WO2004032844A3 - Compositions and methods for treating pain - Google Patents

Compositions and methods for treating pain Download PDF

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Publication number
WO2004032844A3
WO2004032844A3 PCT/US2003/031481 US0331481W WO2004032844A3 WO 2004032844 A3 WO2004032844 A3 WO 2004032844A3 US 0331481 W US0331481 W US 0331481W WO 2004032844 A3 WO2004032844 A3 WO 2004032844A3
Authority
WO
WIPO (PCT)
Prior art keywords
methods
treating pain
compositions
cox
antagonist
Prior art date
Application number
PCT/US2003/031481
Other languages
French (fr)
Other versions
WO2004032844A2 (en
Inventor
Stephen J Peroutka
Original Assignee
Synergia Pharma Inc
Stephen J Peroutka
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Synergia Pharma Inc, Stephen J Peroutka filed Critical Synergia Pharma Inc
Priority to AU2003275433A priority Critical patent/AU2003275433A1/en
Publication of WO2004032844A2 publication Critical patent/WO2004032844A2/en
Publication of WO2004032844A3 publication Critical patent/WO2004032844A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone

Abstract

The present invention relates to methods of treating pain in a subject in need thereof, comprising administering effective amount s of a norepinephrine ('NE') precursor and a prostaglandin ('PG') antagonist. A NE precursor can be threo-3-(3,4 dihydroxyphenyl)serine, a derivative thereof, or a pharmaceutically-acceptable salt thereof. A PG antagonist can be a cyclooxygenase (e.g., COX-1 or COX-2) inhibitor.
PCT/US2003/031481 2002-10-07 2003-10-06 Compositions and methods for treating pain WO2004032844A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2003275433A AU2003275433A1 (en) 2002-10-07 2003-10-06 Compositions and methods for treating pain

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US41626802P 2002-10-07 2002-10-07
US60/416,268 2002-10-07

Publications (2)

Publication Number Publication Date
WO2004032844A2 WO2004032844A2 (en) 2004-04-22
WO2004032844A3 true WO2004032844A3 (en) 2004-10-21

Family

ID=32093834

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2003/031481 WO2004032844A2 (en) 2002-10-07 2003-10-06 Compositions and methods for treating pain

Country Status (2)

Country Link
AU (1) AU2003275433A1 (en)
WO (1) WO2004032844A2 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060105036A1 (en) 2003-05-12 2006-05-18 Stephen Peroutka Threo-dops controlled release formulation
US8158149B2 (en) 2004-05-12 2012-04-17 Chelsea Therapeutics, Inc. Threo-DOPS controlled release formulation
CN101065014A (en) * 2004-09-23 2007-10-31 亚历山大·米哈洛 Methods for regulating neurotransmitter systems by inducing counteradaptations
ES2500053T3 (en) * 2007-03-09 2014-09-29 Chelsea Therapeutics, Inc. Pharmaceutical composition comprising droxidopa for the treatment of fibromyalgia
CA2686723A1 (en) 2007-05-07 2008-11-13 Chelsea Therapeutics, Inc. Droxidopa and pharmaceutical composition thereof for the treatment of mood disorders, sleep disorders, or attention deficit disorders
JP5880913B2 (en) 2011-05-17 2016-03-09 三郎 佐古田 Treatment for trunk symptoms (postural reflex abnormalities) in Parkinson's disease

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5616618A (en) * 1993-01-29 1997-04-01 Sumitomo Pharmaceuticals Company, Limited Threo-3-(3,4-dihydroxyphenyl)serine analgesic composition

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5616618A (en) * 1993-01-29 1997-04-01 Sumitomo Pharmaceuticals Company, Limited Threo-3-(3,4-dihydroxyphenyl)serine analgesic composition

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
KATZUNG B.G.: "Basic & Clinical Pharmacology", A LANGE MEDICAL BOOK, vol. 6TH ED., 1995, pages 312 - 314, XP002951274 *

Also Published As

Publication number Publication date
AU2003275433A1 (en) 2004-05-04
WO2004032844A2 (en) 2004-04-22
AU2003275433A8 (en) 2004-05-04

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