WO2004033431A3 - Hydroxypyrazoles for use against metabolic-related disorders - Google Patents
Hydroxypyrazoles for use against metabolic-related disorders Download PDFInfo
- Publication number
- WO2004033431A3 WO2004033431A3 PCT/US2003/031509 US0331509W WO2004033431A3 WO 2004033431 A3 WO2004033431 A3 WO 2004033431A3 US 0331509 W US0331509 W US 0331509W WO 2004033431 A3 WO2004033431 A3 WO 2004033431A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- inhibitors
- present
- compounds
- related disorders
- enhancers
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Abstract
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU2003282679A AU2003282679A1 (en) | 2002-10-04 | 2003-10-02 | Hydroxypyrazoles for use against metabolic-related disorders |
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US41619302P | 2002-10-04 | 2002-10-04 | |
US60/416,193 | 2002-10-04 | ||
US41712002P | 2002-10-07 | 2002-10-07 | |
US60/417,120 | 2002-10-07 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2004033431A2 WO2004033431A2 (en) | 2004-04-22 |
WO2004033431A3 true WO2004033431A3 (en) | 2004-07-29 |
Family
ID=32096141
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2003/031509 WO2004033431A2 (en) | 2002-10-04 | 2003-10-02 | Hydroxypyrazoles for use against metabolic-related disorders |
Country Status (2)
Country | Link |
---|---|
AU (1) | AU2003282679A1 (en) |
WO (1) | WO2004033431A2 (en) |
Cited By (3)
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US8362248B2 (en) | 2005-01-10 | 2013-01-29 | Arena Pharmaceuticals, Inc. | Substituted pyridinyl and pyrimidinyl derivatives as modulators of metabolism and the treatment of disorders related thereto |
US8410119B2 (en) | 2003-07-14 | 2013-04-02 | Arena Pharmaceuticals, Inc. | Fused-aryl and heteroaryl derivatives as modulators of metabolism and the prophylaxis and treatment of disorders related thereto |
US8933083B2 (en) | 2003-01-14 | 2015-01-13 | Arena Pharmaceuticals, Inc. | 1,2,3-trisubstituted aryl and heteroaryl derivatives as modulators of metabolism and the prophylaxis and treatment of disorders related thereto such as diabetes and hyperglycemia |
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RU2011123647A (en) | 2008-11-10 | 2012-12-20 | Вертекс Фармасьютикалз Инкорпорейтед | COMPOUNDS USEFUL AS ATR KINASE INHIBITORS |
PT3354650T (en) | 2008-12-19 | 2022-06-20 | Vertex Pharma | Compounds useful as inhibitors of atr kinase |
JP2013526540A (en) | 2010-05-12 | 2013-06-24 | バーテックス ファーマシューティカルズ インコーポレイテッド | Compounds useful as ATR kinase inhibitors |
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CN102947272A (en) | 2010-05-12 | 2013-02-27 | 沃泰克斯药物股份有限公司 | 2 -aminopyridine derivatives useful as inhibitors of atr kinase |
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MX2014003796A (en) | 2011-09-30 | 2015-01-16 | Vertex Pharma | Compounds useful as inhibitors of atr kinase. |
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US8841449B2 (en) | 2011-11-09 | 2014-09-23 | Vertex Pharmaceuticals Incorporated | Compounds useful as inhibitors of ATR kinase |
US8846917B2 (en) | 2011-11-09 | 2014-09-30 | Vertex Pharmaceuticals Incorporated | Compounds useful as inhibitors of ATR kinase |
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WO2013071090A1 (en) | 2011-11-09 | 2013-05-16 | Vertex Pharmaceuticals Incorporated | Compounds useful as inhibitors of atr kinase |
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WO2014143240A1 (en) | 2013-03-15 | 2014-09-18 | Vertex Pharmaceuticals Incorporated | Fused pyrazolopyrimidine derivatives useful as inhibitors of atr kinase |
JP6543252B2 (en) | 2013-12-06 | 2019-07-10 | バーテックス ファーマシューティカルズ インコーポレイテッドVertex Pharmaceuticals Incorporated | 2-Amino-6-fluoro-N- [5-fluoro-pyridin-3-yl] pyrazolo [1,5-a] pyrimidine-3-carboxamide compounds useful as ATR kinase inhibitors, their preparation, their different solid forms And radiolabeled derivatives |
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EP3242666A1 (en) | 2015-01-06 | 2017-11-15 | Arena Pharmaceuticals, Inc. | Methods of treating conditions related to the s1p1 receptor |
JP6838744B2 (en) | 2015-06-22 | 2021-03-03 | アリーナ ファーマシューティカルズ, インコーポレイテッド | (R) -2- (7- (4-cyclopentyl-3- (trifluoromethyl) benzyloxy) -1,2,3,4-tetrahydrocyclopenta [b] indole-for use in S1P1 receptor-related disorders Crystalline L-arginine salt of 3-yl) acetic acid (Compound 1) |
CA3000684A1 (en) | 2015-09-30 | 2017-04-06 | Vertex Pharmaceuticals Incorporated | Method for treating cancer using a combination of dna damaging agents and atr inhibitors |
KR20190116416A (en) | 2017-02-16 | 2019-10-14 | 아레나 파마슈티칼스, 인크. | Compounds and Methods for Treating Primary Bile Cholangitis |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS549279A (en) * | 1977-06-24 | 1979-01-24 | Ishihara Sangyo Kaisha Ltd | Tetrazolypyridylketone and herbicides coatining the same |
US4857542A (en) * | 1985-05-20 | 1989-08-15 | Mitsubishi Chemical Industries Limited | Prophylactic and therapeutic composition for circulatory disorders and method of treatment |
JPH0338586A (en) * | 1989-07-04 | 1991-02-19 | Nippon Soda Co Ltd | Substituted pyridine derivative, its production and herbicide |
US5183825A (en) * | 1992-04-07 | 1993-02-02 | American Home Products Corporation | 4-arylmethyl-5-alkyl-3H-pyrazol-3-ones and hypoglycemic use |
WO2001094339A1 (en) * | 2000-06-09 | 2001-12-13 | Syngenta Participations Ag | Substituted pyridine herbicides |
-
2003
- 2003-10-02 AU AU2003282679A patent/AU2003282679A1/en not_active Abandoned
- 2003-10-02 WO PCT/US2003/031509 patent/WO2004033431A2/en not_active Application Discontinuation
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS549279A (en) * | 1977-06-24 | 1979-01-24 | Ishihara Sangyo Kaisha Ltd | Tetrazolypyridylketone and herbicides coatining the same |
US4857542A (en) * | 1985-05-20 | 1989-08-15 | Mitsubishi Chemical Industries Limited | Prophylactic and therapeutic composition for circulatory disorders and method of treatment |
JPH0338586A (en) * | 1989-07-04 | 1991-02-19 | Nippon Soda Co Ltd | Substituted pyridine derivative, its production and herbicide |
US5183825A (en) * | 1992-04-07 | 1993-02-02 | American Home Products Corporation | 4-arylmethyl-5-alkyl-3H-pyrazol-3-ones and hypoglycemic use |
WO2001094339A1 (en) * | 2000-06-09 | 2001-12-13 | Syngenta Participations Ag | Substituted pyridine herbicides |
Non-Patent Citations (2)
Title |
---|
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; NISHIYAMA, RYUZO ET AL: "Pyrazolyl pyridyl ketones", XP002271467, retrieved from STN Database accession no. 90:186940 CA * |
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; UEDA, AKIYOSHI ET AL: "Preparation of pyrazolylpyridine derivatives as herbicides", XP002271466, retrieved from STN Database accession no. 115:29323 CA * |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8933083B2 (en) | 2003-01-14 | 2015-01-13 | Arena Pharmaceuticals, Inc. | 1,2,3-trisubstituted aryl and heteroaryl derivatives as modulators of metabolism and the prophylaxis and treatment of disorders related thereto such as diabetes and hyperglycemia |
US8410119B2 (en) | 2003-07-14 | 2013-04-02 | Arena Pharmaceuticals, Inc. | Fused-aryl and heteroaryl derivatives as modulators of metabolism and the prophylaxis and treatment of disorders related thereto |
US8362248B2 (en) | 2005-01-10 | 2013-01-29 | Arena Pharmaceuticals, Inc. | Substituted pyridinyl and pyrimidinyl derivatives as modulators of metabolism and the treatment of disorders related thereto |
Also Published As
Publication number | Publication date |
---|---|
AU2003282679A1 (en) | 2004-05-04 |
WO2004033431A2 (en) | 2004-04-22 |
AU2003282679A8 (en) | 2004-05-04 |
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