WO2004024128A3 - Modified release ketoprofen dosage form - Google Patents

Modified release ketoprofen dosage form Download PDF

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Publication number
WO2004024128A3
WO2004024128A3 PCT/SI2003/000033 SI0300033W WO2004024128A3 WO 2004024128 A3 WO2004024128 A3 WO 2004024128A3 SI 0300033 W SI0300033 W SI 0300033W WO 2004024128 A3 WO2004024128 A3 WO 2004024128A3
Authority
WO
WIPO (PCT)
Prior art keywords
modified release
dosage form
release
ketoprofen
release ketoprofen
Prior art date
Application number
PCT/SI2003/000033
Other languages
French (fr)
Other versions
WO2004024128A2 (en
Inventor
Judita Sirca
Milojka Mohar
Original Assignee
Lek Pharmaceuticals
Judita Sirca
Milojka Mohar
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lek Pharmaceuticals, Judita Sirca, Milojka Mohar filed Critical Lek Pharmaceuticals
Priority to AU2003261067A priority Critical patent/AU2003261067A1/en
Priority to EP03795550A priority patent/EP1539113A2/en
Publication of WO2004024128A2 publication Critical patent/WO2004024128A2/en
Publication of WO2004024128A3 publication Critical patent/WO2004024128A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5026—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5084—Mixtures of one or more drugs in different galenical forms, at least one of which being granules, microcapsules or (coated) microparticles according to A61K9/16 or A61K9/50, e.g. for obtaining a specific release pattern or for combining different drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Abstract

The present invention relates to a modified release pharmaceutical composition of ketoprofen which comprises uncoated pellets designed to an immediate release of ketoprofen, and coated pellets release designed to a delayed and prolonged release. This composition is suitable for twice daily administration.
PCT/SI2003/000033 2002-09-11 2003-09-10 Modified release ketoprofen dosage form WO2004024128A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
AU2003261067A AU2003261067A1 (en) 2002-09-11 2003-09-10 Modified release ketoprofen dosage form
EP03795550A EP1539113A2 (en) 2002-09-11 2003-09-10 Modified release ketoprofen dosage form

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SI200200220A SI21301A (en) 2002-09-11 2002-09-11 Pharmaceutical form with controlled release
SIP-200200220 2002-09-11

Publications (2)

Publication Number Publication Date
WO2004024128A2 WO2004024128A2 (en) 2004-03-25
WO2004024128A3 true WO2004024128A3 (en) 2004-07-08

Family

ID=31989658

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/SI2003/000033 WO2004024128A2 (en) 2002-09-11 2003-09-10 Modified release ketoprofen dosage form

Country Status (4)

Country Link
EP (1) EP1539113A2 (en)
AU (1) AU2003261067A1 (en)
SI (1) SI21301A (en)
WO (1) WO2004024128A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8802139B2 (en) 2003-06-26 2014-08-12 Intellipharmaceutics Corp. Proton pump-inhibitor-containing capsules which comprise subunits differently structured for a delayed release of the active ingredient

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10624858B2 (en) 2004-08-23 2020-04-21 Intellipharmaceutics Corp Controlled release composition using transition coating, and method of preparing same
ES2434072T3 (en) * 2005-06-09 2013-12-13 Norgine Bv Solid preparation of 2-hexadecyloxy-6-methyl-4H-3,1-benzoxacin-4-one
US10064828B1 (en) 2005-12-23 2018-09-04 Intellipharmaceutics Corp. Pulsed extended-pulsed and extended-pulsed pulsed drug delivery systems
KR100762847B1 (en) * 2006-01-27 2007-10-04 씨제이 주식회사 Multiple unit type sustained release oral formulation and process for the preparation thereof
CA2648280C (en) 2006-04-03 2014-03-11 Isa Odidi Controlled release delivery device comprising an organosol coat
CA2648278C (en) * 2006-04-03 2019-05-28 Isa Odidi Drug delivery composition
US10960077B2 (en) 2006-05-12 2021-03-30 Intellipharmaceutics Corp. Abuse and alcohol resistant drug composition
PE20130574A1 (en) 2010-06-16 2013-06-01 Takeda Pharmaceuticals Usa Inc NEW MODIFIED RELEASE DOSAGE FORMS OF A XANTHINE OXIDOR REDUCTASE INHIBITOR OR XANTHINE OXIDASE INHIBITORS
ES2394888B1 (en) * 2011-06-15 2013-09-23 Farmalider, S.A. PHARMACEUTICAL FORM OF MODIFIED RELEASE OF DEXKETOPROPHENE AND INHIBITOR OF THE PUMP OF PROTONS AND USE OF THE SAME.

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6144811A (en) * 1984-08-10 1986-03-04 Ss Pharmaceut Co Ltd Sustained release diclofenac sodium pharmaceutical
US4980170A (en) * 1988-06-30 1990-12-25 Klinge Pharma Gmbh Pharmaceutical formulation as well as a process for its preparation
EP0438249A1 (en) * 1990-01-15 1991-07-24 Elan Corporation Plc Controlled absorption naproxen formulation for once-daily administration
WO1999012524A1 (en) * 1997-09-11 1999-03-18 Nycomed Danmark A/S MODIFIED RELEASE MULTIPLE-UNITS COMPOSITIONS OF NON-STEROID ANTI-INFLAMMATORY DRUG SUBSTANCES (NSAIDs)
WO2000064432A1 (en) * 1999-04-22 2000-11-02 Laboratoires Des Produits Ethiques Ethypharm Ketoprofen microgranules, method for preparing same and pharmaceutical compositions

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6144811A (en) * 1984-08-10 1986-03-04 Ss Pharmaceut Co Ltd Sustained release diclofenac sodium pharmaceutical
US4980170A (en) * 1988-06-30 1990-12-25 Klinge Pharma Gmbh Pharmaceutical formulation as well as a process for its preparation
EP0438249A1 (en) * 1990-01-15 1991-07-24 Elan Corporation Plc Controlled absorption naproxen formulation for once-daily administration
WO1999012524A1 (en) * 1997-09-11 1999-03-18 Nycomed Danmark A/S MODIFIED RELEASE MULTIPLE-UNITS COMPOSITIONS OF NON-STEROID ANTI-INFLAMMATORY DRUG SUBSTANCES (NSAIDs)
WO2000064432A1 (en) * 1999-04-22 2000-11-02 Laboratoires Des Produits Ethiques Ethypharm Ketoprofen microgranules, method for preparing same and pharmaceutical compositions

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
DITTGEN M ET AL: "INFLUENCE OF THE PELLET COATING ON THE DRUG RELEASE FROM KETOPROFEN SLOW RELEASE CAPSULES", PROCEEDINGS 1ST WORLD MEETING ON PHARMACEUTICS BIOPHARMACEUTICS AND PHARMACEUTICAL TECHNOLOGY APGI-APV, vol. 1, no. 1, 9 May 1995 (1995-05-09), BUDAPEST, pages 385 - 386, XP000874017 *
EL KHODAIRY K A ET AL: "PREPARATION AND IN VITRO EVALUATION OF SLOW RELEASE KETOPROFEN MICROCAPSULES FORMULATED INTO TABLETS AND CAPSULES", JOURNAL OF MICROENCAPSULATION, TAYLOR AND FRANCIS INC. LONDON, GB, vol. 9, no. 3, 1 July 1992 (1992-07-01), pages 365 - 373, XP000276770, ISSN: 0265-2048 *
HUSSON I ET AL: "MODELLING OF DRUG RELEASE FROM PELLETS COATED WITH AN INSOLUBLE POLYMERIC MEMBRANE", JOURNAL OF CONTROLLED RELEASE, ELSEVIER SCIENCE PUBLISHERS B.V. AMSTERDAM, NL, vol. 17, no. 2, 1 October 1991 (1991-10-01), pages 163 - 173, XP000232472, ISSN: 0168-3659 *
PATENT ABSTRACTS OF JAPAN vol. 010, no. 203 (C - 360) 16 July 1986 (1986-07-16) *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8802139B2 (en) 2003-06-26 2014-08-12 Intellipharmaceutics Corp. Proton pump-inhibitor-containing capsules which comprise subunits differently structured for a delayed release of the active ingredient

Also Published As

Publication number Publication date
AU2003261067A1 (en) 2004-04-30
EP1539113A2 (en) 2005-06-15
AU2003261067A8 (en) 2004-04-30
SI21301A (en) 2004-04-30
WO2004024128A2 (en) 2004-03-25

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