43617802P 2002-12-23 2002-12-23
NZ52341102 2002-12-23
US60/436,178 2002-12-23
NZ523410 2002-12-23
NZ52341002 2002-12-23
NZ523411 2002-12-23
US60/436,148 2002-12-23
PCT/NZ2003/000002 WO2003062275A1 (en) 2002-01-18 2003-01-17 Glycoisoforms of adiponectin and uses thereof

Publications (2)

Publication Number Publication Date
WO2004056861A2 WO2004056861A2 (en) 2004-07-08
WO2004056861A3 true WO2004056861A3 (en) 2004-09-30

Family

ID=32686197

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2003/006187 WO2004056861A2 (en) 2002-12-23 2003-01-21 Glycoisoforms of adiponectin and uses thereof

Country Status (2)

Country Link
AU (1) AU2003285686A1 (en)
WO (1) WO2004056861A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8394992B2 (en) 2004-07-19 2013-03-12 Philera New Zealand Limited Synthesis of triethylenetetramines

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1115389B1 (en) 1998-09-25 2014-03-12 PhilERA New Zealand Limited Fructosamine oxidase: antagonists and inhibitors
DK2500018T3 (en) 2002-03-08 2017-10-02 Philera New Zealand Ltd Prevention and / or treatment of cardiovascular disease and / or associated heart failure
JP2006503014A (en) 2002-08-20 2006-01-26 プロテミックス コーポレイション リミティド Dosage forms and related treatments
EP1830873A4 (en) 2004-12-10 2008-04-02 Protemix Corp Ltd Glyponectin (glycosylated adiponectin) for the treatment of diseases and conditions
WO2006104964A2 (en) * 2005-03-28 2006-10-05 University Of Louisville Research Foundation, Inc. Inhibition of wet type age related macular degeneration (amd) by adiponectin or acrp 30
CN103041371A (en) * 2012-12-31 2013-04-17 上海市内分泌代谢病研究所 Application of adiponectin in preparing medicine for curing cerebral arterial thrombosis of old people
WO2020201195A2 (en) * 2019-04-04 2020-10-08 Bayer Aktiengesellschaft Agonists of adiponectin

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002100427A1 (en) * 2001-06-07 2002-12-19 Sankyo Company, Limited Liver generation promoter
WO2003062275A1 (en) * 2002-01-18 2003-07-31 Protemix Corporation Limited Glycoisoforms of adiponectin and uses thereof

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002100427A1 (en) * 2001-06-07 2002-12-19 Sankyo Company, Limited Liver generation promoter
WO2003062275A1 (en) * 2002-01-18 2003-07-31 Protemix Corporation Limited Glycoisoforms of adiponectin and uses thereof

Non-Patent Citations (10)

* Cited by examiner, † Cited by third party
Title
BERG A H ET AL: "The adipocyte-secreted protein Acrp30 enhances hepatic insulin action", NATURE MEDICINE, NATURE PUBLISHING, CO, US, vol. 7, no. 8, August 2001 (2001-08-01), pages 947 - 953, XP002242789, ISSN: 1078-8956 *
BERG ANDERS H ET AL: "ACRP30/adiponectin: An adipokine regulating glucose and lipid metabolism.", TRENDS IN ENDOCRINOLOGY AND METABOLISM, vol. 13, no. 2, March 2002 (2002-03-01), pages 84 - 89, XP002286670, ISSN: 1043-2760 *
COMBS TERRY P ET AL: "Endogenous glucose production is inhibited by the adipose-derived protein Acrp30", JOURNAL OF CLINICAL INVESTIGATION, vol. 108, no. 12, December 2001 (2001-12-01), pages 1875 - 1881, XP002286669, ISSN: 0021-9738 *
HOTTA K ET AL: "Circulating concentrations of the adipocyte protein adiponectin are decreased in parallel with reduced insulin sensitivity during the progression to type 2 diabetes in rhesus monkeys", DIABETES, NEW YORK, NY, US, vol. 50, no. 5, May 2001 (2001-05-01), pages 1126 - 1133, XP002970250, ISSN: 0012-1797 *
OKAMOTO Y ET AL: "ADIPOCYTE-DERIVED PLASMA PROTEIN, ADIPONECTIN, ADHERES TO INJURED VASCULAR WALLS", HORMONE AND METABOLIC RESEARCH, THIEME-STRATTON, STUTTGART, DE, vol. 32, February 2000 (2000-02-01), pages 47 - 50, XP000933764, ISSN: 0018-5043 *
SATO C ET AL: "Identification and adipocyte differentiation-dependent expression of the unique disialic acid residue in an adipose tissue-specific glycoprotein, adipo Q", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY OF BIOLOGICAL CHEMISTS, BALTIMORE, MD, US, vol. 276, no. 31, 3 August 2001 (2001-08-03), pages 28849 - 28856, XP002966354, ISSN: 0021-9258 *
SCHERER P E ET AL: "A NOVEL SERUM PROTEIN SIMILAR TO C1Q, PRODUCED EXCLUSIVELY IN ADIPOCYTES", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY OF BIOLOGICAL CHEMISTS, BALTIMORE, MD, US, vol. 270, no. 45, 1 November 1995 (1995-11-01), pages 26746 - 26749, XP000612012, ISSN: 0021-9258 *
WANG YU ET AL: "Hydroxylation and glycosylation of the four conserved lysine residues in the collagenous domain of adiponectin. Potential role in the modulation of its insulin-sensitizing activity", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY OF BIOLOGICAL CHEMISTS, BALTIMORE, MD, US, vol. 277, no. 22, 31 May 2002 (2002-05-31), pages 19521 - 19529, XP002242790, ISSN: 0021-9258 *
YAMAUCHI T ET AL: "The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity", NATURE MEDICINE, NATURE PUBLISHING, CO, US, vol. 7, no. 8, August 2001 (2001-08-01), pages 941 - 946, XP002242792, ISSN: 1078-8956 *
YANG W S ET AL: "Weight reduction increases plasma levels of an adipose-derived anti-inflammatory protein, adiponectin.", THE JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM. UNITED STATES AUG 2001, vol. 86, no. 8, August 2001 (2001-08-01), pages 3815 - 3819, XP002286668, ISSN: 0021-972X *

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8394992B2 (en) 2004-07-19 2013-03-12 Philera New Zealand Limited Synthesis of triethylenetetramines
US8912362B2 (en) 2004-07-19 2014-12-16 Philera New Zealand Limited Synthesis of triethylenetetramines
US9556123B2 (en) 2004-07-19 2017-01-31 Philera New Zealand Limited Synthesis of triethylenetetramines

Also Published As

Publication number Publication date
AU2003285686A1 (en) 2004-07-14
WO2004056861A2 (en) 2004-07-08
AU2003285686A8 (en) 2004-07-14

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