WO2004033655A3 - Human organic solute transporters - Google Patents

Human organic solute transporters Download PDF

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Publication number
WO2004033655A3
WO2004033655A3 PCT/US2003/032087 US0332087W WO2004033655A3 WO 2004033655 A3 WO2004033655 A3 WO 2004033655A3 US 0332087 W US0332087 W US 0332087W WO 2004033655 A3 WO2004033655 A3 WO 2004033655A3
Authority
WO
WIPO (PCT)
Prior art keywords
transporters
agents
organic solute
substrates
human organic
Prior art date
Application number
PCT/US2003/032087
Other languages
French (fr)
Other versions
WO2004033655A2 (en
Inventor
Noa Zerangue
Christopher Paddon
Original Assignee
Xenoport Inc
Noa Zerangue
Christopher Paddon
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Xenoport Inc, Noa Zerangue, Christopher Paddon filed Critical Xenoport Inc
Priority to AU2003279917A priority Critical patent/AU2003279917A1/en
Priority to US10/763,644 priority patent/US20040161424A1/en
Publication of WO2004033655A2 publication Critical patent/WO2004033655A2/en
Publication of WO2004033655A3 publication Critical patent/WO2004033655A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Peptides Or Proteins (AREA)

Abstract

The invention provides several new transporter proteins, nucleic acids encoding them and methods of using the transporters to screen agents, conjugates or conjugate moieties, linked or linkable to agents, for capacity to be transported as substrates through the transporters. The invention also provides methods of treatment involving oral delivery of agents that either alone, or as a result of linkage to a conjugate moiety, are substrates of one of the transporter.
PCT/US2003/032087 2002-10-08 2003-10-08 Human organic solute transporters WO2004033655A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
AU2003279917A AU2003279917A1 (en) 2002-10-08 2003-10-08 Human organic solute transporters
US10/763,644 US20040161424A1 (en) 2002-10-08 2004-01-22 Human organic solute transporters

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US41729802P 2002-10-08 2002-10-08
US60/417,298 2002-10-08

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US10/763,644 Continuation-In-Part US20040161424A1 (en) 2002-10-08 2004-01-22 Human organic solute transporters

Publications (2)

Publication Number Publication Date
WO2004033655A2 WO2004033655A2 (en) 2004-04-22
WO2004033655A3 true WO2004033655A3 (en) 2005-06-23

Family

ID=32093997

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2003/032087 WO2004033655A2 (en) 2002-10-08 2003-10-08 Human organic solute transporters

Country Status (2)

Country Link
AU (1) AU2003279917A1 (en)
WO (1) WO2004033655A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005075992A1 (en) * 2004-01-30 2005-08-18 Xenoport, Inc. Mct1 transporter expressed in blood brain barrier cells
WO2006001986A2 (en) * 2004-06-04 2006-01-05 Xenoport, Inc. Glut3 transporters expressed in cancer cells

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999061471A2 (en) * 1998-05-29 1999-12-02 Incyte Pharmaceuticals, Inc. Human transmembrane proteins
WO2001049728A2 (en) * 2000-01-06 2001-07-12 Protegene Inc. HUMAN PROTEINS HAVING HYDROPHOBIC DOMAINS AND DNAs ENCODING THESE PROTEINS

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999061471A2 (en) * 1998-05-29 1999-12-02 Incyte Pharmaceuticals, Inc. Human transmembrane proteins
WO2001049728A2 (en) * 2000-01-06 2001-07-12 Protegene Inc. HUMAN PROTEINS HAVING HYDROPHOBIC DOMAINS AND DNAs ENCODING THESE PROTEINS

Also Published As

Publication number Publication date
WO2004033655A2 (en) 2004-04-22
AU2003279917A8 (en) 2004-05-04
AU2003279917A1 (en) 2004-05-04

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