WO2004050663A3 - An improved process for the preparation of cefuroxime sodium - Google Patents

An improved process for the preparation of cefuroxime sodium Download PDF

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Publication number
WO2004050663A3
WO2004050663A3 PCT/IB2003/005563 IB0305563W WO2004050663A3 WO 2004050663 A3 WO2004050663 A3 WO 2004050663A3 IB 0305563 W IB0305563 W IB 0305563W WO 2004050663 A3 WO2004050663 A3 WO 2004050663A3
Authority
WO
WIPO (PCT)
Prior art keywords
preparation
improved process
cefuroxime sodium
sodium
cefuroxime
Prior art date
Application number
PCT/IB2003/005563
Other languages
French (fr)
Other versions
WO2004050663A2 (en
Inventor
Pandurang Balwant Deshpande
Pramod Narayan Deshpande
Bhausaheb Pandharin Khadangale
Gautam Kumar Das
John Muthiah Raja Jeyakumar
Original Assignee
Orchid Chemicals & Pharm Ltd
Pandurang Balwant Deshpande
Pramod Narayan Deshpande
Bhausaheb Pandharin Khadangale
Gautam Kumar Das
John Muthiah Raja Jeyakumar
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US10/310,068 external-priority patent/US20040092735A1/en
Application filed by Orchid Chemicals & Pharm Ltd, Pandurang Balwant Deshpande, Pramod Narayan Deshpande, Bhausaheb Pandharin Khadangale, Gautam Kumar Das, John Muthiah Raja Jeyakumar filed Critical Orchid Chemicals & Pharm Ltd
Priority to AU2003283660A priority Critical patent/AU2003283660A1/en
Publication of WO2004050663A2 publication Critical patent/WO2004050663A2/en
Publication of WO2004050663A3 publication Critical patent/WO2004050663A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Cephalosporin Compounds (AREA)

Abstract

The present invention relates to an improved process for the preparation of the sterile cefuroxime sodium of formula (I).
PCT/IB2003/005563 2002-12-05 2003-12-03 An improved process for the preparation of cefuroxime sodium WO2004050663A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2003283660A AU2003283660A1 (en) 2002-12-05 2003-12-03 An improved process for the preparation of cefuroxime sodium

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US10/310,068 2002-12-05
US10/310,068 US20040092735A1 (en) 2002-11-08 2002-12-05 Process for the preparation of cefuroxime sodium
IN219CH2003 2003-03-17
IN219/MAS/2003 2003-03-17

Publications (2)

Publication Number Publication Date
WO2004050663A2 WO2004050663A2 (en) 2004-06-17
WO2004050663A3 true WO2004050663A3 (en) 2004-10-28

Family

ID=32472234

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2003/005563 WO2004050663A2 (en) 2002-12-05 2003-12-03 An improved process for the preparation of cefuroxime sodium

Country Status (1)

Country Link
WO (1) WO2004050663A2 (en)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008132574A1 (en) * 2007-04-27 2008-11-06 Parabolic Drugs Limited Purification of cefuroxime acid
WO2008155615A2 (en) * 2007-06-18 2008-12-24 Orchid Chemicals & Pharmaceuticals Limited An improved process for the preparation of cephalosporin antibiotic
CN101475579B (en) * 2009-01-20 2011-02-09 广州白云山天心制药股份有限公司 Stable cefuroxime sodium and preparation thereof
CN102295653A (en) * 2010-06-28 2011-12-28 广州白云山制药股份有限公司广州白云山化学制药厂 One-step recovery and preparation method of cefuroxime sodium
CN101967156B (en) * 2010-09-26 2012-07-18 石药集团中诺药业（石家庄）有限公司 Method for recrystallizing cefuroxime sodium
CN102070572B (en) * 2010-12-17 2012-10-03 山东金城医药化工股份有限公司 Method for recovering and preparing furanone acid from syn-2-methoxyimino-2-(2-furayl)-acetic acid-ammonia salt waste residue
CN102702231B (en) * 2012-06-18 2014-10-29 山东大学 Method for preparing 3-descarbamoyl-cefuroxime acid
CN103044452A (en) * 2013-01-10 2013-04-17 潘行远 Preparation method of low-moisture and high-stability sterile cefuroxime sodium
CN103102357B (en) * 2013-02-21 2016-01-13 广东立国制药有限公司 A kind of synthetic method of Cefuroxime sodium
CN103819490B (en) * 2014-03-20 2016-03-30 悦康药业集团有限公司 A kind of cephalofruxin sodium compound
CN104910187A (en) * 2015-05-28 2015-09-16 浙江长典医药有限公司 Children cefuroxime sodium compound entity and preparation thereof
CN105440055B (en) * 2015-12-30 2017-11-07 广东金城金素制药有限公司 A kind of former development quality cefuroxime acid and its pharmaceutical preparation
CN108440568B (en) * 2018-04-11 2019-04-02 广东立国制药有限公司 A kind of preparation method of descarbamoyl cefuroxime
CN109988183B (en) * 2019-04-17 2020-12-08 广东立国制药有限公司 Environment-friendly preparation method of cefuroxime acid intermediate
CN111440196A (en) * 2020-05-22 2020-07-24 山东金城柯瑞化学有限公司 Method for nickel-based catalytic synthesis of 3-decarbamoyl cefuroxime acid
CN112480146B (en) * 2020-10-30 2022-02-22 浙江惠迪森药业有限公司 Cefuroxime acid mixed solvate, crystal form and preparation method
CN113788843B (en) * 2021-09-30 2022-07-19 海南海灵化学制药有限公司 Preparation process of cefuroxime sodium for injection

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1453049A (en) * 1973-08-21 1976-10-20 Glaxo Lab Ltd Cephalosporing antibiotics
US4277601A (en) * 1979-02-15 1981-07-07 Glaxo Group Limited Preparation of sodium cefuroxime
US4284767A (en) * 1978-04-07 1981-08-18 Glaxo Group Limited Process for preparing 3-carbamoyloxymethyl cephalosporins
US4775750A (en) * 1983-07-29 1988-10-04 Glaxo Group Limited Process for preparing sodium cefuroxime
WO2002020532A1 (en) * 2000-09-11 2002-03-14 Biochemie Gesellschaft M.B.H. Intermediates in cephalosporin production

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1453049A (en) * 1973-08-21 1976-10-20 Glaxo Lab Ltd Cephalosporing antibiotics
US4284767A (en) * 1978-04-07 1981-08-18 Glaxo Group Limited Process for preparing 3-carbamoyloxymethyl cephalosporins
US4277601A (en) * 1979-02-15 1981-07-07 Glaxo Group Limited Preparation of sodium cefuroxime
US4775750A (en) * 1983-07-29 1988-10-04 Glaxo Group Limited Process for preparing sodium cefuroxime
WO2002020532A1 (en) * 2000-09-11 2002-03-14 Biochemie Gesellschaft M.B.H. Intermediates in cephalosporin production

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
WILSON, E. M.: "A tale of two cephalosporins.", CHEMISTRY AND INDUSTRY, 1984, pages 217 - 221, XP001180706 *

Also Published As

Publication number Publication date
WO2004050663A2 (en) 2004-06-17

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